Fibroplastic parietal endocarditis with L?ffler's hematic oesinophilia (author's transl)]

The clinical data and autopsy findings in a case of L?ffler endocarditis are reported. The differential diagnosis with endocardial fibrosis of East Africa is discussed. On the basis of their histological findings and recent literature the authors suggest that endocardial fibrosis follows the organization of successive fibrin layers.     

Systemic lupus erythematosus, eosinophilia and L?ffler's endocarditis. An unusual association.

A 24-yr-old male, known since the age of 11 to have a nonerosive arthritis and later diagnosed as having systemic lupus erythematosus (SLE), developed subacute heart failure with diffuse lung infiltrates and died suddenly after having presented a moderate hypereosinophilia for 6 months for which no other causes besides the SLE were found. A post mortem examination revealed L?ffler's endocarditis (endocarditis parietalis fibroplastica) with acute pulmonary capillaritis. This represents L?ffler's endocarditis in the setting of SLE. To the best of the authors' knowledge, this association has not been reported before.     

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??Abstract??Pulmonary Infiltrates with eosinophilia??clinically referred to as eosinophilic lung diseases (ELD)??are a heterogeneous group of disorders characterized by pulmonary infiltration associated with alveolar eosinophilia with or without peripheral eosinophilia.They are classified generally as primary ELD??secondary ELD??and other diseases occasionally associated with eosinophils.Clinical manifestation of these disorders can be varied??and their presentation can be mild or fatal.Accurate diagnosis is based on a full history and examination??along with clinical manifestations??radiological imaging and laboratory findings.Corticosteroids are the mainstay of treatment for ELD and most patients will require prolonged courses of daily steroids.The dose and use duration of corticosteroids should be individualized.     

Chronic left parietal endocarditis. Clinical, paraclinical and peroperative study of 22 cases

From 22 patients with left chronic parietal endocarditis (CPE), conducted an epidemiological, clinical, paraclinical and per-operative study. The CPE is frequently encountered in the Ivory Coast in Akan children living in forest areas in 81 p. cent of the cases. It causes a mitral insufficiency, of the which the essential mechanism is fibrosis of the sub-valvular apparatus. The clinical examination is that of a severe advanced mitral insufficiency. Cardiomegaly is the rule. In 31 p. cent of cases, the ECG shows a Qr in V1. The dip plateau on the apexocardiogram is never found and the protodiastolic endocardial resonance is inconstant on phonomechanical processor. The aspect in M of the interventricular septum, found in 72 p. cent of the cases on echo TM is of major importance when direct signs are missing on bidimensional sonograms. Angiocardiography remains the reference diagnostic examination. But only the surgical survey enables to demonstrate limited forms.     

Pulmonary infiltrates with eosinophilia associated with tetracycline.

We have demonstrated a small but statistically significant decrease in forced vital capacity and in pulmonary flow rates among 126 persons studied daily for the first three days after arrival at an altitude of 2,835 meters (9,300 ft). Nearly half of these individuals had symptoms attributable to altitude sickness, and those with the most dyspnea and worst headache also showed the greatest changes in pulmonary function studied. We suggest that there is a relationship between the symptoms of altitude sickness and pulmonary function consistent with the appearance of early interstitial or alveolar edema.     

Infective endocarditis with perivalvular pseudoaneurysm.

A 16-year-old Japanese woman with infective endocarditis was admitted to hospital. An echocardiography exhibited a perivalvular pseudoaneurysm just under the mitral valve. Left ventriculography demonstrated that the aneurysm had a small neck and dyskinetic motion with oppression to the coronary sinus and right coronary artery.     

Angiolymphoid hyperplasia with eosinophilia

INTRODUCTION: Angiolymphoid hyperplasia with eosinophilia is a rare affection. CASE REPORT: A 36 years-old woman presented an angiolymphoid hyperplasia with eosinophilia manifesting by erythematous nodular lesions on the face and the forearms, severe neuropathy, visual loss and eosinophilia. Corticosteroids, immunosuppressive drugs and interferon-alpha were unsuccessful. DISCUSSION: Angiolymphoid hyperplasia with eosinophilia is a dermatological disease with possible systemic features. Differential diagnosis with Kimura disease is based on clinical presentation and histological findings. Etiopathology remains unknown and the treatment is not codified.     

Four Japanese cases of episodic angioedema with eosinophilia.

Here we describe four young Japanese women aged 25-33 years, whose clinical findings are characterized by episodic angioedema, marked leukocytosis with eosinophilia, benign course with spontaneous remission or low-dose prednisolone treatment. The recognized causes of eosinophilia, such as allergy, parasite, and collagen diseases, and the causes of edema, such as heart, kidney, and liver diseases, were ruled out. The findings in these patients are very similar to those reported as episodic angioedema with eosinophilia, which is clearly distinct from the so-called hypereosinophilic syndrome. We suggest that this syndrome is not rare, and should be widely recognized as a new clinical entity for accurate and prompt diagnosis.