Anterior cruciate ligament reconstruction in skeletally immature patients

Anterior cruciate ligament (ACL) reconstructions in skeletally immature patients present unique difficulties, one major concern being reconstruction-induced growth disturbances. Another issue is the failure of adolescent patients to comply with the treatment programs. Initially, activity limitations and bracing can be recommended for isolated ACL tears in young skeletally immature adolescents who are at stages I, II, and III according to the modified Tanner classification, and for whom reconstruction can be delayed until completion of skeletal maturity provided that any joint instability or meniscal injury do not develop. For symptomatic patients, partial or complete transphyseal techniques or complete transphyseal reconstruction with doubled or quadrupled hamstring tendon grafts can be applied, with special care being afforded to keep clear distance between fixation materials and the physeal plates. In patients who are at pubertal stages of IV or V or with skeletal ages above 13 (F) or 14 (M) years, a transphyseal reconstruction with hamstring autografts seems to be the best solution. It should be kept in mind that functional outcomes of ACL reconstructions in skeletally immature patients are inferior to those obtained in adults even after a prudent surgical approach without associated growth disturbances.     

Special considerations. Anterior cruciate ligament reconstruction in the skeletally immature

ACL injury in children is being recognized with greater frequency because of improved diagnostic techniques as well as heightened awareness of the condition. Unfortunately, the diagnosis is still missed because the attitude persists that children do not suffer ligament injuries. Hemarthrosis must be considered an indication of a significant intra-articular injury. During the past decade, ACL reconstruction has evolved to a reproducible technique with low morbidity. Aggressive rehabilitation programs allow accelerated return to activity while allowing the biology of graft maturation to progress. The basic principle of diagnosis and the treatment goals in the skeletally immature patient are the same as those in the adult patient. The diagnosis approach to ACL injury in the scholastic-age patient, however, must also include evaluation of the patient's skeletal maturity because it plays a major role in treatment decisions. Maturity is evaluated on the basis of the patient's chronologic age; various physiologic factors, such as family height, patient's projected height, and estimation of sexual development; and radiographic findings in the knee, pelvis (Risser sign), or hand and wrist (bone-age study). Because of the special characteristics of the skeletally immature patient, the orthopedic surgeon must act as "knee counselor" by attempting to identify at-risk patients, particularly those who abuse their knees for any of a variety of reasons. The nonoperative treatment principles are the same as those in an adult. Consideration of surgical treatment must take into account assessment of skeletal maturity. If questions remain about the status of the femoral and tibial physes, polytomography or MRI is used to assess the extent of physeal closure. The surgical reconstruction used reflects the patient's skeletal maturity. As the skeletal maturity threshold is reached, transphyseal reconstructions may be done with diminished reservation about causing sequelae of physeal arrest.     

Anterior cruciate ligament injury in the skeletally immature

Although ACL injuries in truly skeletally immature patients are relatively uncommon events, they are experienced more frequently than initially reported--especially in the adolescent population. Natural history data is limited but appears to mirror the natural history in adults with this injury if return to high-risk activity is allowed. Treatment of this injury presents unique challenges because of the substantial growth that occurs through the distal femoral and proximal tibial physes. The physiologic skeletal maturity of the patient must be determined prior to deciding treatment. Techniques of reconstruction include physeal sparing, partial transphyseal, and transphyseal methods. Reconstruction is recommended for any patient with an "ACL +" knee (a complete ACL tear and concomitant meniscal injury) or one who is non-compliant with a nonoperative treatment program and develops symptoms of persistent instability. Short-term outcomes of functional return postreconstruction appear promising, but study numbers are small and follow-up times relatively brief in truly immature patients. Long-term outcome studies are still needed.     

Anterior cruciate ligament injuries in the skeletally immature patient

Injuries of the anterior cruciate ligament (ACL) in children are more frequent than once thought. Special factors must be taken into consideration when treating ACL injuries in the skeletally immature patient. Risks of surgery must be weighed against potential damage to the knee caused by repeated injury. The authors prefer the use of both tibial and femoral centrally placed drill holes, hamstring tendon autografts, fixation distant from the physis, and avoidance of dissection near the physis. This technique will minimize damage to the physis and should not hinder normal growth.     

Anterior cruciate ligament injuries in the skeletally immature patient

Injuries to the anterior cruciate ligament in children and youth pose a complex clinical challenge. The literature does not provide the clinician with a well-defined natural history or pathoanatomy, nor does it show agreement as to the outcomes of various treatment choices. Decision making is made difficult by the patients' skeletal and emotional immaturity and by associated intra-articular fracture, physeal fracture, and combination injuries. In an effort to place the problem of ACL injury in children and youth into some perspective and to present an algorithm for management, this article reviews issues in its diagnosis, classification, anatomy, mechanism of injury, and management.     

Graft remodeling during growth following anterior cruciate ligament reconstruction in skeletally immature sheep

Introduction  Ruptures of the anterior cruciate ligament are being diagnosed with increasing frequency in skeletally immature individuals. It was our aim to investigate the graft remodelling process following an autologous, transphyseal reconstruction of the anterior cruciate ligament (ACL) in skeletally immature sheep. We hypothesized that the ligamentisation process in immature sheep is quicker and more complete when compared to adult sheep. Materials and methods  Skeletally immature sheep with an age of 4 months underwent a fully transphyseal ACL reconstruction using an autologous tendon. The animals were subsequently sacrificed at 3, 6, 12 and 24 weeks following surgery. Each group was characterised histomorphometrically, by immunostaining (VEGF, SMA), by transmission electron microscopy (TEM) and biomechanically (UFS Roboter). Results  The histomorphometric analysis and presence of VEGF and SMA positive cells demonstrated a rapid return to a ligament like structure. The biomechanical analysis revealed an anteroposterior translation that was still increased even 6 months following surgery. Conclusion  As in adult sheep models, the remodeling of a soft tissue graft used for ACL reconstruction results in a biomechanically inferior substitute. However, the immature tissue seems to remodel faster and more complete when compared to adults. R. Meller and G. Brandes contributed equally to this work.     

Transphyseal anterior cruciate ligament reconstruction in a skeletally immature knee using anterior tibialis allograft

Anterior cruciate ligament (ACL) injury in the skeletally immature individual is being recognized with increasing frequency. Nonoperative treatment of ACL injuries in skeletally immature patients have not been favorable. Surgical treatment options for complete ACL tears include primary ligament repair, extraarticular tenodesis, transphyseal reconstruction, partial transphyseal reconstruction, and physeal-sparing reconstruction. The advantage of transphyseal reconstruction is placement of the graft tissue in an isometric position, which provides better results, according to the literature. The potential disadvantage is angular or limb-length discrepancy caused by physeal violation. Controversy exists in allograft selection about whether bone or soft tissue passes into physes. The use of standard tunnels provides reliable results, but carries the risk of iatrogenic growth disturbance from physeal injury.This article presents 4 cases of transphyseal ACL reconstruction using anterior tibialis allograft in skeletally immature patients that had satisfactory functional outcomes with no growth disturbances. This is the first report of transphyseal ACL reconstruction using anterior tibialis allograft in skeletally immature patients in the English-speaking literature. All patients underwent transphyseal ACL reconstruction using anterior tibialis tendon allograft. None of the patients had angular deformities. No early physeal arrest was measured between the preoperative and postoperative radiographs. At last follow-up, the results of the Lachman test were normal for 3 patients and nearly normal for 1 patient. All patients demonstrated full range of knee motion (comparing the reconstructed knee to the contralateral knee). The results of the pivot-shift test were normal for 3 patients and nearly normal for 1 patient. No patients reported giving way.     

Anterior cruciate ligament reconstruction in the immature athlete: long-term results of intra-articular reconstruction.

From 1986-1992, a total of 21 ACL reconstructions were completed in 20 skeletally immature athletes with an average age of 13.7 years (range: 11.8-15.6 years). Fifteen patients underwent operative reconstruction with hamstring tendons with wide open physes and 6 patients with bone-patellar tendon-bone (BPTB). All grafts were anatomically placed through transphyseal bone tunnels in the femur and tibia. Nineteen of 20 patients (20 of 21 reconstructions) returned for follow-up at an average of 34 months (range: 17-89 months). All patients had reached skeletal maturity at follow-up. No patient had limb-length discrepancy >1 cm postoperatively. No change in tibiofemoral alignment was noted (average 4.5 versus 4.25, P=.69). Modified Lysholm score was 93/95, and 19 of 20 athletes returned to preinjury level sports activity. Ligament laxity side-to-side difference was <3 mm in 16 patients, 3-6 mm in 2 patients, and >6 mm in 2 patients. One patient developed recurrent symptomatic laxity and was lost to follow-up. Two late graft ruptures (1 hamstring and 1 BPTB graft) occurred after major reinjury during sports. In this group of patients, ACL reconstruction through bone tunnels successfully eliminated instability although the failure rate, including late graft ruptures, was higher than that usually reported for adults. No limb length or angular deformity developed as a result of the transphyseal tunnels.     

Management of anterior cruciate ligament injuries in skeletally immature individuals

Anterior cruciate ligament (ACL) injuries in skeletally immature individuals remain a challenge for the child, the parents, orthopaedic surgeons, and physical therapists. The main challenges are the potential risk of recurrent instability, secondary injuries following nonoperative treatment, and the risks involved with surgical treatment due to the vulnerability of the epiphyseal growth plates. We first present the physiological background for considerations that must be made when advising on treatment alternatives for skeletally immature individuals after ACL injury. The implications of continuous musculoskeletal development for treatment decisions are emphasized. No randomized controlled trials have been performed to investigate outcomes of different treatment algorithms. There is no consensus in the literature on clinical treatment decision criteria for whether a skeletally immature child should undergo transphyseal ACL reconstruction, physeal sparing ACL reconstruction, or nonoperative treatment. Additionally, well-described rehabilitation programs designed for either nonoperative treatment or postoperative rehabilitation have not been published. Based on the currently available evidence, we propose a treatment algorithm for the management of ACL injuries in skeletally immature individuals. Finally, we suggest directions for future prospective studies, which should include development of valid and reliable outcome measures and specific rehabilitation programs.     

Physeal sparing reconstruction of the anterior cruciate ligament in skeletally immature prepubescent children and adolescents

BACKGROUND: The management of anterior cruciate ligament injuries in skeletally immature patients is controversial. Conventional adult reconstruction techniques risk potential iatrogenic growth disturbance due to physeal damage. The purpose of this study was to evaluate the results of a physeal sparing, combined intra-articular and extra-articular reconstruction technique in prepubescent skeletally immature children. METHODS: Between 1980 and 2002, forty-four skeletally immature prepubescent children and adolescents who were in Tanner stage 1 or 2 (with a mean chronological age of 10.3 years) underwent physeal sparing, combined intraarticular and extra-articular reconstruction of the anterior cruciate ligament with use of an autogenous iliotibial band graft. Twenty-seven patients had additional meniscal surgery. Functional outcome, graft survival, radiographic outcome, and growth disturbance were evaluated at a mean of 5.3 years after surgery. RESULTS: Two patients underwent a revision reconstruction for graft failure at 4.7 and 8.3 years postoperatively. In the remaining forty-two patients, the mean International Knee Documentation subjective knee score (and standard deviation) was 96.7 +/- 6.0 points, and the mean Lysholm knee score was 95.7 +/- 6.7 points. The results of the Lachman examination for anterior cruciate ligament integrity was normal for twenty-three patients, nearly normal for eighteen patients, and abnormal for one patient. The results of the pivot-shift examination were normal for thirty-one patients and nearly normal for eleven patients. Four of the twenty-three patients who underwent concurrent meniscal repair had a repeat arthroscopic meniscal repair or partial meniscectomy. The mean growth in total height from the time of surgery to the final follow-up evaluation was 21.5 cm. No patient had an angular deformity measured radiographically or a discrepancy in the length of the lower extremities measured clinically. CONCLUSIONS: Physeal sparing, combined intra-articular and extra-articular reconstruction of the anterior cruciate ligament with use of an autogenous iliotibial band graft in skeletally immature prepubescent children and adolescents provides excellent functional outcome with a low revision rate and a minimal risk of growth disturbance.     

Anterior cruciate ligament reconstruction in an 84-year-old man

Anterior cruciate ligament (ACL) reconstruction is typically reserved for younger patients. Several recent articles have reported expanding traditional age barriers for ACL reconstruction in patients up to 62 years old. We report a case of a successful ACL reconstruction in an active 84-year-old rancher. Physiologic age is more important than chronologic age when considering ACL reconstruction.Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 17, No 1 (January), 2001: pp 70–72     

Management of anterior cruciate ligament disruptions in skeletally immature patients.

Proper treatment of anterior cruciate ligament injuries in skeletally immature patients is a highly debated topic. More aggressive surgical approaches have been explored as a consequence of the potential long-term detrimental intra-articular effects of nonoperative treatment. Concerns of growth disturbances secondary to physeal injury have been reduced as a result of various alternative surgical techniques. Estimates of the amount of growthplate disruption necessary to induce changes in osseous development have also been attempted. Ultimately, the final decision to intervene surgically is influenced by joint instability and by the patient's symptoms and compliance with nonoperative treatment. Long-term repercussions of severe intraarticular destruction with nonoperative treatment should be compared with the potential detrimental effects of surgery. If more advanced techniques are combined with an increase in clinical awareness of these risk factors, then an earlier surgical approach may be a suitable option.     

Arthroscopic treatment of an anterior cruciate ligament avulsion fracture in a skeletally immature patient

Anterior cruciate ligament injuries in skeletally immature patients usually involve tibial bony avulsion fractures rather than the midsubstance tears usually observed in adults. Several surgical techniques have been reported to provide stable fixation and avoid physeal injury in this pediatric population. The authors propose a novel, reproducible surgical technique using bioabsorbable anchors to obtain biomechanical stability and minimal physeal or articular cartilage damage.