共查询到20条相似文献,搜索用时 15 毫秒
1.
Georgios Tsoulfas Tatsuo Kawai Nahel Elias S. C. Ko Polyxeni Agorastou A. Benedict Cosimi Martin Hertl 《Journal of gastroenterology》2011,46(2):249-256
Background
The effect of the model for end-stage liver disease (MELD) system on the post-transplant survival of patients with hepatocellular carcinoma (HCC) has not been fully elucidated. Our objective is to review the results of liver transplantation (LT) for HCC at the Massachusetts General Hospital over a period of 12 years, with special emphasis on the effect of the MELD system. 相似文献2.
See Ching Chan Sheung Tat Fan Kenneth S. H. Chok Tan To Cheung Albert C. Y. Chan James Y. Y. Fung Ronnie T. P. Poon Chung Mau Lo 《Hepatology International》2012,6(3):646-656
Purpose
Microvascular invasion of hepatocellular carcinoma (HCC) is considered a poor prognostic factor of liver resection (LR) and liver transplantation (LT), but its significance for lesions within the up-to-7 criteria is unclear. This study investigated the survival benefit of primary LT against LR for HCC with microvascular invasion and within the up-to-7 criteria. 相似文献3.
Myron J. Tong Hai-En Sun Carlos Hsien David S. K. Lu 《Digestive diseases and sciences》2010,55(3):826-835
Background
Hepatocellular carcinoma (HCC) is a common malignancy in Asians with hepatitis B virus infection. HCC patients often present with poor liver function and large tumors resulting in rapid mortality. The impact of HCC surveillance and subsequent therapy on patient survival remain controversial. 相似文献4.
Background
Laparoscopic liver resection (LLR) remains to be established as a safe and effective alternative to open liver resection (OLR) for hepatocellular carcinoma (HCC). 相似文献5.
Cheng JW Shi YH Fan J Huang XW Qiu SJ Xiao YS Wang Z Dai Z Tang ZY Zhou J 《Journal of cancer research and clinical oncology》2011,137(10):1445-1453
Purpose
An immune function assay has been proposed as a new strategy to monitor immunosuppression after organ transplantation. However, there are limited data regarding its role in liver transplant recipients with hepatocellular carcinoma (HCC). In this study, we sought to determine the utility of this functional assay in assessing the risk of infection, rejection, and tumor recurrence in liver transplant recipients. 相似文献6.
Background
The risk of hepatocellular carcinoma (HCC) among patients with autoimmune hepatitis (AIH) is believed to be low compared with other chronic liver diseases, and uncertainty exists over the need to perform HCC surveillance. If surveillance is initiated, the optimal timing is also not yet defined. 相似文献7.
Kuo YH Lu SN Hung CH Kee KM Chen CH Hu TH Lee CM Changchien CS Wang JH 《Hepatology International》2010,4(4):700-706
Backgroud/aims
The risk of hepatocellular carcinoma (HCC) increased with progression of hepatic fibrosis as assessed by liver stiffness measurement (LSM). This study used LSM to assess the risk of HCC presence in patients with chronic hepatitis. 相似文献8.
Sharma P Welch K Hussain H Pelletier SJ Fontana RJ Marrero J Merion RM 《Digestive diseases and sciences》2012,57(3):806-812
Background and Aims
Deceased donor liver transplantation (DDLT) rates for candidates with hepatocellular carcinoma (HCC) have significantly increased in the MELD era because of the extra priority given to these candidates. We examined the incidence and pre-DDLT radiological and donor factors associated with post-DDLT HCC recurrence in the MELD era. 相似文献9.
Natsuko Kawada Kazuho Imanaka Tsukasa Kawaguchi Chie Tamai Ryu Ishihara Takashi Matsunaga Kunihito Gotoh Terumasa Yamada Yasuhiko Tomita 《Journal of gastroenterology》2009,44(12):1190-1194
Purpose
Characteristics of hepatocellular carcinoma (HCC) complicating nonalcoholic steatohepatitis (NASH) are still controversial. Most NASH related HCCs are believed to develop from cirrhotic liver, but case reports about HCC arising from non-cirrhotic NASH have been accumulating recently. This study is designed to elucidate characteristics of NASH related HCC diagnosed with high accuracy by using surgically resected specimens that contain larger areas to validate than biopsy specimens. 相似文献10.
Janice H. Jou Po-Hung Chen Alison Jazwinski Iliana Bouneva Alastair D. Smith Andrew J. Muir 《Digestive diseases and sciences》2010,55(12):3591-3596
Objectives
The treatment of choice for HCC with cirrhosis is liver transplantation (LT). We assessed if patients evaluated for hepatocellular carcinoma are being diagnosed by surveillance, the proportion of patients meeting Milan criteria at diagnosis, and rates of liver transplantation. 相似文献11.
Xian-huan Yu Lei-bo Xu Chao Liu Rui Zhang Jie Wang 《Digestive diseases and sciences》2011,56(1):252-259
Background
Hepatocellular carcinoma (HCC) with bile duct tumor thrombi (BDTT) is a rare type of primary liver cancer, and its clinical and pathological characteristics remain to be defined. 相似文献12.
Chuanxing Li Fujun Zhang Weidong Zhang Liang Zhang Zilin Huang Peihong Wu 《Journal of cancer research and clinical oncology》2010,136(11):1633-1640
Purpose
To evaluate 125I seed brachytherapy combined with sorafenib in the treatment of patients with multiple lung metastases after orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC). 相似文献13.
Singal AG Chan V Getachew Y Guerrero R Reisch JS Cuthbert JA 《Digestive diseases and sciences》2012,57(2):580-586
Background
Liver transplantation for patients with hepatocellular carcinoma (HCC) affords excellent long-term survival but is limited to patients with early stage tumors. Predictors for orthotopic liver transplantation eligibility are not well defined for patients in a safety-net hospital system. 相似文献14.
Jing-Houng Wang Hung-Da Tung Tai-Yi Chen Chao-Hung Hung Chien-Hung Chen Chi-Sin Changchien Tsung-Hui Hu Chuan-Mo Lee Sheng-Nan Lu 《Hepatology International》2011,5(1):567-574
Purpose
Synergy between radiofrequency ablation (RFA) and chemotherapy was demonstrated for liver malignancy. We assess the efficacy of intravenous pegylated liposomal doxorubicin (PLD) for RFA in patients with small hepatocellular carcinoma (HCC). 相似文献15.
Diabetes mellitus not an unfavorable factor on the prognosis of hepatitis C virus‐related hepatocellular carcinoma
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Naoki Yoshida Yutaka Midorikawa Tokio Higaki Hisashi Nakayama Shingo Tsuji Shunichi Matsuoka Hisamitsu Ishihara Mitsuhiko Moriyama Tadatoshi Takayama 《Hepatology research》2018,48(1):28-35
Aim
Diabetes mellitus (DM) is a potential risk factor for hepatocarcinogenesis, especially in patients with hepatitis C virus (HCV) infection. We aimed to elucidate whether DM influences the surgical outcomes of patients with hepatocellular carcinoma (HCC).Methods
Our patients were routinely controlled to keep urinary glucose excretion to less than 3.0 g/day before surgery, and the serum glucose level under 200 mg/dL after surgery. The surgical outcomes and postoperative complications of 112 patients with HCV‐related HCC with DM (DM group) were compared to those of 112 propensity‐matched patients without DM (non‐DM group).Results
After a median follow‐up of 3.2 years (range, 0.2–11.3 years), the median overall (5.2 years; 95% confidence interval, 3.8–6.5 years) and recurrence‐free survival (2.2 years; 1.7–2.9 years) in the DM group were not significantly different from those (6.3 years; 5.4–7.1 years, P = 0.337; and 2.2 years; 1.7–3.6 years, P = 0.613) in the non‐DM group. The independent factors related to overall survival were the background liver (hazard ratio, 2.06; 95% confidence interval, 1.27–3.39, P = 0.014) and tumor differentiation grade (2.07; 1.14–4.05, P = 0.015). Thirty‐two patients (28.5%) in the DM group and 32 patients (28.5%) in the non‐DM group had morbidities after operation, with no significant difference between the groups (P = 1.000). Furthermore, postoperative control status of DM did not affect the prognostic outcome.Conclusion
Diabetes mellitus does not affect the surgical outcomes of patients with HCV‐related HCC, and it is not an unfavorable factor when selecting candidates for liver resection of HCC. 相似文献16.
Chia-Yang Hsu Yun-Hsuan Lee Yi-Hsiang Huang Cheng-Yuan Hsia Chien-Wei Su Han-Chieh Lin Rheun-Chuan Lee Yi-You Chiou Fa-Yauh Lee Teh-Ia Huo Shou-Dong Lee 《Hepatology International》2013,7(1):188-198
Purpose
Ascites may develop in patients with hepatocellular carcinoma (HCC) with coexisting liver cirrhosis. Few studies had specifically evaluated the role of ascites in HCC. This study investigated its prevalence, associated factors, prognostic impact, and staging strategy in a large HCC patient cohort.Patients and methods
A total of 2,203 HCC patients were analyzed. The grading of ascites was according to the European Association for the Study of Liver. The prognostic ability of the Cancer of the liver Italian Program (CLIP), Barcelona Clinic Liver Cancer, Japan Integrated Scoring system, and Taipei Integrated Scoring system in HCC patients with ascites was compared using the Akaike information criterion (AIC).Results
Ascites was present in 498 (23%) patients at diagnosis. Grades 1, 2, and 3 ascites were found in 13, 5, and 5% of the patients, respectively. The severity of ascites significantly correlated with hyperbilirubinemia, hypoalbuminemia, hyponatremia, prothrombin time (PT) prolongation, and renal insufficiency (all p < 0.001). Large tumor burden and more frequent vascular invasion were often observed in patients with more severe ascites (both p < 0.001). In the Cox proportional hazard model, ascites was identified as an independent prognostic predictor with 80–94% increased risk of mortality (p < 0.001). Among HCC patients with ascites, the CLIP system had the lowest AIC value.Conclusions
Ascites is often seen in HCC patients and is associated with both tumoral and cirrhosis factors and decreased long-term survival. The CLIP staging system is a more feasible prognostic model for HCC patients with ascites. The optimal treatment strategy for these patients remains to be investigated. 相似文献17.
Han ZB Chen HY Fan JW Wu JY Tang HM Peng ZH 《Journal of cancer research and clinical oncology》2012,138(1):153-161
Purpose
MicroRNAs play important roles in cancer development, progression, and metastasis. The aim of this study was to determine whether altered microRNA-155 expression is associated with hepatocellular carcinoma (HCC) recurrence and prognosis following orthotopic liver transplantation (OLT). 相似文献18.
Victoria Hamill Will Gelson Douglas MacDonald Paul Richardson Stephen D. Ryder Mark Aldersley Stuart McPherson Sumita Verma Rohini Sharma Sharon Hutchinson Jennifer Benselin Eleanor Barnes Indra Neil Guha William L. Irving Hamish Innes 《Liver international》2023,43(4):917-927
Background
Previous studies show the uptake of biannual ultrasound (US) surveillance in patients with cirrhosis is suboptimal. Here, our goal was to understand in broader terms how surveillance is being delivered to cirrhosis patients with cured hepatitis C in the UK.Methods
Hepatitis C cirrhosis patients achieving a sustained viral response (SVR) to antiviral therapies were identified from the national Hepatitis-C-Research-UK resource. Data on (i) liver/abdominal US examinations, (ii) HCC diagnoses, and (iii) HCC curative treatment were obtained through record-linkage to national health registries. The rate of US uptake was calculated by dividing the number of US episodes by follow-up time.Results
A total of 1908 cirrhosis patients from 31 liver centres were followed for 3.8 (IQR: 3.4–4.9) years. Overall, 10 396 liver/abdominal USs were identified. The proportion with biannual US was 19% in the first 3 years after SVR and 9% for all follow-up years. Higher uptake of biannual US was associated with attending a liver transplant centre; older age and cirrhosis decompensation. Funnel plot analysis indicated significant inter-centre variability in biannual US uptake, with 6/29 centres outside control limits. Incident HCC occurred in 133 patients, of which 49/133 (37%) were treated with curative intent. The number of US episodes in the two years prior to HCC diagnosis was significantly associated with higher odds of curative-intent treatment (aOR: 1.53; 95% CI: 1.12–2,09; p = .007).Conclusions
This study provides novel data on the cascade of care for HCC in the UK. Our findings suggest biannual US is poorly targeted, inefficient and is not being delivered equitably to all patients. 相似文献19.
Ye Lu Jie Liu Chengzhao Lin Haijian Wang Ying Jiang Jiyao Wang Pengyuan Yang Fuchu He 《BMC gastroenterology》2010,10(1):115
Background
Liver fibrosis is a middle stage in the course of chronic Hepatitis B virus (HBV) infection, which will develop into cirrhosis and eventually hepatocellular carcinoma (HCC) if not treated at the early stage. Considering the limitations and patients' reluctance to undergo liver biopsy, a reliable, noninvasive diagnostic system to predict and assess treatment and prognosis of liver fibrosis is needed. The aim of this study was to identify biomarkers for early diagnosis of HBV related liver fibrosis. 相似文献20.
Tokushige K Hashimoto E Horie Y Taniai M Higuchi S 《Journal of gastroenterology》2011,46(10):1230-1237