修补术加PGV与修补术加奥美拉唑方案治疗十二指肠溃疡穿孔的疗效对比

目的 研究十二指肠溃疡穿孔的两种不同疗法——穿孔修补术加近侧胃迷走神经切断术(PCV)与穿孔修补术加奥美拉唑方案的临床疗效,方法 将1994年1月-1996年12月相继入院的48例十二指肠溃疡穿孔患随机分为A、B两组。A组（21例）在穿孔修补术的基础上．加行PGV。B组(27例)仅作穿孔修补术,术后辅予奥美拉唑方案(即口服奥美拉唑加羟氨苄青霉素加灭滴灵)。术后定期随访。随访结果按Visick标准分级。结果 A组术后半年和2年氨疗效优良（Visick Ⅰ加Ⅱ级)分别为18例（85.7％)和17例(81.0％),溃疡复发(Visick Ⅳ级)分别为1例(4．8%半年)和2例(9.5％2年).B维术后半年和2年疗效优良分别为19例(66．7％)和10例(37．0％),溃疡复发分别为5例（18.5％)和12例(44.5％)A组疗效优于B组(P＜0.01)。Hp检测,A组术后半年和两年的Hp阳性率分别为81.0％和85.7％(P＞0.05)：B组分别为18．5％和51．9％(P＜0．01)。结论 十二指肠溃疡穿孔在施行修补术后．应同时加行PCV,以提高时溃疡病的根治效果。     

十二指肠溃疡急性穿孔大网膜填塞缝合术与单纯缝合术的疗效对比

目的 对比研究十二指肠溃疡急性穿孔的两种不同术式——大网膜填塞缝合术与单纯缝合术的临床疗效。方法 将1996年1月～1999年3月相继入院的56例十二指肠溃疡急性穿孔患者随机分为A、B两组。A组(30例)施行大网膜填塞缝合术,B组(26例)施行单纯缝合术。术后3～4天恢复饮食时,所有患者均开始接受奥美拉唑方案治疗,即口服奥美拉唑(20mg,bid) 羟氨苄青霉素(0.75,tid) 灭滴灵(0.4,tid),连续2周;然后再单独口服奥美拉唑(20mg,qd),连续4周。术后1年全面随访。随访内容包括症状问诊、胃镜复查和幽门螺杆菌(Hp)检测。随访结果按Visick标准分级。结果 胃镜下溃疡完全愈合且无任何临床症状者(Visick Ⅰ级)A组8例,B组4例。胃镜下溃疡虽愈合,但仍有轻微溃疡症状者(VisickⅡ级)A组4例,B组2例(P<0.01)。Hp检测两组无统计学差异(P>0.05)。结论 对于十二指肠溃疡急性穿孔,大网膜填塞缝合术的溃疡愈合率较高,优于单纯缝合术。     

消除幽门螺杆菌对十二指肠溃疡穿孔单纯修补术后的临床意义

目的 评估消除幽门螺杆菌(HP)对十二指肠溃疡穿孔单纯修补术后复发的影响和临床意义。方法 将123例十二指肠溃疡穿孔单纯修补术中的HP阳性110例随机分成抗HP组和非抗HP组各55例,进行随访及内镜检查,比较溃疡的初步愈合及1年后溃疡复发请况。结果 抗HP组和非抗HP组HP消除分别为53例及9例(P<0.001),溃疡早期完全愈合分别为52例及51例(P>0.5),1年后溃疡复发分别为2例及18例(P<0.01),有显著差异。结论 消除幽门螺杆菌可减少十二指肠溃疡穿孔单纯修补术后的溃疡复发,减少并发症出现。对于十二指肠溃疡穿孔的患者,除非有并发幽门梗阻、大出血或恶变等,否则一般可予单纯修补术,加以抗HP治疗,而不必予彻底性手术。     

改良高选择性迷走神经切断术治疗十二指肠溃疡急性穿孔

目的观察改良高选择性迷走神经切断术治疗十二指肠溃疡急性穿孔的远期临床效果。方法应用改良高选择性迷走神经切断术治疗十二指肠溃疡急性穿孔148例。随访观察术后并发症、胃酸下降情况及胃排空和溃疡复发情况,并按Visick标准进行分级。结果全组病例无围手术期死亡。126例获随访,随访时间6个月～9年,术后3年基础酸排出量(BAO)、最高酸排出量(MAO)、高峰酸排出量(PAO)仍保持术后低水平。Visick分级,Ⅰ级102例(81.0%),Ⅱ级15例(11.9%),Ⅲ级5例(4.0%),Ⅳ级4例(3.2%)。有2例患者溃疡复发(1.6%)。结论改良高选择性迷走神经切断术治疗十二指肠溃疡急性穿孔,设计合理、操作简单、效果确切,值得在基层医院推广应用。     

良性急性胃十二指肠溃疡穿孔两种手术方式的疗效比较

目的探讨良性急性胃十二指肠溃疡穿孔两种不同手术方式治疗的临床效果。方法对本院132例良性急性胃十二指肠溃疡穿孔病例,A组90例为单纯穿孔修补术加抑酸、根除幽门螺杆菌;B组42例胃大部切除进行疗效比较。结果所有病例治愈出院,随访3-120个月．两组的疗效按改良Visick分级评分标准I、II级分别为84．4％、76．1％,溃疡复发率分别为5．5％、7．1％,术后再次穿}L率均为零,两组比较差异均无统计学意义（P〈0．05）。B组切口感染发生率高于A组,差异有统计学意义（P〉O．05）。结论消化性溃疡穿孔修补加抑酸、根除幽门螺杆菌治疗,操作简单、创伤小、并发症少、远期疗效好,可作为良性急性胃十二指肠溃疡穿孔治疗的首选方式。     

十二指肠溃疡急性穿孔218例治疗分析

目的探讨十二指肠溃疡急性穿孔行单纯修补及术后药物治疗的效果。方法对我院2001年1月~2005年12月收治的十二指肠球部溃疡急性穿孔218例实施单纯修补术208例,术后给予抗溃疡药物及根除幽门螺杆菌(helicobacetr pylori,HP)治疗;保守治疗10例。结果本组近期效果良好。术后随访190例,随访半年~4年,溃疡复发13例,复发率为6%。失访28例。结论十二指肠溃疡急性穿孔行单纯修补术疗效确切。术后行正规抗溃疡及根除HP治疗能有效降低溃疡的复发率和并发症的发生率。     

32例十二指肠球部溃疡穿孔修补术加高选择性迷走神经切断术疗效分析

目的探讨十二指肠球部溃疡穿孔根治性修补术的可行性。方法将64例十二指肠球部溃疡穿孔患者,分成十二指肠球部溃疡穿孔修补加高选择性迷走神经切断术(高选迷切术)组(治疗组,32例)和十二指肠球部溃疡穿孔修补术组(对照组,32例)。对两组病例的疗效和安全性进行比较。结果术后6个月胃镜检查,治疗组溃疡愈合率(100%)高于对照组(71.9%);术后12个月复查,治疗组溃疡复发1例(3.1%),对照组10例复发(31.3%),8例(25.0%)未愈合;两组比较,P<0.01,差异有统计学意义。结论高选迷切术加穿孔修补对十二指肠溃疡穿孔的疗效明显优于单纯溃疡修补。     

迷走神经切断治疗十二指肠溃疡穿孔

迷走神经切断术治疗十二指肠溃疡在临床上已得到肯定、完善和推广。尽管药物治疗十二指肠溃疡的效果很好，但当并发溃疡穿孔仍需手术治疗，而且在十二指肠溃疡手术中的比例越来越高。因而研究迷走神经切断术治疗溃疡穿孔理所当然地成为一个极有实用价值的课题。采用高选择性迷走神经切断（HSV），加溃疡穿孔修补术治疗溃疡穿孔是一个合理的选择。Ceneviva等就单纯溃疡穿孔修补与高选择迷走神经切断加溃疡穿孔修补十二指肠溃疡穿孔的疗效作了前瞻性研究：两组各38例，其死亡率均为零，随访1～7年，单纯溃疡穿孔修补组58％溃疡复发，Visick…     

扩大壁细胞迷走神经切断术治疗十二指肠溃疡急性穿孔体会

目的探讨扩大壁细胞迷走神经切断术（EPCV）治疗十二指肠溃疡急性穿孔的效果。方法回顾性分析2002年1月至2006年10月29例十二指肠溃疡急性穿孔患者行扩大壁细胞迷走神经切断术治疗的临床资料。结果本组病例均临床治愈出院,其中21例获随访。Visick分级,Ⅰ级24例（82.9%）;Ⅱ级3例（10.3%）;Ⅲ级1例（3.4%）;Ⅳ级1例（3.4%）;Ⅰ级和Ⅱ级共占27例（93.2%）。十二指肠溃疡复发1例（3.4%）。结论规范化EPCV手术治疗十二指肠溃疡急性穿孔的术后复发率低,临床效果满意。因此,EPCV术是目前治疗十二指肠溃疡急性穿孔首选的术式。     

单纯修补术治疗十二指肠溃疡穿孔84例疗效分析

目的 观察单纯修补术治疗十二指肠溃疡穿孔的长期疗效。方法 采用小切口和传统开腹单纯修补术治疗十二指肠溃疡穿孔病人84例。术后口服奥美拉唑、呋喃唑酮及阿莫西林1～2周，继续服用奥美拉唑等药物1～2个月，随访3个月～2年。结果 术后3个月内溃疡愈合率为94％(79／84)，术后1年、2年复发率分别为3．9％(2／52)及5．2％(1／19)。全组无因溃疡复发而再手术病例。传统开腹组与小切口组住院天数差异有非常显著性。结论 溃疡穿孔单纯修补术简单可靠，配合术后药物治疗，疗效满意，单纯修补术作为治疗十二指肠溃疡穿孔的术式有着重要的临床价值。     

Simple suture with or without proximal gastric vagotomy for perforated duodenal ulcer

To assess the results of proximal gastric vagotomy (PGV) in the definitive treatment of perforated duodenal ulcers, a prospective study was carried out comparing PGV in association with omental patch suture (PGV + S) with the simple omental patch suture procedure (S). The PGV + S series consisted of 38 consecutive patients with perforated duodenal ulcer and the S series consisted of 38 survivors of a similar series of 41 consecutive patients. Surgical mortality was zero in the PGV + S series. The patients were followed up for 1 to 7 years. No cases of dumping or diarrhoea were observed. Thirty-three patients in the PGV + S series (87 per cent) were classified as Visick grade I and only two (5 per cent) as Visick grade IV. In contrast, 11 patients (29 per cent) were Visick grade I and 22 (58 per cent) were Visick grade IV in the S series. Recurrent ulcer was detected endoscopically in 58 per cent of the patients who had been treated with simple suture and in only 5 per cent after suture plus PGV. PGV is a safe operation with a negligible morbidity rate and with a significant rate of effective control of ulcer disease. Depending on the general condition of the patient and on the surgeon's skill, it appears preferable to treat not only the acute perforation but also the ulcer disease by PGV.     

Proximal gastric vagotomy. Follow-up of 109 patients for 6-13 years

From January 1973 through December 1979, 131 patients underwent proximal gastric vagotomy (PGV) for duodenal ulcer. There were 78 men and 53 women, whose age ranged from 19 to 73 years, with a mean age of 45 years. One hospital death occurred as a result of pulmonary embolism (0.7% mortality). There were 12 late deaths unrelated to ulcer disease, and each of the 12 patients was graded Visick I or II prior to death. Nine patients were lost to follow-up. This report is an analysis of the remaining 109 patients followed from 6 to 13 years. One hundred two patients (93.5%) underwent PGV for intractability. Seven patients (6.5%) who underwent PGV in selective circumstances for either acute perforation (3 patients), bleeding (1 patient), and moderate outlet obstruction (3 patients) are included. Follow-up results reveal that 52 patients (47%) are graded Visick I, 40 patients (36%) Visick II, five patients (5%) Visick III, and 12 patients (12%) Visick IV. Mild diarrhea occurred in 2.8% and mild dumping in 1.9%, and no reflux gastritis or esophagitis was noted. Recurrent ulceration took place in 10 patients, and seven subsequently required reoperation. Two additional patients had the antral pump mechanism denervated and later required antrectomy. PGV has yielded satisfactory results over a 6-13 year follow-up when operation was done for intractability. The low incidence of unpleasant long-term side effects is an appealing feature of the operation. A recurrent ulcer rate of 9.2% (10 patients) has, however, been of major concern. Those with a prime interest in gastric surgery are urged to continue the use of PGV in cases of intractability. Another 10 years of clinical investigative work will no doubt be necessary to determine the ultimate rate of recurrent ulceration.     

Proximal gastric vagotomy, truncal vagotomy with drainage, and truncal vagotomy with antrectomy for chronic duodenal ulcer. A prospective, randomized controlled trial.

The relative merits of proximal gastric vagotomy (PGV), truncal vagotomy with drainage (TV + D), and truncal vagotomy with antrectomy (TV + A) in the treatment of chronic duodenal ulcer were evaluated and compared in 152 patients in a prospective, randomized and controlled clinical trial. One death occurred after TV + A, resulting in an operative mortality of 2% after gastrectomy and 0.7% for the entire series. After one to six years, stomal and duodenal ulcers proven by endoscopy occurred in eight patients after PGV (16%) and in six patients after TV + D (11.8%); the difference was not statistically significant (p greater than 0.5). One additional patient developed a gastric ulcer nine months after PGV. There was so far no ulcer recurrence after TV + A. Majority (13 patients) of the recurrent ulcers were discovered within three years after surgery. Patients after PGV experienced significantly less unwanted side effects than those after either TV + D or TV + A; particularly, dumping, epigastric fullness, and diarrhea. When the functional status was graded according to a modified Visick system that excluded ulcer recurrence, significantly more PGV patients were placed in the near-perfect grade (82.1%) than TV + A patients (58%). Patients after TV + D fared better than patients after TV + A; but the differences were not significant. However, when ulcer recurrence was included in the functional assessment, the advantage of PGV was lost.     

Proximal gastric vagotomy compared with vagotomy and antrectomy and selective gastric vagotomy and pyloroplasty.

A prospective, randomized study of proximal gastric vagotomy without drainage (PGV) was done in 174 adult men with chronic duodenal ulcer intractable to medical therapy. PGV was randomized against truncal vagotomy with antrectomy (TV + A) and against selective gastric vagotomy with Finney pyloroplasty (SGV + P). Postgastrectomy sequelae (dumping, diarrhea and reflux gastritis) were less after PGV. One patient after PGV developed a recurrent ulcer as did one patient after SGV + P. Two patients developed gastric ulcers after PGV. Good to excellent results (Visick I and II) were obtained in 96% of patients with PGV, 94% with TV + A and 86% with SGV + P. Follow-up studies were from six months to four years.     

扩大壁细胞迷走神经切断术治疗十二指肠溃疡及其并发症

目的：评价扩大壁细胞迷走神经切断术（EPCV）治疗十二指肠溃疡及其并发症的远期临床疗效。方法：采用EPCV共治疗十二指肠溃疡及其并发症321例。其中慢性溃疡56例,并发急性穿孔204例,出血21例,狭窄40例。评价内容包括：术后并发症发生率、胃酸分泌功能、胃排空功能、胃镜和上消化道钡餐检查、营养状态、Visick分级。结果：全组321例患者中289例获得随访,随访率为90%,随访期为0.5-22.0年,平均为11.3年。全组无手术死亡,无纵隔炎和倾倒综合征发生。发生粘连性肠梗阻4例（1.4%）,进食后上腹胀19例（6.5%）,返酸17例（5.8%）,总的溃疡复发16例（5.5%）,其中慢性十二指肠溃疡为19.5%,出血为0,狭窄为5.3%,穿孔为3.1%。16例复发溃疡经内科药物治疗后溃疡愈合10例,其余6例经胃部分切除或胃窦切除痊愈。EPCV总的优良率（VisickⅠ和Ⅱ级）为91.7%,其中穿孔为95.3%,效果最佳。结论：EPCV具有手术操作简便、术后并发症较少、溃疡复发率低、术后远期患者营养状况良好、生活质量较高的特点,疗效优良。EPCV术是治疗十二指肠溃疡及其并发急性穿孔、出血和狭窄首选的安全有效术式。     

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??Long-term follow-up of lesser gastric curve and fundus seromyotomy for the treatment of duodenal ulcer and its complication: an analysis of 55 cases JIANG Xiao-chun*??XU Rui-yun. *Department of Surgery, the 113th Hospital of PLA, Ningbo 315040,China Corresponding author: JIANG Xiao-chun??E-mail: jiangxc1963@yahoo.cn Abstract Objective To research the long-term curative effects of lesser gastric curve and fundus seromyotomy (LGCFS) for the treatment of duodenal ulcer and its complications. Methods Fifty-five cases of duodenal ulcer performed LGCFS from 1983 to 1991 at the Third Affiliated Hospital of SUN Yat-sen University were followed up by means of letters, telephone and outpatient reexamine. The curative effects were classified by the Visick scale. Results Forty-seven cases were followed up.The Visick classification results were: (1) Twenty-five (78.1%), 2(6.3%), 3(9.4%) and 2(6.3%) cases being classified as Visick I,II,III,IV respectively among 32 cases without any complication.(2) Five (33.3%), 2(13.3%), 2(13.3%) and 6(40.0%) cases being classified as Visick I,II,III,IV respectively among 15 cases with complications. (3) Thirty (63.8%), 4 (8.5%), 5 (10.6% ) and 8 (17.0% ) cases were classified as Visick I,II,III,IV respectively among 47 cases. Conclusion LGCFS is simple and has few complications.The long term curative effect is good for duodenal ulcer without any complication.But it is bad for duodenal ulcer with complications,especially for duodenal ulcer with pyloric obstruction because of the high recurrent rate of pyloristenosis after LGCFS plus pylorodiosis.     

Prospective randomized multicentre trial of proximal gastric vagotomy or truncal vagotomy and antrectomy for chronic duodenal ulcer: interim results.

In three centres, 222 patients (Birmingham 70, London 87 and Rotterdam 65 patients) with chronic duodenal ulcer were treated by proximal gastrict vagotomy (PGV) (116 patients) or truncal vagotomy and antrectomy (TVA) (106 patients) in a prospective randomized trial. After 1 year 5 recurrent duodenal ulcers (4.3 per cent) have been recorded in the PGV group, compared with 1 (1 per cent) in the TVA group. The reoperation rate was high in both groups-6 after PGV, usually for recurrent ulcer, and 7 after TVA, mostly for gastric retention. PGV showed a marked superiority in the number of patients with a good clinical result Visick I or II) at 1 year after operation, i.e. 82 per cent compared with 56 per cent for TVA.     

逆行游离高选择性胃迷走神经切断术治疗十二指肠溃疡

目的：探讨逆行游离高选择性胃迷走神经切断术治疗十二指肠溃疡的可行性和有效性,评估该术式的远期效果,为临床治疗提出新思路。方法：应用逆行游离高选择性胃迷走神经切断术治疗十二指肠溃疡主其工发穿孔、出血和狭窄患者70例,其溃疡穿孔61例,出血6例,狭窄3。结果：65例患者获得访,总的溃复发率为7.69%,再出血率为0。随访30-120个月,属改良VisickⅠ级56例占86.2%,Ⅱ级4例占6.1%,Ⅲ级2例占3.0%,Ⅳ级3例占4.6%,Ⅰ、Ⅱ级共占92.3%。结论：逆行游离高选择性胃迷走神经切断术治疗十二指肠溃疡及其并发症,具有缩短手术时间、简化手术操作、患者远期预后好等优点,可作为治疗十二指肠溃疡合并症的一种有效的方法。     

Prospective randomized multicentre trial of proximal gastric vagotomy or truncal vagotomy and antrectomy for chronic duodenal ulcer: results after 5-7 years

In a prospective, randomized study 145 patients with duodenal ulcer have been followed 5-7 years after proximal gastric vagotomy (PGV) or truncal vagotomy with antrectomy (TVA). Postoperative complications were significantly higher after TVA (P less than 0.0005). There was one death due to anastomotic leakage after TVA. The recurrence rate was significantly higher after PGV (9.9 per cent). Postoperative symptoms were less after PGV (P less than 0.01). Due to the recurrence rate after PGV there was no overall significant difference in the Visick grading, although perfect results (Visick I) were seen significantly more often (P less than 0.01). It is concluded that better results follow PGV.     

How do clinical results after proximal gastric vagotomy compare with the Visick grade pattern of healthy controls?

Recently, the 5-year results of a multicenter trial on proximal gastric vagotomy (PGV) have been reported. Symptomatic results in 415 duodenal ulcer patients, according to the Visick grading, were as follows: grade 1, 64%; 2, 28%; 3, 4%; and 4, 4%. It appears that one-third of the patients are symptomatic, and the question arises as to which standard such a Visick grade pattern should be compared. Five hundred sixty-one healthy controls (blood donors), without history of peptic ulcer or previous gastric operation, have been examined according to a standard questionnaire identical to that used for follow-up interrogation in the PGV trial. The control group was matched for sex and age with the trial population. Answers to 3 screening questions were compared with the result of detailed interrogation. The control group's Visick pattern was as follows: grade 1, 64.5%; 2, 28.9%; 3, 6.4%; and 4, 0.2%. Symptoms most frequently encountered were those of dyspepsia (pain, epigastric fullness) and gastroesophageal reflux. Dumping (2%) and diarrhea (4%) were also noted. Our conclusions are these: (1) The Visick grade pattern 5 years after PGV is almost identical with that of healthy controls. (2) Dull pain, epigastric fullness, and reflux symptoms are not specific signs after PGV. (3) Screening questions are misleading and follow-up examinations must be based on a standard questionnaire to provide valid information. (4) The separation between Visick grade 1 and 2 should be abandoned, as it has no clinical importance. (5) PGV has virtually no specific long-term sequelae except recurrence.