五香粉脐疗治疗带状疱疹

我科应用中药五香粉脐疗治疗带状疱疹,疗效较好,现报道如下：１临床资料：１１共治疗带状疱疹４２例,男２３例,女１９例,均为门诊病人,年龄２１—６３岁,平均３８岁,病程１０小时至１６天,平均６５天。其中三叉神经受累９例,颈部神经５例,胸段神经１７例,...     

明竹欣治疗带状疱疹临床疗效观察

我们于１９９７年１０月～１９９８年５月用明竹欣治疗带状疱疹进行疗效观察，现报告如下：１　临床资料和方法１１　病例选择　根据典型的临床症状和体征而确定的带状疱疹患者，病程不超过１周，且１周内未服用或外用过抗病毒药物者。妊娠、哺乳期妇女，严重肝肾功能不全者均不作为治疗对象。１２　一般资料　所有患者均来于皮肤科，其中男２３例，女２１例，年龄１５～６５岁之间，病程２～５天，皮疹侵犯三叉神经１２例，肋间神经２３例，坐骨神经５例，臂丛神经４例，将患者随机分治疗组３５例及对照组１０例。１３　治疗方法　治…     

220例带状疱疹临床分析

现将我所收集的从１９９２年至１９９６年门诊及住院诊治的资料完整的２２０例带状疱疹病例分析如下：临床资料１病例：带状疱疹患者２２０例，门诊１７２例，住院４８例，男１２６例，女９４例。２分组：年龄最小９岁，最大８４岁。Ａ组２０岁以下２２例（１００％），...     

拔火罐在脓疖肿治疗中的应用

成熟的脓疖肿切开后及早期换药时，我们采用拔火罐排脓法（Ａ组１３４例），并随机设立常规切开引流法（Ｂ组１２６例）作对照，Ａ组疗效较好，现报道如下。１临床资料１１一般资料：男１４２例，女１１８例。年龄３—６５岁，平均３４岁。１２临床情况：脓疖肿切开...     

α—干扰素为主的综合疗法对带状疱疹的疗效观察

我科采用α—干扰素为主的综合疗法治疗带状疱疹，取得了较好疗效。报告如下：一、临床资料：６０例均为住院病人。其中男性３１例，女性５９例，年龄３０—７２岁。病程３—７天。发病部位：肋间神经３２例（５３３％），腰骶神经１６例（２６７％），三叉神经６例（...     

560例带状疱疹临床分析

５６０例带状疱疹临床分析王埃胜①我科从１９９３年７月～１９９５年７月共收治带状疱疹５６０例，现分析报告如下。１临床资料１．１性别、年龄：５６０例中，住院患者４５例，门诊患者５１５例；男３７８例，女１８２例，男∶女＝２∶１；年龄１１～８２岁，其中１１～...     

迪银片和氨苯砜联合治疗寻常型银屑病疗效观察

我们于１９９５年１２月起,采用迪银片和氨苯砜联合用药治疗寻常型银屑病,取得了比较满意的疗效,现将临床观察总结如下。１　材料和方法１１　临床资料　本组所有患者均为门诊病人,共计２１２例,男１５０例,女６２例,年龄１８～５５岁。平均年龄为３３６５岁。病期１月～１０年不等,平均３５年。其中进行期１８６例,稳定期２６例。按年龄、病期和分期等随机分为三组：Ａ组（迪银片加氨苯砜）１１０例,Ｂ组（单纯迪银片）６２例,Ｃ组（单纯氨苯砜）４０例。１２　治疗方法　Ａ组：迪银片,每日二次,每次５片,加氨苯砜,…     

伊曲康唑1周疗法治疗浅部真菌病

我科使用伊曲康唑（商品名斯皮仁诺）１周短程疗法治疗皮肤癣菌、花斑癣的临床验证，现将结果报告如下：１一般资料：３０例患者，其中男１８例，女１２例，年龄在１８—６２岁之间，平均４０岁，病程不足１年者４例，１—５年１２例，６—１０年８例，１０年以上６例，...     

复方丹参注射液治疗老年带状疱疹后遗神经痛的疗效观察

我科应用复方丹参注射液治疗老年带状疱疹后遗神经痛２２例，均获较好的治疗效果，现将治疗结果报告如下：一、临床资料：２２例中，男７例，女１５例。年龄５２—７６岁。病程最短半月２例，１—３月１５例，３月以上至１年内４例，１年以上１例。发病部位：胸部１１例，...     

儿童头癣122例分析

我们对１９９６年１２月～１９９８年２月发现的１４岁以下小儿头癣１２２例进行了临床及病原菌分析,现报道如下。一临床资料（一）病例：１２２例头癣患儿均来自我院皮肤病门诊,男６８例,女５４例,年龄１５—１４岁,平均６２５岁。病程１个月～２年,平均３６...     

特异性免疫治疗对单核细胞及其来源的树突状细胞表型的早期影响

目的探讨抗原特异性免疫治疗对单核细胞及其来源的树突状细胞表达与免疫相关的重要表型的早期影响。方法 20名接受黄蜂毒液免疫治疗的患者,在治疗前(day0)和治疗后第1天(day1)、第3天(day3)和第5天(day5)抽取外周静脉血分离单核细胞(Mo),其中10名患者的单核细胞在体外培养6d诱导分化为单核细胞来源的树突状细胞(MoDC),流式细胞仪检测其表面ILT3,ILT4,B7H1,B7H2,MHCⅠ,MHCⅡ,CD80和CD86的表达。结果单核细胞和MoDC表面ILT3和ILT4表达显著增高,B7H1和CD86表达显著降低,与治疗前比较,差异有统计学意义(P<0.01)。未观察到B7H2,MHCⅠ,MHCⅡ和CD80的显著性改变(P>0.05)。结论单核细胞和MoDC表面的ILT3,ILT4,B7H1和CD86分子参与抗原特异性免疫治疗的早期耐受。     

Effects of low-frequency ultrasound on microcirculation in venous leg ulcers

Background:

Therapeutic low-frequency ultrasound (US) has been used for many years to improve wound healing in chronic wounds like venous leg ulcers. No human data are available for the possible effects of single US applications on microcirculation and their frequency-dependency.

Aims:

To investigated the role of therapeutic low-frequency US on microcirculation of venous leg ulcers in vivo.

Patients and Methods:

This is a pilot study on an inpatient basis. We use a newly developed low-frequency continuous-wave US-equipment composed of a US transducer based on piezo-fiber composites that allow the change of frequency. In this study, we apply US of 34 kHz, 53.5 kHz, and 75 kHz respectively. Twelve patients with chronic venous leg ulcers are analyzed. As an adjunct to good ulcer care, therapeutic US is applied, non-contacting, once a day, in a subaqual position for 10 minutes. Microcirculation is assessed in the ulcers adjacent to skin before US-therapy, immediately after the treatment and 30 minutes later. We use a micro-light guide spectrophotometer (O2C, LEA Medizintechnik GmbH, Gieίen, Germany) for calculation of blood flow velocity, hemoglobin oxygen saturation (SCO₂) and relative hemoglobin concentration (rHb) in 2 and 8 mm depth. Contact-free remission spectroscopy (SkinREM3, Color Control Chemnitz GmbH, Chemnitz, Germany) allows contact free measurements in the VIS-NIR range of the spectrum (400 ± 1600 nm).

Results:

It is seen that therapeutic US is well tolerated. One patient dropped out from a treatment series since he developed erysipelas responding to standard antibiotic. Effects were seen at 34 kHz only. The SO₂ values increased after single US application. The values for rHb were higher in the superficial layer of the wound bed (depth 2 mm) compared to deeper parts (8 mm depth). US treatment did not result in significant changes of rHb and blood cell velocity. The data obtained by remission spectroscopy disclose an increase of oxygenized hemoglobin.

Conclusions:

The major findings are that continuous-wave low-frequency US of 34 kHz, but not, 53.5 kHz or 75 kHz, has a temporary stimulatory effect on microcirculation mainly due to an improved oxygenation. Further studies with treatment series are necessary.     

高能超脉冲CO_2激光皮肤磨削术466例的护理体会

目的观察高能超脉冲CO2激光皮肤磨削术后的治疗效果,并探讨有效的护理措施。方法对466例面部良性肿瘤和痤疮凹陷性瘢痕患者进行高能超脉冲CO2激光磨削术治疗,将入选患者按皮损面积大小分为非暴露疗法护理组(>20cm2)和暴露疗法护理组(<20cm2)。分别予以术前心理咨询和有效干预,并配合治疗全程进行健康宣教,非暴露疗法护理组术后严格按操作规章制度换药。结果 466例患者均术后恢复良好,有效率为81.20%,非暴露疗法护理组除色沉发生率低于暴露疗法护理组外(P<0.05),平均脱痂时间、感染率和瘢痕发生率比较,两组差异均无统计学意义(P均>0.05)。结论术前进行必要的心理咨询和有效干预及治疗全程健康宣教,术后对创面按时换药及包扎,可降低感染率,缩短脱痂时间,减少术后色素沉着等并发症。     

窄谱中波紫外线对寻常性银屑病患者血清和皮损中IFN-γ,IL-4的影响

目的研究311nm窄谱中波紫外线(NB-UVB)对寻常性银屑病患者血清和皮损中IFN-γ和IL-4的影响。方法40例寻常性银屑病患者随机分为NB-UVB和对照两组,每组20例,NB-UVB组每周光疗3次,共4周,对照组不予光疗。治疗前后分别以银屑病严重程度PASI评分标准评分,以ELISA法测定血清中IFN-γ和IL-4含量,以免疫组化方法和图像分析系统分析IFN-γ和IL-4在银屑病皮损中的表达,结果以积分光密度值(IOD值)表示。结果两组患者治疗后PASI评分均显著下降(P<0.05),且NB-UVB组低于对照组(P<0.05);血清IFN-γ水平均下降(P<0.05),而IL-4水平无明显变化;皮损中IFN-γ表达明显下降(P<0.05),且NB-UVB组低于对照组(P<0.05);IL-4水平增高(P<0.05),且NB-UVB组高于对照组(P<0.05)。结论NB-UVB可以调节寻常性银屑病血清IFN-γ水平和皮损中IFN-γ,IL-4的表达,改善患者体内Th1,Th2失衡状态达到治疗效果。     

Photoprotection of bacterial-derived melanin against ultraviolet A–induced cell death and its potential application as an active sunscreen

Background  The increase in the incidence of non-melanoma skin tumours, photoaging, and immunosuppression demand for more effective sunscreen on ultraviolet A (UVA) irradiation.
Objectives  The aim of the study is to evaluate the photoprotective effects of a bacterial-derived melanin against UVA-induced damages in vitro and in vivo .
Methods  Human fibroblasts were used to assess the role of the bacterial-derived melanin on cell viability against UVA. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and nuclear morphology were employed to evaluate the photoprotection at the cellular level. Fluorometric assays were performed to detect the formation of reactive oxygen species (ROS) in the cells. Evaluations of the bacterial-derived melanin as a sunscreen were measured by transmission test and persistent pigment darkening on human skin.
Results  Bacterial-derived melanin efficiently scavenged ROS in the fibroblasts after UVA irradiation. The cell viability of xeroderma pigmentosum (XP) fibroblast treated with varied doses of melanin increased dramatically in comparison with untreated control and the treated XP fibroblasts became more resistant to UVA-induced apoptosis than normal fibroblasts. Although the relative transmission didn't change too much with different concentration of bacterial-derived melanin, this melanin could keep UVA-irradiated skin from pigment darkening and act as an active sunscreen on skin.
Conclusions  The bacterial-derived melanin provided significant protection to fibroblast cell and human skin against the UVA radiation. It has the potential to be developed as an active sunscreen for the patients with photosensitivity skin to sun exposure.     

流产后关爱服务模式在首次人工流产未婚女性中的应用效果观察

目的:探究PAC服务模式对首次人工流产未婚女性心理状况的影响。方法:选取我院妇产科实行PCA服务模式后首次人工流产未婚女性100例,及未实行PCA服务模式前首次人工流产女性100例。每位患者共需接受两次心理状况测评,首次测评时间为患者首次确定妊娠并确认施行人工流产时,二次测评时间为实施常规无痛人流手术留院观察2h后确定离院前。结果:两组女性第一次SCL-90结果与中国常模比较,精神病性、强迫症状、躯体化、恐怖、焦虑、抑郁、其他(主要为与睡眠质量相关项目)等7个项目均高于全国常模。第二次SCL-90结果强迫症状、躯体化、恐怖、焦虑、抑郁、其他(主要为与睡眠质量相关项目)等6个项目均高于全国常模。PCA组女性两次SCL-90结果比较,强迫症状、躯体化、精神病性、焦虑、抑郁等5个项目均有显著降低。对照组女性两次SCL-90结果比较,强迫症状、精神病性2个项目均有显著降低。结论:常规护理与PCA均可以改善首次人工流产未婚女性心理状况,PCA服务模式较常规护理在改善患者心理状态中有较高的改善作用。     

枣环磷酸腺苷提取液抗缺氧作用实验研究

目的观察枣环磷酸腺苷提取液对人体的抗缺氧作用的有效性,为其应用提供数据支持。方法采用双盲对照的研究方法,选取120名武警战士为实验对象,随机分为高剂量组（CAMP浓度为15mg／100g）、低剂量组（CAMP浓度为7．5mg／100g）和对照组（糖浆）,连续服用实验样品40d,分别于干预前和末次干预后,利用3公里跑造成机体缺氧环境测定血氧饱和度;同时抽血5mL,测定血乳酸和血红蛋白含量。结果连续服用40d后,与空白对照组相比,高、低剂量组血乳酸含量较空白对照组明显降低,P〈0．01;高剂量组血红蛋向含量低于对照组,有统计学意义,P〈0．05;高剂量组血氧饱和度与空白对照组相比升高,P〈0．01。结论枣环磷酸腺苷提取液具有较为明显的抗缺氧作用。能降低运动缺氧条件下血乳酸、血红蛋白含量,提高缺氧条件下的血氧饱和度。     

Oral mucosal diseases investigated by patch testing with a dental screening series

The rôle of contact allergies in oral mucosal diseases was studied. The subjects were 24 patients out of 479 tested, who had oral mucosal symptoms and positive patch test reactions in a dental series during 1987–1994 at the Department of Dermatology. Helsinki University Hospital. The clinical diagnoses were oral lichen planus (LPO, 13 patients), leukoplakia (2), glossodynia, i.e., 'burning mouth syndrome' (4), stomatitis (3) and recurrent angioedema (2), Only 1 patient had symptoms in relation to dental care. All but 2 patients had allergic reactions to mercury (Hg) (12 patients), gold sodium thiosulfate (Au) (13 patients) or both. A clinical connection between oral symptoms and contact allergy was seen in 10 patients, 9 patients (7 LPO, 2 leukoplakia) had Hg allergy in these cases, the oral lesions disappeared after the amalgam fillings had been removed. 1 patient had recurrent stomatitis and perioral eczema after dental care and 2,2-bis(4-(2-hydroxy 3-methacryloxypropoxy)phenyl)propane (BIS-GMA) allergy. Her symptoms were caused by drilling of acrylic fillings. In addition, a connection between localized stomatitis and contact allergy was considered probable in 2 cases. 1 patient had stomatitis from contact with an orthodontic device and nickel allergy. The other had stomatitis from contact with a dental gold crown and gold allergy. No clinical connection was found between gold allergy and the oral symptoms of other patients.     

大剂量重组人α-2b干扰素治疗晚期黑色素瘤的疗效及对血清LDH、TIL和PD-L1表达的影响

目的 探讨大剂量重组人α-2b干扰素联合常规化疗在晚期黑色素瘤患者中的应用安全性和有效性,以及对血清乳酸脱氢酶(LDH)、肿瘤浸润淋巴细胞(TIL)和抗程序性死亡因子配体1(PD-L1)表达的影响.方法 回顾性总结2016年8月—2018年8月入我院确诊为晚期黑色素瘤患者共86例(Ⅲ期51例和Ⅳ期35例),均接受大剂量...