The analgesic and antipyretic effects of a non-steroidal antiinflammatory agent, EB-382, in experimental animals

The analgesic and antipyretic effects of EB-382 as a new non-steroidal antiinflammatory agent were examined in mice and rats. EB-382 had an equipotent inhibition to ibuprofen on the writhing syndrome caused by acetic acid, phenylquinone and acetylcholine in mice, but phenylbutazone was less potent in these experiments. EB-382 had a much more potent inhibition on the pain by the Randall-Selitto method and silver nitrate-induced arthritic pain in rats than ibuprofen and phenylbutazone. EB-382 had no analgesic effect on the pain of non-treated foot by the Randall-Selitto method in rats and by the hot-plate method in mice. EB-382 had a much more potent inhibition on the yeast-induced chronic inflammatory and adjuvant arthritic pains in rats than ibuprofen and phenylbutazone. The antipyretic activity of EB-382 was almost equipotent to that of ibuprofen in rats. EB-382 had no effect on the normal body temperature in rats, which was different from aminopyrine. The above results suggest that EB-382 will be a useful analgesic agent with an antipyretic antiinflammatory activity in clinical studies.     

桂皮醛解热镇痛抗炎作用的实验研究

目的：观察桂皮醛解热镇痛抗炎作用。方法：采用酵母发热大鼠模型，观察桂皮醛解热作用；采用小鼠扭体法和热板法，观察桂皮醛镇痛作用；通过小鼠耳肿胀及对腹腔毛细血管通透性的影响观察桂皮醛抗炎作用。结果：桂皮醛能显著减轻酵母所致大鼠发热反应，明显提高热板痛阈和抑制醋酸所致扭体反应，亦能显著抑制腹腔毛细血管通透性的增高及二甲苯所致小鼠耳廓肿胀。结论：桂皮醛具有明显的解热镇痛抗炎作用。     

Anti-inflammatory, analgesic and antipyretic activities of loxoprofen sodium given intramuscularly in animals

The evaluation of the anti-inflammatory, analgesic and antipyretic activities of loxoprofen sodium given in intramuscular route was investigated as compared to oral application in rats and mice. The intramuscular ED50 values of loxoprofen sodium in carrageenan edema and vascular permeability tests are 1.15 and 7.8 mg/kg, respectively, which represent more potent than in case of oral application. Its therapeutic effects in adjuvant arthritis were shown at 6 mg/kg i.m. and 3mg/kg p.o. Analgesic effect was shown to be more potent as given intramuscularly. Similar potency of antipyretic effects was shown in both administration routes. Considerably weak gastric damages were observed in intramuscular application.     

三叶青提取物抗炎、镇痛及解热作用的实验研究

目的:探讨三叶青提取物(ERT)的抗炎、镇痛及解热作用,并验证其相关功效.方法:以小鼠腹腔毛细血管通透法、小鼠耳肿胀法及大鼠足肿胀法观察其抗炎作用;以小鼠扭体法、热板法观察其镇痛作用;以干酵母致热法及2,4-二硝基苯酚致热法观察其解热作用.结果:三叶青提取物能明显抑制小鼠腹腔毛细血管炎性渗出,抑制二甲苯所致小鼠耳廓肿胀及10%蛋清致大鼠足跖肿胀;减少醋酸致小鼠扭体次数,提高热板法小鼠痛阈值;并降低干酵母和2,4-二硝基苯酚致大鼠发热模型的体温.结论:三叶青提取物具有较好的抗炎、镇痛及解热作用,与其相关的中医临床功效及主治相符.     

Mechanistic assessment of the analgesic,anti-inflammatory and antipyretic actions of Dalbergia saxatilis in animal models

Context: Aqueous root extract of Dalbergia saxatilis, Hook, f., (Leguminosae) (DS) is reported useful for toothache, pains, and fever, but not scientifically proven.

Objective: This study determined its effectiveness in pain, inflammation, and fever, applying scientific models.

Materials and methods: Swiss mice or Sprague–Dawley rats (n?=?5) were pretreated with distilled water, DS (100 or 200?mg/kg), or standard drug for 30?min. The analgesic activity was measured by acetic acid writhing, tail flick, tail immersion, tail clip, hot plate, and formalin pain tests; anti-inflammatory effects were determined via carrageenan and dextran rat paw oedema tests; antipyretic activity was measured by Escherichia coli lipopolysaccharide (ECL) and turpentine in rabbits, and d-amphetamine sulphate (d-AS) pyrexia test in rats.

Results: Writhing frequency inhibition was produced by 200?mg/kg DS (33.10%), aspirin (38.19%) and morphine (93.68%). Unlike morphine, DS did not produce significant prolongation of the reaction times in the hot-plate, tail immersion, tail flick, and tail clip tests. In the first and second phases of formalin test, respectively, % inhibition was: 200?mg/kg DS (25.70% and 0%), aspirin (4.76% and 67.33%), morphine (81.42% and 66.11%); for carrageenan and dextran tests, significant difference was recorded between 200?mg/kg DS and control up to 6?h. Significant reduction in ECL, turpentine and d-AS pyrexia was recorded at 100 and 200?mg/kg DS.

Conclusion: DS produces mild non-steroidal analgesic and anti-inflammatory, as well as significant antipyretic actions involving cyclooxygenase, α₂ adrenoceptor and interleukin-1 β1 due to any of glycosides, saponins or phenolic tannins.     

Anilides with analgesic and antipyretic activity

Several trimethylcyclopentyl and trimethylcyclopentenyl acetanilides, mono- and di-substituted on the aromatic nucleus as well as the corresponding acyl derivatives from aniline it self and corresponding phenylacetanilides, were prepared and tested as analgesics and antipyretics. Several compounds exhibit considerable activity in some cases superior to that of acetanilide.     

右酮洛芬对实验动物的解热镇痛和抗炎作用

目的 :研究右酮洛芬的解热镇痛和抗炎作用。方法 :采用小鼠热板法和热辐射甩尾法 ;角叉菜胶诱导的大鼠和伤寒疫苗诱导的兔体温升高 ;二甲苯诱导的小鼠耳水肿 ,大鼠角叉菜胶诱导的足肿胀和大鼠棉球肉芽肿胀实验模型。结果 :右酮洛芬( 7.5,15,30mg·kg- 1)能明显延长小鼠热板和热辐射甩尾的痛阈时间 ;右酮洛芬 ( 7.5,15,30mg·kg- 1)对角叉菜胶诱导的大鼠体温升高 ,右酮洛芬( 1.9,3.8,7.5mg·kg- 1)对伤寒疫苗诱导的兔体温升高均有明显的降温作用 ;右酮洛芬 ( 7.5,15,30mg·kg- 1)对二甲苯诱导的小鼠耳水肿有显著的抑制作用 ;右酮洛芬 ( 3.8,7.5,15mg·kg- 1)对大鼠角叉菜胶引起的足肿胀及棉球诱导的大鼠肉芽肿均有显著的抑制作用。结论 :实验结果表明 ,右酮洛芬具有良好的解热镇痛和抗炎作用     

Analgesic,antipyretic, anti-inflammatory and toxic effects of andrographolide derivatives in experimental animals

Andrographolide (1) and 14-deoxy-11,12-didehydroandrographolide (2) are active constituents of Andrographis paniculata (Burm. f.), family Acanthaceae. A. paniculata extracts are reported to have antiviral, antipyretic, immunostimulant and anticancer activities. In this study, 1 and its 14-acetyl- (4) and 3,19-isopropylidenyl- (3) derivatives, as well as 2 and its 3,19-dipalmitoyl-derivative (5), were intraperitoneally tested for their analgesic, antipyretic, anti-inflammatory and acute toxicity effects in animal models. Analgesic effects were tested in mice using hot plate and writhing tests to distinguish the central and peripheral effects, respectively. The results showed that, at 4 mg/kg, all tested substances have significant analgesic effects, and the highest potency was seen with 3, 4 and 5. Increasing the dose of 3 and 5 to 8 mg/kg did not increase the analgesic effect. In the writhing test, 3 and 5, but not 1, showed significant results. In a baker’s yeast-induced fever model, 3 and 5 significantly reduced rats’ rectal temperature (p < 0.05). In a carrageenan-induced inflammation model, 1, 3 and 5 significantly reduced rats’ paw volume. Doses of 3 and 5 up to 100 mg/kg did not show any serious toxic effects. From this study, 3 and 5 are the most interesting derivatives, showing much greater potency than their parent compounds. These could be further developed as analgesic, antipyretic and anti-inflammatory agents, without any serious toxicity.     

赖氨匹林的解热、镇痛和抗炎作用

目的：应用大鼠及小鼠研究赖氨匹林的抗炎、镇痛及解热作用。方法：用大鼠足跖肿胀研究抗炎作用，用小鼠醋酸扭体法及热板法测定镇痛作用，用鲜酵母法测定解热作用。结果：赖氨匹林对大鼠足跖肿胀有明显抑制作用，最大抑制率为８０％（Ｐ＜０．０１）。小鼠醋酸扭体法测得镇痛ＥＤ５０＝７２±２３ｍｇ／ｋｇ，对鲜酵母致大鼠体温升高有明显抑制作用。小鼠半数致胃溃疡剂量ＵＤ５０＝０．１８±０．０６ｍｍｏｌ／ｋｇ，是阿司匹林的２．４倍。结论：赖氨匹林具有和阿司匹林相当的解热、镇痛和抗炎作用，而对胃肠道的毒副作用比阿司匹林小。     

Anti-inflammatory, analgesic and antipyretic activity of pyrimidant

In experiments on rats with different models of pathology it was demonstrated that a new non-steroidal anti-inflammatory drug pyrimidant exerts pronounced anti-inflammatory, analgesic and antipyretic effects. In some cases its activity exceeds that of indomethacin, brufen, butadione, mefenamic acid, sodium salicylate.     

风热流浸膏解热镇痛和抗炎作用的实验研究

目的观察风热流浸膏的抗炎、镇痛和解热作用。方法采用二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足趾肿胀的模型观察抗炎作用;采用乙酸和热刺激致小鼠疼痛的模型观察镇痛作用;采用2,4-二硝基酚和酵母粉致大鼠发热的模型观察解热作用。结果风热流浸膏能减轻小鼠耳肿胀和大鼠足趾肿胀炎症反应,缓解乙酸和热刺激所致疼痛,降低2,4-二硝基酚和酵母粉致大鼠发热的体温。结论风热流浸膏具有显著的抗炎、镇痛和解热作用。     

我院门诊解热镇痛抗炎药物应用分析

目的分析门诊解热镇痛抗炎药物的使用情况,以期为临床合理选择解热镇痛抗炎药物提供参考。方法采用金额统计法,回顾性统计2016年6月门诊各类解热镇痛抗炎药物应用情况,对解热镇痛抗炎药物销售金额、构成比、各用药科室使用频率及其排序进行分析。结果 2016年6月门诊使用解热镇痛抗炎药物处方总金额为30 682.40元,占门诊药品销售总金额的1.17%;塞来昔布胶囊总销售金额排在解热镇痛抗炎药物第一位占47.33%;门诊解热镇痛抗炎药物使用频率最高的是外科门诊。结论解热镇痛抗炎药物合理使用疗效显著,不合理使用可导致严重不良反应。临床医师应正确合理地选择解热镇痛抗炎药物,更好地为患者的健康服务。     

解热镇痛抗炎药在门诊患儿中的应用分析

<正>解热镇痛抗炎药是一类具有解热、镇痛且大多数具有抗炎、抗风湿作用的药物。由于儿童在感染疾病时出现发热症状占有相当大的比例,所以解热镇痛抗炎药在儿科的药物使用中占有很重要的位置。普通感冒、急性扁桃体炎、肺炎和某些急性传染病     

Preliminary studies on antipyretic and analgesic properties of Taverniera abyssinica

In an attempt to ascertain the pharmacological basis of the use of the marketed traditional drug Taverniera abyssinica A. Rich. (Amharic name Dingetegna), crude extracts as well as purified substances of this plant were tested for their antipyretic and analgesic properties. Antipyretic activity was determined on rats made hyperthermic by yeast injection and analgesic activity was determined by the hot plate, as well as the acetic acid induced writhing, methods. The study showed that the plant possesses significant antipyretic and analgesic activities.     

地塞米松抑制巨噬细胞产生氧自由基和一氧化氮

为探讨糖皮质激素对巨噬细胞功能的影响，观察了地塞米松对巨噬细胞产生氧自由基和一氧化氮的作用。结果表明地塞米松明显抑制巨噬细胞杀伤念珠菌以及抑制巨噬细胞产生氧自由基（Ｐ＜０．０１），减少内毒素诱导的一氧化氮生成（Ｐ＜０．０１）。提示了地塞米松抑制巨噬细胞杀菌功能的机制。     

滇乌碱的抗炎和镇痛作用

YAc对毛细血管通透性、不同致炎剂产生的足跖肿胀、白细胞游走和棉球肉芽组织增生均有明显抑制作用。摘除双侧肾上腺后YAc 抗炎作用仍存在,但不延长生存时间。3种测痛方法证实YAc有镇痛作用。对酵母致热大鼠有明显解热作用。