早期添加肠外营养对创伤患者营养摄入和预后的影响

目的 观察创伤患者早期添加肠外营养(PN)后蛋白质和能量摄入的变化,及对预后的影响.方法 采用回顾性对照研究方法,将195例创伤患者按伤后7d内是否添加PN分为对照组(105例)和混合营养组(90例).比较两组的营养支持时间、14d内蛋白质和能量的摄入及临床结局的差异.结果 两组患者伤情程度一致,急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分、损伤严重度评分(ISS)和格拉斯哥昏迷评分(GCS)无明显差异.与对照组相比,混合营养组开始营养支持的时间(h)较早(40.0±21.0比55.1±23.5,P＜0.01),肠内营养(EN)开始时间(h)延迟(75.2±54.5比55.1±23.5,P＜0.01),48 h内EN比例低[14.4％(13/90)比43.8％(46/105),P＜0.01],恢复口服饮食的时间(d)无统计学差异(10.8±3.7比11.4±3.6,P＞0.05).混合营养组在治疗3、7、t4d摄人的能量(kJ)均优于对照组(3d:3981.6±2209.3比2683.2±1414.9,7 d:5477.5±2008.4比3619.1 ± 1429.9,14 d:6250.2±2533.2比5199.9±1972.7,P＜0.05或P＜0.01);两组蛋白质的摄入量(g)均较低,混合营养组治疗3d明显低于对照组(20.6±18.4比26.5± 13.8 P＜0.05).与对照组比较,混合营养组住院时间(d)明显延长(73.9±62.5比50.9±33.3,P＜0.01),而病死率[4.4％(4/90)比3.8％(4/t05)]、感染和急性呼吸窘迫综合征(ARDS)的发生率[8.9％(8/90)比3.8％(4/105),5.6％(5/90)比7.6％(8/105)]、机械通气时间(d:8.3±4.6比7.3±4.7)、ICU停留时间(d:17.6±13.2比14.2±11.3)均无统计学差异(均P＞0.05).结论 虽然创伤患者早期加用PN能增加能量摄入,但不规范的PN不能改变创伤患者的预后,并可增加住院天数.     

容量负荷对脓毒性急性肾损伤预后的影响

目的 探讨容量负荷对脓毒性急性肾损伤(AKI)患者预后的影响.方法 采用回顾性研究方法,选择2009年10月至2011年9月收住滨州医学院附属医院重症监护病房(ICU)的脓毒性AKI患者作为研究对象,对比观察第一个72 h内液体正平衡与负平衡患者的28 d病死率、28 d肾功能恢复率、住ICU时间及机械通气率.观察连续性肾脏替代治疗(CRRT)对患者容量负荷及预后的影响.结果 160例脓毒性AKI患者人选本研究,液体负平衡组(81例)28 d病死率[37.0％(30/81)比68.4％(54/79),P＜0.01]、住ICU时间(d:10.1 ±4.9比12.4±8.0,P＜0.05)及机械通气率[50.6％(41/81)比68.4％(54/79),P＜0.01]较液体正平衡组(79例)明显降低.根据急性肾损伤协作网(AKIN)分期,在AKI 1、2、3期(分别为49、52、59例),经CRRT治疗者第一个72 h内日平均容量(ml)均明显低于未行CRRT治疗者(-10比716,324比778,521比1177,均P＜0.05),同时AKI2期CRRT治疗者28 d病死率显著低于未行CRRT治疗者[38.7％(12/31)比66.7％(14/21),P＜ 0.05].结论 容量负荷与脓毒性AKI患者预后有关,液体负平衡可以降低患者28 d病死率,CRRT可以调节容量负荷,改善患者的预后.     

七叶皂苷钠对重型颅脑创伤患者脑脊液肿瘤坏死因子-α及白细胞介素-6表达的影响

目的 观察七叶皂苷钠对重型颅脑创伤患者脑脊液肿瘤坏死因子-α (TNF-α)及白细胞介素-6(IL-6)表达的影响,探讨其临床意义.方法 将73例重型颅脑创伤患者按入院先后顺序分为对照组(36例)及治疗组(37例).对照组采用西医常规治疗,治疗组在西医治疗的基础上加用七叶皂苷钠每日20 mg静脉滴注,连续治疗10d.采用放射免疫法测定两组患者不同时间点脑脊液中TNF-α及IL-6的含量,同时监测患者颅内压(ICP)变化,并在伤后6个月根据格拉斯哥预后评分(G0S)判断预后.结果 治疗组治疗前及伤后1d脑脊液TNF-α及IL-6水平与对照组无明显差异(均P＞ 0.05),伤后3、7及14d均较对照组明显降低(P＜0.05或P＜0.01).在治疗前及伤后1d,治疗组ICP与对照组比较无明显差异(均P＞ 0.05),在伤后3、7、14 d均较对照组明显降低(均P＜ 0.01);治疗组病死率低于对照组(27.03％比38.89％,P＜0.05),预后改善明显.结论 七叶皂苷钠可明显降低重型颅脑创伤患者脑脊液TNF-α及IL-6表达水平,降低ICP,促进神经功能恢复,改善预后.     

重型颅脑损伤昏迷患者的营养支持

目的 探讨肠内、肠外复合营养支持对重型颅脑损伤昏迷患者的临床意义及对预后的影响.方法 采用前瞻性研究方法,选择56例重型颅脑损伤昏迷患者,按入院顺序随机分为治疗组(28例)和对照组(28例).治疗组采用肠内营养(EN)+肠外营养(PN)复合营养,患者于伤后2d开始应用EN,用PN补充EN的不足,7d后EN达全量.对照组采用常规延迟性EN治疗.治疗前后测定患者的血清白蛋白(Alb)、血红蛋白(Hb)、外周血淋巴细胞总数(TLC),上臂围(MAC)、三头肌皮褶厚度(TSF),并计算上臂肌围(MAMC);观察并发症发生情况及预后.结果 治疗组治疗14 d营养状态明显好于对照组[Alb (g/L):35.28±2.13比30.30±2.56,Hb (g/L):135.7± 13.5比113.5±15.5,TLC(×109/L):1.62±0.41比1.35±0.48,MAC (cm):26.62± 1.97比23.19±1.56,TSF (mm):10.95±3.80比8.87±2.25,MAMC (cm):23.63±2.36比20.30±2.07,均P＜0.05],治疗组发生并发症例数[感染5例,多器官功能障碍综合征(MODS)2例,反复消化道出血4例]明显少于对照组(分别为6、4、7例),且预后转好例数多于对照组(16比7),病死率明显低于对照组(14.3％比25.0％,P＜0.05).结论 EN+PN复合营养支持符合重型颅脑损伤患者的病理生理要求,能使该类患者营养状况和生存率提高,有利于颅脑损伤患者尽早恢复.     

亚低温对创伤性脑损伤患者脑脊液髓鞘基本蛋白的影响

目的 探讨亚低温对创伤性脑损伤患者脑脊液髓鞘基本蛋白(MBP)水平的影响.方法 36例重型颅脑损伤患者,随机分为亚低温治疗组及常温治疗组,在不同时间点评价颅内压变化、GOS预后,通过酶联免疫吸附实验(ELISA)分析治疗各时间点脑脊液MBP的变化,综合分析亚低温对重型颅脑损伤患者的影响.结果 两组比较,治疗1d脑脊液MBP浓度差异无统计学意义[分别为(24.95±2.07)、(26.72±2.43)μg/L,t=2.36,P＞0.05].在治疗7、14 d亚低温治疗组比常温治疗组脑脊液MBP浓度明显降低,差异均有统计学意义[(12.41±0.74)、(19.54±1.38)μg/L,t=19.86,P＜0.05;(7.85±0.32)、(13.51±1.46)μg/L,t=16.89,P＜0.05].而颅内压监测显示,两组治疗1d颅内压变化差异无统计学意义,在治疗7、14 d颅内压变化差异均有统计学意义[(19.0±2.1)、(26.0±2.6)mm Hg,t=8.94,P＜0.05;(13.0±1.8)、(19.0±1.6)mm Hg,=10.43,P＜0.05].两组预后比较差异有统计学意义(Z=-2.82,P＜0.05);亚低温治疗组预后良好率明显高于常温治疗组(P＜0.05),但在病死率方面差异无统计学意义(P＞0.05).结论 亚低温治疗可能通过减少MBP降解来稳定中枢神经系统髓鞘,达到脑保护作用,从而改善重型颅脑损伤患者的预后.     

重型颅脑损伤患者能量平衡及影响预后的因素分析

目的：观察和分析重型颅脑损伤患者能量平衡以及预后的影响因素。方法对100例重型颅脑损伤患者进行格拉斯哥昏迷评分（GCS ）预后评估,能量平衡计算,并观察各项凝血指标变化情况。结果颅内血肿量、瞳孔变化、GCS评分、并发症的发生情况是影响重型颅脑损伤患者预后的重要因素;预后不良组患者凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（FIB）、D二聚体（DD）、血小板计数（PLT）等各项凝血功能指标明显优于预后良好组,差异具有统计学意义（ P＜0．05）;在伤后第3周住院时,患者的摄入能量为（8276．56±1542．29）J ,大于目标能量[（8239．36±1493．57）J],呈现能量正平衡状态。结论影响重型颅脑损伤患者预后因素包括颅内血肿量、瞳孔变化、GCS评分、脑挫裂伤范围、并发症等,可以作为临床治疗的参考依据。     

亚甲蓝排泄试验在重型颅脑损伤早期合理营养支持中的应用研究

目的 探讨亚甲蓝排泄试验在重型颅脑损伤患者早期实施合理营养支持中的应用价值.方法 将2010年1月至2012年6月入院的133例重型颅脑损伤患者作为治疗组,将2007年1月至2009年12月入院的同类患者127例作为对照组.治疗组患者于受伤第3、8、15天进行亚甲蓝排泄试验,根据患者尿液变蓝色的时间确定营养支持方式;对照组常规先采用肠内营养支持治疗,15 d后仍不能耐受肠内营养者改为肠外营养治疗.观察两组患者体质量、血清白蛋白及血红蛋白等营养情况以及并发症的发生情况.伤后3个月随访格拉斯哥预后评分(GOS)情况判断疗效.结果 治疗前两组体质量差异无统计学意义,3周后治疗组平均体质量为(56.3±5.5) kg,对照组为(52.6±5.3) kg,两组比较差异有统计学意义(t=5.93,P＜0.01);伤后第14、21天治疗组的血清白蛋白分别为(32.7±3.4)、(34.3±3.8)g/L,血红蛋白为(113.4±12.5)、(118.5±13.3) g/L,对照组分别为(28.8±3.1)、(30.7±3.3) g/L,(102.2±11.6)、(106.7±12.4) g/L,治疗组营养状态明显优于对照组(P均＜0.05);3个月后治疗组有效率为93.23％(124/133),对照组为84.25％(107/127),差异有统计学意义(x2=5.29,P＜0.05).结论 根据亚甲蓝排泄试验来确定重型颅脑损伤患者早期合理营养支持方式,可为患者合理提供全面营养,增强机体抵抗力,降低并发症发生率,对改善预后有重要的临床价值.     

中重度颅脑损伤患者脑脊液中可溶性神经趋化蛋白含量的变化及临床意义

目的 探讨中、重度颅脑损伤患者脑脊液中可溶性神经趋化蛋白(sFkn)含量变化及与预后的相关性.方法 采用前瞻性研究方法,选择本院收治的30例中、重度颅脑损伤患者,按格拉斯哥昏迷评分(GCS)分为重度组(GCS 3～8分,11例)和中度组(GCS 9～12分,19例);按格拉斯哥预后评分(GOS)分为预后良好组(Ⅳ～Ⅴ级,23例)和预后不良组(Ⅰ～Ⅲ级,7例).采用双抗体夹心酶联免疫吸附试验(ELISA)检测伤后1、3、10 d患者脑脊液中sFkn含量.结果 在颅脑损伤中度、重度组及预后良好和不良组,脑脊液sFkn含量均随损伤时间的延长逐渐下降,伤后10d降至最低水平,与1d和3d比较差异有统计学意义.重度组各时间点脑脊液sFkn含量(ng/L)均较中度组明显升高(1 d:676.35±205.95比454.25±297.67,3 d:573.11±295.38比403.90±175.04,10d:359.37±186.07比103.62±78.33,均P＜0.05);预后不良组各时间点脑脊液sFkn含量均较预后良好组明显升高(1 d:702.41±276.80比585.34±217.26,3 d:697.58±164.41比431.23±220.70,10d:563.27±225.71比166.54±80.97,P＜ 0.05或P＜0.01);尤以伤后10 d差异较大(均P＜0.01).结论 sFkn作为前炎症因子参与了颅脑损伤的病理生理过程,脑脊液sFkn含量与颅脑损伤严重程度及患者预后密切相关,可以作为创伤后炎症反应的标志物.     

急性脑损伤时内脂素和超敏C-反应蛋白的变化

目的 检测急性颅脑损伤后患者外周血内脂素和超敏C-反应蛋白(hs-CRP)水平的动态变化,探讨其临床意义.方法 120例急性脑损伤患者均为滕州市中心人民医院神经外科及ICU科2009年8月至2010年6月收治住院的患者,其中男60例,女 60例,年龄(43.2±6.2)岁.所有患者均符合颅脑损伤诊断标准.根据入院时格拉斯哥评分(GCS)将患者分为轻度(13～15分)40例,中度(9～12分)40例,重度(3～8分)40例.60例健康体检人员作为对照,其中男30例,女30例,年龄(42.2±6.7)岁.患者于入院后12 h内(即0时间点)及1,3,7,15 d空腹抽取静脉血3 mL用于检测外周血hs-CRP和内脂素的含量变化.结果 急性颅脑损伤患者血清hs-CRP水平均显著高于正常人对照组(3.05±2.08)mg/L(P＜0.01),且患者hs-CRP水平与病情呈正相关;急性颅脑损伤患者血清内脂素含量明显高于正常对照组(17.61±2.45)μg/L(P＜0.01),与病情呈正相关;各组患者在入院当天hs-CRP水平有所升高,并在入院后继续升高,hs-CRP在1 d达高峰,3 d开始下降;内脂素含量在入院当天有所升高,3 d达到高峰,以后逐渐上升;患者内脂素水平与hs-CRP呈正相关(r=0.63,P＜0.01).结论 急性颅脑损伤患者外周血内脂素和hs-CRP水平的变化与病情严重程度密切相关.     

早期限制性液体正平衡策略对严重创伤患者预后的影响

目的 观察早期限制性液体正平衡策略对创伤患者预后的影响.方法 采用前瞻性对照研究方法,选择本院重症医学科收治的严重创伤后毛细血管渗漏综合征(PTCLS)患者作为研究对象,于PTCLS渗漏期,按照胸腔内血容积指数(ITBVI)、平均动脉压(MAP)、心排血指数(CI)和中心静脉血氧饱和度(ScvO2)进行液体治疗调整.根据液体治疗量的不同分为限制性液体正平衡组(限制组)和非限制性液体正平衡组(非限制组),每组30例.统计两组间治疗7d内液体平衡量及预后指标的差异.结果 与非限制组比较,限制组患者治疗1 ～6d液体日平衡量(ml/d)减低(l d:5968.8±1818.0比7109.7±2186.4,2 d:3653.7±1525.1比6080.3±1538.8,3 d:1953.6±621.3比3223.3±875.1,4 d:-2808.7±888.0比-4169.9±1302.5,5 d:-5969.1±1470.8比-6896.5±1619.4,6 d:-1938.1±746.0比-4964.0±1389.6,P＜0.05或P＜0.01),治疗2d和3 d ITBVI(ml/m2)、血管外肺水指数(EVLWI,ml/kg)明显下降(ITBVI 2 d:689.2±60.6比807.7±67.8,3 d:729.6 ±43.3比825.5±71.5:EVLWI 2 d:6.9±2.0比8.3±2.1,3 d:7.6± 2.0比8.9±1.9,P＜ 0.05或P＜ 0.01).与非限制组比较,限制组治疗7d时呼吸功能障碍(46.7％比76.7％)、胃肠功能障碍(33.3％比60.0％)及颅压增高(26.7％比56.7％)发生率明显减低(均P＜0.05),机械通气时间(d:3.6±11比5.1±1.5)和重症监护病房(ICU)停留时间(d:5.5±1.5比7.0±1.9)明显缩短(均P＜0.01),但两组间心血管、凝血、肝脏、肾脏功能障碍发生率,血液净化率和血液净化时间,以及28 d病死率比较差异无统计学意义.结论 早期限制性液体正平衡策略可以减少PTCLS渗漏期患者液体正平衡的量,减少部分器官功能障碍的发生,缩短机械通气时间和ICU停留时间.     

Determination of creatine kinase isoenzyme MB activity in serum using immunological inhibition of creatine kinase M subunit activity. Activity kinetics and diagnostic significance in myocardial infarction.

This is a new method for the determination of creatine kinase isoenzyme MB activity in serum. The method uses direct activity measurement of creatine kinase B subunit activity after blocking of CK-M subunit activity by inhibiting antibodies. The test takes no longer than 15 min. The method yields an intra-serial C.V. of 2.0-12.9%, and a C.V. from day to day of 5.5%. The detection limit is 3.4 U/l creatine kinase MB. In the 95 cases with proven myocardial infarction several types of creatine kinase MB activity kinetics could be determined. The percentage of creatine kinase MB of peak CK-total is 6-25%, with a mean of 11.1%. The amount of creatine kinase MB with respect to total CK activity after reinfarction is higher than the amount after initial infarction.     

Dissociable correlates of two classes of retrieval processing in prefrontal cortex

Although substantial evidence suggests that the prefrontal cortex (PFC) implements processes that are critical for accurate episodic memory judgments, the specific roles of different PFC subregions remain unclear. Here, we used event-related functional magnetic resonance imaging to distinguish between prefrontal activity related to operations that (1) influence processing of retrieval cues based on current task demands, or (2) are involved in monitoring the outputs of retrieval. Fourteen participants studied auditory words spoken by a male or female speaker and completed memory tests in which the stimuli were unstudied foil words and studied words spoken by either the same speaker at study, or the alternate speaker. On "general" test trials, participants were to determine whether each word was studied, regardless of the voice of the speaker, whereas on "specific" test trials, participants were to additionally distinguish between studied words that were spoken in the same voice or a different voice at study. Thus, on specific test trials, participants were explicitly required to attend to voice information in order to evaluate each test item. Anterior (right BA 10), dorsolateral prefrontal (right BA 46), and inferior frontal (bilateral BA 47/12) regions were more active during specific than during general trials. Activation in anterior and dorsolateral PFC was enhanced during specific test trials even in response to unstudied items, suggesting that activation in these regions was related to the differential processing of retrieval cues in the two tasks. In contrast, differences between specific and general test trials in inferior frontal regions (bilateral BA 47/12) were seen only for studied items, suggesting a role for these regions in post-retrieval monitoring processes. Results from this study are consistent with the idea that different PFC subregions implement distinct, but complementary processes that collectively support accurate episodic memory judgments.     

俯卧位通气对高海拔地区肺复张治疗无效急性呼吸窘迫综合征患者氧合的影响

目的 探讨俯卧位通气对高海拔地区肺复张术(RM)治疗无效急性呼吸窘迫综合征(ARDS)患者的治疗作用.方法 从海拔2260m的地区医院筛选RM治疗无效的41例ARDS患者[平均氧合指数( PaO2/FiO2)较RM前升高＜20％视为RM无效],依不同病因分为肺内源性ARDS组(ARDSp组)和肺外源性ARDS组(ARDSexp组),每组再按信封法随机分为俯卧位组和仰卧位组,即ARDSp俯卧位组(11例)、ARDSp仰卧位组(9例)、ARDSexp俯卧位组(10例)、ARDSexp仰卧位组(11例).在通气前及通气1、2、3、4h监测动脉血氧分压( PaO2)、PaO2/FiO2、静态顺应性(Cst)、气道阻力(Raw)的变化.结果 通气lh时,ARDSexp俯卧位组PaO2/FiO2( mm Hg,l mm Hg=0.133 kPa)即较通气前显著升高(157.4±40.6比129.3±48.7,P＜0.05),并随通气时间延长呈持续增高趋势,4h达峰值(219.1 ±41.1);且ARDSexp俯卧位组通气3h内PaO2/FiO2较其他3组显著增高,另3组间则差异无统计学意义.ARDSp俯卧位组、ARDSexp俯卧位组通气4h时PaO2/FiO2均较相应仰卧位组显著增高(208.8±39.7比127.4±47.1,219.1±41.1比124.9±50.8,均P＜0.05).4组通气前后Cst无显著改变,各组间差异也无统计学意义.ARDSp俯卧位组通气4h时Raw(cmH2O·L-1·s-1)较通气前显著降低(6.8±1.7比10.7±1.8,P＜0.05),且明显低于其他3组;其他3组各时间点Raw组内及组间比较差异均无统计学意义.结论 俯卧位通气作为ARDS机械通气重要策略之一,可以改善RM无效高原ARDS患者的氧合,为抢救患者赢得宝贵的时间.     

Digital imaging among medical facilities

The Department of Veterans Affairs (VA) in the USA operates a network of 172 medical centres which all utilize a hospital information system (HIS) which has been developed and is currently maintained by the VA. During the past several years, an image management and communication module has been developed, installed and clinically utilized at the Washington DC and Maryland VA Medical Centres. This image management and communication system, referred to as the decentralized hospital computer program (DHCP) imaging system, is fully integrated with a commercial picture archiving and communication system (PACS). The system is utilized to capture, archive, and display all images generated within the hospital including radiology, nuclear medicine, pathology, endoscopy, bronchoscopy, and dermatology, intraoperative photographs, ECG data, and a limited number of paper documents. The ultimate goal of the project is to have all patient text and image data available at any clinical workstation to any authorized user anywhere within the network of medical centres. Clinical requirements for an imaging workstation include ease of use, rapid and reliable access to the complete set of patient information, and images which are of acceptable quality to meet the requirements of the user and the subspecialty. Patient confidentiality and data security must be safeguarded at all times. Integration of the images with the remainder of the patient's database was found to be critical to the success of the project. The experience at the Washington and Maryland facilities suggests that an imaging system that is successfully integrated with a hospital information system can provide substantial clinical and economic benefits both within and among medical centres. Clinical acceptance and utilization of the system has been excellent, particularly in diagnostic radiology where DHCP Imaging has been interfaced to a commercial PAC system. Based upon this initial experience, the VA has begun to deploy the system throughout its large network of medical centres.     

Myocardial elastography at both high temporal and spatial resolution for the detection of infarcts

Myocardial elastography is a novel method for noninvasively assessing regional myocardial function, with the advantages of high spatial and temporal resolution and high signal-to-noise ratio (SNR). In this paper, in-vivo experiments were performed in anesthetized normal and infarcted mice (one day after left anterior descending coronary artery [LAD] ligation) using a high-resolution (30 MHz) ultrasound system (Vevo 770, VisualSonics Inc., Toronto, ON, Canada). Radiofrequency (RF) signals of the left ventricle (LV) in longitudinal (long-axis) view and the associated electrocardiogram (ECG) were simultaneously acquired. Using a retrospective ECG gating technique, 2-D full field-of-view RF frames were acquired at an extremely high frame rate (8 kHz) that resulted in high-quality incremental displacement and strain estimation of the myocardium. The incremental results were further accumulated to obtain the cumulative displacements and strains. Two-dimensional and M-mode displacement images and strain images (elastograms), as well as displacement and strain profiles as a function of time, were compared between normal and infarcted mice. Incremental results clearly depicted cardiac events including LV contraction, LV relaxation and isovolumetric phases in both normal and infarcted mice, and also evidently indicated reduced motion and deformation in the infarcted myocardium. The elastograms indicated that the infarcted regions underwent thinning during systole rather than thickening, as in the normal case. The cumulative elastograms were found to have higher elastographic SNR (SNR(e)) than the incremental elastograms (e.g., 10.6 vs. 4.7 in a normal myocardium, and 6.0 vs. 2.4 in an infarcted myocardium). Finally, preliminary statistical results from nine normal (m = 9) and seven infarcted (n = 7) mice indicated the capability of the cumulative strain in differentiating infracted from normal myocardia. In conclusion, myocardial elastography could provide regional strain information at simultaneously high temporal (>/=0.125 ms) and spatial ( approximately 55 microm) resolution as well as high precision ( approximately 0.05 microm displacement). This technique was thus capable of accurately characterizing normal myocardial function throughout an entire cardiac cycle, at the same high resolution, and detecting and localizing myocardial infarction in vivo.     

手转胎头术失败的原因与分娩结局临床分析

目的 探讨手转胎头术失败的原因与分娩结局.方法 选择2008年1月至2010年12月于我院住院分娩的持续性枕横位、枕后位产妇198例,根据行手转胎头术后结果分为成功组126例、失败组72例.比较两组分娩结局,对比分析失败原因.结果 失败组胎儿体质量≥3500 g的发生率[76.4％(55/72)]明显高于成功组[31.7％(40/126)],差异有统计学意义(x2=30.177,P=0.001)、失败组宫缩乏力发生率[58.3％(42/72)]高于成功组[38.1％ (48/126)],差异有统计学意义(x2=7.569,P=0.006)、失败组骨盆临界或轻度狭窄发生率[38.9％ (28/72)]高于成功组[23.8％(30/126)],差异有统计学意义(x2 =5.030,P=0.002)、失败组手转胎头时机不当(宫口开大＜6 cm、胎头位于坐骨棘上及宫口开大8～10 cm、胎头位于坐骨棘下≥2 cm)发生率[61.1％(44/72)]高于成功组[38.9％(49/126)],差异有统计学意义(x2=9.084,P=0.003).失败组母儿并发症(产后出血、产褥病率、胎儿窘迫、新生儿窒息)发生率高于成功组(x2 =9.586,P=0.002、x2=9.334,P=0.002、x2=5.910,P=0.015、x2=5.240,P=0.022)、失败组剖宫产发生率[72.2％(52/72)]明显高于成功组[34.1 ％(43/126),x2=26.641,P=0.001)].结论 手转胎头术能使难产变顺产,降低剖宫产率,减少母儿并发症,但须积极预防、处理导致手转胎头术失败的原因,对矫正失败后继续矫正及试产应慎重.