肺结核病人淋巴细胞IL－2产生能力及IL－2R表达的初步观察

本文结果显示肺结核患者淋巴细胞经ＰＨＡ刺激后产生ＩＬ－２水平仅为正常对照的５０％左右，ＩＬ－２Ｒ表达和淋转增殖反应也明显降低。本结果对了解结核患者Ｔ细胞功能状态提供了一定依据。     

FD患者胃十二指肠运动功能的研究

目的通过胃窦十二指肠压力测定，研究功能性消化不良（ＦＤ）患者胃十二指肠的运动功能．方法ＦＤ患者２８例，健康人１３例．采用导管灌注技术测定胃窦和十二指肠的腔内压，消化间期测压３５ｈ，餐后测压１５ｈ．结果在消化间期，２８例ＦＤ中１３例未出现移行运动复合波（ＭＭＣ）３期，１３例健康人１例未出现ＭＭＣ３期，两者相比有显著性差异（Ｐ＜００５）；ＭＭＣ２期和３期收缩的平均频率、平均强度和动力指数，在ＦＤ患者和健康人间相比无差异（Ｐ＞００５）．ＦＤ患者餐后胃窦收缩的频率、强度和动力指数均低于健康对照组（Ｐ＜００５）．结论ＦＤ患者消化间期缺乏ＭＭＣ３期或ＭＭＣ３期延迟出现，餐后胃窦动力减低．     

功能性消化不良患者的自主神经功能评价

功能性消化不良患者的自主神经功能评价刘芳魏建西王增春何平白求恩国际和平医院河北省石家庄市０５００８２Ｓｕｂｊｅｃｔｈｅａｄｉｎｇｓｄｙｓｐｅｐｓｉａ／ｐｈｙｓｉｏｐａｔｈｏｌｏｇｙ；ａｕｔｏｎｏｍｉｃｎｅｒｖｏｕｓｓｙｓｔｅｍ／ｐｈｙｓｉｏｐａｔ...     

FD患者红霉素对胃十二指肠动力的影响

目的研究红霉素对功能性消化不良（ＦＤ）患者消化间期胃窦和十二指肠的运动功能的影响．方法ＦＤ患者２０例，采用导管灌注技术测定胃窦和十二指肠的压力，空腹连续测定３５ｈ，若未发现移行运动复合波（ＭＭＣ）３期，于ＭＭＣ１期匀速静滴红霉素２００ｍｇ，滴速６６ｍｇ／ｍｉｎ，测定静滴红霉素期间胃窦和十二指肠的压力．结果空腹测定３５ｈ，８例ＦＤ未出现ＭＭＣ３期，仅１期和２期交替出现，此后在静滴红霉素期间，胃窦和十二指肠均出现了宽大的收缩波，５例出现了ＭＭＣ３期，且各项动力参数值较静滴红霉素前显著增加（Ｐ＜００５）．结论部分ＦＤ于消化间期胃窦和十二指肠缺乏ＭＭＣ３期，动力减低，静滴红霉素能诱发ＭＭＣ３期，促进胃和十二指肠的运动功能     

消化性溃疡愈合的动力学及影响因素

溃疡愈合是一个由增殖或移行上皮细胞和结缔组织成分去补充已损伤或坏死粘膜的主动过程［１．２］，需要许多组织和细胞系统的参与才能完成，其间影响因素众多．它不同于急性胃粘膜损伤（如糜烂）后的快速修复，后者是由损伤周围完好的上皮细胞迁移覆盖到相邻的损伤表面，...     

冠心病合并2型糖尿病病理生理机制和治疗进展

2型糖尿病(DM)是冠心病(CAD)最重要的危险因子之一，DM病人比非DM具有较高的CAD的发病率，预后差，死亡率高。45～74岁男性和女性DM病人患CAD危险是非DM的2．4和5．1倍。DM对大血管的危害不仅表现在较高的CAD的发病率，也体现在具有较高的脑血管病、周围血管病和充血性心衰发病率。DM患第一次心肌梗死的危险等危于非DM病人曾有过心肌梗死的危险。     

硝苯吡啶治疗胆绞痛36例

临床经验通讯作者李应钦收稿日期1998－03－111对象和方法l．1对象1993－02／1996－10我院住院胆绞痛病例67例，均有明显胆绞痛，伴或不伴右肩区放射痛，有轻度黄疽、恶心、呕吐，上腹不适等；胆囊区有压痛．全部病例经B超协诊．随机分为硝苯毗峻组和阿托品组，两组在就诊前均未曾治疗硝苯毗埃组36例，男15例，女ZI例．年龄18岁～65岁．其中急性单纯性胆囊炎14例，胆石症并胆囊炎13例，胆道蛔虫症6例，胆囊息肉并胆囊炎3例．阿托品组31例，男15例，女16例．年龄ZI岁～69岁其中急性单纯性胆囊炎13例，胆石症并胆囊炎12例，胆道蛔虫症3例，…     

Role Of MMP-2 and MMP-9 in Resistance to Drug Therapy in Patients with Resistant Hypertension

Background

Despite the increased evidence of the important role of matrix metalloproteinases (MMP-9 and MMP‑2) in the pathophysiology of hypertension, the profile of these molecules in resistant hypertension (RHTN) remains unknown.

Objectives

To compare the plasma levels of MMP-9 and MMP-2 and of their tissue inhibitors (TIMP-1 and TIMP-2, respectively), as well as their MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios, between patients with controlled RHTN (CRHTN, n=41) and uncontrolled RHTN (UCRHTN, n=35). In addition, the association of those parameters with clinical characteristics, office blood pressure (BP) and arterial stiffness (determined by pulse wave velocity) was evaluate in those subgroups.

Methods

This study included 76 individuals diagnosed with RHTN and submitted to physical examination, electrocardiogram, and laboratory tests to assess biochemical parameters.

Results

Similar values of MMP-9, MMP-2, TIMP-1, TIMP-2, and MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios were found in the UCRHTN and CRHTN subgroups (P>0.05). A significant correlation was found between diastolic BP (DBP) and MMP-9/TIMP-1 ratio (r=0.37; P=0.02) and DPB and MMP-2 (r=-0.40; P=0.02) in the UCRHTN subgroup. On the other hand, no correlation was observed in the CRHTN subgroup. Logistic regression models demonstrated that MMP-9, MMP-2, TIMP-1, TIMP-2 and their ratios were not associated with the lack of BP control.

Conclusion

These findings suggest that neither MMP-2 nor MMP-9 affect BP control in RHTN subjects.     

Characteristics of saliva secreted by patients with TCM-Piyinxu

AIM: To investigate various characteristics of saliva secreted by patients with TCM-Piyinxu (Spleen-yin deficiency).METHODS: Twenty-five individuals with Piyinxu (15 males and 10 females; age range 26-70 years, mean age = 45 years) diagnosed based on criteria used in traditional Chinese medicine, were compared with 20 individuals with Shenyinxu (Kidney-yin deficiency) (11 males, 9 females; age range 35-75 years, mean age = 50) and 30 normal individuals (17 males, 13 females; age range 35-65 years, mean age = 49 years). After acid stimulation, the saliva flow in each group was measured, and the levels of amylase and protein in saliva were determined using an automatic biochemical analyzer. The resultant data were analyzed using the Kruskal-Wallis test and one-way factorial ANOVA test.RESULTS: The flow rates of saliva and amylase in Piyinxu patients (0.27 ± 0.016 mL/min and 2134.13 ± 343.51 IU/min, respectively) were lower than those in normal subjects (0.46 ± 0.027 mL/min and 3501.63 ± 1099.63 IU/min, respectively, P < 0.01), but higher than those in the Shenyinxu group (0.13 ± 0.051 mL/min and 951.62 ± 383.17 IU/min, respectively, P < 0.01). The three groups showed no significant difference in their level of total salivary protein (Piyinxu group, 3.07 ± 0.60 g/L; Shenyinxu group, 3.01 ± 0.90 g/L, and control group, 2.94 ± 1.13 g/L, P = 0.869), amount of amylase per saliva volume, or their ratio of amylase to protein in secreted saliva (P = 0.173 and P = 0.436, respectively).CONCLUSION: Piyinxu patients showed altered rates of saliva and amylase secretion when compared with those parameters in patients with Shenyinxu and normal subjects.     

急性病毒性肝炎患者胆囊排空功能研究

目的研究急性病毒性肝炎（ＡＶＨ）患者胆囊（ＧＢ）排空功能及其与病情程度和转归的关系．方法用实时超声研究了３２例ＡＶＨ患者及２６例健康对照者ＧＢ排空功能．结果空腹ＧＢ容量（ＦＧＶ）ＡＶＨ患者（１０２２±２３１）明显小于对照组（１９７９±１５１）（Ｐ＜０００１），随病程延长，ＦＧＶ渐增多．ＦＧＶ减少与病情程度呈显著负相关（Ｐ＜００５）．餐后ＧＢ排出量（ＧＥＦ）ＡＶＨ组显著少于对照组（Ｐ＜０００１），其减少与病情程度呈明显负相关（Ｐ＜００１），与血清胆红质、ＡＬＴ水平呈显著负相关（Ｐ＜００５～００１）．６０ｍｉｎ最大ＧＥＦ及ＧＢ排空速度明显减少、减慢（Ｐ＜０００１）．恢复期ＦＧＶ及餐后ＧＥＦ均恢复正常．结论ＡＶＨ患者存在ＦＧＶ和餐后ＧＥＦ异常．其机制与肝细胞损害，泌胆功能障碍及神经—激素调控失调有关．     

Saliva secreting functions in patients with TCM-Piyinxu

ＳａｌｉｖａｓｅｃｒｅｔｉｎｇｆｕｎｃｔｉｏｎｓｉｎｐａｔｉｅｎｔｓｗｉｔｈＴＣＭＰｉｙｉｎｘｕＧＵＡＮＸｕｅＺｈｏｎｇ，ＷＥＩＭｕＸｉｎ，ＣＨＥＮＤｅＺｈｅｎ，ＧＵＹｕＣｈｕｎ，ＳＵＮＺｈｅｎＨｅａｎｄＢＥＩＳｈｕＹｉｎｇＤｅｐａｒｔ...