输尿管炎性肌纤维母细胞瘤一例报告

炎性肌纤维母细胞瘤是一种间叶组织肿瘤,好发于全身各部位,但输尿管少见。其临床表现和影像学检查缺乏特异性,确诊需依靠病理检查,治疗以手术切除为主,预后良好。本文报告1例输尿管炎性肌纤维母细胞瘤患者,全麻下接受输尿管节段性切除术+输尿管皮肤造口术,疗效良好。     

肾炎性肌纤维母细胞瘤1例

正患者,男,68岁,因"左腰部疼痛2周,血尿4 d"于2016年10月19日收治我院。患者2周前于劳累后出现左腰部疼痛,休息后缓解,4 d后无明显诱因出现间断无痛性肉眼血尿,呈淡红色,尿中无血凝块及腐肉组织,无尿频、尿急、尿痛,院外B超示:左肾下极探及一低回声包块,实性为主,大小约7.0 cm×6.2 cm,形态欠规整,建议进一步检查,遂于我科就诊。患者有吸烟史35年,无放化疗史。实验室检查:血常规:Hb 113 g/L,尿常规:红细胞+     

肝巨大炎性肌纤维母细胞瘤伴出血1例报告

肝炎性肌纤维母细胞瘤是一种罕见的肝脏肿瘤,我科收治1例。报告如下。病人女性,53岁。因上腹部胀痛1d于2011-01-16急诊来我院。入院查体:神情、贫血貌,上腹部膨隆,全腹部压痛阳性,尤以剑突下压痛明显,上腹部可触及一质硬包块,移动度差,行腹腔穿刺抽出不凝血。既往健康,无肝炎     

膀胱炎性肌纤维母细胞瘤一例

正病人,男性,38岁。因肉眼血尿伴尿痛2个月,加重伴排尿困难2天,于2018年11月13日急诊入院。2个月前无明显诱因出现全程血尿伴尿痛,尿液淡红色,无血块,曾自服中药治疗,未见明显缓解。2天前出现排尿困难,尿液呈鲜红色,有血块。体格检查:尿道口滴血,膀胱区明显膨隆,扪及直径约10 cm质硬肿物。既往体健,吸烟20余年,20支/天。查血常规:红细胞计数:2. 51×1012/L,血红蛋白:73 g/L,尿素氮:56. 61mmol/L,血肌酐:2709. 34μmol/L,血钾:6. 1 mmol/L。腹部CT平扫提示膀胱偏     

脾脏炎性肌纤维母细胞瘤一例

患者,女,34岁,因体检发现脾脏占位20余天入院。体格检查:体表未触及明显肿大淋巴结,腹平软,无压痛及反跳痛,肝脾肋下未触及。实验室检查:血常规和肝肾功能正常。腹部CT示肿块呈低密度单发灶,边界清楚,动脉期未见明显强化,与增强的脾实质形成强烈对比,静脉期有较轻度不     

泌尿系炎性肌纤维母细胞瘤二例报告并文献复习

目的 提高对泌尿系炎性肌纤维母细胞瘤的认识.方法 分析2例泌尿系炎性肌纤维母细胞瘤患者资料并复习文献.例1,女,50岁.主诉尿痛、排尿困难2个月,B超、膀胱镜检示右侧输尿管口肿物直径约3 cm.例2,男,63岁.主诉无痛性肉眼血尿2 d,B超、膀胱镜检见膀胱三角区实性占位,直径约7 cm.结果 2例肿瘤均完整切除.例1标本光镜下见肿瘤细胞多呈长梭形,平行排列,核分裂象少见,未见病理性核分裂象,有散在炎细胞浸润,免疫组化染色示MyoD1(-),SMA(+),Vimentin(+),诊断为输尿管炎性肌纤维母细胞瘤.例2标本光镜下见肿瘤细胞呈长梭形,核仁嗜碱性,未见病理性核分裂象,间质中有散在的炎细胞浸润,少量梭形细胞明显侵蚀平滑肌束,免疫组化染色示CD34(+),MyoD1(+),符合膀胱炎性肌纤维母细胞瘤诊断.术后每3个月复查膀胱镜,例1随诊6个月,例2随诊2年,均未见复发.结论泌尿系炎性肌纤维母细胞瘤是一种特殊类型的炎性假瘤,本质上是一种良性肿瘤,临床诊断困难,治疗以手术切除为主,术后应加强随访.     

脾脏炎性肌纤维母细胞瘤二例诊治分析

目的 探讨脾脏炎性肌纤维母细胞瘤（splenicinflammatorymyofibroblastictumor,SIMT）的临床、CT、病理学表现及治疗与预后。方法 回顾性分析2例SIMT的临床资料并复习文献。结果 2例临床主要表现为左上/中腹部隐痛不适,查体左腹部轻度压痛,1例触及质韧肿块。CT均表现为脾脏单发低密度肿块,边界较清晰,增强轻至中度渐进式不均匀强化,未见周边侵犯、腹腔积液及肿大淋巴结。2例均经脾切除完整切除病灶,病理学显示肿瘤由增生的梭形细胞、慢性炎细胞及胶原纤维组成;免疫组化Vimentin、SMA、CD8及CD30（+）。术后分别随访19个月及32个月,未见复发及转移。结论 SIMT罕见,临床及CT表现缺乏特异性,最终需病理学确诊。脾脏切除术可以达到根治切除的目的,由于少数IMT术后可复发,极少数可发生转移,术后一般需长期随访。     

膀胱炎性肌纤维母细胞瘤10例临床分析

目的通过对膀胱炎性肌纤维母细胞瘤的诊断、治疗分析,提高对该病的认识。方法选取2010-01—2019-01间在郑州大学第一附属医院确诊为膀胱炎性肌纤维母细胞瘤的10例患者,对其临床资料和定期随访结果进行回顾性分析。结果本组患者均成功完成手术治疗,血尿在术后2天内消失,术后未见明显并发症,均好转出院。住院时间为6~11 d。术后病理肉眼所见为灰黄灰红组织,切面灰白色,质中到硬,免疫组化间变性淋巴瘤激酶ALK(+)(8例、80%)、波形蛋白Vimentin(+)(10例、100%)、平滑肌抗体SMA(+)(7例、70%)、细胞角蛋白CK(+)(8例、80%),确诊为膀胱炎性肌纤维母细胞瘤。术后随访平均37个月(6个月~96个月),未见复发及转移病例。结论膀胱炎性肌纤维母细胞瘤易与膀胱恶性肿瘤混淆,主要依据病理及免疫组化确诊,完整切除手术是有效的治疗方法。     

膀胱炎性肌纤维母细胞瘤1例

患者,女,47岁。因“尿频、尿痛12天”于2008年5月4日入院。体检：双肾区无隆起和叩痛,双侧输尿管移行区无压痛;耻骨上区无膨隆及压痛;双侧腹股沟淋巴结不大。膀胱镜检查见膀胱肿瘤;B超示膀胱实质占位性病变;盆腔CT平扫加增强示膀胱占位性病变。入院后5天在硬麻下行膀胱部分切除术。术中见膀胱底部黏膜组织呈滤泡样隆起,直径约3Cm。其中心占位明显突出,质硬,     

Retroperitoneal inflammatory myofibroblastic tumor

Inflammatory myofibroblastic tumors are rare, and those located retroperitoneally are even rarer. The authors present the case of a 52-year-old male farmer with a lump in the lower abdomen of 2 months in duration that was retroperitoneal in location. It was excised, and histopathologic examination revealed an inflammatory myofibroblastic tumor. The present case is presented by virtue of its rare location.     

泌尿系统炎性肌纤维母细胞瘤的CT影像学特征分析

目的 探讨泌尿系统炎性肌纤维母细胞瘤(inflammatory myofibroblastic tumor,IMT)的CT影像学特征,以提高诊断水平. 方法 回顾性分析2003年8月至2010年9月经手术病理证实的8例IMT患者资料.女6例,男2例.年龄13 ～62岁,平均35岁.临床主要表现为血尿、尿痛等.病程2周～5个月.病变位于膀胱5例,输尿管2例,尿道1例.行CT平扫检查8例,多期增强扫描5例,观察分析影像学表现特征. 结果 CT平扫5例膀胱病变呈菜花样或类圆形软组织肿物,密度均匀或不均匀或伴有坏死,CT值11.5 ～36.0 HU,可伴有邻近膀胱壁增厚及周围脂肪间隙模糊;2例输尿管病变均呈边缘光滑的实性肿物,密度均匀并与肌肉等密度,CT值40.3 HU;1例尿道病变呈境界较清的肿物伴有钙化,密度稍低不均匀,CT值17.5～22.6 HU.增强扫描肿瘤动脉期呈均匀或不均匀轻到中度强化,延迟期持续性明显强化,CT值102.7～118.6 HU. 结论 CT影像学特征特别是延迟期强化明显而持久能为泌尿系统IMT的诊断提供重要的信息.     

An inflammatory myofibroblastic tumor of the nasal dorsum

Inflammatory myofibroblastic tumor of the nose is an uncommon benign proliferative lesion that clinically mimics a neoplastic process. Our case arose in a 4-year-old girl presenting with a mass in the nasal dorsum. The mass was completely excised without any difficulty under general anesthesia. This tumor is a localized and completely benign lesion. Surgical resection is proper management for this condition.     

Abdominal inflammatory myofibroblastic tumor a clinicopathologic study with reappraisal of biologic behavior

Background and Purpose

Inflammatory myofibroblastic tumor (IMT) is a proliferative lesion of controversial nosology and uncertain prognosis. In an attempt to acquire further understanding of pathogenesis and biologic behavior, we surveyed abdominal IMTs managed over the last 12 years at a single institution.

Methods

Intra-abdominal IMTs treated between 1995 and 2007 were reviewed concerning demographic, clinical, and pathologic features as well as therapeutic management and outcome. All specimens were reevaluated by histologic examination and immunohistochemistry.

Results

There were 7 patients (4 males; age range, 28 days to 14 years). Five lesions were located in alimentary tract: 1 gastric presenting with bleeding, 1 hepatic presenting with a thoracic wall mass, 1 pancreatic and 2 colonic presenting with obstructive symptoms. One splenic IMT was found incidentally. The remaining case arose from the adrenal gland and presented with a palpable mass. The gastric and adrenal IMTs had evidence of a previous or concomitant infectious setting. Five lesions were excised. The pancreatic IMT underwent a drainage procedure followed by steroid administration, and the hepatic lesion received antibiotics. Histopathology revealed characteristic findings of IMT. Expression of anaplastic lymphoma kinase was negative in all cases. At a median follow-up of 6 years (range, 3-15), all children were asymptomatic with no recurrences. The hepatic and pancreatic IMT displayed complete and near total regression, respectively.

Conclusion

A benign behavior of abdominal IMTs was observed even in patients not undergoing surgical excision. Although IMT remains a surgical disease, a conservative approach may be reasonable in select cases.     

Inflammatory myofibroblastic tumor of the liver

Inflammatory myofibroblastic tumor is a rare benign entity formerly known as inflammatory pseudotumor. Involvement of the liver is extremely rare. There are controversies about the optimal treatment of this benign entity. Newer reports suggest an association with autoimmune sclerosing pancreatitis and primary sclerosing cholangitis. We present a case of an 18-year-old patient with biliary obstruction from a perihilar mass of the liver requiring hepatic resection. Division of the hepatic bile duct resulted in drainage of yellow, thick, gelatinous material in the presence of benign margins and absence of cholangitis. Histological examination showed a mass with fibroblastic and myofibroblastic cells set in a loose myxoid matrix containing scattered lymphocytes, consistent with an inflammatory myofibroblastic tumor. One-year recovery was uneventful. This report discusses the presentation, diagnosis, and controversies in management of this disease.     

Pulmonary inflammatory myofibroblastic tumor associated with nephrotic syndrome

Inflammatory myofibroblastic tumor (IMT) of the lung is a benign, non-metastasizing tumor with the possibility of local infiltration, recurrence or persistent local growth. This kind of tumor arises due to an unregulated growth of inflammatory cells. To our knowledge, IMT associated with nephrotic syndrome has not yet been recognized. Therefore, we present the case of a 14-year-old girl with lung IMT associated with secondary nephrotic syndrome (NS), which was cured after tumor removal.     

中国近25年脾脏炎性肌纤维母细胞瘤的流行病学特征及诊治经验

目的：探讨中国近25年来脾脏炎性肌纤维母细胞瘤（SIMT）的流行病学特征及诊治经验。方法：联合检索中国知网、维普等多家中文数据库获取国内近25年有关SIMT的病例资料进行回顾性分析。结果：本组64例中,男39例,女25例,男女比例1.56：1。年龄24～74岁,平均49.2岁。多为查体时B超或CT发现,部分表现为上腹部不适、乏力、低热等非特异性症状。影像学检查提示脾内单发或多发,界限多清楚占位性病变。有明确病理结果描述者43例：少细胞纤维型26例,黏液样/血管型12例,丰富梭形细胞型5例;免疫组化示多数病例梭形细胞对Vimentin、SMA等抗体阳性。治疗方式主要为脾脏切除,随访无复发及转移。结论：SIMT极为罕见,临床表现无特异性,通过影像学检查、病理组织学特点及免疫组化结果可与其他脾脏占位性病变相鉴别,术前诊断较为困难,治疗主要为脾切除术,预后良好。     

MRI诊断大腿炎性肌纤维母细胞瘤1例

<正>患者男,43岁,发现右大腿包块1个半月入院。查体:右大腿包块约20mm×20mm×25mm,质韧,伴压痛,无红肿及皮温升高。实验室检查提示肿瘤标志物均为阴性。MRI:右大腿类圆形占位,T1WI呈稍高信号(图1A),T2WI呈不均匀高信号(图1B),DWI呈高信号,增强呈不均匀持续强化(图1C)。行右下肢肿物切除术,术中于股四头肌内侧头见约17 mm×