Antigen-specific tolerance induced by IL-10 gene modified immature dendritic cells in experimental autoimmune myocarditis in rats

Idiopathic dilated cardiomyopathy (IDC) is the most common cause of heart failure mainly in the young and middle-aged patients, and as a result, is responsible for severe disability in otherwise healthy and productive individuals. Evidence suggests that autoimmune responses to cardiac antigens exposed after heart damage may play an important role in prolonged damage of myocardium in the pathogenesis of IDC.1 Nevertheless, little progress has been made in treating myocarditis or IDC by immun…