Clonal haematopoiesis and cardiovascular diseases: A growing relationship

Central illustration. Clonal haematopoiesis of indeterminate potential (CHIP) occurs particularly in the elderly; it is the result of an acquired mutation occurring in a population of haematopoietic stem cells, conferring a growth advantage to their progeny. Because of the pro-inflammatory phenotype, it favours atherothrombosis, leading to coronary artery diseases such as myocardial infarction, and is also associated with heart failure (ischaemic and non-ischaemic), as well as aortic stenosis, altering the prognosis of CHIP carriers.

     

In vitro comparison of three percutaneous atrial septal defect closure devices for endothelialisation and haemocompatibility

Central illustration. Endothelial progenitor cell (EPC) extraction, culture and characterisation, and adhesion, proliferation and haemocompatibility testing on three devices. ASD: atrial septal defect; NS: not significant; PC: positive control.

     

Myocardial glucotoxicity: Mechanisms and potential therapeutic targets

Central illustration. The concept of myocardial glucotoxicity and protective action of the AMP-activated protein kinase (AMPK).

     

Predictive factors for long-term mortality in miscellaneous cardiogenic shock: Protective role of beta-blockers at admission

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The role of hyperglycaemia in the development of diabetic cardiomyopathy

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Imaging of myocarditis and inflammatory cardiomyopathies

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The difficult balance between thrombosis and bleeding after transcatheter aortic valve replacement: A translational review

The difficult balance between thrombosis and bleeding after transcatheter aortic valve replacement. TAVR: transcatheter aortic valve replacement.

     

Focus on stereotactic radiotherapy: A new way to treat severe ventricular arrhythmias?

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Impact of obesity on atrial fibrillation ablation

Central illustration. Summary of strategies to improve atrial fibrillation (AF) ablation outcomes in obese patients. BMI: body mass index; BS: bariatric surgery; CT: computed tomography; CV: cardiovascular; EAM: electro-anatomical mapping system; EAT: epicardial adipose tissue; MRI: magnetic resonance imaging; NOAC: non-vitamin K antagonist oral anticoagulant; PAF: paroxysmal atrial fibrillation; TOE: transoesophageal echocardiography; TTE: transthoracic echocardiography; US: ultrasound; VKA: vitamin K antagonist.

     

Colchicine and myocardial infarction: A review

Central illustration. Potential impact of colchicine on the pathways involved in atherosclerosis. IL: interleukin; MMP: matrix metalloproteinase; SMC: smooth muscle cells. Adapted from [42].

     

Mesenchymal Plasticity Regulated by Prrx1 Drives Aggressive Pancreatic Cancer Biology

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Clinical Outcomes in Biopsy-Proven Nonalcoholic Fatty Liver Disease Patients: A Multicenter Registry-based Cohort Study

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X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

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Transcatheter ductus arteriosus stenting in paediatric cardiology: Indications,results and perspectives

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Prognostic Value of Fecal Calprotectin to Inform Treat-to-Target Monitoring in Ulcerative Colitis

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Barrett’s esophagus after sleeve gastrectomy: a systematic review and meta-analysis

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Five-year clinical outcomes using the bioresorbable vascular scaffold: Insights from the FRANCE ABSORB registry

Central illustration: cumulative major adverse cardiac events (MACE) and bioresorbable vascular scaffold (BVS) thrombosis rates after 1, 2, 3, 4 and 5 years.

     

Diagnostic yield and technical performance of the novel motorized spiral enteroscopy compared with single-balloon enteroscopy in suspected Crohn's disease: a prospective study (with video)

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Incidence,clinical features and outcome of Takotsubo syndrome in the intensive care unit

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Watchful waiting care or early intervention in asymptomatic severe aortic stenosis: Where we are

Central illustration. Patient-centred benefit versus risk analysis of early aortic valve replacement (AVR) for asymptomatic severe aortic stenosis. AKI: acute kidney injury; PM: pacemaker; PPM: patient prosthesis mismatch.