Two new compounds from Trifolium resupinatum var. microcephalum

An investigation of CH₂Cl₂ and EtOH extracts of Trifolium resupinatum L. var. microcephalum Zoh. has led to the isolation of two new compounds characterized as 4,15-dimethyl-2-(1,2-dihydroxyethyl)-hexadecene (1) and 1-undecene-1-O-β-2′,3′,4′,6′-tetraacetyl glucopyranoside (2a). Their structures were established by 1D and 2D NMR techniques, and mass spectroscopy.     

Aromatic compounds and triterpenoidal saponins fromClematis koreana var.umbrosa

From the methanolic extract of aerial parts ofClematis koreana var.umbrosa, one new triterpenoidal saponin, 3-O-β-D-xylopyranosyl(1–3)-α-L-arabinopyranosyl oleanolic acid 28-O-α-L-rhamnopyranosyl(1–4)-β-D-glucopyranosyl(1–6)-β-D-glucopyranosyl ester, along with five known aromatic compounds and two known triterpenoidal saponins were isolated.     

Phenolic compounds on the leaves ofBetula platyphylla var.latifolia

Chemical examination ofBetula platyphylla var. latifolia afforded a novel diarylheptanoid named betulatetraol, together with a phenylpropanoid (3,4′-dihydroxypropiophenone), flavan-3-ol [(+)-catechin] and its glycosides [(+)-catechin 5-O-β-D-glucopyranoside, (+)-catechin 7-O-β-D-glucopyranoside] and two proanthocyanidins (procyanidins B-1 and B-3).     

分蘖葱头中含氮化合物的分离与鉴定

目的 研究分蘖葱头中的非挥发性成分。方法 用硅胶和凝胶柱色谱进行分离,根据理化性质和波谱特征鉴定结构。 结果 从分蘖葱头的乙酸乙酯和正丁醇萃取部分中分离得到两个含氮化合物,分别鉴定为N-反式-对羟基苯乙基香豆酰胺（I）和1,6-己内酰胺（II）。结论 化合物I和II均为首次从分蘖葱头中分离得到的单体,其中化合物II为首次从植物中分离得到的天然产物。     

Antiplasmodial activity of compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the Madagascar rain forest

Bioassay-directed separation of the butanol-soluble portion of an extract of Sloanea rhodantha (Baker) Capuron var. Rhodantha (Elaeocarpaceae) active against the drug-sensitive HB3 strain of Plasmodium falciparum led to the isolation of seven phenolic compounds, gallic acid (1), 3,5-di-O-galloylquinic acid (2), 1,6-di-O-galloyl glucopyranoside (3), 3,4,5-tri-O-galloylquinic acid (4), 1-O-eudesmoylquinic acid (5), 1,2,3,6-tetra-O-galloyl glucopyranoside (6), and 3,4,5-trimethoxyphenyl-(6'-O-galloyl)-O-b-D-glucopyranoside (7). The structure of the new compound 5 was established on the basis of interpretation of its 1D and 2D NMR spectroscopic data. Compounds 2, 3, 4, 6, and 7 showed weak inhibitory activity against the drug-sensitive HB3 and the drug-resistant FCM29 strains of P. falciparum, with IC (50) values ranging from 8.0 - 43.0 and 16.1 - 93.0 microg/mL, respectively.     

Alkaloids from Lupinus argenteus var. stenophyllus

TLC and GLC of an alkaloid extract of the aboveground portions of Lupinus argenteus Pursh. var. stenophyllus (Rydb.) Davis (Leguminosae) suggested the presence of sparteine, beta-isosparteine, delta5-dehydrolupanine, alpha-isolupanine, lupanine, thermopsine, and anagyrine. GLC-mass spectrometry confirmed these preliminary findings. Preparative TLC was used to isolate sparteine, and this alkaloid was further characterized by IR spectral analysis and derivatization.     

Sesquiterpenes from Artemisia giraldii var. longipedunculata

A phytochemical investigation on the aerial parts of Artemisia giraldii var. longipedunculata led to the isolation of 10 known sesquiterpenes, including12-hydroxy-α-cyperone (1), 1β,6α-dihydroxyeudesma-4(15)-ene (2), carainterol A (3), oplodiol (4),douglanin (5), 1α-hydroxyisodauc-4-en-15-al (6), 3α,6α-dihydroxybisabola-4,10-diene (7), 4α,5β-dihydroxybisabola-2,10-diene(8), opposit-4(15)-ene-1β,7-diol (9), and saniculamoid D (10), respectively. Their structures were elucidated by analysis of the MS and NMR spectroscopic data and comparison with the literature. All the isolates were obtained from A. giraldii var. longipedunculata for the first time, and five of them were obtained from the genus Artemisia for the first time. Additionally, the ¹³C NMR data of 1 were fully assigned based on the 2D NMR data for the first time.     

丰城鸡血藤异黄酮类化合物的分离鉴定

为建立丰城鸡血藤质量控制方法提供对照品, 对其化学成分进行了研究, 从中分离鉴定了8个化合物, 分别为丰城鸡血藤异黄酮苷F (1), 芒柄花素 (2), 芒柄花苷 (3), 奥刀拉亭7-O-β-D-吡喃葡萄糖苷 (4), 澳白檀苷 (5), 阿夫罗摩辛 (6), 圆荚草双糖苷 (7) 和丰城鸡血藤异黄酮苷B (8)。化合物1为新化合物, 化合物3～5和7为首次从本属植物中分离得到, 2为首次从本植物中分离得到。     

丰城鸡血藤黄酮类化合物的分离鉴定

目的对丰城鸡血藤Millettia nititavar.hirsutissima的化学成分进行研究。方法应用色谱技术分离纯化化合物,利用波谱技术确定化合物的结构。结果从丰城鸡血藤中分离鉴定了4个化合物,分别为甘草素(1),柚皮素(2),马卡因(3), 3R-牛角花酮(4)。结论化合物1和2为首次从本属植物中分离得到;3和4为首次从本植物中分离得到。     

Ent-kauranoids from Isodon rubescens var. taihangensis

Two new compounds, rubescensins Q and R (1 and 2), and a new acetonide derivative (3) of lasiodonin, together with thirteen known analogues, oridonin (4), ponicidin (5), wikstroemioidin B (6), lasiodonin (7), lasiokaurin (8), enmenol (9), 1-O-beta-D-glucopyranosyl-enmenol (10), trichokaurin (11), the acetonide of maoyecrystal F (12), rabdoternins A-D (13-16), have been isolated from Isodon rubescens var. taihangensis. The structures of the new compounds were elucidated on the basis of spectroscopic methods, especially the 2D NMR spectral analysis. Compound 3 exhibited cytotoxicity against K562, Bcap37, CA, CNE, BIU87, BGC823, and HeLa cell lines.     

Phytotoxic arylethylamides from limnic bacteria using a screening with microalgae

N-Phenylethylamides 1a-1f, were isolated from cultures of three limnic strains GW90a, GW102a and GW73a. Strain GW102a delivered additionally the compound cyclo(isoleucyldehydroalanyl) (2). The structure of these compounds were assigned by a detailed spectral analysis. Due to their potential use as herbicides, various related compounds 1a, 3, 4a and 4b were synthesized. The minimum inhibitory concentration (MIC) against Chlorella vulgaris, Chlorella sorokiniana, Chlorella salina and Scenedesmus subspicatus ranged from 100 to 12.5 microg/ml. All these amides were found to be inactive against Mucor miehei, Candida albicans, and some bacteria.     

New pseudoguaianolides from Gaillardia megapotamica var. scabiosoides

The aerial parts of Gaillardia megapotamica var. scabiosoides afforded known pseudoguaianolides and three new ones. Furthermore, a new guaianolide and an acetylenic sulfoxide were isolated.     

Antibacterial diterpenoids from Fabiana densa var. ramulosa

A biologically monitored fractionation of the resinous exudate of Fabiana densa Remy var. ramulosa Wedd. led to the isolation of the two new diterpenes: ent-beyer-15-en-18-O-succinate and ent-beyer-15-en-18-O-oxalate as the unique compounds responsible for the observed antibacterial activity of this extract. Their structures were determined by 1D and 2D NMR spectroscopy.