涎腺肿瘤3461例临床病例分析

目的 :了解涎腺肿瘤发病情况、构成特点及发展趋势。方法 :对四川大学华西口腔医院 195 5～ 2 0 0 2年间收治的 3 461例涎腺肿瘤临床资料进行回顾性分析。结果 :良恶性的平均发病年龄分别是 41.3 8岁和 45 .2 0岁 ,良恶性的男女之比分别是 0 .99∶1和 1.3 4∶1。腮腺、腭部的小涎腺和颌下腺分别列为涎腺肿瘤原发部位前3位 ;多形性腺瘤、腺淋巴瘤、基底细胞腺瘤与粘液表皮样癌、腺样囊性癌、腺癌分别列为良、恶性肿瘤前三位。结论 :涎腺肿瘤发病有增加的趋势 ;男性患者的构成比恶性肿瘤高于良性 ;女性患者构成比有增加趋势 ;腮腺和腭部分别是大、小涎腺肿瘤的高发部位 ;多形性腺瘤和粘液表皮样癌是最常见的涎腺良、恶性肿瘤。     

265例涎腺肿瘤临床分析

目的:总结分析近10多年来涎腺肿瘤临床及发病特点的一些变化.方法:对265例涎腺肿瘤进行临床分析.结果及结论:涎腺肿瘤近10多年来发病逐渐增多,其占口腔颌面部肿瘤的构成比在增加,尤其是腮腺Warthin瘤发病增多最为明显;多形性腺瘤仍是涎腺肿瘤中发病最多的肿瘤,但其构成比在降低,在腮腺肿瘤中,Warthin瘤的构成比已超过多形性腺瘤而居第一位.     

腺淋巴瘤发病因素与机制研究的新进展

腺淋巴瘤 (ａｄｅｎｏｌｙｍｐｈｏｍａ)亦称乳头状淋巴囊腺瘤 (ｐａｐｉｌｌａｒｙｃｙｓｔａｄｅｎｏｍａｔｏｓｕｍ)或Ｗａｒｔｈｉｎ ｓ瘤 ,系 1 972年ＷＨＯ涎腺肿瘤组织学分类中的正式命名。该病是常见的涎腺良性肿瘤 ,其发病仅次于多形性腺瘤 ,约占涎腺良性肿瘤的 6%～ 1 0 % [1] 。近年来 ,腺淋巴瘤的发病呈上升趋势 ,Ｋｅｎｎｅｄｙ报道腺淋巴瘤占涎腺良性肿瘤的 1 / 3 [2 ] ;俞光岩[3 ] 发现腺淋巴瘤在涎腺良性肿瘤的构成比由 70年代的 7.1 %上升到 90年代早期的 2 9.7%。现综述如下。1　与腺淋巴瘤发病的相关因素基于流行病学调…     

572例涎腺肿瘤及瘤样病变构成比分析

涎腺肿瘤占口腔颌面部肿瘤的很大比例 ,其病理类型及发病情况较复杂 ,分类方法较多。随着组织学新技术的发展 ,积累了大量新的资料 ,1 991年ＷＨＯ制定了新的涎腺肿瘤组织学分类。本文按照新的分类法 ,对我院 5 72例涎腺肿瘤及瘤样病变患者的构成比、发病年龄、性别、部位分布进行分析 ,以有助于临床的诊断和治疗。1　材料与方法　　1 977年 1月～ 2 0 0 0年 1 2月间 ,我科收治的涎腺肿瘤及瘤样病变患者 5 72例 ,手术切除的肿瘤组织经 1 0 %甲醛溶液固定 ,常规ＨＥ染色。组织学诊断按 1 991年ＷＨＯ提出的涎腺肿瘤组织学新分类标准。对数据…     

1612例老年唾液腺肿瘤构成比分析

目的:了解老年人唾液腺肿瘤疾患的构成现状,为临床早期诊断和治疗提供依据。方法:回顾分析我科2000年1月—2009年12月10年间(21c10s)老年人唾液腺肿瘤住院患者的临床资料,并与20世纪90年代(20c90s)、80年代(20c80s)统计数据进行比较。结果:伴随着老年口腔颌面-头颈肿瘤患者住院人数的迅速增加,老年唾液腺肿瘤患者总数亦呈明显上升趋势,尤其是良性肿瘤患者数量快速上升。沃辛瘤首次成为最常见的老年唾液腺良性肿瘤。恶性肿瘤中,腺样囊性癌继续位居首位,而癌在多形性腺瘤中上升为第3位,并位居腮腺恶性肿瘤之首。小唾液腺良、恶性肿瘤构成比接近1∶1;而腭腺良、恶性比例倒置为1.34∶1。腮腺区发病仍最多见,其次为腭腺和下颌下腺。女性患者构成比有下降趋势。结论:21c10s老年唾液腺肿瘤构成现状与20c90s及20c80s资料有所不同,临床诊治工作中应注意其相应变化。     

涎腺小管腺瘤的免疫组织化学分析

小管腺瘤是一种良性涎腺肿瘤,好发于老年人,上唇多见;曾被认为是基底细胞腺瘤的一个亚(?),但最近WHO将其列为涎腺肿瘤中单独的一型。它常和某些涎腺肿瘤如腺样囊性癌,腺癌等相混淆。本文目的是研究分析涎腺小管腺瘤的免疫组织化学特征。 材料和方法 6例小管腺瘤患者。男3例,女3例;5例位于上唇,1例位于颊粘膜,年龄54～73岁。为进     

615例小涎腺上皮性肿瘤的临床病理分析

目的　探讨小涎腺上皮性肿瘤的临床病理特点。方法　对615例小涎腺上皮性肿瘤的部位分布、发病年龄、性别及组织学类型进行回顾性分析。结果　615例小涎腺上皮性肿瘤中腺瘤265例,癌350例,良恶性肿瘤之比为1∶1·3。良性肿瘤中以多形性腺瘤最为常见(81·1%),其次为肌上皮瘤(14·7%)。恶性肿瘤中以腺样囊性癌最常见(32·9%),其次为粘液表皮样癌(21·4%),腺癌(11·7%)。小涎腺上皮性肿瘤以腭部最为好发,分别占良、恶性肿瘤的77·0%和60.0%。腺瘤中女性患者(51·3%)稍多于男性(48·7%);小涎腺癌患者中男性(56·3%)多于女性 (43·7%)。小涎腺腺瘤患者平均发病年龄40·9岁,小涎腺癌平均发病年龄49·1岁,恶性肿瘤的发病年龄显著高于良性肿瘤(P<0·05)。结论　小涎腺上皮性肿瘤在病理类型构成比、部位、年龄、性别分布上具有其独到的特点。     

涎腺癌伴发第二次原发瘤

一些研究表明涎腺癌患者患第二次原发性肿瘤的危险性有增高的趋势。Dunn等人对349名女性涎腺恶性肿瘤患者进行复查,发现患乳腺癌的人数要比预计的高两倍。Prior和Waterhouse复查了收集15年得来的825名原发性涎腺良恶性肿瘤,也发现二次原发性肿瘤明显增多,女性患者主要累及乳腺及支气管、男性则常为前列腺及皮肤。Spiro等对367例大小涎腺的粘液表皮样癌的临床病理研究中发现46名(18%)患者伴有多处原发性肿瘤。作者在本文详细报告了一例53岁女性系     

诱骗受体3在涎腺肿瘤中的表达及其意义

目的:探讨诱骗受体3(DcR3)在涎腺肿瘤中的表达及其临床病理意义。方法:通过免疫组化和原位杂交法检测涎腺肿瘤中DcR3的表达情况,并分析其表达与患者临床病理参数的关系。结果:DcR3主要表达在涎腺肿瘤的肿瘤性上皮细胞胞质和正常涎腺闰管和纹管的细胞质中;DcR3在恶性涎腺肿瘤中的表达高于良性肿瘤(P<0.05);DcR3在恶性涎腺肿瘤中的表达与其恶性程度和淋巴结转移有关(P<0.05);DcR3蛋白和mRNA的表达显著相关(P<0.01)。结论:DcR3可能参与了涎腺肿瘤的发生发展。     

2489例涎腺上皮性肿瘤临床病理分析

目的:了解涎腺上皮性肿瘤的临床病理特点。方法:对2489例涎腺上皮性肿瘤临床病理资料进行统计分析。结果:涎腺恶性上皮性肿瘤840例,腺样囊性癌、黏液表皮样癌、癌在多形性腺瘤中居其前3位;涎腺良性上皮性肿瘤1649例,多形性腺瘤、Warthin瘤、基底细胞腺瘤居其前3位。涎腺恶性、良性上皮性肿瘤男女之比为1.13∶1和0.99∶1;平均发病年龄47.86岁和44.86岁;腮腺和腭部为好发部位。结论:腺样囊性癌和多形性腺瘤是最常见的涎腺恶性、良性上皮性肿瘤。     

Analysis of the proportion of salivary gland tumors in 528 elder patients]

OBJECTIVE: To analyse the clinical characteristic, evolution and prognosis of undifferentiated carcinoma with lymphoid stroma(malignant lymphoepithelial The purpose of this study was to investigate the present proportional ratio of salivary gland tumors in elder patients, to provide references for early diagnosis and treatment clinically. METHODS: The medical data of 528 elder patients with salivary gland tumors treated in our department in 1990s were reviewed and analyzed. RESULTS: The number of salivary gland tumors in elder patients had increased in recent years. These tumors were frequently found in patients of 60-74 years. The ratio of benign to malignant was 1.7:1. In benign tumors, the proportion of adenolymphoma approached pleomorphic adenoma. While in malignant tumors, adenoid cystic carcinoma accounted the most. These tumors were most commonly found in the parotid gland, followed by the palate. The prevalence of female had an increase trend. CONCLUSION: The proportion of salivary gland tumor in elder patients in 1990s was different from that in 1980s. This change should attract enough attention form the surgeons.     

2456例唾液腺肿瘤临床病理分析

目的探讨唾液腺肿瘤的发病、病理类型等临床特点。方法收集中山大学孙逸仙纪念医院口腔颌面外科1973年1月至2018年12月间确诊的唾液腺肿瘤病例2456例患者的相关资料,回顾分析其性别、年龄、病理类型、发病部位、良恶性构成比等特点。结果46年间收治的唾液腺肿瘤患者2456例,女性比例占41.9%,男性占58.1%,40~60岁年龄段为发病高峰,其中良性肿瘤1863例(75.9%),恶性肿瘤593例(24.1%),良恶性之比为3.1∶1。良性肿瘤构成比前2位是多形性腺瘤(58.7%)、Warthin瘤(33.6%),恶性肿瘤构成比前2位是黏液表皮样癌(27.7%)、腺样囊性癌(26.1%)。最常见的良性肿瘤多形性腺瘤的好发部位是腮腺、腭部、颌下腺,而恶性肿瘤中粘液表皮样癌则常见于腮腺和腭部的小唾液腺。本组资料中唾液腺肿瘤发病呈逐年递增的趋势,近10年病例占总病例数的53.3%。结论唾液腺肿瘤病人数量逐年增加;唾液腺肿瘤的总发生率男性高于女性;大唾液腺以良性肿瘤为主,小唾液腺恶性肿瘤多见;多形性腺瘤、Warthin瘤、黏液表皮样癌最常见;40~60岁是唾液腺良、恶性肿瘤高发年龄段。     

Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases

In a demographic and histologic study of 426 oral minor salivary gland tumors, 57.5% were classified as benign and 42.5% were classified as malignant or potentially malignant. There was an overall female preponderance (1.59/1). The mean age for females was 53.1 years and for males was 50.6 years. The mean age for patients with malignant tumors was 5.4 years greater than for patients with benign tumors and was statistically significant. The palate was the most common site for oral minor salivary gland tumors followed by the upper lip and the buccal mucosa. These three sites accounted for 76.1% of all cases. Pleomorphic adenoma was the most common benign tumor (41% of all cases and 71% of benign tumors) followed by monomorphic adenoma of the canalicular and basal cell subtypes (10% of all tumors and 18.9% of benign lesions). Mucoepidermoid carcinoma was the most commonly encountered malignant tumor, accounting for 15.2% of all tumors and 35.9% of malignant lesions. Low-grade (terminal duct, lobular, polymorphous) adenocarcinoma was the most second most common type, making up 11% of all tumors and 26.4% of all malignant tumors. The results of this study are compared with other recent studies.     

Epithelial salivary gland tumors of children and adolescents in southern Portugal. A clinicopathologic study of twenty-four cases.

During a 30-year period 24 epithelial salivary gland tumors were diagnosed in children and adolescents less than 18 years of age. The cases were retrieved from a series of 759 consecutive cases of salivary gland tumors (3.2%) from the area corresponding to southern Portugal during the same period of time. The mean age of the patients was 13.4 years, and one case was congenital. There was a slight female predominance (male/female ratio 1:1.7). The parotid gland was affected in most cases (70.8%). Seventeen neoplasms were benign, and the remaining seven were malignant. As in the adult group, pleomorphic adenoma was the most frequent benign tumor (66.6%), with similar histologic findings and clinical course. Mucoepidermoid carcinoma was the prevalent malignant tumor (20.8%), had a high grade of differentiation, and had a favorable outcome. The histologic pattern of the congenital neoplasm was similar to that of adult epithelial-myoepithelial carcinoma.     

Salivary gland tumors in an Iranian population: a retrospective study of 130 cases.

PURPOSE: Tumors of the salivary glands are uncommon, comprising 3% to 10% of head and neck neoplasia. In the absence of epidemiologic studies of these neoplasms in an Iranian population, we conducted a preliminary survey of 130 cases over the last 20 years in Hamedan, Iran. PATIENTS AND METHODS: The medical records and case notes of all patients with histologically confirmed salivary gland tumors were reviewed retrospectively from February 1984 to March 2003. This review found 89 patients with benign tumors and 41 patients with malignant tumors. The collection of data included gender, age, location, and histopathology of the tumor. Other recorded data included diagnostic procedures, operative reports, complications, additional treatment, and follow-up. RESULTS: We studied 78 females and 52 males with a mean age of 44.9 years. Patients with benign and malignant tumors presented with a mean age of 41.3 and 47 years, respectively. The frequency of benign tumors was 68.4% (n = 89) and 31.6% for malignant tumors (n = 41). Tumors were localized in the parotid gland (63%; n = 82), the submandibular gland (23%; n = 30), and in the minor salivary glands (14%; n = 18). The most common benign tumor was pleomorphic adenoma (65.4%; n = 85). Among malignant tumors, mucoepidermoid carcinoma was the most frequent (11.5%; n = 15), followed by adenocarcinoma (10%; n = 13). Greater than 63% of malignant tumors were treated surgically, and the remaining with combined therapy. Seven patients died over the follow-up period (6 with persistent disease), 5 were lost to follow-up, and 23 remained cancer-free. CONCLUSION: Between benign and malignant salivary gland tumors, frequency of pleomorphic adenoma and mucoepidermoid carcinoma was in keeping with studies reported previously. In other salivary gland tumors, however, diversity was obvious and showed significant difference, requiring further studies.     

A retrospective study of 60 cases of salivary gland tumors in a Thai population.

Sixty cases of salivary gland tumors were diagnosed in the Oral Pathology Department, Faculty of Dentistry, Mahidol University, Bangkok, Thailand, from 1973 to 2002. Fifty-two cases (86.7%) involved the intraoral minor salivary glands, six cases (10%) were found in the major glands, and two cases (3.3%) were intrabony. The predominance of malignant over benign tumors was evident with 68.3% being malignant and 31.7% benign. Patients ranged in age from 9 to 75 years. The female to male ratio of benign intraoral salivary gland tumors was 1.4 to 1 and of malignant types was 1.1 to 1. The principle site of occurrence was the palate (65.4%), followed by buccal mucosa (13.5%). Pleomorphic adenoma (30%) was the most common benign tumor, and mucoepidermoid carcinoma (44.3%) was the most common malignant tumor. Comparing the data from the present study with other series, some discrepancies exist.     

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目的    探讨舌下腺恶性肿瘤的发病情况、病理特征、治疗方式及疗效特点。方法    对1979—2010年中国医科大学附属口腔医院及中国医科大学附属第一医院收治的34例经病理确诊的舌下腺恶性肿瘤病例临床资料进行回顾性分析。结果    34例舌下腺恶性肿瘤患者中,男15例,女19例;年龄20～86岁,平均52.12岁;40～60岁年龄段为22例（64.71%）;病理类型中腺样囊性癌居首位（70.59%）;治疗方式主要是局部扩大切除+颈淋巴结清扫术;3、5、10年存活率分别为82.35%、76.47%、47.06%。结论    舌下腺恶性肿瘤女性患者发病率略高于男性;腺样囊性癌和黏液表皮样癌是舌下腺常见的恶性肿瘤;首次正确选择术式,且术后辅助放化疗是降低复发和转移的主要因素。     

A clinico-pathologic study of 311 intra-oral salivary gland tumors in Thais

Background:  There have been several epidemiologic studies on intra-oral salivary gland tumors in several countries, but little is known of these tumors in Thailand.
Objectives:  To determine the relative frequency and distribution of various types of intra-oral salivary gland tumors in the Thai population.
Methods:  The files of the Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, from 1969 to 2007 were searched for intra-oral salivary gland tumors. Histopathologic slides were reviewed and reclassified according to the 2005 WHO Classification of Head and Neck Tumors. The age, gender, race, and anatomical distribution of the tumors were collected from the patients' records.
Results:  Of the 16,358 accessioned cases, 311 cases (1.90%) were diagnosed as intra-oral salivary gland tumors. One hundred and forty-seven cases (47.27%) were benign tumors, while 164 cases (52.73%) were malignant tumors. The mean age of the patient ± SD = 41.57 ± 16.65 years. Females outnumbered male patients by a ratio of M:F = 1:1.38. Almost all except one patient were Thais. Pleomorphic adenoma was the most common intra-oral salivary gland tumor. The majority of cases occurred at the palate.
Conclusions:  Pleomorphic adenoma is the most common intra-oral salivary gland tumor and the most common benign intra-oral salivary gland tumor, while mucoepidermoid carcinoma is the most common malignant intra-oral salivary gland tumor. Intra-oral salivary gland tumors in Thailand elicit similar trend as in previous studies, with only minor differences such as the ranking of some tumors, the higher incidence of intra-bony location, and the lower incidence of polymorphous low-grade adenocarcinoma.