社区老年人久坐行为与睡眠质量对认知功能的影响

目的 了解久坐行为与睡眠质量对社区老年人认知功能的影响。方法 采用匹兹堡睡眠质量指数量表、国际体力活动问卷短卷、简易精神状态量表及一般资料调查表,于2019年12月按照分层整群抽样法,从济南市随机抽取1 091名老年人开展问卷调查。结果 调整人口学变量后,二元logistic 回归分析结果显示,存在久坐行为的社区老年人患认知功能障碍的风险为非久坐行为者的1.880倍（OR值 = 1.880, 95 % CI = 1.267～2.790）,存在睡眠障碍的老年人发生认知功能障碍的风险为无睡眠障碍者的2.160倍（OR值 = 2.160,95 % CI = 1.391～3.356）。交互作用分析结果显示,久坐行为与睡眠障碍对老年人认知功能障碍患病率具有负相乘交互作用OR值（95%CI） = 0.414（0.174～0.984）。结论 久坐行为与睡眠障碍是老年人认知功能的危险因素,且二者存在相乘交互作用。     

济南市老年人社会隔离与睡眠质量及其交互作用对抑郁的影响

目的 了解济南市老年人社会隔离与睡眠质量及其交互作用与抑郁的关联。方法 采用社会网络简化版量表、匹兹堡睡眠质量指数量表、简版老年抑郁量表,于2019年10至11月按照分层整群抽样法,从济南市随机抽取915名老年人开展问卷调查。结果 存在社会隔离、睡眠障碍和抑郁者分别为227人（24.8%）、180人（19.7%）、155人（16.9%）。不同年龄、家庭经济状况、受教育程度、患慢性病数量的老年人抑郁发生率比较,差异有统计学意义（均P<0.05）。控制混杂因素后,多因素logistic 回归分析结果显示,存在社会隔离的老年人发生抑郁的风险为非社会隔离的2.259倍（OR=2.259, 95%CI:1.528~3.337）,存在睡眠障碍的老年人发生抑郁的风险为无睡眠障碍者的2.491倍（OR=2.491,95%CI:1.660~3.737）。交互作用分析结果显示,社会隔离与睡眠障碍对抑郁患病率存在相乘（OR（95%CI）=2.393（1.034~5.539））和相加交互作用（OR=7.120, 95%CI:3.950~12.834）。RERI（95%CI）=4.657（0.681~8.633）,AP（95%CI）=0.654（0.419~0.889）,S（95%CI）=4.183（1.548~11.307）。结论 社会隔离和睡眠障碍是老年人抑郁的危险因素,且二者存在交互作用。     

贵州省部分农村地区老年人轻度行为损害流行现状及影响因素分析

目的 了解贵州省部分农村地区老年人轻度行为损害（mild behavioral impairment,MBI）流行现状及影响因素，为改善老年人精神健康和预防认知功能下降提供参考。方法 采用多阶段整群随机抽样方法，抽取贵州省1 298名≥60岁农村老年人为研究对象，进行问卷调查和体格检查。使用轻度行为损害量表（mild behavioral impairment checklist, MBI-C）评估研究对象MBI患病情况，采用多因素logistic回归分析评估MBI的影响因素。结果贵州省部分农村地区老年人MBI患病率为32.97%(95%CI:30.41%～35.53%)。多因素logistic回归分析结果显示，患有慢性病（OR=1.32,95%CI:1.01～1.72）、日常生活功能受损（OR=1.61,95%CI:1.24～2.09）和自评不健康（OR=1.81,95%CI:1.40～2.35）的老年人MBI患病风险较高，参加体育锻炼（1～30 min:OR=0.74, 95%CI:0.55～0.99;>30 min:OR=0.65, 95%CI:0.48～0.89）、睡眠状...     

贵州农村老年人可逆认知衰弱与日常生活功能受损、住院、跌倒的关联研究

目的 了解农村老年人可逆认知衰弱与日常生活功能受损、住院、跌倒的关联，为预防老年人发生功能残疾、住院等不良结局及促进健康老龄化提供参考。方法 采用现况调查设计，多阶段整群抽样方法，选取贵州省2个县（区）内12个村60岁及以上老年人为研究对象，进行问卷调查及体格检查。通过多因素logistic回归模型分析并计算比值比（OR）和95%置信区间（CI）分析可逆认知衰弱与ADL受损、住院、跌倒之间关联。结果 此次纳入老年人1 279人，可逆认知衰弱的检出率为37.8%,ADL受损率为4.3%，住院率为19.0%，半年内跌倒率为10.7%。多因素二分类logistic回归调整混杂因素后结果显示，与无可逆认知衰弱的老年人相比，有可逆认知衰弱的老年人ADL受损风险较高（OR=4.492,95%CI:2.405～8.389），与住院风险存在关联（OR=1.371,95%CI:1.020～1.841），但与跌倒风险没有关联（OR=0.897,95%CI:0.612～1.313）。进一步对慢性病分层分析发现，可逆认知衰弱与ADL受损的关联依然存在（P<0.05），可逆认知衰弱与住院风险的关联仅存在于...     

中国老年人衰弱状况与社会参与及其交互作用对抑郁影响研究

目的 了解我国老年人衰弱状况与社会参与及其交互作用对抑郁影响。方法 收集2018年中国健康与养老追踪调查数据（CHARLS）中4 521名≥60岁老年人相关数据,采用logistic回归分析老年人抑郁的影响因素,并将衰弱状况和社会参与作为2个交互项,调整混杂因素,评价衰弱状况和社会参与交互作用对老年人抑郁的影响。结果 有抑郁症状者1 414人（31.27%）。抑郁与非抑郁老年人在性别（χ2 = 49.237,P＜0.001）、年龄（χ2 = 119.612,P＜0.001）、婚姻状况（χ2 = 14.016,P＜0.001）、文化程度（χ2 = 50.851,P＜0.001）、居住地（χ2 = 32.584,P＜0.001）方面有统计学差异。控制混杂因素后,多因素logistic回归分析结果显示,社会隔离(OR = 2.457,95%CI:1.384～3.532)和衰弱前期(OR = 1.201,95%CI:1.121～1.289)、衰弱(OR = 1.860,95%CI:1.290～1.976)是老年人抑郁发生的影响因素。交互作用结果显示,衰弱与社会隔离对老年人抑郁发生存在相乘(P交互＜0.001)和相加交互作用(OR = 7.715,95%CI:5.426～12.062),RERI(95%CI)、API(95%CI)、Index S(95%CI)分别为1.137(0.252～1.807)、0.316(0.158～0.476)、3.972(1.639～4.665)。结论 衰弱和社会隔离是老年人抑郁的危险因素且二者存在交互作用。     

老年痴呆状况调查及影响因素分析

目的 分析我国老年人痴呆患病,探讨相关影响因素,及抑郁与日常生活活动能力(activity of daily living, ADL)受损的交互作用对老年痴呆的影响。方法 利用2018中国老年健康影响因素跟踪调查数据(CLHLS),对7 588例60岁以上老年人的痴呆状况进行统计学描述,基于logistic回归模型探究抑郁及不同类型ADL对老年痴呆患病的交互作用。结果 高慢病共病水平(OR=1.634,95%CI:1.133～2.355)、抑郁(OR=2.141,95%CI:1.505～3.044)、基础性日常生活活动能力(Basic Activities of Daily Living, BADL)受损(OR=5.576,95%CI:4.249～7.317)、工具性日常生活活动能力(Instrumental Activity of Daily Living, IADL)受损(OR=2.663,95%CI:1.738～4.082)等均为老年人患痴呆的危险因素;抑郁症状与BADL受损之间存在相加交互作用,有抑郁症状且BADL能力受损的老年人患痴呆的风险是对照组的13.917倍(OR=13...     

老年人抑郁症状和焦虑症状共存与轻度认知功能障碍的关联性研究

目的 了解老年人抑郁症状和焦虑症状共存与轻度认知功能障碍（mild cognitive impairment,MCI）的关系，为预防老年人认知功能下降和痴呆的发生发展提供理论依据。方法 数据来源于2019年7—8月中国贵州农村老年人健康状况队列研究（SHGROC）的基线调查，选取其中1 654名≥60岁农村老年人的有效数据进行分析。采用简易精神状态评价量表（MMSE）评估老年人的认知功能，采用简短的2项患者健康问卷（PHQ-2）和广泛性焦虑障碍量表（GAD-2）分别评估抑郁症状和焦虑症状。采用多因素二元logistic回归分析并计算抑郁症状和焦虑症状共存与MCI之间关联的比值比（OR）和95%置信区间（CI）。结果 贵州省农村老年人抑郁症状和焦虑症状共存的检出率为32.2%,MCI患病率为34.2%。多因素二分类logistic回归调整混杂因素后结果显示，与既无抑郁也无焦虑症状的老年人相比，抑郁症状和焦虑症状共存的老年人MCI患病风险较高（OR=1.43,95%CI:1.13～1.81），而单独的抑郁症状（OR=0.98,95%CI:0.63～1.51）和单独的焦虑症状（OR=0.85...     

安徽省农村老年人睡眠质量和认知功能相关性分析

目的 分析安徽省农村老年人睡眠质量和认知功能之间的关系，为防止老年人认知功能减退提供科学依据。方法 数据来自安徽省健康长寿调查(AHLS)，该调查于2021年7—8月采用典型抽样策略抽取调查对象，共纳入1 516名60岁以上的农村老年人进行简易精神状态检查量表(MMSE)和匹兹堡睡眠质量指数量表(PSQI)调查，测量老年人的睡眠质量及认知状况。采用SPSS 17.0和Stata 12.0软件进行χ²检验，多因素logistic回归分析和Pearson相关性分析。结果 多因素logistic回归分析结果显示，女性(OR=1.53,95%CI:1.18～1.97)、70～<80岁(OR=1.49,95%CI:1.16～1.92)、80岁及以上(OR=2.77,95%CI:2.00～3.83)、文盲(OR=1.53,95%CI:1.19～1.96)、睡眠质量差(OR=2.21,95%CI:1.42～3.42)与安徽省农村老年人认知功能障碍发生高风险相关。在MMSE 5个维度中，定向力(r=-0.06)、记忆力(r=-0.06)、计算力(r=-0.14)以及语言能力...     

轻度认知障碍与ApoE基因多态性关系

目的探讨ApoE基因多态性与轻度认知障碍（MCI）的关系。方法采用等位基因特异PCR（ASPCR）法对74例轻度认知障碍患者和134例认知功能正常的老年人进行ApoE基因多态性检测。结果非条件Logistic回归单因素分析显示,性别（OR=1.859,95%CI=1.016～3.402）、年龄（OR=2.044,95%CI=1.454～2.872）、职业（OR=5.845,95%CI=2.710～11.099）、婚姻状况（OR=2.713,95%CI=1.428～5.152）、携带ApoEε4（OR=2.641,95%CI=1.430～4.879）和轻度认知障碍的发生有关。多因素分析表明,年龄（OR=2.228,95%CI=1.511～3.287）、职业（OR=5.854,95%CI=2.741～12.501）、ApoEε4（OR=2.573,95%CI=1.296～5.217）、ApoEε2（OR=0.288,95%CI=0.091～0.905）与轻度认知障碍有关。交互作用分析显示,ApoEε4和较低水平的低密度脂蛋白（LDL）存在拮抗作用。结论年龄、职业、ApoEε4和轻度认知障碍的可疑危险因素,ApoEε2可能降低轻度认识障碍的发病危险性。ApoEε4和LDL间的交互作用对研究ApoE基因多态性的致病机制有重要意义。     

贵州省农村老年人睡眠障碍对认知功能损害影响

目的了解贵州省农村老年人睡眠障碍对认知功能损害的影响,为改善老年人认知功能提供参考依据。方法于2019年7—8月采用多阶段整群随机抽样方法在贵州省花溪区和贵定县抽取5个乡(镇)共1 651名≥60岁老年人进行问卷调查,分析老年人睡眠障碍对认知功能损害的影响。结果贵州省1 651名农村老年人中,有认知功能损害者517例,认知功能损害率为31.3%;其中,定向力、即刻回忆力、注意力和计算力、延时回忆、语言能力损害者分别为296、199、518、752、179例,损害率分别为17.9%、12.1%、31.4%、45.5%、10.8%;无睡眠障碍老年人1 167人(70.7%),有睡眠障碍老年人484人(29.3%)。在控制了性别、年龄、民族、文化程度、婚姻状况、职业等混杂因素后,多因素非条件logistic回归分析结果显示,贵州省有睡眠障碍农村老年人发生认知功能损害、即刻回忆力损害、注意力和计算力损害的风险分别为无睡眠障碍老年人的1.348倍(OR=1.348,95%CI=1.056～1.719)、1.410倍(OR=1.410,95%CI=1.024～1.943)、1.302倍(OR=1.302,95%CI=1.025～1.654)。结论贵州省农村老年人的认知功能损害率较高,睡眠障碍是其认知功能损害的主要危险因素,主要对其即刻回忆力、注意力和计算力影响较大。     

成都市社区老年人睡眠障碍与抑郁症状的相关性研究

目的 探讨成都市社区老年人睡眠障碍与抑郁症状发生之间的关联。方法 以成都市锦江区60岁及以上的老年人为研究对象,采用中文版匹兹堡睡眠质量指数量表（Pittsburgh sleep quality index,PSQI）评估社区老年人的睡眠障碍,包括主观睡眠质量、入睡时间、睡眠时长、睡眠效率、睡眠紊乱、日间功能障碍、催眠药物使用共7个睡眠维度。采用老年抑郁问卷自评版（the self-reported version of geriatric depression inventory,GDI-SR）评估老年人抑郁症状发生情况。采用二分类logistic回归分析社区老年人不同睡眠维度问题与抑郁症状之间的关系。结果 本研究共纳入587名社区老年人,抑郁症状检出率为16.0%,总体睡眠障碍率为39.5%。社区老年人主观睡眠质量（OR=2.738,95%CI:1.394～5.378）、睡眠紊乱（OR=2.351,95%CI:1.060～5.211）、日间功能障碍（OR=5.063,95%CI:2.911～8.805）、使用催眠药物（OR=2.521,95%CI:1.164～5.461）与抑郁症状...     

Principal lifetime occupation and cognitive impairment in a French elderly cohort (Paquid).

The purpose of the present study was to examine the relation between principal lifetime occupation and cognitive performance with the initial data collected (1988-1989) in a cohort of 3,777 community residents of the area of Bordeaux, France, aged 65 years and older. Subjects were considered as cognitively impaired if they scored under 24 on the French version of the mini-mental state examination. Cognitive impairment was found to vary significantly across the different occupational categories. Results of the logistic regression show that age, sex, and educational level are significantly related to cognitive impairment. Moreover, after controlling for these and other covariates, farmworkers (odds ratio (OR) = 6.1, 95% confidence interval (CI) 3.3-11.4), farm managers (OR = 2.9, 95% CI 1.6-5.1), domestic service employees (OR = 2.8, 95% CI 1.5-5.1), and blue-collar workers (OR = 2.5, 95% CI 1.4-4.4) had a higher risk of cognitive impairment than did subjects who had an intellectual occupation. Follow-up of the cohort will permit precise determination of the role of principal lifetime occupation in subsequent cognitive deterioration. Occupational status should be taken into consideration when studying brain aging.     

广州地区健康体检人群睡眠模式及其与糖尿病关系的分析

  目的  了解广州地区成年人睡眠模式的特征，并探讨睡眠模式对糖尿病（diabetes mellitus，DM）患病的影响。  方法  回顾性分析2012年11月至2013年12月在广东省人民医院参加体检的5 666名广州市职工的生活方式调查和体检资料。采用潜在类别分析（latent class analysis，LCA）对人群睡眠的潜在模式及分布特征进行探索性分析，通过多因素Logistic回归模型分析睡眠模式与DM的关系。  结果  LCA识别出5种睡眠模式，分别为“睡眠时间过短伴失眠”（类别1，5.6%）、“睡眠不足伴日间功能轻度减退”（类别2，20.4%）、“睡眠状况良好”（类别3，47.7%）、“睡眠不足伴日间功能障碍”（类别4，4.7%）、“睡眠不足伴夜间睡眠质量差”（类别5，21.6%）。调整相关混杂因素后，与类别3相比，类别1（OR=2.28，95%CI:1.51~3.43，P<0.001）、类别4（OR=2.48，95%CI:1.54~4.00，P<0.001）和类别5（OR=1.31，95%CI:1.01~1.71，P=0.045）人群罹患DM的风险升高。  结论  成年人群的睡眠因素之间存在关联，并表现为不同的睡眠模式；不良睡眠模式可增加DM患病风险。     

The Relationship between Food Security Status and Sleep Disturbance among Adults: A Cross-Sectional Study in an Indonesian Population

Background: The relationship between food insecurity and the experience of sleep disturbance has received little attention among researchers, although food insecurity is associated with poor physical and mental health globally. This study aimed to investigate the relationship between food security status and sleep disturbance among adults 20–64 years old. Methods: The study’s population-based sample included 20,212 Indonesian adults who participated in the fifth wave of the Indonesia Family Life Survey (IFLS5) in 2014. Dietary intake data, gathered using a food frequency questionnaire (FFQ), were used to assess the food security status. Sleep disturbance was assessed using the 10-item Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaire. We used multiple linear and logistic regression models to test the study hypothesis. Results: A higher likelihood of experiencing sleep disturbance was recorded in people aged older than 56 years (OR = 1.78, 95% CI: 1.17–2.72, p = 0.007), people with depressive symptoms (OR = 3.57, 95% CI: 2.77–4.61, p < 0.001), and food-insecure people (OR = 1.32, 95% CI: 1.02–1.70, p = 0.036). A lower likelihood of experiencing sleep disturbance was recorded in people with low educational attainment (OR = 0.41, 95% CI: 0.30–0.57, p < 0.001). Sleep disturbance was dependent on the food consumption groups and food security status among men (p = 0.004). Conclusions: Sleep disturbance may be affected by the food-insecure status of adults, and later, may lead to serious health outcomes.     

中国老年人慢性病患病、失能与失智状况对死亡风险的影响:基于人群的前瞻性队列研究

  目的  利用基于人群的前瞻性队列研究,分析协同控制后中国老年人慢性病患病、失能和失智对死亡风险的影响。  方法  基于中国老年健康影响因素,跟踪调查2002―2018年共6期数据中13 540位65岁及以上老年人,采用Cox比例风险模型分析慢性病患病、失能和失智与死亡风险的关系。  结果  65岁及以上老年人的生存平均时间为5.75(2.33. 13.00)年。在充分调整混杂因素并协同控制三个维度健康因素后,本研究发现在慢性病患病维度,癌症患者比未患癌症者死亡风险高50%(HR=1.50, 95% CI: 1.16~1.94),而非癌慢性病患病与否与死亡风险的关系差异无统计学意义。在失能维度,日常活动能力受限者比不受限者死亡风险高40%(HR=1.40, 95% CI: 1.32~1.47)。在失智维度,认知受损者相较于未受损者死亡风险高30%(HR=1.30, 95% CI: 1.23~1.37),痴呆患者相较于未患痴呆者死亡风险高26%(HR=1.26, 95% CI: 1.09~1.46)。  结论  在过去20年里,中国老年人健康相关的死亡风险因素主要来自患癌、日常活动能力受限、认知受损和罹患痴呆,提示对于老年人的死亡风险,相较于疾病特别是非癌慢性病患病本身,罹患疾病后的失能与失智尤为值得关注。     

Fall-related factors in a cohort of elderly community residents

OBJECTIVE: To identify factors associated to fall and recurrent fall episodes among elderly living in a community, and to determine the relative risk of each factor as a fall predictor. METHODS: A two-year follow-up study with two segments of multi-dimensional household surveys (1991-1992 and 1994-1995) was carried out in a cohort of 1,667 elderly, aged 65 or older, living in a community in the city of S?o Paulo, Brazil. The instrument used for data collection was the BOMFAQ, the Brazilian version of the Multidimensional Functional Assessment Questionnaire (OARS). A stepwise logistic regression analysis was conducted with p<0.05 and 95% CI. RESULTS: About 31% of the elderly referred a fall episode and around 11% referred two or more fall episodes in the previous year of the first survey. After follow-up, 53.4% didn't refer any fall episodes, 32.7% referred a fall episode either in the first survey or in the second one and almost 14% referred fall episodes in both surveys. The predictive model of recurrent falls was composed by the following variables: absence of a spouse (OR=1.59 95% CI 1.00-2.52), not having a reading habit (OR= 1.56 95% CI 1.03-2.37), history of fractures (OR=4.6 95% CI 2.23-9.69 difficulty to perform one to three activities of daily life (OR=2.37 95% CI 1.49-3.78), difficulty to perform four or more activities of daily life (OR=3.31 95%CI 1.58-6.93) and among those whose sight is most impaired (OR=1.53 95%CI 1.00-2.34). CONCLUSIONS: Population ageing and increase in life expectancy demand preventive and rehabilitation actions in order to reduce risk factors for falls, such as impaired functional capacity, impaired eye sight and lack of cognitive stimulation.     

社区老年人运动认知风险综合征患病率及相关因素的系统评价和Meta分析

目的 对社区老年人运动认知风险综合征的患病率和相关因素进行系统评价和meta分析。方法 计算机检索Pub Med、Embase、Web of Science、CINAHL、Sino Med、Cochrane Library、Psyc Info、知网、万方和维普等数据库,检索时限为建库至2022年5月。纳入有关社区老年人运动认知风险综合征患病率及其相关因素的研究。横断面研究采用美国卫生保健质量和研究机构推荐的质量评价标准进行评价。队列研究和病例对照研究使用纽卡斯尔-渥太华量表进行质量评价。使用Stata 15.0软件对提取的数据进行meta分析。结果 共纳入16篇文献,涉及51 364例社区老年人。结果显示,社区老年人运动认知风险综合征总患病率为8.0%(95%CI:7.0%～10.0%)。亚组分析结果显示,美洲、亚洲和欧洲患病率分别为8.9%(95%CI:6.9%～10.8%)、9.0%(95%CI:7.2%～10.7%)和5.1%(95%CI:0.1%～10.0%)。中国社区老年人运动认知风险综合征患病率为10.2%(95%CI:7.5%～12.9%)。社区老年人运动认知风险综合征的...     

Association Between Cognitive Status and Falls With and Without Injury During a Skilled Nursing Facility Short Stay

ObjectivesTo examine the relationship between cognitive status and falls with and without injury among older adults during the first 18 days of a skilled nursing facility (SNF) and determine if this association is mediated by limitations in activities of daily living (ADL) and impaired balance.DesignCohort study of Medicare fee-for-service beneficiaries admitted to an SNF between October 1, 2016, and September 31, 2017.Settings and Participants815,927 short-stay nursing home residents admitted to an SNF within 3 days of hospital discharge.MethodsCognitive status at SNF admission was classified as intact, mild, moderate, or severe impairment. Residents were classified as having no falls, a fall without injury, and a fall with a minor or major injury. We used ordinal logistic regression to model the association between cognitive status and falls adjusting for resident and facility characteristics. A causal mediation analysis was used to test for the mediating effects of ADL limitations and impaired balance on the association between cognitive status and falls with an injury.ResultsMild, moderate, and severe cognitive impairment were associated with 1.72 (95% CI: 1.68-1.75), 2.72 (95% CI: 2.66-2.78), and 2.61 (95% CI: 2.48-2.75) higher odds of being in a higher fall severity category, respectively, compared to being cognitively unimpaired. Greater ADL limitations and impaired balance were significantly associated with falls, but each mediated the association between cognitive status and falls by less than 2%.Conclusions and ImplicationsOlder adults with cognitive impairment are more likely to experience a fall during an SNF stay. ADL limitations and impaired balance are risk factors for falls but may not contribute to the increased fall risk for SNF residents with cognitive impairment. Continued research is needed to better understand the risk factors for falls among SNF residents with cognitive impairment.     

Associations Between Active Mobility Index and Disability

ObjectivesTo develop a questionnaire-based Active Mobility Index (AMI) to assess going-out behavior with physical and social activity among older adults, and to assess the criterion-related and predictive validity of the AMI.DesignProspective cohort study.Setting and ParticipantsGeneral community setting. Participants comprised 4432 older adults [mean age: 75.9 ± 4.3 (70-96) years; 2100 men (47.4%)].MethodsAMI assessed life-space and activities in each life-space (distance from the respondent's home: <1 km, 1-10 km, or >10 km) according to physical or social activity during the past 1 month by noting frequency, purpose, type of transportation, interaction with others, and physical activity. Baseline characteristics and outcomes were compared by AMI score quartiles (highest: Q4). To examine the criterion-related validity of AMI, depressive symptoms, frailty, and cognitive function were assessed. During follow-up, incident disability was monitored by Long Term Care Insurance certification.ResultsLower scores (Q1-Q3 groups) were associated with more depressive symptoms, frailty, and cognitive impairment compared with the Q4 group (all P < .001). Multiple logistic regression analyses revealed significantly higher odds ratios in the Q1 group in all health adverse outcomes compared with the Q4 group [depressive symptoms, odds ratio (OR) 3.94, 95% confidence interval (CI) 2.95-5.28; frailty, OR 3.20, 95% CI 2.31-4.44; cognitive impairment, OR 1.28, 95% CI 1.04-1.57]. Cox proportional hazards modeling indicated that the Q1 group had a higher risk of incident disability compared with the group (hazard ratio 1.53, 95% CI 1.24-1.88).Conclusions and ImplicationsAMI to assess life-space with physical and social activity among older people was associated with depressive symptoms, frailty, and cognitive impairment. Lower AMI scores were associated with higher incident disability risk. Further studies are needed to elucidate whether AMI is causally associated with incident adverse health outcomes.