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1.
Golombok S.; Brewaeys A.; Cook R.; Giavazzi M.T.; Guerra D.; Mantovani A.; van Hall E.; Crosignani P.G.; Dexeus S. 《Human reproduction (Oxford, England)》1996,11(10):2324-2331
Findings are presented of a European study (conducted in theUK, Italy, Spain and The Netherlands) of family relationshipsand the social and emotional development of children in familiescreated as a result of the two most widely used reproductivetechnologies, in-vitro fertilization (IVF) and donor insemination(DI), in comparison with control groups of families with a naturallyconceived child and adoptive families. Mothers of children conceivedby assisted reproduction expressed greater warmth towards theirchild, were more emotionally involved with their child, interactedmore with their child and reported less stress associated withparenting than mothers who conceived their child naturally.Similarly, assisted reproduction fathers were found to interactmore with their child and to contribute more to parenting thanfathers with a naturally conceived child. With respect to thechildren themselves, no group differences were found for eitherthe presence of psychological disorder or for children's perceptionsof the quality of family relationships. The findings relatingto the quality of parenting and the socio-emotional developmentof the children were similar in each of the four countries studied. 相似文献
2.
Golombok S Murray C Jadva V Lycett E MacCallum F Rust J 《Human reproduction (Oxford, England)》2006,21(7):1918-1924
BACKGROUND: Findings are presented of the third phase of a longitudinal study of children conceived by assisted reproduction procedures involving surrogacy and/or donor conception. METHODS: At the time of the child's third birthday, 34 surrogacy families, 41 donor insemination families and 41 oocyte donation families were compared with 67 natural conception families on standardized interview and questionnaire measures of the psychological well-being of the parents, mother-child relationships and the psychological well-being of the child. RESULTS: The differences found between family types reflected higher levels of warmth and interaction between mothers and their 3-year-old children in assisted reproduction families than in families with a naturally conceived child. A higher proportion of surrogacy parents than donor conception parents had told their children about the nature of their birth. CONCLUSIONS: It appears that the absence of a genetic and/or gestational link between parents and their child does not have a negative impact on parent-child relationships or the psychological well-being of mothers, fathers or children at age 3. 相似文献
3.
Barnes J Sutcliffe AG Kristoffersen I Loft A Wennerholm U Tarlatzis BC Kantaris X Nekkebroeck J Hagberg BS Madsen SV Bonduelle M;European Study 《Human reproduction (Oxford, England)》2004,19(6):1480-1487
BACKGROUND: ICSI is used with increasing frequency, but there is less information about the children born following this method of assisted reproduction than other forms of IVF. Some authors have suggested that it may contribute to more family stress than IVF. METHODS: ICSI conceived children were compared with IVF conceived children and naturally conceived (NC) controls. They were selected in five European countries: Belgium, Denmark, Greece, Sweden and the UK, and seen for psychological testing and a paediatric examination when they were 5 years old. In all countries, except Greece, mothers and fathers were asked to complete questionnaires about parental well-being, family relationships, parenting and child behaviour. RESULTS: Very few differences were found between the ICSI and NC group or the ICSI and IVF group. The only significant differences were that mothers in the ICSI conceived group reported fewer hostile or aggressive feelings towards the child and higher levels of commitment to parenting than the mothers of NC children. CONCLUSIONS: The study confirms the results of previous work with IVF families. This should be encouraging for families using these techniques in the future. 相似文献
4.
Donor insemination: Dutch parents' opinions about confidentiality and donor anonymity and the emotional adjustment of their children 总被引:1,自引:4,他引:1
Brewaeys A; Golombok S; Naaktgeboren N; de Bruyn JK; van Hall EV 《Human reproduction (Oxford, England)》1997,12(7):1591-1597
Results from a comparative study investigating 38 donor insemination (DI)
Dutch families with 4-8 year old children are presented. The aims of this
study were to investigate parents' opinions on the issues of
confidentiality and donor anonymity, to assess the emotional development of
the children, and to examine in DI families the association between secrecy
with regard to the use of a donor and the emotional adjustment of the
children. The DI families were compared to families with a child conceived
by in-vitro fertilization (IVF) and to families with a naturally conceived
child. Secrecy appeared to be associated with DI and not with IVF: 74% of
the DI parents intended not to inform the child about the way in which
she/he was conceived, whereas none of the IVF parents intended to keep the
secret. Only one set of DI parents and two sets of IVF parents had actually
told the child. As to donor anonymity, a spread of opinions appeared among
DI parents; 57% preferred an anonymous donor, 31% would have liked non-
identifying information about the donor, 9% preferred the donor's identity
to be registered and 3% remained unsure. Parents' major concern was to know
more about the medical/genetic background of the donor. Mothers and fathers
in the DI families differed in their opinions concerning the issues of
confidentiality and donor anonymity: fathers, more often than mothers, were
secretive with regard to the use of a donor and husbands, more often than
their wives, were in favour of donor anonymity. With regard to the
emotional development of the children, more emotional/behavioural problems
were revealed among DI children than among children who were naturally
conceived. No association was found between secrecy and the
emotional/behavioural adjustment of the children.
相似文献
5.
Cognitive development of 12 month old Greek infants conceived after ICSI and the effects of the method on their parents 总被引:8,自引:0,他引:8
Papaligoura Z Panopoulou-Maratou O Solman M Arvaniti K Sarafidou J 《Human reproduction (Oxford, England)》2004,19(6):1488-1493
BACKGROUND: ICSI is widely used as a method of assisted reproduction in Greece. Research shows that children conceived after the application of ICSI develop normally. However, Bowen et al. (1998) reported that children conceived after ICSI had lower scores in the Mental Development Index (MDI) of the Bayley Scales of Infant Development compared with infants conceived naturally or by standard IVF treatment. This finding raised concerns about the effects of ICSI on infants' cognitive development. The aim of the present study was twofold. First to compare the cognitive development of Greek infants conceived after ICSI treatment to a control group of infants conceived after IVF treatment and to a further control group conceived naturally (NC). Second, to investigate the psychological effects of ICSI compared to IVF on Greek parents. METHODS: The Bayley Scales of Infant Development were employed to assess cognitive development of infants. A 37 item semi-structured interview was devised to obtain demographic information and to assess and compare the psychological effects of ICSI and IVF on parents. RESULTS: The mental development of infants in all three groups was within the normal range (ICSI 101.4, IVF 95.7, NC 98.9). The differences between the three groups were not statistically significant. The duration of pregnancy and the birthweight differed in the three groups. Furthermore, mothers in the IVF and the ICSI groups experienced anxiety during pregnancy. IVF mothers differed in the mode of delivery and a smaller number of these mothers breastfed their infants. CONCLUSIONS: This study has shown that Greek infants, born after the application of ICSI, have mental and motor scores within the normal range. With regard to the psychological effects, it appears that mothers in the ICSI and IVF groups experience greater anxiety during their pregnancies than those in the NC group. 相似文献
6.
Golombok S Olivennes F Ramogida C Rust J Freeman T;Follow-Up Team 《Human reproduction (Oxford, England)》2007,22(11):2896-2902
BACKGROUND: The aim of the study was to examine the quality of parenting and the psychological development of three-year-old children in IVF/ICSI families with triplets. METHODS: Comparisons were carried out between a representative sample of 10 families with triplets and matched groups of 15 families with twins and 30 families with singletons. The families were recruited from Follow-Up, a national organization in France that was established to study children conceived by assisted reproduction. Standardized measures of the mother's psychological well-being (parenting stress, depression and quality of marriage) and standardized measures of the child's psychological development (emotional/behavioural problems and general development) were completed by the mother. RESULTS: Mothers with a multiple birth were found to experience greater difficulties in parenting than mothers of singletons, with no differences between mothers of triplets and mothers of twins. Regarding the children, there were no differences in emotional or behavioural problems between triplets, twins and singletons. However, there were indications of mild delay among triplets and twins in some aspects of language development in comparison with the singleton children. CONCLUSIONS: The birth of triplets or twins does appear to cause difficulties for parents in the early years, however, the children themselves do not seem to experience markedly raised levels of psychological or developmental problems. 相似文献
7.
C S Hahn 《Journal of pediatric psychology》2001,26(8):525-538
OBJECTIVE: To critically review the empirical literature published from 1980 through June 2000 on the psychosocial well-being of parents and their children born after assisted reproduction. METHODS: A computer-based literature search of PsycINFO and Medline was conducted. Empirical studies were reviewed to document the psychosocial impact of infertility and its treatment on the families involved in terms of quality of parenting, family functioning, and child development. RESULTS: Several common findings appeared across the studies reviewed. With regard to quality of parenting and family functioning, mothers of children born using assisted reproduction report less parenting stress and more positive mother- and father-child relationships than mothers of naturally conceived children. In most cases, no statistically significant differences in child functioning in terms of emotions, behavior, self-esteem, or perceptions of family relationship have been reported. CONCLUSIONS: The summary findings are positive and reassuring for parents and their children born after assisted reproduction. This critique of the published literature provides interpretative and methodological refinements for future research. 相似文献
8.
BACKGROUND: This report details a follow-up study of the parent-child relationship and the child's psychosocial development after IVF. The pilot study compared 31 IVF families and 31 families with a naturally conceived child when the children were aged 2 years. Twenty-seven IVF and 23 control families participated again when the children were aged 8-9 years. METHODS: Fathers and mothers completed questionnaires assessing parenting variables and the child's behaviour. For most children, behavioural ratings were also obtained from the child's teacher. RESULTS: No significant differences were found between IVF and control parents' reports of child behaviour, parenting behaviour, parenting stress and most of the parenting goals. The parenting goal adjustment was significantly more important for IVF than for control fathers; religion was more important for IVF than for naturally conceiving mothers. Teacher ratings of the child's behaviour did not differ significantly between the IVF and control groups. All couples but one had talked to other persons about the IVF conception; 75% of the IVF parents had not yet informed their children. IVF parents who had informed their child observed more (internalizing and for fathers also overall) problem behaviours in their child, compared with IVF parents who had not yet disclosed the IVF conception. CONCLUSIONS: Parenting and the children's psychosocial development do not differ significantly between IVF families and control families. 相似文献
9.
BACKGROUND: Findings are presented of the second phase of a longitudinal study of solo-mother families created through donor insemination (DI). METHODS: At the time of the child's second birthday, 21 solo DI mother families were compared with 46 married DI families on standardized interview and questionnaire measures of the psychological well being of the mothers, mother-child relationships and the psychological development of the child. RESULTS: The solo DI mothers showed greater pleasure in their child and lower levels of anger accompanied by a perception of their child as less 'clingy'. Fewer emotional and behavioural difficulties were shown by children of solo than married DI mothers. CONCLUSIONS: The findings from this first cohort of solo DI families to be studied lend further weight to the view that these women represent a distinct subgroup of single parents, who, out of a strong desire for a child, have made the active choice to go it alone. Moreover, this route to parenthood does not necessarily seem to have an adverse effect on mothers' parenting ability or the psychological adjustment of the child. 相似文献
10.
Congenital malformations in 4224 children conceived after IVF 总被引:10,自引:0,他引:10
Anthony S Buitendijk SE Dorrepaal CA Lindner K Braat DD den Ouden AL 《Human reproduction (Oxford, England)》2002,17(8):2089-2095
BACKGROUND: The percentage of children born after IVF will continue to increase due to demographic changes such as increasing maternal age and new developments in assisted reproduction techniques. IVF conceptions may carry an increased risk of congenital malformations. METHODS: We compared overall and specific congenital malformation rates calculated for IVF children (n = 4224) and naturally conceived children (n = 314 605), using records from the same Dutch national database for the years 1995 and 1996 and controlling for confounding maternal factors. RESULTS: The overall crude odds ratio (OR) for the risk of any malformation for IVF children compared with naturally conceived children was 1.20 [95% confidence interval (CI): 1.01-1.43]. After correction for differences in maternal age, parity and ethnicity between the IVF and control population the OR was 1.03 (95% CI: 0.86-1.23). The crude OR for IVF children appeared higher for the cardiovascular organ system and for several specific minor congenital malformations. However, these could be chance findings due to comparison of many malformation categories or may result from remaining differences in ascertaining malformations between IVF and naturally conceived children. CONCLUSIONS: The small increase in overall congenital malformations observed in the IVF children appears to be attributable to differences in maternal characteristics and not to any aspect of the IVF procedure. 相似文献
11.
A preliminary study of parental stress and child behaviour in families with twins conceived by in-vitro fertilization 总被引:3,自引:3,他引:3
This paper reports on a preliminary study of parenting quality, parental
stress and child behaviour in families with twins conceived by in-vitro
fertilization (IVF) in comparison with families with naturally conceived
twins. No differences were found between the types of family in parenting
quality or child behaviour. However, parents whose children were conceived
by IVF reported greater stress associated with parenting than parents with
naturally conceived twins.
相似文献
12.
Bonduelle M Wennerholm UB Loft A Tarlatzis BC Peters C Henriet S Mau C Victorin-Cederquist A Van Steirteghem A Balaska A Emberson JR Sutcliffe AG 《Human reproduction (Oxford, England)》2005,20(2):413-419
BACKGROUND: Over a million children have been born from assisted conception worldwide. Newer techniques being introduced appear less and less 'natural', such as intracytoplasmic sperm injection (ICSI), but there is little information on these children beyond the neonatal period. METHODS: 540 ICSI conceived 5-year-old children from five European countries were comprehensively assessed, along with 538 matched naturally conceived children and 437 children conceived with standard IVF. RESULTS: Of the 540 ICSI children examined, 63 (4.2%) had experienced a major congenital malformation. Compared with naturally conceived children, the odds of a major malformation were 2.77 (95% CI 1.41-5.46) for ICSI children and 1.80 (95% CI 0.85-3.81) for IVF children; these estimates were little affected by adjustment for socio-demographic factors. The higher rate observed in the ICSI group was due partially to an excess of malformations in the (boys') urogenital system. In addition, ICSI and IVF children were more likely than naturally conceived children to have had a significant childhood illness, to have had a surgical operation, to require medical therapy and to be admitted to hospital. A detailed physical examination revealed no further substantial differences between the groups, however. CONCLUSIONS: Singleton ICSI and IVF 5-year-olds are more likely to need health care resources than naturally conceived children. Assessment of singleton ICSI and IVF children at 5 years of age was generally reassuring, however, we found that ICSI children presented with more major congenital malformations and both ICSI and IVF children were more likely to need health care resources than naturally conceived children. Ongoing monitoring of these children is therefore required. 相似文献
13.
Donor insemination: child development and family functioning in lesbian mother families 总被引:1,自引:5,他引:1
Brewaeys A; Ponjaert I; Van Hall EV; Golombok S 《Human reproduction (Oxford, England)》1997,12(6):1349-1359
Findings are presented of a comparative study investigating the family
relationships and the emotional and gender development of children raised
in lesbian mother families. A total of 30 lesbian mother families with 4-8
year old children created as a result of donor insemination (DI) were
compared with 38 heterosexual families with a DI child and with 30
heterosexual families who had a naturally conceived child. A variety of
assessment measures, including a standardized interview and questionnaires
from the parents and psychological testing of the child were used to
collect the data. The quality of the couples' relationships and the quality
of the mother-child interaction did not differ between lesbian mother
families and either of the heterosexual family groups. The quality of the
interaction between the social mother and the child in lesbian families was
superior to that between the father and the child in both groups of
heterosexual families. Childrens' own perception of their parents was
similar in all family types; the social mother in lesbian families was
regarded by the child to be as much a 'parent' as the father in both types
of heterosexual families. With regard to their emotional/behavioural
development, boys and girls raised in lesbian mother families were well
adjusted and their gender role development did not differ from that of
children raised in heterosexual families. These results indicate that child
and family development in lesbian mother families is similar to that of
heterosexual families.
相似文献
14.
Delbaere I Goetgeluk S Derom C De Bacquer D De Sutter P Temmerman M 《Human reproduction (Oxford, England)》2007,22(10):2763-2767
BACKGROUND: The objective of this study is to analyse differences in cord characteristics between naturally conceived twins and twins born after assisted reproduction. METHODS: Between 1985 and 2004, the East Flanders Prospective Twin Survey (EFPTS) registered 4159 twin pairs. We compared cord characteristics between 2119 naturally conceived dizygotic (DZ) twin members and 2243 DZ twin members originating from assisted reproductive technologies (ART). Data were adjusted for intra-twin correlation, year of birth, maternal age, gestational age, parity, sex of the child and number of placentas. RESULTS: Marginal cord insertion, velamentous cord insertion and single umbilical artery (SUA) occur more frequently in twins following infertility treatment (P < 0.001). The incidence of velamentous cord insertion increases proportionate with 'invasiveness' of reproductive techniques: 3.6% in naturally conceived twins versus 5% in twins after artificial induction of ovulation (AIO) [odds ratio (OR) 1.45; 95% confidence interval (CI) 0.99-2.11], 7.4% in twins after IVF (OR 1.49; 95% CI 1.26-1.77) and 10.4% in twins after ICSI (OR 1.31; 95% CI 1.14-1.51). SUA has the highest incidence in twins after AIO: 1.9% compared with 0.6% in naturally conceived twins (OR 3.19; 95% CI 1.66-6.11). CONCLUSIONS: Umbilical cords of twins born after ART have more pathologic characteristics when compared with cords of naturally conceived twins. 相似文献
15.
Raoul-Duval A.; Bertrand-Servais M.; Letur-Konirsch H.; Frydman R. 《Human reproduction (Oxford, England)》1994,9(6):1097-1101
We have studied from birth up to the 3rd year the psychologicalattitude of 33 in-vitro fertilization (IVF) children comparedto two other groups: children born after ovarian stimulationwithout IVF (n = 33) and children conceived naturally (n = 33)during the same period. Fourteen children, born by oocyte donation,were also studied by the same methodology. In the IVF group,we found some feeding difficulties and sleep disorders in theinfants at 9 months and some signs of depression in mothers.All these symptoms disappeared afterwards. The development ofall the children is satisfactory and the relationship with theirmother is excellent. In this preliminary study, we concludethat the method of assisted reproduction has no bad influenceon the psychomotor development of these children. 相似文献
16.
H Klip C W Burger J de Kraker F E van Leeuwen 《Human reproduction (Oxford, England)》2001,16(11):2451-2458
BACKGROUND: Over the past decade attention has been increasingly focused on the long-term health effects of assisted reproductive technologies (ART), such as IVF, in both women and their offspring. To determine the risk of cancer in children conceived by IVF we used a large population-based historical cohort that was initially designed to examine the risk of gynaecological disorders in women who underwent IVF. METHODS: Children were included in the exposed group if they were conceived by IVF or other related fertility techniques (n=9484). The unexposed group consisted of 7532 children whose mothers were diagnosed with subfertility disorders but who were conceived naturally. All cohort members were asked to complete a mailed questionnaire that inquired about reproductive variables and cancer in the offspring (response rate 66.9%). RESULTS: During an average follow-up period of 6.0 years, 16 cancers were observed in the exposed and unexposed group combined, whereas 15.5 were expected [standardized incidence ratio (SIR) = 1.0; 95% confidence interval (95% CI) 0.6-1.7]. A direct comparison between children conceived after ART and naturally conceived children revealed no increased risk for childhood malignancies [risk ratio (RR) = 0.8; 95% CI 0.3-2.3]. CONCLUSIONS: Despite the small numbers of observed cancer cases, these findings demonstrate that children conceived by ART have no greatly increased risk of cancer during childhood compared with the general population and the internal reference group. 相似文献
17.
Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age 总被引:5,自引:0,他引:5
Leslie GI Gibson FL McMahon C Cohen J Saunders DM Tennant C 《Human reproduction (Oxford, England)》2003,18(10):2067-2072
BACKGROUND: Concerns about possible adverse outcomes for children conceived using ICSI were highlighted in 1998 when 1-year-old ICSI children were found to be at increased risk (relative risk = 9.2) of delayed mental development compared with children conceived naturally or using IVF. As the findings were biologically plausible, it was considered important to reassess child development when a more accurate measure of long-term cognitive ability could be obtained. METHODS: The mental development of 97 ICSI, 80 IVF and 110 naturally conceived (NC) children at 5 years of age was assessed using intelligence quotients (IQ) obtained from the Wechsler Preschool and Primary Scales of Intelligence. RESULTS: The mean full-scale IQ was 110 +/- 18 for ICSI, 111 +/- 13 for IVF and 114 +/- 13 for NC children (P = 0.21, non-significant). ICSI children were not at increased risk for delayed (full-scale IQ <85) cognitive development (ICSI 5.2%, IVF 2.5%, NC 0.9%; P = 0.18, non-significant). The only significant independent predictor of below-average full-scale IQ on multivariate analysis was lower maternal education level. CONCLUSIONS: These findings suggest that the genetic influence of parental cognitive ability is more important than the mode of conception in determining the long-term intellectual ability of children conceived using ICSI. 相似文献
18.
Aboulghar MA 《Croatian medical journal》2005,46(5):751-758
The main perinatal complications of assisted reproduction include congenital malformation, chromosomal aberrations, multiple pregnancy, and prematurity. Earlier studies and in vitro fertilization (IVF) registries showed that there was no increased incidence of congenital malformations in children conceived by IVF/intracytoplasmic sperm injection (ICSI). However, a large Australian study has found that by one year of age, the incidence of congenital malformations in IVF/ICSI children is increased in comparison with those naturally conceived. Several investigators found a slight but increased risk of chromosomal aberrations in ICSI children. Multiple pregnancy is a major cause of increased perinatal mortality due to increased incidence of both prematurity and congenital malformations. Even in singleton pregnancies conceived by assisted reproductive technologies, the risk of prematurity and newborns small for gestational age is increased. In this article, recently published work on perinatal complications associated with assisted reproductive technologies is reviewed. 相似文献
19.
Brewaeys A 《Human reproduction update》2001,7(1):38-46
The present article reviews the empirical research regarding the parent-child relationships and the development of children in donor insemination (DI) families. Over the years, follow-up studies have appeared sporadically and, despite the varying quality of the research methods, preliminary findings have emerged. Heterosexual DI parents were psychologically well adjusted and had stable marital relationships. DI parents showed a similar or higher quality of parent-child interaction and a greater emotional involvement with their children compared with naturally conceived families. The majority of studies which investigated several aspects of child development found that, overall, DI children were doing well. Findings with regard to emotional/behavioural development, however, were divergent in that some studies identified an increase of such problems while others did not. A steadily growing group within the DI population is lesbian mother families. More recently, follow-up studies have been carried out among DI children who were raised from birth by two mothers. Despite many concerns about the well-being of these children, no adverse effects of this alternative family structure on child development could be identified. As the DI children in all investigations were still young, our knowledge about the long-term effects of DI remains incomplete. 相似文献
20.
Brewaeys A.; Devroey P.; Helmerhorst F.M.; Hall E.V. Van; Ponjaert I. 《Human reproduction (Oxford, England)》1995,10(10):2731-2735
This study investigated the development of family relationshipsin lesbian families who conceived after donor insemination (DI).The main characteristics of this unknown family structure wereanalysed. An anonymous donor was used to conceive, the familyunit consisted of two mothers and a father was non-existent,and both women had a homosexual orientation. A total of 50 lesbiancouples who conceived after DI with children aged between 1and 2 years participated in this study, using a standardizedinterview created for this study. After the birth of their child,56% of the lesbian mothers (n = 100) would have wanted the identityof the donor to be registered, while 10% would have done soat the time of the insemination. Opinions differed in 12 ofthe 50 couples: the biological mother was in favour of identityregistration while the social mother was not. Both women consideredthemselves a parent of the child with equally shared responsibilities.Mothers were open about the special features of their familystructure with children and within their immediate social network.Only 30% disclosed their lesbian identity in a broader socialenvironment. The features of these newly created families mayinfluence the psychological development of the children andtherefore make long-term follow-up studies indispensable. 相似文献