共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
N. A. Agadzhanyan M. L. Khachatur'yan L. A. Panchenko 《Bulletin of experimental biology and medicine》1999,127(6):567-570
The resistance of rats to hypoxia was measured by survival time after exposure to high-altitude (11.5 km) hypoxia. The first
exposure to acute hypoxia caused phasic changes in the survival time: short-term in high-resistant rats (about 24 h) and long-term
in moderate- and lowresistant rats (38–39 days) starting from 1 h and 6–7 days after the first exposure, respectively. Adaptive
reactions were more pronounced in low- and moderate-resistant rats, while disadaptation was typical of high-resistant animals.
In all rats, the adaptive effect dominated until days 22–23. Throughout the testing, the initial type of resistance was retained
in 79% of high-resistant rats, in 41% of low-resistant and in 33% of moderate-resistant rats, i. e., the initially homogenous
groups formed after the first exposure in accordance with the type of resistance became mixed, which reduced the intergroup
differences.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 6, pp. 625–628, June, 1999 相似文献
3.
M. A. Vlasova A. S. Borovik E. N. Timin A. L. Chernyaev L. M. Mikhaleva O. S. Tarasova I. M. Rodionov 《Bulletin of experimental biology and medicine》2000,130(2):749-751
In rats with hypertension modeled by the one kidney-one clamp method, constrictory responses of the isolated caudal artery
to norepinephrine differed under various perfusion conditions. Vascular reactions in hypertensive rats were more potent at
a constant flow rate, and less potent at a constant pressure compared to those in normotensive rats. Previous experiments
demonstrated similar changes in constrictory responses of the caudal artery in spontaneously hypertensive rats. It is assumed
that these peculiarities of the vascular reactivity during hypertension are determined by thickening of the smooth muscle
layer of the vascular wall.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 159–162, August, 2000 相似文献
4.
S. V. Gorbachevskii A. I. Gorchakova I. I. Lepikhova T. I. Musatova 《Bulletin of experimental biology and medicine》1994,118(5):1237-1240
Thirty-nine patients with a diagnosis of common arterial trunk and high pulmonary hypertension were examined. Radical correction
of the anomaly was performed in 22 patients with a hospital lethality of 36%. Residual pulmonary hypertension was the cause
of death in all cases. Results of surgical treatment as well as the indexes of hemodynamics and biopsy and autopsy data were
analyzed during the investigation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
11, pp. 540–543, November, 1994
Presented by V. I. Burakovskii Member of the Russian Academy of Medical Sciences 相似文献
5.
N. K. Eriskovskaya Yu. G. Tsellarius 《Bulletin of experimental biology and medicine》1976,82(5):1727-1730
During adaptation of rats to high-altitude hypoxia evidence of stimulation of both formative and lytic processes was observed, and either one process or the other was predominant in different cells. The ratios between volumes of mitochondria and myofibrils were substantially unchanged. The relative volume of the microcirculation was increased on account of dilatation of the small vessels with no increase in their number.Laboratory of Pathomorphology, Institute of Cytology and Genetics, Siberian Branch, Academy of Sciences of the USSR, Novosibirsk. (Presented by Academician of the Academy of Medical Sciences of the USSR N. N. Zhukov-Verezhnikov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 82, No. 11, pp. 1380–1382, November, 1976. 相似文献
6.
Obrezchikova MN Tarasova OS Borovik AS Koshelev VB 《Bulletin of experimental biology and medicine》2000,129(4):327-329
A 3-week course of adaptation to high-altitude hypoxia (4500 m above sea level) inhibited baroreflex avagal bradycardia induced
by a rapid rise of systemic blood pressure in conscious rats. Bradycardic responses to electrical stimulation of peripheral
end of the right vagus nerve and methacholine (M2 muscarinic receptor agonist) in hypoxia-adapted rats did not differ from the control. It is concluded that hypoxia inhibits
baroreflex vagal bradycardia by acting on a central element of the baroreceptor reflex arch
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 386–389, April, 2000 相似文献
7.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1996,121(1):22-25
Lipid peroxidation and the antioxidant system of the heart, liver, and brain are studied in adult male Wistar rats with high
and low resistance to hypoxia tested by “raising” to an altitude of 11.5 km and in intact outbred rats. These parameters are
found to be the same in the brain of low- and high-resistance rats, while the brain content of lipid peroxidation products
is higher in both groups of Wistar rats compared with outbred rats. The heart and liver parameters are coupled to the resistance
to hypoxia. Antioxidant activity prevails over lipid peroxidation in the hearts and livers of high-resistance rats, confirming
that oxidation plays a major role in the damaging and lethal effects of acute hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
1, pp 26–29, January, 1996
Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences 相似文献
8.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1995,120(1):733-736
Lipid peroxidation and the antioxidant system of the myocardium of adult male Wistar rats with low and high resistance to
acute hypoxia tested by “raising” to an altitude of 11.5 km are studied in winter and in summer. It is found that the winter
season is a mild stressor inducing changes in the myocardial antioxidant system and lipid peroxidation which are similar to
those observed at the early stages of catecholamine stress in the summer season. In both cases alterations are more pronounced
in low-resistance than in high-resistance rats. In winter, in low-resistance rats the intensity of lipid peroxidation and
the activity of the antioxidant system are lower, while the ratio of their parameters (chemiluminescence data) is higher.
At the same time, the levels of thiobarbituric acid-reactive substances are higher in winter in both groups. The relationship
between the studied parameters and the resistance of rats to hypoxia is more obvious in winter than in summer, i.e., it is
season-dependent and is also more pronounced in catecholamine stress.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, Nolo 7, pp. 87–90, July, 1995
Presented by N. A. Agadzhanyan, Member of the Russian Academy of Medical Sciences 相似文献
9.
10.
11.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1996,121(2):126-131
The relationship between the intensity of lipid peroxidation and the activity of the antioxidant system in the heart, liver,
and brain is studied in male Wistar rats with low and high resistance to hypoxia tested by being “raised” to an altitude of
11.5 km and in intact outbred rats. It is found that in all groups of rats the content of lipid peroxidation products is highest
in the liver, lower in the heart, and lowest in the brain. In all groups, the rate of the ascorbate-induced lipid peroxidation
is highest in the brain, lower in the liver, and lowest in the heart. The activity of the antioxidant system is highest in
the brain, lower in the liver, and lowest in the heart of low-resistance and outbred rats, while in high-resistance rats it
is the same in all the organs. Thus, the difference in the parameters of lipid peroxidation and, particularly, of the antioxidant
system in the studied organs is most pronounced in rats with a low resistance to hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
2, pp. 138–143, February, 1996
Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences 相似文献
12.
N. A. Agadzhanyan L. V. Sorokin E. P. Tambovtsev V. I. Torshin 《Bulletin of experimental biology and medicine》1995,120(3):878-881
It is shown that the geometric mean of survival time and the deviation of σ from τ are measures of a population's resistance
to acute hypoxia; that a measure of the individual resistance of an animal to such hypoxia is Student's parameter for that
animal; that the distribution of Student's parameter in a population is a lognormal distribution under any conditions; and
that the number of animals with low resistance is always equal to the number of highly resistant animals. The procedure described
makes it possible to limit the number of animals used in an experiment by recording with the requisite accuracy the proposed
measures of resistance to acute hypoxia at the population and individual levels.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
9, pp. 239–241, September, 1995 相似文献
13.
G. V. Petrova V. A. Adarichev A. A. Krivenko G. S. Dymshits A. L. Markel' G. S. Yakobson 《Bulletin of experimental biology and medicine》1997,124(2):773-775
Sensitivity of normotensive Wistar rats and NISAG rats (with hereditary arterial hypertension) to heat stress is compared
at the organism and cell levels. High temperature sensitivity of NISAG rats correlates with a low content of the main heat
shock protein HSP70. This relationship can serve as a biochemical marker of predisposition to arterial hypertension.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 171–173, August, 1997 相似文献
14.
N. P. Kazarinov M. D. Shmerling A. L. Markel' G. S. Yakobson 《Bulletin of experimental biology and medicine》1999,127(5):522-525
Structure of juxtaglomerular apparatus of the kidney in NISAG rats and morphometric parameters of renin-producing juxtaglomerular,
cells of afferent arterioles attest to its activation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 5, pp. 576–579, May, 1999 相似文献
15.
A. R. Antonov A. V. Efremov V. V. Letyagina Yu. V. Nacharov A. L. Markel' G. S. Yakobson 《Bulletin of experimental biology and medicine》1997,124(1):652-654
Hemolymphatic interactions of electrolytes and plasma contents of aldosterone and insulin are studied in rats with genetically-determined
stress-induced arterial hypertension (NISAG) and in normotensive rats (Wistar). Correlation analysis shows that alterations
in electrolyte metabolism in NISAG are strongly determined by endocrine influences. These alterations are regarded, on the
one hand, as a mechanism responsible for generically-determined arterial hypertension, and, on the other hand, as a variant
of “adaptation disease” accompanied by transformation of primarily adaptive reactions into a pathogenic factor of arterial
hypertension.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 36–38, July, 1997 相似文献
16.
G. S. Yakobson A. R. Antonov V. V. Letyagina D. G. Sakharov A. L. Markel' 《Bulletin of experimental biology and medicine》1995,120(4):1006-1009
A comparative electrocardiographic evaluation of changes in cardiac function in rats with hereditary arterial hypertension
(NISAG strain) and normotensive (Wistar) rats in response to a single epinephrine injection revealed much more pronounced
changes in NISAG rats, including an unfavorable time course of electrocardiographic waves (left ventricle overload) and impaired
conduction (blockade) and excitability (extrasystoles). The results indicate that the myocardium of NISAG rats is much more
responsive to the acute stimulation of adrenergic receptors by epinephrine than is the myocardium of normotensive rats.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
10, pp. 372–375, October, 1995
Presented by V. A. Trufakin, Member of the Russian Academy of Medical Sciences 相似文献
17.
L. A. Balakireva N. A. Mahanova M. N. Nosova G. M. Dymshitz A. L. Markel' G. S. Yakobson 《Bulletin of experimental biology and medicine》1998,126(2):762-764
In vitro experiments on isolated segments of abdominal aorta of NISAG hypertensive rats with assessment of32P incorporation showed that hypertension in these rats is developed as due to enhanced metabolism of phosphatidylinositol
phosphates under the effect of norepinephrine resulting in higher vascular reactivity to norepinephrine.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 8, pp. 136–138, August, 1998 相似文献
18.
N. I. Artyukhina K. Yu. Sarkisova 《Bulletin of experimental biology and medicine》1994,118(5):1226-1231
Structural changes in the brain were studied at later (one and three months) stages of cerebral hypoxia caused by occlusion
of the common carotid arteries, which were indicative of the development of recovery and destructive processes. Brain ultrastructure
was found to be better preserved in rats with an active type of behavior one month after the onset of ischemia than in rats
of the other groups; motor activity was restored to the baseline level, thus demonstrating a higher rate of recovery processes.
Significant ultrastructural damage to the brain at the same stage of ischemia was observed in rats with a passive type of
behavior (especially in rats of the middle group), while motor activity was increased.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
11, pp. 529–534, November, 1994
Presented by P. V. Simonov, Member of the Russian Academy of Sciences 相似文献
19.
20.
N. A. Bondarenko E. L. Germanova L. D. Luk'yanova 《Bulletin of experimental biology and medicine》2000,130(3):849-851
Locomotor activity in the open field test did not correlate with rat resistance to acute hypobaric hypoxia; there was a correlation
between this resistance and rat behavior during acute stress. Immobility was characteristic of rats with low and particularly
medium resistance to hypoxia; this reaction can be abolished by antidepressants. By contrast, highly resistant rats were mainly
hyperactive. The resistance to hypoxia was associated with extreme parameters of dopaminergic neuron functioning. In low-resistant
rats locomotor stereotypia was maximal, while perioral stereotypia was the minimal; highly resistant rats were characterized
by an opposite pattern, and medium-resistant rats occupied an intermediate position.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 9, pp. 275–278, September, 2000 相似文献