联合脏器切除应用于局部进展期右半结肠癌的疗效

目的探讨右半结肠联合周围脏器切除治疗局部进展期右半结肠癌的疗效。方法回顾性分析13例因局部进展期结肠癌并侵犯邻近组织器官而行联合脏器切除的右半结肠切除患者的临床资料。结果13例患者中男8例,女5例,年龄39-76（平均58．6）岁。原发肿瘤位于结肠肝曲6例。升结肠5例．横结肠2例。肿瘤仅侵犯十二指肠3例,同时侵犯十二指肠和其他组织器官9例,另1例侵犯胰腺和胃。手术均采用右半结肠联合胰十二指肠和（或）其他脏器切除术。13例患者术后1年、3年及5年生存率分别为69％、54％和30％。结论右半结肠联合脏器切除术对于局部进展期右半结肠癌具有积极的治疗意义。     

结肠癌侵犯十二指肠的手术方式探讨

目的探讨结肠癌侵犯十二指肠的手术方式,评估临床疗效。 方法回顾性分析第四军医大学附属西京医院2013年1月至2014年12月收治的结肠癌侵犯十二指肠患者共26例,结合患者不同的临床特点及手术方式进行生存分析。 结果根治性右半结肠切除术8例,根治性右半结肠切除术+十二指肠壁缺损间断全层缝合术10例,右半结肠切除、空肠十二指肠端侧吻合+空肠Roux-en-Y吻合、空肠营养管造瘘术4例,右半结肠切除、胰十二指肠切除术1例,根治性右半结肠切除、胃窦及球部切除、胃空肠吻合术1例,横结肠-回肠侧侧吻合术2例。术后除1例发生横结肠回肠吻合口瘘,未发生十二指肠瘘、胰瘘等严重并发症,12个月生存率84.6%,30个月生存率76.9%。 结论结肠癌侵犯十二指肠时,术前影像学评估、合理的手术方式选择和积极的外科处理将有助于减少术后并发症,提高临床疗效,改善预后。     

右半结肠癌侵犯十二指肠的外科处理

目的:探讨右半结肠癌侵犯十二指肠的外科处理方法:方法:近十年中对9例右半结肠癌侵犯十二指肠的病人,根据不同情况作了手术处理,术式包括十二指肠局浸润部分切除,并缝合修补;缝合修补加带蒂肠壁浆肌复盖加固并行十二指肠憩室化;胰头十二脂肠切除等。结果:9例术后均一期恢复。其中6例生存3年以上。结论:原来普遍认为右半结肠癌浸润十二指肠即失去根治机会,多予姑息处理是不全面的。而根据临床分型作出积极的外科处理将有助于改善病情或使病人得以痊愈。     

腹腔镜辅助右半结肠癌根治术57例临床分析

目的探讨腹腔镜辅助右半结肠癌切除的手术方法和疗效。方法回顾性分析57例行腹腔镜辅助右半结肠癌切除手术患者的临床资料。结果51例顺利完成腹腔镜辅助右半结肠癌根治术,3例中转开腹（其中1例因肿瘤侵犯十二指肠,2例回盲部肿瘤〉8 cm）,3例因广泛转移仅行开关腹手术,无手术死亡。平均手术时间160（130-250）min,平均出血量110（50-150）ml,平均术后住院天数9.6（7-13）d。1例术后2 d发现肺部感染,1例术后第5 d出现不完全性肠梗阻,经对症处理后好转。57例随访6-36月,其中2例腹腔镜手术患者发生双肺部转移而死亡,1例开腹手术患者发生肝转移,1例发现Trocar穿刺处肿瘤种植并腹腔内远处转移,后2例患者放弃治疗。结论只要严格掌握手术适应证,熟练应用腹腔镜技术,腹腔镜辅助右半结肠癌切除是安全可行的。     

右半结肠癌因阑尾炎误诊24例临床分析

目的探讨右半结肠癌因阑尾炎误诊、漏诊原因及预防措施。方法回顾性分析我科2000年1月至2012年1月间因阑尾炎而误诊、漏诊的患者的右半结肠癌患者24例的临床诊治资料。结果 16例患者在阑尾炎手术中诊断右半结肠癌;5例被误诊为阑尾炎性包块而保守治疗,后经确诊右半结肠癌方手术治疗;3例术后复诊时确诊右半结肠癌并再次手术。结论右半结肠癌并存阑尾炎容易发生误诊、漏诊。术前要详细询问病史和仔细检查,术中注意探查,术后随访,避免右半结肠癌误诊和漏诊。     

结肠肝曲癌侵犯门静脉行联合肠系膜上静脉-门静脉切除对端吻合重建手术

目的 探讨结肠肝曲癌侵犯门静脉行右半结肠根治切除(right hemicolectomy,RH)联合肠系膜上静脉-门静脉切除的胰十二指肠切除术(pancreaticoduodenectomy,PD)血管端端吻合的可行性.方法 总结2004-2011年吉林大学普通外科疾病诊疗中心、吉林大学第二医院普通外科行右半结肠根治切除术及胰十二指肠切除、联合肠系膜上-门静脉切除术后血管进行端端吻合5例患者的临床资料.结果 5例患者手术过程均顺利,肿瘤完全切除,无严重术后并发症及围手术期死亡,5例患者均康复出院.结论 结肠肝曲癌极易侵犯胰头十二指肠及(或)门静脉,行右半结肠癌根治切除术及胰十二指肠切除,联合肠系膜上-门静脉切除后均未间置人工血管进行端端吻合是一项安全可行的技术.     

右半结肠癌侵犯十二指肠的外科处理

目的：探讨右半结肠癌侵犯十二指肠的外科处理方法，方法：在近１０年中对１０例右半结肠癌侵犯十二指肠病人根据不同病理特点作了处理，术式包括十二指肠局部切除，穿孔修补，扩大胰头十二指肠联合切除等，根据肿瘤浸润十二指肠程度，提出将浸润程度分为３型，结果：术后９例一期恢复，另１例在处理并发症后也恢复出院，其中２例已生存３年以上，结论：根据临床分型作出积极的外科处理将有助于改善病情或使病人得以痊愈。     

结肠癌侵犯十二指肠的外科治疗（附16例报告）

总结近５年１６例结肠癌侵犯十二指肠外科治疗经验。手术探查：除十一指肠侵犯外，多数病人还合并多脏器受累，本后病理组织学检查，４例肿瘤仅浸润肌层，７例区域淋巴结未见转移，右半结肠切除并十二指肠粘连松解４例，十二指肠部分切除空肠侧侧双Ｒｏｕｘ－Ｙ空肠浆膜瓣或吻合共５例，十二指肠成形术５例及胰头十二指肠切除２例。结果近期十二指肠瘘２例，因器官衰竭死亡３例，２年内二次手术探查５例，以局部复发为主。认为重视初     

带蒂末端回肠瓣修补右半结肠癌切除术后的十二指肠缺损

目的 探讨右半结肠癌切除术所致十二指肠缺损的修补方法.方法 对5例右半结肠癌根治术后遗留的十二指肠巨大缺损采用了带蒂末端回肠瓣修补,附加减压、引流术.结果 5例均一期恢复,无围手术期死亡,术后未发生十二指肠瘘和十二指肠狭窄,术后上消化道造影显示十二指肠蠕动和排空正常.结论 带蒂末端回肠瓣修补右半结肠癌术后的十二指肠巨大缺损安全可靠.     

局部进展期胃癌或结肠癌联合胰十二指肠切除术：附15例报告

目的探讨局部进展期胃癌或结肠癌行胃癌或结肠癌切除联合胰十二指肠切除术的可行性及临床价值。方法回顾性分析2004年5月—2010年12月15例侵犯胰头十二指肠区域的局部进展期胃癌或结肠癌联合胰十二指肠切除术患者的临床资料,其中原发或复发胃癌12例,结肠癌3例。结果中位手术时间6 h(4～12 h),中位术后住院时间21 d(7～63 d)。并发症发生率为46.7%(7/15),再手术率为6.7%(1/15),病死率为6.7%(1/15)。中位生存期为23个月;1,2,3年累积生存率分别为62.2%,44.4%,22.2%。结论联合胰十二指肠切除术可作为局部进展期胃癌或结肠癌侵犯胰头十二指肠区域患者的治疗选择。该术式可延长部分患者的生存期。     

Combined resection of the duodenum and pancreas for locally advanced colon cancer

Colorectal cancer invading adjacent organs is a frequent event occurring in 5.5% to 12% of all colorectal malignancies. Colon cancer directly invading the duodenum and pancreas is rare and may require combined resection of the colon, pancreas, and duodenum, which represents a complex operation with significant morbidity and mortality rates. In this article, a case of a 41-year-old patient with a right colon cancer directly infiltrating the duodenum and head of the pancreas is presented. The patient was treated by radical combined resection of the colon, duodenum, and pancreas. Pathological examination confirmed neoplastic invasion of the adjacent organs and absence of lymph node metastasis (T4N0). The patient recovered uneventfully. Patients with colorectal cancer infiltrating adjacent organs such as the duodenum and the pancreas should be treated by radical en bloc resection of the tumor. This procedure is the preferred treatment strategy because it seems to be associated with improved overall survival rates.     

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目的探讨右半结肠癌行腹腔镜完整系膜切除(LCME)的外科平面构成和手术路径,并评估其安全性和可行性。方法回顾性分析2011年1月至2013年12月南方医科大学附属顺德第一人民医院收治的行LCME的44例右半结肠癌病人临床资料,术中观察右半结肠癌LCME外科平面位置、构成和毗邻关系,总结手术路径,分析手术安全性及可行性。结果 44例病人均未发生肠系膜上静脉、十二指肠、输尿管、生殖血管损伤等并发症,术中出血量(73.0±32.3)m L,手术时间(200.0±33.3)min,清扫淋巴结(22.0±9.7)枚,术后首次排气时间(74.0±19.9)h,术后住院时间(10.0±2.2)d;术后无吻合口漏、腹腔脓肿发生。随访6~40个月,中位随访时间为24个月,仅2例术后出现远处转移。结论按照基于3个外科平面(即升结肠系膜后叶-肾前筋膜间隙、升结肠系膜后叶-胰头十二指肠筋膜前叶间隙、右半横结肠系膜后叶-右侧胃背系膜间隙)的手术路径进行右半结肠癌LCME,可安全有效地达到根治效果。     

A case of transverse colon cancer secondarily involving the liver,duodenum, and pancreas

A 68-year-old woman presented with transverse colon cancer invading the liver, duodenum, and pancreas. The patient underwent a curative resection including a right hemicolectomy, partial hepatectomy, and pancreaticoduodenectomy (PD). The pathological examination showed adenocarcinoma of the colon with a direct extension into the duodenum, liver, and pancreas. Several lymph nodes were also involved. The patient is still alive and disease-free 2 years and 6 months after the operation. This case illustrates that even in patients with locally advanced colon cancer, a favorable prognosis can be obtained by aggressive surgery incorporating the resection of the adjacent involved organs.     

右半结肠癌行腹腔镜完整系膜切除外科平面及手术路径研究（附44例报告）

目的 探讨右半结肠癌行腹腔镜完整系膜切除（LCME）的外科平面构成和手术路径,并评估其安全性和可行性。方法 回顾性分析2011年1月至2013年12月南方医科大学附属顺德第一人民医院收治的行LCME的44例右半结肠癌病人临床资料,术中观察右半结肠癌LCME外科平面位置、构成和毗邻关系,总结手术路径,分析手术安全性及可行性。结果 44例病人均未发生肠系膜上静脉、十二指肠、输尿管、生殖血管损伤等并发症,术中出血量（73.0±32.3）mL,手术时间（200.0±33.3）min,清扫淋巴结（22.0±9.7）枚,术后首次排气时间（74.0±19.9）h,术后住院时间（10.0±2.2）d;术后无吻合口漏、腹腔脓肿发生。随访6～40个月,中位随访时间为24个月,仅2例术后出现远处转移。结论 按照基于3个外科平面（即升结肠系膜后叶-肾前筋膜间隙、升结肠系膜后叶-胰头十二指肠筋膜前叶间隙、右半横结肠系膜后叶-右侧胃背系膜间隙）的手术路径进行右半结肠癌LCME,可安全有效地达到根治效果。     

En bloc resection of the duodenum for locally advanced right colon adenocarcinoma

Direct invasion of colorectal adenocarcinoma into adjacent structures occurs frequently, but only rarely is the duodenum involved. This study was undertaken to assess the safety and efficacy of en bloc resection of locally advanced right colon carcinoma invading the duodenum. A retrospective review of 49 patients with locally advanced colon cancer, surgically managed between 2000 and 2005, was performed. Forty-six patients underwent en bloc resection of colon and adjacent organs not involving the duodenum. Three patients with duodenal invasion underwent en bloc partial duodenectomy. The mean operative blood loss, length of stay, postoperative morbidity, and mortality compare favorably between these two groups of patients. Of the 46 patients with en bloc resection of other organs, 27 are alive at 12 to 60 months follow up. Two patients with duodenal invasion are alive without recurrence at 15 and 20 months follow up. En bloc resection of colon cancer invading the duodenum can be performed safely because morbidity and mortality rates are comparable to those attending extended resections of other locally advanced colon carcinomas. Overall survival in patients who underwent surgery with curative intent justifies en bloc duodenal resection in selected patients.     

结肠肝曲癌侵犯十二指肠的外科治疗

目的:探讨结肠肝曲癌侵犯十二指肠的治疗方法。方法:对15例结肠肝曲癌侵犯十二指肠患者的临床资料进行回顾性分析。结果:结肠肝曲癌15例分别侵犯十二指肠第2或第3段，其中6例为癌性粘连，5例侵犯浆肌层，4例穿通十二指肠形成十二指肠结肠瘘。15例均行手术治疗。黏液腺癌8例，低分化腺癌4例，中分化腺癌2例，印戒细胞癌1例。手术并发症手术死亡1例，5年生存率为46.7%（7/15）。结论:十二指肠是结肠肝曲癌肿最易受侵器官，根治性联合脏器的整块切除为首选治疗方法，十二指肠创缘的正确处理是术后恢复的关键。     

Pancreatoduodenectomy for locally advanced or recurrent colon cancer: Report of two cases

A 66-year-old man, who had ascending colon cancer which invaded the duodenum, pancreas, and superior mesenteric vein, underwent a curative resection including an extended right hemicolectomy, pylorus-preserving pancreatoduodenectomy, and a partial resection of the superior mesenteric vein. The pathological examination revealed adenocarcinoma of the colon, which directly invaded the duodenum and pancreas, thus causing duodenocolic fistula. Tumor infiltration to the superior mesenteric vein was not histologically proven. Two out of 40 lymph nodes were also involved. The patient is still alive and disease-free 37 months after the operation. A 72-year-old man, with a history of surgery two previous times for ascending colon cancer and its recurrence, underwent a third operation including a resection of the former ileocolic anastomosis en bloc by means of a pylorus-preserving pancreatoduodenectomy with a curative intent. The pathological examination revealed adenocarcinoma of the colon, which directly invaded the duodenum and pancreas. Seven out of 31 lymph nodes were also involved. The patient died of recurrence 24 months after the third operation. These two cases demonstrated the usefulness of a resection of the colon en bloc by means of a pancreatoduodenectomy in patients with either locally advanced colon cancer or locally advanced recurrent colon cancer.     

右半结肠肿瘤侵犯十二指肠的外科治疗

目的探讨右半结肠肿瘤侵犯十二指肠的外科处理方法及疗效。方法右半结肠肿瘤侵犯十二指肠患者26例,根据肿瘤浸润十二指肠程度,行十二指肠局部切除后直接修补6例、带蒂补片十二指肠浆肌层修补7例、扩大胰头十二指肠联合切除5例和姑息性手术8例。结果 6例十二指肠局部切除后直接修补者,1例术后发生修补处狭窄;7例带蒂补片修补十二指肠缺损者中,6例采用带蒂回肠瓣修补,1例采用胃浆肌层瓣修补,其中1例带蒂回肠瓣修补患者术后发生十二指肠修补处漏,经充分引流后痊愈,1例胃浆肌层瓣修补患者术后发生胃梗阻,2周后加作胃空肠吻合后康复;5例扩大胰头十二指肠联合切除者,1例围手术期因呼吸衰竭死亡;8例姑息性手术包括4例回肠横结肠侧侧吻合和4例十二指肠浸润旷置的结肠姑息性切除。结论合理的术式选择和积极的外科处理将有助于改善结肠肿瘤侵犯十二指肠患者的症状和预后。     

Pedicled Ileal Flap to Repair Large Duodenal Defect After Right Hemicolectomy for Right Colon Cancer Invading the Duodenum

Although right-sided colon cancer occasionally invades the second part of the duodenum, there is no standard procedure for reconstructing a large duodenal defect after resection. This report describes a new approach we recently devised. After resecting the right hemicolon and the involved duodenum, a segment of terminal ileum was isolated on the vascular pedicle, sacrificing the adjacent ileum. We created a flap by opening the segment along the antimesenteric border, and used this flap to cover the defect. This method does not create a nonanatomical bypass and fewer intestinal anastomoses are required than for Roux-en-Y reconstruction.