原位推进骨瓣技术与不植骨在开放楔形胫骨高位截骨术中对截骨间隙愈合的影响比较

目的比较原位推进骨瓣技术与不植骨在开放楔形胫骨高位截骨术(OW-HTO)中对截骨间隙愈合效果的影响。方法回顾性分析2021年3-12月于河北医科大学第三医院创伤急救中心行OW-HTO的85例内侧间室骨关节炎伴膝内翻患者的临床资料。根据是否植骨将患者分为2组:推进骨瓣组(术中采用原位推进骨瓣技术)42例, 女32例, 男10例;年龄(63.7±6.6)岁。未植骨组(术中不植骨)43例, 女31例, 男12例;年龄(63.2±9.4)岁。记录并比较的两组患者指标包括:术后3、6、12、18个月截骨间隙愈合率, 术后6、18个月西安大略和麦克马斯特大学骨关节炎指数(WOMAC)、疼痛视觉模拟评分(VAS)、膝关节损伤和骨关节炎评分(KOOS), 术后即刻、术后18个月胫骨近端内侧角(MPTA)、股胫角, 以及术后并发症发生情况。结果两组患者术前一般资料比较差异均无统计学意义(P>0.05), 具有可比性。术后3、6、12、18个月推进骨瓣组患者的截骨间隙愈合率均显著高于未植骨组, 差异均有统计学意义(P<0.05)。术后6个月推进骨瓣组患者的WOMAC[(26.1±5.9)分]、...     

胫骨高位嵌插截骨与传统高位截骨治疗高龄屈曲型膝内侧间隙骨关节炎的对比研究

目的:报告胫骨高位嵌插截骨治疗高龄屈曲型膝内侧间隙骨关节炎的方法疗效,并与传统高位胫骨截骨的疗效进行比较。方法:2003年7月至2007年7月对年龄60～82岁,病史3～20年,屈曲度7°～19°的膝内侧间隙骨关节炎的30例患者随机分成2组,分别进行胫骨高位嵌插截骨和传统高位截骨手术治疗。术后观察骨折愈合时间、膝关节内翻畸形和屈曲畸形恢复、膝关节功能恢复等情况。要求患者术后第4、6、8、9、10、12、14、16周及5、7、9、12个月复查,记录骨折愈合时间及内翻、屈曲角度纠正情况。术后12个月时根据Lysholm膝关节评分标准进行评分,并对2组的疗效进行比较。结果:胫骨高位嵌插截骨组平均骨折愈合时间(9.26±2.23)周,传统高位截骨组平均(11.53±3.15)周,2组相比差异有统计学意义(P0.05)。膝关节功能恢复方面,术后1年,根据Lysholm评分标准进行评分,胫骨高位嵌插截骨平均(88.5±4.4)分,优14例,良1例;传统高位截骨组平均(78.1±5.7)分,优8例,良5例,可2例。胫骨高位嵌插截骨组术后膝关节伸直位角度0°～-1.1°,术后平均矫正(13±3.3)°;传统高位截骨组术后膝关节伸直位角度与术前相同,为(14°±3.3)°。两组术后站立位X线测量,FTA平均170.2°(l69.1°～172.3°),平均矫正12.3°～12.5°。结论:胫骨高位嵌插截骨手术治疗膝关节内侧间隙骨关节炎缩短了骨折愈合时间,同时矫正了膝关节内翻畸形和屈曲畸形,更好地恢复了膝关节的功能,此手术方式明显优于传统的高位截骨术。     

两种截骨术治疗膝内侧间室骨关节炎的近期疗效比较

目的 比较腓骨截骨和内侧开放楔形胫骨高位截骨治疗膝内侧间室骨关节炎的近期临床疗效.方法 将40例膝内侧骨关节炎患者按截骨方式的不同分为腓骨截骨组(18例,采用腓骨截骨治疗)与胫骨截骨组(22例,采用内侧开放楔形胫骨高位截骨治疗).记录术后并发症发生情况和胫骨近端内侧角(MPTA),比较两组术后各时间点疼痛VAS评分、H...     

胫骨内侧高位楔形截骨治疗膝内翻畸形的临床疗效观察

[目的]探讨胫骨内侧高位楔形截骨治疗膝内翻畸形的疗效.[方法]1998年7月～2007年10月,采用胫骨内侧张开式高位楔形截骨结合植骨钢板内固定术治疗膝内翻畸形共49例72个膝关节.患者术前、术后8周、术后1.5年行患肢全长X线片检查,测量胫股角、胫股内侧关节间距大小.按HSS膝关节功能评定标准评定术前、术后膝关节功能.[结果]72膝术后随访18～128个月,平均58个月;胫股角术前187.5°±5.3°,术后172.6°±3.6°,膝关节功能由(47.2±17.6)分增至(83.2±15.3)分,胫股内侧关节间距由(2.4±1.2)mm增至(4.3±1.2)mm.植骨均愈合满意,无膝内翻复发.术后疼痛缓解及行走功能改善显著.术中出现关节内骨折3例,无神经血管损伤.术后皮肤感染切口延迟愈合2例.[结论]胫骨内侧高位楔形截骨结合植骨钢板内固定术,可作为治疗膝内翻畸形的有效方法之一.     

胫骨高位截骨联合膝关节镜下外侧支持带松解及清理术的临床疗效评价

目的 回顾性研究探讨胫骨高位截骨联合膝关节镜下外侧支持带松解及清理术的临床疗效.方法 将68例(85膝)膝关节疾患分成A组和B组(n=34),A组施行胫骨高位截骨联合膝关节镜下清理术:B组施行胫骨高位截骨联合膝关节镜下清理及外侧支持带松解术.然后对A组和B组进行比较及B组术前和术后进行比较.结果 术后测的数据均为随访15个月以上测得,髌骨中心的外侧位移A组为(6.1±2.3)mm,B组(1.2±0.8)mm髌股适合角(CA)A组术后(12.3±7.2)°,B组术后(4.2±2.5).髌骨倾斜角(PTA)A组术后(11.4±3.6)°,B组术后(3.3±2.1)°HSS膝关节评分A组术前(42±6.0)分,术后(73±12.3)分,B组术前(40±4.5)分,术后(85±9.0)分,结果术后A组和B组存在明显差异(P<0.05).B组术前和术后存在明显差异(P<0.01).结论 胫骨高位截骨联合膝关节镜下外侧支持带松解及清理外术明显优于胫骨高位截骨联合膝关节镜下清理术式,它不仅解决了胫股关节的问题同时解决了髌股关节的问题,消除了髌股关节由于胫骨高位截骨而随之产生力线异常,对提高近期及远期疗效有积极的临床意义.     

内侧撑开和外侧闭合胫骨高位截骨术治疗膝内翻骨关节炎

目的 比较两种胫骨高位截骨术的手术方法和临床结果.方法 膝内翻骨关节炎患者68例,其中37例采用外侧闭合胫骨高位截骨术(closed wedge high tibial osteotomy,CWO),31例采用内侧撑开胫骨高位截骨术(open wedge high tibial osteotomy,OWO).术后摄X线片测量胫骨平台后倾角、髌骨高度、胫骨股骨角、内侧胫股关节间隙宽度,并行HSS和Lysholm功能评分.结果 患者均随访24个月以上.术前、术后两组HSS和Lysholm评分差异均无统计学意义.(1)CWO组术前胫骨平台后倾角8.57°±1.63°、术后5.03°±1.24°,OWO组术前8.71°±1.66°、术后10.10°±1.30°,差异均有统计学意义.(2)CWO组术前Insall-Salvati指数0.880±0.053、术后0.820±0.049,差异有统计学意义;OWO组术前0.892±0.043、术后0.897±0.042,差异无统计学意义.CWO组术前Blackburne-Peel指数0.804±0.040、术后0.801±0.339,差异无统计学意义;OWO组术前0.815±0.039、术后0.766±0.037,差异有统计学意义.(3)术后CWO组外翻8.06°±2.75°,OWO组外翻8.65°±1.46°.结论 膝内翻骨关节炎的内侧撑开和外侧闭合胫骨高位截骨术有相似的手术效果,内侧撑开截骨术截骨角度更加准确.外侧闭合胫骨高位截骨术后可出现胫骨后倾减小和髌韧带短缩,内侧撑开截骨术后易出现胫骨后倾增加和髌骨至关节线距离减小.     

胫骨高位双平面截骨术治疗膝内侧间室骨关节炎

目的探讨胫骨高位双平面截骨术治疗膝内侧间室骨关节炎的近期疗效。方法采用胫骨高位双平面截骨术治疗37例膝内侧间室骨关节炎患者。测量手术前后膝关节站立负重位X线片胫股解剖角、髋—膝—踝角,记录手术前后膝关节损伤和骨关节炎KOOS评分、KSS评分和疼痛VAS评分。结果患者均顺利完成手术。术后未出现感染、骨筋膜室综合征、腓总神经损伤、下肢深静脉血栓等并发症,截骨处愈合良好,患者膝内翻畸形情况均得到矫正。37例均获得随访,时间6~30(18.6±7.0)个月。胫股解剖角、髋—膝—踝角、KOOS评分、KSS评分、VAS评分术后3个月较术前明显改善,差异均有统计学意义(P<0.001)。结论胫骨高位双平面截骨术治疗膝内侧间室骨关节炎能够纠正下肢异常力线,缓解或者消除膝关节疼痛症状,短期疗效满意。     

胫骨高位开放截骨联合人工骨植入术治疗中年患者膝关节内侧间室骨关节炎的疗效

目的 探讨胫骨内侧高位开放截骨联合人工骨植入术治疗中年患者膝骨关节炎的临床疗效。方法 2017年1月至2019年1月,华北医疗健康集团邢台总医院关节骨科对16例(17膝)中年膝骨关节炎伴有内翻畸形的患者,进行了关节镜清理、胫骨内侧高位开放性楔形截骨、人工骨植入及国产胫骨截骨锁定钢板内固定手术。其中男性4例5膝;女性12例12膝;年龄40～65岁,平均(52±7)岁。术前检查膝关节X线片和下肢全长X线片,进行术前测量及评估,评估截骨间隙愈合情况,通过比较患者术前与术后3个月、6个月、12个月的股胫角(femorotibial angle, FTA)、疼痛视觉模拟评分(visual analogue scale, VAS)评分,评估胫骨内侧高位开放截骨联合人工骨植入术治疗中年患者膝关节内侧间室骨关节炎的疗效,记录并发症的发生及处理情况。结果 随访1年,患者膝内翻畸形均得到纠正。术后3、6、12个月VAS低于术前,差异有统计学意义(P<0.001);术后3、6、12个月的FTA低于术前(P<0.001)。术后6个月的X线片可见植入人工骨后的截骨间隙愈合良好,无不愈合及延迟愈合。1...     

胫骨内侧高位截骨术后胫骨相关角度的变化

目的通过测量,观察胫骨内侧高位截骨术对胫骨后倾角等相关角度的影响,探讨其临床意义。方法1997~2002年,对33例(36膝)膝关节内侧间室骨性关节炎患者行胫骨内侧高位截骨术。男6例,女27例;年龄45~72岁,平均58岁。在手术前后X线片上测量胫骨后倾角,Insall-Salvati指数,胫骨结节高度。采用配对t检验进行统计学分析。结果胫骨内侧高位截骨,术后胫骨后倾角、胫骨结节高度无丢失,差别有显著意义(P<0·05)。结论胫骨内侧高位截骨术后,胫骨后倾角无减小,无低位髌骨等并发症出现,提示该术较胫骨外侧截骨术具有优势。     

胫骨高位内外侧截骨治疗膝关节骨性关节炎临床研究

目的比较胫骨内外侧高位截骨治疗膝关节骨性关节炎的疗效,探讨影响疗效的因素。方法采用胫骨内外侧高位截骨术治疗膝关节骨性关节炎内翻畸形58例（62膝）。分别对两种术式进行综合评分。结果随访时间：内侧组平均2．1年,外侧组3．6年。采用HSS标准,内侧组优良率为97％,外侧组83．2％,经x^2检验,差异无显著性,但手术时间、膝关节术后活动改善度和术后并发症分别经x^2检验和t检验,差异有显著性。结论胫骨高位内侧截骨治疗膝关节骨性关节炎内翻畸形有手术难度小、便于膝部其他术式的联合、术后可早期活动、并发症发生率低等优点。     

Vasopressor hormone response following mesenteric traction during major abdominal surgery

Background : We investigated the vasopressor hormone response following mesenteric traction (MT) with hypotension due to prostacyclin (PGI₂) release in patients undergoing abdominal surgery with a combined general and epidural anesthesia. Methods : In a prospective, randomized, placebo-controlled study we administered 400 mg ibuprofen (i.v.) in 42 patients scheduled for abdominal surgery. General anesthesia was combined with epidural anesthesia (T4-L1). Before as well as 5, 15, 30, 45, and 90 min after MT we recorded plasma osmolality, hemodynamics and measured 6-keto-PGFlα (stabile metabolite of PGI₂), TXB₂ (stabile metabolite of thromboxane A₂) active renin, and arginine vasopressin (AVP) plasma concentrations by radioimmunoassay. Catecholamine levels were assessed by high-pressure liquid chromatography (HPLC) with electrochemical detection. Results : Following MT, arterial hypotension occurred along with a substantial PGI₂ release. This was completely abolished by ibuprofen administration. Although plasma levels of 6-keto-PGF_1α (1133 (708) vs. 60 (3) ng/L, median (median absolute deviation), P=0.0001, placebo vs. ibuprofen) remained significantly elevated, blood pressure was restored within 30 min after MT in the placebo group. At the same point in time plasma concentrations of TXB² (164 (87) vs. 58 (1) ng/L, P=0.0001), epinephrine (46 (33) vs. 14 (6) ng/L, P=0.001), AVP (41 ± (18) vs. 12 (7) ng/L, P=0.0004), and active renin (27 (12) vs. 12 (4) ng/L, P = 0.001) were significantly higher in placebo-treated patients. Conclusion : Under combined general and epidural anesthesia arterial hypotension following MT due to endogenous PGI₂ release is associated with enhanced release of AVP, active renin, epinephrine and thromboxane A₂, presumably contributing to hemodynamic stability within 30 min after MT.     

A Teaspoon Pump for Pumping Blood with High Hydraulic Efficiency and Low Hemolysis Potential

Abstract: Virtually all blood pumps contain some kind of rubbing, sliding, closely moving machinery surfaces that are exposed to the blood being pumped. These valves, internal bearings, magnetic bearing position sensors, and shaft seals cause most of the problems with blood pumps. The original teaspoon pump design prevented the rubbing, sliding machinery surfaces from contacting the blood. However, the hydraulic efficiency was low because the blood was able to "slip around" the rotating impeller so that the blood itself never rotated fast enough to develop adequate pressure. An improved teaspoon blood pump has been designed and tested and has shown acceptable hydraulic performance and low hemolysis potential. The new pump uses a nonrotating "swinging" hose as the pump impeller. The fluid enters the pump through the center of the swinging hose; therefore, there can be no fluid slip between the revolving blood and the revolving impeller. The new pump uses an impeller that is comparable to a flexible garden hose. If the free end of the hose were swung around in a circle like half of a jump rope, the fluid inside the hose would rotate and develop pressure even though the hose impeller itself did not "rotate"; therefore, no rotating shaft seal or internal bearings are required.     

Microspheres Based Detoxification System: A New Method in Convective Blood Purification

Abstract: A variety of protein-bound or hydrophobic substances, accumulating as a result of pathologic conditions such as exogenous or endogenous intoxications, are removed poorly by conventional detoxification methods because of low accessibility (hemodialysis), insufficient adsorption capabilities (hemosorption), low efficiency (peritoneal dialysis), or economic limitations (high-volume plasmapheresis). Combining advantages of existing methods with microspheric technology, a module-based system was designed. Major operating parameters of the latter can be modified to allow for adjustment to individual clinical situations. An extracorporeal blood circuit including a plasmafilter is combined with a secondary high-velocity plasma circuit driven by a centrifugal pump. Different microspheric adsorbers can be combined in one circuit or applied in sequence. Thus, a prolonged treatment can be tailored using specially designed selective adsorber materials. Comparing this system with existing methods (high-flux hemodialysis, molecular adsorbent recycling system), results from our in vitro studies and animal experiments demonstrate the superior efficiency of substance removal.     

Tissue perfusion in relation to cardiac output during continuous positive-pressure ventilation and administration of propranolol or verapamil

Background : Our objective was to determine whether administration of propranolol or verapamil modifies the hemodynamic adaptation to continuous positive-pressure ventilation (CPPV), in particular the regional distribution of cardiac output (CO).
Methods : General hemodynamics and regional blood flows assessed by microsphere technique (15 (μm) were recorded in 16 anesthetized pigs during spontaneous breathing (SB) and CPPV with 8 cm H₂O end-expiratory pressure (CPPV8) before and after intravenous administration of propranolol (0.3 mg · kg⁻¹ followed by 0.15 mg · kg⁻¹ · h⁻¹, n=8) or verapamil (0.1 mg · kg⁻¹ followed by 0.3 mg · kg⁻¹ · h⁻¹, n=8).
Results : CPPV8 depressed CO by 25% without shifts in its relative distribution with the exception of a noteworthy increase in adrenal perfusion. Propranolol increased arterial blood pressure, and due to a fall in heart rate, CO dropped by 25%. The kidneys and, to a lesser extent, the splanchic region and central nervous system received increased fractions of the remaining CO at the expense of skeletal muscle flow. Similar patterns were seen during SB and CPPV8 such that the combination of propranolol and CPPV8 depressed CO by 50%. The circulatory effects of verapamil were less evident but myocardial perfusion tended to increase.
Conclusions : The combination of propranolol or verapamil with CPPV does not result in any specific hemodynamic interaction in anesthetized pigs, except that the combined effect of propranolol and CPPV may severely reduce CO.     

Bariatric Surgery in Some "Central and East-European (former Eastern bloc)"Countries - Current Status and Prediction for the Next Millennium

Background: Obesity is increasing globallly, including in the formerly "Eastern Bloc" countries. Methods: A survey was made of obesity and bariatric surgery. Results: In the 8 East and Central European countries studied, with total population 300 million, roughly 43% of the population was overweight (BMI 25-30), 23% obese (BMI > 30), with about 15 million people morbidly obese (BMI > 40). From 0-10 morbidly obese individuals/100,000/year undergo bariatric surgery. Conclusion: Most countries were found to provide inadequate treatment for obesity.The majority of the morbidly obese are not treated effectively. However, health-care awareness of obesity and bariatric surgeons are slowly increasing.     

Volatile anaesthetics reduce adhesion of blood platelets under low-flow conditions in the coronary system of isolated guinea pig hearts

Background : Inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion has not been elucidated so far.
Methods : Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for 25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets was applied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined.
Results : At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1±1.2% (mean±SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reduced with each 1 MAC isoflurane (to 6.2±1.2%), sevoflurane (to 4.4±0.9%) or halothane (to 3.2±1.5%) (each P <0.05 vs. control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics.
Conclusion : Volatile anaesthetics in a concentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress.     

Synergistic interaction between the effects of propofol and midazolam with fentanyl on phrenic nerve activity in rabbits

Background: It has been shown that the depressive effects of both propofol and midazolam on consciousness are synergistic with opioids, but the nature of their interactions on other physiological systems, e. g. respiration, has not been fully investigated. The present study examined the effect of propofol and midazolam alone and in combination with fentanyl on phrenic nerve activity (PNA) and whether such interactions are additive or synergistic. Methods: PNA was recorded in 27 anaesthetised and artificially ventilated rabbits. In three groups, propofol, fentanyl and midazolam were administered intravenously in incremental doses to construct dose-response curves for the depressant effects of each one on PNA. In another two groups, the effect of pretreatment with either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. on the effects of propofol and fentanyl respectively on PNA were studied. Results: Propofol and fentanyl caused a dose-dependent depression of PNA with complete abolition at the highest total doses of 16 mg · kg^?1 i. v. and 32 μg · kg^?1 i. v., respectively. In contrast, midazolam in incremental doses to a total of 0.8 mg · kg^?1 reduced mean PNA by 63%, but approximately 12% of PNA remained at a total dose as high as 6.4 mg · kg^?1. The mean ED₅₀s, calculated from dose-response curves, were 5.4 mg · kg^?1, 3.9 μg · kg^?1 and 0.4 mg · kg^?1 for propofol, fentanyl and midazolam, respectively. Initial doses of either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. acted synergistically with subsequent doses of either propofol or fentanyl to abolish PNA at total doses of 8 mg · kg^?1 and 8 μg · kg^?1, respectively. Conclusion: Fentanyl has a synergistic interaction with both propofol and midazolam on PNA and hence potentially on respiration.     

Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Background: Catecholaminergic support is often used to improve haemodynamics in patients undergoing major abdominal surgery. Dopexamine is a synthetic vasoactive catecholamine with beneficial microcirculatory properties. Methods: The influence of perioperative administration of dopexamine on cardiorespiratory data and important regulators of macro- and microcirculation were studied in 30 patients undergoing Whipple pancreaticduodenectomy. The patients received randomized and blinded either 2 μg · kg^?1 · min^?1 of dopexamine (n=15) or placebo (n=15, control group). The infusion was started after induction of anaesthesia and continued until the morning of the first postoperative day. Endothelin-1 (ET-1), vasopressin, atrial natriuretic peptide (ANP), and catecholamine plasma levels were measured from arterial blood samples. Measurements were carried out after induction of anaesthesia, 2 h after onset of surgery, at the end of surgery, 2 h after surgery, and on the morning of the first postoperative day. Results: Cardiac index (CI) increased significantly in the dopexamine group (from 2.61±0.41 to 4.57±0.78 1 · min^?1 · m^?2) and remained elevated until the morning of the first postoperative day. Oxygen delivery index (DO₂I) and oxygen consumption index (VO₂I) were also significantly increased in the dopexamine group (DO₂I: from 416±91 to 717±110 ml/m² · m²; VO₂I: from 98±25 to 157±22 ml/m² · m²), being significantly higher than in the control group. pHi remained stable only in the dopexamine patients, indicating adequate splanchnic perfusion. Vasopressive regulators of circulation increased significantly only in the untreated control patients (vasopressin: from 4.37±1.1 to 35.9±12.1 pg/ml; ET-1: from 2.88±0.91 to 6.91±1.20 pg/ml). Conclusion: Patients undergoing major abdominal surgery may profit from prophylactic perioperative administration of dopexamine hydrochloride in the form of improved haemodynamics and oxygenation as well as beneficial influence on important regulators of organ blood flow.     

A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits

Background: Halothane inhibits in vitro and in vivo activity of cytochrome P-450 (CYP) 2E1. There are several fluorinated volatile anaesthetics besides halothane, and most of them are defluorinated by CYP2E1. It is unclear whether other fluorinated anaesthetics inhibit the in vivo activity of CYP2E1.
Methods: We compared the inhibitory effects of therapeutic concentrations of four inhalational anaesthetics, halothane, enflurane, isoflurane, and sevoflurane, on chlorzoxazone metabolism in rabbits receiving artificial ventilation.
Results: All four inhalational anaesthetics decreased arterial blood pressure and increased plasma chlorzoxazone concentration. However, no significant differences in the plasma chlorzoxazone concentration were found between the four anaesthetics. The estimated chlorzoxazone clearance increased after beginning inhalation with all four agents, but no significant difference in clearance was noted between agents.
Conclusions: At therapeutic concentrations, the in vivo inhibitory effect on chlorzoxazone metabolism was similar for all four inhalational anaesthetics examined, even though their chemical characteristics and extent of hepatic metabolism differ considerably.     

Systemic analgesia adapted to the children's condition

A concept of balanced analgesia using nonsteroidal anti-inflammatory drugs (NSAIDs), paracetamol (acetaminophen), opioids, and corticosteroids can also be used in patients with pre-existing illnesses. NSAIDs are the most effective treatment for acute pain of moderate intensity in children; however, these drugs should be avoided in patients at increased risk for serious side effects, e.g. patients with renal impairment, bleeding tendency, or extreme prematurity. NSAIDs can be given with minimal risks to the younger child with mild to moderate asthma, and, in these patients, the use of steroids can be encouraged; in addition to their antiemetic and analgesic action, a beneficial effect on asthma symptoms can be expected. In the non-intubated child with cerebral trauma, exaggerated sedation caused by opioids and increased bleeding tendency caused by NSAIDs must be avoided. In neonates and small infants, the oral administration of sucrose or glucose is helpful to minimize pain reaction during short uncomfortable interventions.