以下肢肿胀疼痛伴血栓形成为首发表现的弥漫大B细胞淋巴瘤1例并文献复习

目的探讨以下肢肿胀疼痛伴血栓形成为首发表现的弥漫大B细胞淋巴瘤(DLBCL)的临床特点, 避免漏诊误诊。方法回顾性分析临沂市人民医院2021年10月收治的1例以下肢肿胀疼痛伴血栓形成为首发表现的DLBCL患者的临床资料, 并复习相关文献。结果患者, 男性, 60岁, 因下肢肿胀疼痛就诊结合下肢磁共振成像(MRI)、PET-CT等影像学及术后病理检查结果, 诊断为原发性骨骼肌DLBCL。给予抗凝治疗控制血栓, R-CHOP方案化疗3个周期后, 患者一般情况良好。结论伴有血栓形成的原发性骨骼肌DLBCL较为罕见, 对于疑诊病例应尽早采取病理活组织检查明确诊断, 尽早治疗。     

原发子宫弥漫大B细胞淋巴瘤1例并文献复习

目的提高对生殖系统来源淋巴瘤诊疗过程的认识。方法回顾性分析2021年8月内蒙古医科大学附属医院收治的1例以腹痛起病, 术后病理诊断为弥漫大B细胞淋巴瘤(DLBCL)患者的临床资料, 并进行文献复习。结果患者为59岁女性, 临床表现为腹痛, 影像学资料提示子宫占位性病变, 之后行子宫附件切除术后病理支持DLBCL。按照淋巴瘤诊疗指南治疗后患者腹痛明显缓解, 治疗有效。结论生殖系统肿瘤诊疗过程中, 要注意与淋巴瘤的鉴别诊断, 防止误诊、漏诊。     

淋巴瘤合并实体瘤4例临床病理学分析

目的探讨淋巴瘤合并实体瘤的多原发恶性肿瘤的临床病理特征。方法回顾性分析陕西省人民医院2013年7月至2021年8月收治的4例淋巴瘤合并实体瘤患者的临床病理资料, 结合文献对其临床病理特征、诊治情况进行分析。结果 4例患者均经术后多部位标本或多部位穿刺标本病理学检查确诊, 其中弥漫大B细胞淋巴瘤3例, 霍奇金淋巴瘤1例;合并甲状腺乳头状癌2例, 肾透明细胞癌1例, 前列腺腺癌1例。给予不同方案化疗后, 2例完全缓解, 1例部分缓解, 1例正在治疗中。结论淋巴瘤合并实体瘤少见, 主要依靠病理学诊断, 目前尚无标准治疗方案;需提高疾病诊断与鉴别诊断能力, 避免误诊。     

小肠弥漫大B细胞淋巴瘤颊部转移一例并文献复习

目的 提高对小肠弥漫大B细胞淋巴瘤(DLBCL)颊部转移的认识.方法 分析1例小肠DLBCL颊部转移患者的临床资料,复习相关文献并讨论其临床特征及诊疗方法.结果 患者为男性,45岁,发现小肠恶性淋巴瘤8个月,左侧面颊部肿胀1周入院.左颊部肿物活组织检查病理结果倾向恶性淋巴瘤,给予CHOPE方案化疗1个周期后左颊部肿胀消失.结论 小肠DLBCL伴颊部转移罕见,是一种高度侵袭性肿瘤,预后较差.颊部转移易被误诊为感染性疾病.组织学形态及免疫组织化学染色有助于明确诊断,手术切除后辅助化疗及放疗可能提高临床疗效.     

粘膜相关淋巴瘤和结外弥漫大B细胞淋巴瘤临床病理特征和预后分析

目的:比较粘膜相关淋巴瘤和结外弥漫大B细胞淋巴瘤的临床病理特征和预后,探讨两类淋巴瘤的预后影响因素.方法:94例结外B细胞淋巴瘤(粘膜相关淋巴瘤62例,结外弥漫大B细胞淋巴瘤32例),经诊断复查后,收集其临床病理和随访资料,进行统计学分析.结果:两类淋巴瘤相比较,MALT淋巴瘤发病的中位年龄、临床病理分期、复发率、淋巴结累及率和细胞增殖活性均偏低,5年生存率较高.94例结外B细胞淋巴瘤的生存影响因素分析:肿瘤细胞增殖指数＞20%的患者生存状况较＜20%的患者低,I E期以上患者生存状况较I E期患者差,伴有淋巴结累及的患者生存状况较无累及患者低.结论:粘膜相关淋巴瘤与结外弥漫大B细胞淋巴瘤在发病年龄、细胞增殖水平、临床分期、复发等临床病理特征上有明显差异.肿瘤细胞增殖活性、临床病理分期及淋巴结累及对两种淋巴瘤的生存状况和预后有明显影响.     

继发性肺弥漫大B细胞淋巴瘤一例并文献复习

目的 提高对继发性肺淋巴瘤的认识.方法 报道滨州医学院烟台附属医院1例继发性肺弥漫大B细胞淋巴瘤患者的诊治经过,并对该病的影像学表现、 发病率及治疗进行文献复习.结果 该患者初诊为弥漫大B细胞淋巴瘤,治疗半年后肺CT示右肺下叶及肺门区多发团块灶,肺穿刺活组织检查诊断为继发性肺弥漫大B细胞淋巴瘤,给予二线方案R-EDOCH治疗有效.结论 继发性肺淋巴瘤比较少见,临床医师应提高警惕,早期诊断、早期治疗.     

鼻腔NK/T细胞淋巴瘤临床病理特征及诊断分析

目的 探讨鼻腔NK/T细胞淋巴瘤的临床、病理特征,诊断和误诊原因.方法 复习62例鼻腔NK/T细胞淋巴瘤的临床资料,应用组织病理学、免疫组化和原位杂交技术分析其临床特点、诊断、病理特征和免疫表型.结果 鼻腔NK/T细胞淋巴瘤以鼻塞、涕血和头痛为主要症状,表现为面部中线破坏性病变.病理改变为肿瘤性淋巴样细胞弥漫或散在分布于凝固性坏死和多种炎细胞混合浸润的背景上.所有病例表达T细胞标记,不表达B细胞标记;NK细胞标记阳性5例;EB病毒mRNA阳性56例(90%).结论 鼻腔NK/T细胞淋巴瘤临床表现不典型,易误诊误治.免疫组化检查是确诊的重要方法.患者以T细胞为主,大多有EBV感染.     

EB病毒阳性不一致性淋巴瘤1例并文献复习

目的探讨不一致性淋巴瘤(DL)的临床表现、实验室检查及诊疗特点。方法回顾性分析泰州市人民医院2019年11月收治的1例EB病毒阳性不一致性淋巴瘤患者的临床资料, 并复习相关文献。结果患者起病时行颈部淋巴结活组织病理检查提示为血管免疫母细胞性T细胞淋巴瘤(AITL);后因消化道出血行肠道病灶切除术, 术后病理提示弥漫大B细胞淋巴瘤(DLBCL), 最终诊断为DL。予以R2-CHOP方案化疗, 患者病程中反复出现消化道出血, 一般情况较差, 后患者拒绝化疗, 改为来那度胺单药治疗。最终患者因多脏器衰竭死亡, 总生存时间13个月。结论 DL临床少见, 而同时患AITL和DLBCL更为罕见, 临床医生需提高对该病的认识, 避免误诊和漏诊。     

血管内大B细胞淋巴瘤一例并文献复习

目的 探讨血管内大B细胞淋巴瘤(IVLBCL)的临床病理特征.方法 对1例IVLBCL患者的临床表现、组织形态学和免疫表型进行分析,并复习相关文献.结果 肿瘤细胞位于毛细血管内,细胞体积较大,核圆形、 椭圆形或不规则形,部分细胞可见核仁,免疫组织化学CD20阳性.结论IVLBCL是一种罕见的弥漫大B细胞淋巴瘤亚型,临床表现多种多样,诊断困难,多次皮肤活组织检查可提高阳性诊断率.     

颈部不一致性淋巴瘤一例并文献复习

目的 探讨不一致性淋巴瘤的临床病理学特征.方法 结合临床、影像学、病理形态和免疫组织化学检测,对1例不一致性颈部淋巴结结节硬化型霍奇金淋巴瘤及甲状腺左叶及峡部弥漫大B细胞淋巴瘤进行病理分析,并复习相关文献.结果 患者,女性,46岁,以甲状腺双叶实性肿物及双颈部多发淋巴结肿大为首发症状,手术切除甲状腺双叶及颈部淋巴结,术后病理诊断为不一致性淋巴瘤,右颈及部分左颈部淋巴结为经典型霍奇金淋巴瘤,甲状腺左叶及峡部为弥漫大B细胞淋巴瘤.结论 不一致性淋巴瘤较为罕见,表现形式多样,且发生的解剖部位不同,应引起临床和病理医师的足够重视,其治疗方案及预后判断由恶性程度高的肿瘤类型决定.     

Skeletal muscle lymphoma

Lymphoma usually presents with painless lymphadenopathy. However, it can also present at an extranodal site. Presentation with skeletal muscle infiltration is relatively uncommon and can be confused with a wide variety of both inflammatory as well as neoplastic conditions. We report a patient who presented with progressive swelling of the lower extremity resembling inflammatory necrosis on computed tomography scan, but was later diagnosed as skeletal muscle lymphoma on biopsy.     

Primary non-Hodgkins lymphoma of muscle

A retrospective analysis was made of all patients with primary muscle non-Hodgkin's lymphomas registered with the Scotland and Newcastle Lymphoma Group over a 15-year period. Only eight patients were identified. The median age was 69 years (range 27-93). Five patients were male and six lymphomas were of high grade histology. The glutei and upper arm muscles were the main sites of origin, with the additional involvement of adjacent bone in four patients; only three had lymph node involvement at presentation. Most patients (6/8) received both chemotherapy and radiotherapy. The median survival was 33 months. The conclusion is that this is a small group of patients whose outlook is not as poor as has been suggested in previous reports.     

Efficient electrotransfection into canine muscle

Two different types of electroporation protocols have been developed for efficient electrotransfer of plasmid DNA into skeletal muscle of experimental animals. At first, only low voltage electric pulses have been used, but lately, a combination of high and low voltage pulses has been suggested as more efficient. Up to date, in dogs, this type of electroporation protocol has never been used for muscle targeted plasmid DNA electrotransfection. In this study, we used two different DNA plasmids, one encoding green fluorescent protein and one encoding human interleukin-12. Five different electroporation protocols were evaluated. Three of them featured different combinations of high and low voltage pulses, and two were performed with delivery of low voltage pulses only. Our study shows that combination of 1 high voltage pulse (600 V/cm, 100 mus), followed by 4 low voltage pulses (80 V/cm, 100 ms, 1 Hz) yielded in the same transfection efficiency as the standard trains of low voltage pulses. However, this protocol is performed quicker and, thus, more suitable for potential use in clinical practice. In addition, it yielded in detectable systemic expression of human interleukin-12. Electrotransfer of either of the plasmids was associated with only mild and transitory local side effects, without clinically detectable systemic side effects. The results indicate that electrotransfection is a feasible, effective, and safe method for muscle targeted gene therapy in dogs, which could have potential for clinical applications in veterinary medicine of small animals.     

Intramyofiber metastasis in skeletal muscle

Malignant epithelial cells were noted within the sarcolemmal sheath of skeletal muscle fibers in a case of recurrent laryngeal carcinoma. Literature is reviewed to evaluate the diagnostic and prognostic significance of this rare intramyofiber skeletal metastasis by cancer cells.     

Effect of electrochemotherapy on muscle and skin

The efficient delivery of drugs to tumors is an important tool for the treatment of a variety of cancers. Electric pulses have been shown to facilitate the uptake of molecules through the cell membrane. This procedure has been successful in increasing the effectiveness of anti-tumor agents (electrochemotherapy; ECT). Response rates of >80% have been obtained in both animal and human trials for several types of skin malignancies. The study reported here examined the effect of ECT on normal tissue. The hind limbs of Sprague Dawley rats were treated with 1-3 electroporation sequences in the presence or absence of the drug (bleomycin) which was administered at 4, 8 or 16 units/ml. The treated sites were examined histologically 3, 14 and 56 days later. Limb function was not affected by the treatment and skin and muscle necrosis was only seen at the higher doses.