Matrix可脱弹簧圈栓塞治疗颅内动脉瘤

目的　探讨Matrix可脱弹簧圈血管内栓塞治疗颅内动脉瘤的临床价值。方法　对 5 1例共 5 6枚颅内动脉瘤施行血管内Matrix可脱弹簧圈栓塞治疗 ,5 1例患者按Hunt Hess分级 :Ⅰ级 15例、Ⅱ级 2 4例、Ⅲ级 8例、Ⅳ级 4例 ,所有病例均经CT扫描和DSA造影诊断。 4例宽颈动脉瘤和 2例梭形动脉瘤采用Neuroform支架结合Matrix可脱弹簧圈栓塞治疗。结果　应用Matrix可脱弹簧圈栓塞成功 4 8例 5 3枚动脉瘤 ,占 94 .3% ;3例因严重血管痉挛导致微导管无法到位而实施动脉瘤夹闭术 ;1例弹簧圈尾端残留于载瘤动脉 ,但未导致临床后果 ;无死亡及严重并发症 ;4 8例随访 3～ 12个月无再次出血和并发症。结论　Matrix可脱弹簧圈血管内能够有效栓塞颅内各部位动脉瘤 ,术中有明显的促进动脉瘤腔内形成血栓的作用 ,术后促进血管内皮细胞生长覆盖动脉瘤颈口的作用。可以防止再次破裂出血。     

电解可脱卸弹簧圈栓塞颅内动脉瘤术中出血的原因和防治

目的　分析颅内动脉瘤电解可脱卸弹簧圈 (GDC)栓塞治疗术中动脉瘤破裂的原因和防治对策。方法　 178例颅内动脉瘤患者采用GDC栓塞治疗。 6例GDC栓塞过程中出血 ,立即中和肝素 ,并继续栓塞止血。 1例为术后CT证实的出血。术后对症治疗。结果　 7例术中破裂者中 5例致密栓塞 ,<90 %栓塞 2例。 4例恢复好 ,1例轻残 ,2例术后 1周死于颅内高压。结论　GDC栓塞颅内动脉瘤发生术中出血与术中操作、动脉瘤以及患者血管条件有关 ,继续栓塞可以挽救大部分患者的生命     

Matrix可脱弹簧圈栓塞治疗颅内动脉瘤的临床应用

目的探讨Matrix可脱弹簧圈血管内栓塞治疗颅内动脉瘤的临床价值。方法对56例共61个颅内动脉瘤施行血管内Matrix可脱弹簧圈栓塞治疗,4例宽颈动脉瘤和2例梭形动脉瘤采用Neuroform支架结合Matrix可脱弹簧圈栓塞治疗。结果应用Matrix可脱弹簧圈栓塞成功53例58个动脉瘤,占95.1%;3例因严重血管痉挛导致微导管无法到位而实施动脉瘤夹闭术;2例弹簧圈尾端残留于载瘤动脉,但未导致临床后果;无死亡及严重并发症;53例随访3～12个月无再次出血和并发症。结论Matrix可脱弹簧圈可有效栓塞颅内各部位动脉瘤,术中有明显的促进动脉瘤腔内形成血栓的作用,可以防止再次破裂出血。     

可脱微弹簧圈栓塞术治疗颅内动脉瘤

目的 探讨颅内动脉瘤可脱微弹簧圈栓塞治疗术的效果。方法 经股动脉Seldinger穿刺法,将导引管送至C2以上,将微导管置于动脉瘤腔,结合不同的方式,进行可脱微弹簧圈栓塞动脉瘤。结果 36例用GDC,6例Metrix,18例DCS,2例ORBIT,3例EDC,4例配合支架栓塞;65例患者,59例康复,3例后遗偏瘫,1例自动出院,5例死亡。59例随访,头颅平片GDC均在瘤腔,无再出血,5例患者复查DSA,无复发。结论 微弹簧圈栓塞是治疗颅内动脉瘤微创有效安全的方法。     

电解可脱卸弹簧圈栓塞治疗颅内动脉瘤

目的　探讨电解可脱卸弹簧圈 (Guglielmidetachablecoil,GDC)栓塞治疗颅内动脉瘤的方法及效果。方法　颅内动脉瘤患者 11例 ,其中男 5例 ,女 6例 ,年龄 2 3～ 6 5岁。颈内动脉瘤 4例 ,后交通支动脉瘤 4例 ,前交通支动脉瘤 3例 ,动脉瘤直径最小为 4mm ,最大为 2 3mm ,所有患者均采用GDC材料进行栓塞。结果　 10 0 %栓塞 7例 ,90 %～ 99%栓塞 3例 ,70 %～ 90 %栓塞 1例 ,术后临床随访 1～ 12个月 ,无一例再出血。结论　血管内栓塞治疗动脉瘤是一种安全、微创、有效的治疗方法 ,使用GDC栓塞材料操作方便、手术并发症少。     

GDC血管内栓塞治疗颅内动脉瘤

目的 探讨电解可脱性弹簧圈（GDC）血管内栓塞治疗颅内动脉瘤的疗效和技术要点。方法 对31例动脉瘤患者应用微导管技术,通过数字减影全脑血管造影,采用GDC作动脉瘤囊内填塞治疗。结果 31例31枚动脉瘤中28枚瘤腔完全闭塞,3枚95％闭塞。术后30例临床痊愈;1例死亡;病死率3．2％。术中并发动脉瘤再破裂出血1例;术后弹簧圈末端逸出1例。术后随访0．5～3年均无再出血。结论 GDC血管内栓塞治疗颅内动脉瘤疗效可靠,早期栓塞及有效的术后处理是提高治愈率的重要方法。     

电解铂金微弹簧圈栓塞治疗颅内动脉瘤中并发症原因及防治

目的探讨电解铂金弹簧圈(GDC)栓塞治疗颅内囊状动脉瘤术中并发症及防治。方法对162例患者171枚颅内动脉瘤栓塞中出现9例并发症,其中5例动脉瘤破裂出血,立即中和肝素继续栓塞,2例GDC脱出动脉瘤立即手术取出,动脉瘤夹闭,2例血栓形成,术中溶栓,术后均采用腰穿置管持续引流,解痉及对症处理。结果5例恢复良好,2例永久性轻度功能障碍,2例死亡。结论GDC栓塞颅内动脉瘤术中发生并发症与手术操作,动脉瘤患者血管条件有关。     

电解可脱性弹簧圈栓塞颅内动脉瘤的体会

目的　评价电解可脱性弹簧圈栓塞 (GDC)治疗颅内动脉瘤的疗效并总结GDC的操作要点。方法　DSA检查 32例 ,发现颅内动脉瘤共 34枚 ,其中前交通动脉瘤 16枚 ,后交通动脉瘤 14枚 ,大脑中动脉动脉瘤 2枚 ,大脑后动脉 ,眼动脉各 1枚。随后用GDC进行栓塞治疗。结果　 32例 (34枚 )颅内动脉瘤栓塞成功 ,其中完全致密栓塞 (瘤颈完全封闭 ) 2 0例 ,部分栓塞 (瘤体、瘤颈可见残余 ) 12例。并发动脉瘤破裂 1例 ,治疗后痊愈。并发脑血管痉挛 2例 ,治疗后 1例遗留轻偏瘫。术后 1年内随访 6例 7枚动脉瘤 ,无明显变化。结论　GDC栓塞治疗颅内动脉瘤是一种安全可靠、有效的治疗方法 ,术者的操作技术及对并发症的正常处理是影响手术成败的重要因素 ,对部分栓塞者有必要随访观察。     

电解可脱式弹簧圈栓塞治疗颅内动脉瘤破裂

目的　探讨血管内电解可脱式铂金微弹簧圈 (GDC)早期栓塞治疗破裂后颅内动脉瘤的临床价值。方法　对 15例破裂后颅内动脉瘤施行血管内GDC早期栓塞治疗 ,15例患者按Hunt Hess分级 :I级 8例、II级 6例、IV级 1例 ,所有病例均经DSA造影和CT扫描诊断。结果　GDC栓塞手术成功13例 ,占 86 .7% (13/ 15 ) ;13例随访 3～ 2 5个月无再次出血和并发症 ,其中 2例 6个月后复查DSA未见复发 ,全部病例头颅正侧位片显示GDC形态、位置无改变 ;栓塞手术失败的 2例患者分别于术后第 4天和 4个月死亡。结论　早期GDC血管内栓塞治疗破裂后颅内动脉瘤为有效方法 ,可以防止再次破裂出血。     

电解可脱性弹簧圈栓塞颅内动脉瘤相关问题的探讨

目的　总结使用电解可脱性弹簧圈 (GDC)栓塞颅内动脉瘤时旋转DSA的应用及GDC操作要点。方法　对 38例共 4 0个颅内动脉瘤常规行旋转DSA检查 ,动脉瘤直径 4～ 2 5mm ,平均(12 5 1± 5 37)mm。瘤体直径 <12mm的小动脉瘤 2 9个 ,12～ 2 5mm的大动脉瘤 11个。术前Hunt Hess分级Ⅰ～Ⅳ级分别是 2 6例、8例、3例、1例。随后使用GDC栓塞治疗。结果　 37例 39个颅内动脉瘤栓塞成功 ,1例死亡。完全栓塞 (>95 % ) 2 2个 ,大部分栓塞 (80 %～ 95 % ) 12个 ,部分栓塞(<79% ) 5个。并发动脉瘤破裂 2例 ,治疗后痊愈。并发脑动脉痉挛 6例 ,治疗后 2例遗留轻偏瘫和单瘫。 2例弹簧圈部分遗留于动脉瘤外 ,经抗凝治疗未发生并发症。 2例复发再次栓塞后痊愈。结论GDC栓塞治疗颅内动脉瘤是 1种安全、可靠、有效的治疗方法。合理应用旋转DSA技术、熟练的GDC操作可提高诊断的准确性及治疗的安全性     

Guglielmi detachable coils versus matrix coils: a comparison of the immediate posttreatment results of the embolization of 364 cerebral aneurysms in 307 patients: a single-center, single-surgeon experience

BACKGROUND: Matrix coils are based on Gugliemi detachable coils (GDC) but are covered with polyglycolic/polylactic acid. We present our experience regarding the immediate posttreatment results of aneurysm embolization using the 2 coil systems. PATIENTS: We embolized 219 aneurysms in 187 patients with the use of GDCs and 145 aneurysms in 120 patients with the use of Matrix coils. Age, sex distribution, unruptured aneurysm cases, and multiple aneurysm cases were similar in the 2 groups. The percentage of patients in severe clinical condition was significantly higher in the Matrix group. The mean aneurysm size was slightly larger in the GDC group but the mean neck size was larger in the Matrix group. RESULTS: Satisfactory occlusion (at least 90%) was achieved in 95.9% of GDC-treated aneurysms and in 98.6% of Matrix-treated aneurysms. Procedure-related complications occurred in 19.6% of GDC procedures and in 15.6% of the Matrix ones resulting in procedure-related mortality and morbidity of 3.7% and 2.7% for the GDC group and 2.5% and 1.7% for the Matrix group. In the GDC group, outcome was good (modified Rankin Scale 0-2) in 92.6% of patients with unruptured aneurysms, in 82.6% of patients with Hunt and Hess grade I-III, and in 20.5% of those with Hunt and Hess grade of IV-V. The respective figures were 95%, 85.7%, and 22.7% in the Matrix group. CONCLUSION: In our series, Matrix coils have yielded slightly better results regarding satisfactory occlusion rate and clinical outcome but these differences are not statistically significant and probably reflect our increased experience in aneurysm embolization during the period we used Matrix coils.     

Comparison of platinum and first-generation Matrix coils in under-packed canine side-wall aneurysms: evaluation of progressive thrombosis

Introduction There is much speculation in reference to the occurrence and mechanisms of progressive aneurysm occlusion after treatment with bioactive coils. However, to our knowledge, there are no studies documenting the impact on progressive occlusion in aneurysms that are intentionally under-packed. Methods A total of 24 experimental side-wall aneurysms were created in canine common carotid arteries. Of these 24, 9 were treated with Guglielmi detachable coils (GDC) and 15 with first-generation Matrix (Matrix1) coils to packing densities of 22% or less. Angiograms were obtained immediately after treatment and again at the time of explant at 2 weeks, 8 weeks, or 12 weeks, and were graded utilizing the Raymond scale. At the time of the final angiography and explant all aneurysms were histologically processed and evaluated. Results At the conclusion of initial coiling, near or complete occlusion was achieved in 7 of the 15 aneurysms (47%) treated with Matrix1 coils and in 2 of the 9 (22%) treated with GDC. Of the aneurysms that were incompletely occluded, six of eight (75%) treated with Matrix1 coils and two of seven (29%) treated with GDC showed progressive thrombosis at explant. Histopathological analysis demonstrated that the aneurysms treated with Matrix1 coils had increased fibrocellular tissue and inflammation, with less histological recanalization or vascular spaces, relative to those treated with GDC. Conclusion Experimental wide-necked side-wall canine aneurysms suboptimally treated with first-generation Matrix1 coils had a higher incidence of progressive occlusion and on histological analysis showed evidence of more advanced thrombus organization than did those treated with GDC.     

Long-term results with Matrix coils vs. GDC: an angiographic and histopathological comparison

INTRODUCTION: The aim of the study was to compare standard platinum Guglielmi detachable coils (GDC) with coated platinum coils (Matrix; both Boston Scientific, Fremont, CA) regarding handling, complications, occlusion and recanalization rate after 3 and 6A months. METHODS: Aneurysms in the right common carotid artery were created in 25 rabbits. The animals were divided into five groups of five animals each. The animals of group 1 (the control group) received no treatment of the induced aneurysms, the animals of groups 2 and 3 (killed at 3 and 6A months) were treated with standard GDC, and the animals of groups 4 and 5 (killed at 3 and 6A months) were treated with Matrix coils. RESULTS: Histopathological evaluation showed organized thrombus formation and connective tissue with neovascularization around the implanted coils in all the treated groups. The achieved occlusion rates in groups 2 and 3 were identical to those in groups 4 and 5. Thus the long-term results of aneurysm treatment with GDC and Matrix coils show no differences regarding occlusion and recanalization rates. The only noticeable difference was the difference in handling. More force was required to pushing the Matrix coils forward through the microcatheter and there was more friction in coil interaction in the aneurysm. CONCLUSION: The bioactive coating of the Matrix coil produces no significant benefit in achieving higher occlusion and lower recanalization rates, and the coil is more difficult to handle. Future bioactive coils must be shown to produce significantly better long-term results than GDC and their ease of handling has to be improved.     

Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils

Introduction  It is claimed that bioactive coils induce accelerated and more durable aneurysm healing. Data supporting this claim are quite limited. Our purpose was to compare the angiographic and histological results obtained following treatment with different coil types. Methods  Bifurcation type aneurysms were surgically created in 24 dogs and treated using standard clinical techniques. Eight were treated with Guglielmi detachable coils (GDC), eight with first-generation Matrix coils, and eight with a combination of GDC and Matrix coils. The aneurysms were explanted and final angiographic evaluations performed 12 weeks after treatment. Angiographic and histological outcomes were documented. Results  Increased coil compaction with aneurysm recurrence was found in aneurysms treated with first-generation Matrix coils as compared to standard GDC (P = 0.0001). In aneurysms treated with first-generation Matrix coils thrombus organization was better than in those treated with either standard GDC coils (P = 0.008) or with a combination of GDC and Matrix coils (P = 0.04). In aneurysms treated with first-generation Matrix coils there were no endothelialized vascular clefts within the coil mass, but they were seen in the majority of aneurysms treated with GDC or a combination of GDC and Matrix coils (P = 0.003). Conclusion  Aneurysms treated with first-generation Matrix coils showed the greatest degree of coil compaction and aneurysm recurrence on the final angiographic evaluation. Aneurysms treated with first-generation Matrix coils showed enhanced thrombus organization and absence of vascular clefts at the aneurysm neck that were markedly different from those treated with bare platinum coils or a combination of GDC and Matrix coils.

Packing performance of GDC 360 degrees coils in intracranial aneurysms: a comparison with complex orbit coils and helical GDC 10 coils

BACKGROUND AND PURPOSE: The purpose of this study was to compare obtained packing densities of aneurysms treated with the newly introduced GDC 360 degrees coils with packing densities of aneurysms treated with either complex Orbit/Trufill coils or helical GDC 10 coils. PATIENTS AND METHODS: Twenty-two aneurysms in 20 patients were coiled with GDC 360 degrees coils. For each of the 22 aneurysms coiled with GDC 360 degrees coils, 2 volume-matched controls treated with either complex Orbit/Trufill coils or helical GDC coils were identified from our data base. The packing of these matched controls was compared with the calculated packing of the 22 aneurysms treated with GDC 360 degrees coils. RESULTS: There was no difference in mean aneurysm volume between aneurysms treated with any of the 3 types of coils (P = .9). Mean packing of 22.1% of aneurysms treated with GDC 360 degrees coils was significantly lower than mean packing of 30.3% of aneurysms treated with complex Orbit/Trufill coils (P = .0015). Mean packing of 22.1% of aneurysms treated with GDC 360 degrees coils was not different from mean packing of 21.6% of aneurysms treated with helical GDC 10 coils (P = .81). CONCLUSION: The use of complex-shaped GDC 360 degrees coils does not lead to increased packing in comparison with that of helical GDC 10 coils. The use of complex Orbit/Trufill coils results in significantly higher packing than that of both GDC 360 degrees coils and helical GDC 10 coils.     

可脱性微弹簧圈栓塞治疗脑动脉瘤(附86例报道)

为探讨应用可脱性弹簧圈（ＭＤＳ或ＧＤＣ）栓塞脑动脉瘤的效果和经验,在神经安定麻醉和全身肝素化条件下,采用可脱性弹簧圈经Ｍａｇ３Ｆ／２Ｆ或Ｔｒａｃｋｅｒ－１０微导管对８６例脑动脉瘤病人进行栓塞治疗,其中ＭＤＳ栓塞５４例６０个动脉瘤。ＧＤＣ栓塞３２例３８个动脉瘤。治疗结果：成功栓塞９４个动脉瘤,其中１００％闭塞６４个,９５－９８％闭１６个,９０－９５％闭塞８个,８０－９０％闭塞６个。４个动脉瘤未栓塞成     

Assessment of Matrix coils in a canine model of a large bifurcation aneurysm

Introduction Controversy exists as to whether Matrix coils are an improvement over bare platinum coils in preventing aneurysm recanalization in endosaccularly coiled large aneurysms. We investigated Matrix coils in a dog model of a wide-necked large bifurcation aneurysm. Methods Six experimental aneurysms were created in dogs and these aneurysms were endosaccularly coiled with 100% Matrix coils. Angiographic and histopathological data were analyzed at 2 weeks and at 3 months. Results Average aneurysm dimensions were length 17.8 mm, width 8.3 mm, and neck 6.2 mm. Aneurysm coil filling ranged 24.1–41.8% by volume. At 14 days, three of six Matrix-treated aneurysms showed coil compaction and aneurysm recanalization. At 3 months, one additional Matrix-treated aneurysm showed delayed coil compaction and aneurysm recanalization. At 3 months, in three harvested aneurysms, the average measured neck neointima was 0.150 ± 0.14 mm. However, in two of the three aneurysms harvested at 3 months, aneurysm recanalization had occurred with neointimal tissue not completely covering the aneurysm orifice. Thick connective fibrous intercoil tissue was observed. No immediate or delayed thrombus formation had occurred. Conclusion Based on limited data in an experimental bifurcation aneurysm in dogs, Matrix coils appear to induce a thicker aneurysm neck neointima tissue and intercoil granulation response but appear prone to coil compaction and aneurysm recanalization. Modifications to the Matrix coil are likely needed to improve angiographic results in large aneurysms.     

经血管治疗颅内动脉瘤：可脱性弹簧（GDC）的临床应用

目的：评价可脱性弹簧（ＧＤＣ）栓塞颅内动脉瘤的临床效果。材料和方法：对３２例临床表现为急性蛛网膜下腔出血、颅内占位、颅神经压迫、癫痫，并经影像学证实的颅内动脉瘤患者，经血管途径用ＧＤＣ栓塞动脉瘤腔，分别在栓塞后当时，１周，３个月，６个月，１２个月后随访血管造影，观察栓塞效果和临床情况。结果：３２只动脉瘤中，获完全栓塞１８例（５６％）．部分栓塞１２例（３８％）．２例手术失败（４％）。手术并发症７例，其中４例脑内动脉血栓，１例动脉瘤破裂，２例术后５天死亡。２例部分栓塞患者术后６个月随访血管造影示残留腔扩大行第二次栓塞。存在临床症状的所有患者经治疗后临床症状改善。结论：ＧＤＣ可控性好，可靠性、安全性强，是目前经血管治疗颅内动脉瘤的较为成熟的材料。