基于云平台泌尿外科医学信息获取分析系统的研究

针对目前临床科研工作者在获取网络信息过程中信息资源过于分散、信息质量良莠不齐、信息滞后等问题,以泌尿外科为切入点,研究实现了基于云计算平台的临床科研信息定制自动采集和个性化推荐功能,初步建立基于互联网的临床信息服务系统,能为临床医生提供较好的网络医学信息服务.     

COPD生物资源库管理平台设计与实现

慢性阻塞性肺疾病(COPD)临床标本是医学研究的重要资源。笔者应用.NET环境及软件,将临床各种COPD标本资源及附属信息进行规范化数据处理,构建了COPD生物资源库数据化管理平台。该管理平台将标本管理系统与临床信息系统进行无缝接合,实现了标准化样本编号、样本识别及存贮定位、标本与临床信息自动化整合、信息查询与输出等功能,对于提高标本资源的管理与使用效率具有积极作用。系统支持类似Excel单元格的拖拉、复制、剪切、删除操作,布局信息直观简洁,各架子、盒子的容量、用量均一目了然,且整合了识别及打印QR码功能。     

虚拟护理信息服务系统的设计与实现

目的整合网络护理学科信息资源和Internet技术,进行一体化设计建立虚拟护理信息资源服务系统。方法系统采用模块化结构,学科信息资源包括复旦图书馆订购的网络数据库、网上免费护理资源、护理科研人员知识积累。系统平台构架采用Web的多层体系结构Browse Server模式,数据库为SQL Server 2000,开发工具为Jbuilder 9．0。结果系统在一个完整的平台上实现系统管理功能、信息处理功能和通讯功能,具有共享性、安全性、开放性、可扩展等特点。系统实现了护理学科信息资源数字化、一体化、网络化管理。结论建立“基于学科”的网络信息资源服务平台能够充分有效地利用生物医学网络资源,必将在生物医学领域的临床和研究工作中起到重要作用。     

临床学院教务管理系统的需求分析与设计

临床学院教务管理与大学的教务管理有所不同.文章分析了临床学院教务管理内容及规律特点,设计了该系统由学生管理、教师管理、教材与课程管理、教案管理、评教管理、授课津贴管理、题库管理、考试管理及教学计划、教学大纲和系统操作说明等9个模块组成,并明确了相关功能.     

区域医疗信息共享平台研究与实现

提出区域医疗信息共享平台总体架构、逻辑架构和应用架构,分析平台技术特点,在此基础上建立中山大学医疗信息共享平台功能实现模型,即在标准化前提下,以电子病历为核心,建设临床协同工作系统、医患互动系统、医疗管理系统、医疗资源信息中心及医疗信息门户网站,实现医疗资源的优化配置和有效利用。     

靳三针治疗中风病信息管理系统的研发与应用

从系统设计(系统整体框架、系统条目设计、数据库设计、系统平台、权限对应表)、系统技术路线及安全性、功能实现效果等方面介绍了靳三针治疗中风病信息管理系统的研发思路。认为靳三针治疗中风病信息管理系统基于数据共享和临床应用,结合现代医学信息管理技术,以软件模块的形式应用在各个靳三针技术推广医院和工作站,高效、准确地管理临床资料信息,为传承靳三针治疗中风病经验方法实现了数据的信息化管理,可更好地继承和发扬针灸治疗的临床经验。该系统的建立与应用为最大程度保存名老中医经验,提高医疗服务质量,以及提升医院的医疗水平提供了思路。     

虚拟数据库技术在集成化医院信息系统中的应用研究

随着医院各个部门信息化的建设和发展,信息资源的异构性在医院信息管理系统中广泛存在,形成了大量的信息孤岛,这使得如何在复杂的各个子系统中实现异构系统之间的互联、互访和数据共享,成为一个重要的研究方向.针对当前医院各个子系统之间缺乏有效的信息整合平台、信息集成度差的现状,本文提出采用虚拟数据库的信息集成方法为不同自治、异构...     

鼻咽癌病案信息数据库的设计与实现

目的 开发针对鼻咽癌单病种的鼻咽癌病案信息数据库管理系统,为临床和科研提供服务.方法 根据鼻咽癌信息管理的需要,使用Microsoft SQL Server数据库软件,设计完成了包含用户管理模块、信息管理模块、信息查询模块、系统维护模块和辅助功能模块等功能模块的鼻咽癌病案信息数据库管理系统.结果 该系统完成了3055例鼻咽癌病例的数据库信息资料的收录,并达到快速信息查询、统计分析等使用功能,为临床和科研提供服务的目标.结论 本系统能大大地降低了临床、科研的工作量,提高了工作效率,提高鼻咽癌病案信息数据资料的利用率,实现了鼻咽癌临床病例资料数据的计算机管理及数据资源共享,对指导临床治疗及科研发挥了较好的作用.     

现代医院信息网络综合体系的建立

充分利用现代化硬件通信平台 , 拓展医院信息高速公路 , 构建医院管理信息系统、临床医疗信息系统、办公自动化系统、文献检索服务系统、 WWW发布系统、多媒体导医系统、 IC卡就医系统、临床药物信息咨询系统、远程信息服务系统等多种应用系统 , 最终建立以经济信息、医疗信息、材料物资信息及科研资源信息为主线的全过程、全方位的现代医院信息网络综合体系 . 一网多用 , 实现院内数据资源的高度共享 , 使医院的管理、临床、科研及卫勤保障工作驶入信息化的快车道 .     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.