氟中毒动物模型尺神经应力松弛特性研究

目的研究氟中毒对肘关节尺神经应力松弛的影响,为临床提供生物力学参数。方法复制氟中毒动物模型,取动物模型肘关节尺神经进行应力松弛实验。结果得出了对照组和实验组动物肘关节尺神经应力松弛数据和曲线。结论实验组肘关节尺神经7200S应力松弛量显著低于对照组,氟中毒对动物尺神经应力松弛特性有一定影响。     

氟中毒对肘关节尺神经力学性质影响研究

目的研究氟中毒对肘关节尺神经力学性质的影响,为临床提供生物力学参数。方法复制氟中毒动物模型,取动物模型肘关节尺神经进行拉伸实验。结果得出了对照组和实验组动物肘关节尺神经拉伸最大载荷,最大应力,最大应变,弹性模量等数据。结论实验组肘关节尺神经各项拉伸力学性能指标显著低于对照组。     

氟中毒对膝关节前交叉韧带蠕变影响实验研究

目的研究氟中毒对膝关节前交叉韧带蠕变的影响,为临床提供生物力学参数。方法复制氟中毒动物模型,取动物模型膝关节前交叉韧带进行蠕变实验。结果得出了对照组和实验组动物膝关节前交叉韧带蠕变数据和曲线。结论实验组膝关节前交叉韧带7200 s蠕变量显著低于对照组。     

氟骨症肘关节尺神经损害及畸形矫治的研究

目的 研究氟中毒对尺神经的损害及肘关节畸形矫治。方法 (1)流行病学调查；(2)手术矫治；(3）建立动物模型。结果 氟骨症患尺神经损害与非病区比较差异有显性(P＜0．01)。病人活体尺神经外膜明显增粗增厚、水肿。大鼠尺神经超微结构有明显病理改变。结论 高氟可直接损害尺神经组织，肘关节畸形矫治能改善运动功能。     

氟中毒动物模型骨蠕变实验研究

目的研究正常与氟中毒动物模型骨的蠕变力学特性,确定氟中毒对动物模型骨蠕变力学特性是否具有影响。方法复制氟中毒动物模型,取氟中毒动物模型股骨和正常对照组动物骨进行对比试验。结果得出了正常对照组和模型组动物股骨蠕变实验数据和曲线、应变与时间的变化规律。正常对照组股骨7 200 s蠕变量为0.3%,模型组7 200 s蠕变量为0.2%。结论氟中毒对模型组股骨蠕变力学特性具有一定影响。     

正常与氟中毒动物模型骨生物力学性质实验研究

目的 研究正常与氟中毒动物模型骨的拉伸、压缩、弯曲、冲击、扭转、剪切力学性质,为临床提供生物力学参数.方法 复制氟中毒动物模型,取动物模型和正常对照组动物股骨、胫骨、肱骨,进行生物力学性质实验.结果 得出了对照组和实验组动物骨的拉伸、压缩、弯曲、剪切、最大载荷、最大应力、最大应变等,得出对照组和实验组动物骨的扭转最大扭矩、扭转角、扭转切应力,还得出了对照组和实验组动物骨冲击功、冲击韧性指标.结论 氟中毒骨各项力学性能指标显著下降,氟中毒对骨的力学性能具有一定的影响.     

氟中毒对膝关节前交叉韧带应力松弛影响实验研究

目的研究氟中毒对膝关节前交叉韧带应力松弛的影响，为临床提供生物力学参数。方法复制氟中毒动物模型，取动物模型膝关节前交叉韧带进行应力松弛实验。结果得出了对照组和实验组动物膝关节前交叉韧带应力松弛数据和曲线。结论实验组膝关节前交叉韧带7200S应力松弛量显著低于对照组。     

实验性氟中毒大鼠尺神经病理观察

机体摄入过量氟除造成骨骼和牙齿损害外,还可引起广泛的全身性病变。许多学者报道氟中毒对神经系统损害的动物实验结果,但尺神经损害报道甚少。本文对饮100mg/L高氟水180d大鼠的尺神经进行病理观察,以探讨高氟对尺神经是否有直接损害。1 材料和方法 Wistar大鼠32只,体重50～60g,随机分2组,雌雄各半。实验组(16只)饮含100mg/L氟化钠的水;对照组饮用自来水(含氟0.40mg/L)。2组同食常备     

氟中毒肘关节病伴尺神经损伤的手术治疗效果观察

1996年6月至2006年8月,作者对氟中毒肘关节病伴尺神经损伤患者35例(40肘)进行了手术松解、关节清理联合尺神经探查和松解前移术,术后效果满意,报告如下。1对象与方法1.1病例资料:患者35例,男性19例,女性16例,年龄32～68岁,平均年龄为42.8岁。所有患者均生活在高水氟地区,饮高氟水时间平均23年,血、尿含氟     

氟关节病情肘管综合征

氟关节病情肘管综合征马新会，芦风霞尺神经于肘尺神经沟处受压产生一系列的临床症状，谓之肘管综合征。主要致病原因为骨折、外伤按摩，退行性变。我们收治１７例由于慢性氟中毒导致氟关节病继发尺神经受压，我们谓之氟关节病性肘管综合征。其致病原因与一般的肘管综合征...     

Influence of previous open synovectomy on the outcome of Souter-Strathclyde total elbow prosthesis

OBJECTIVES: Open synovectomy of the elbow joint is often performed in early stages of rheumatoid arthritis. Because of poor long-term results after synovectomy, insertion of a total elbow prosthesis is commonly used as a secondary procedure. The aim of this study is to evaluate the influence of previous synovectomy on the outcome after placement of a total elbow prosthesis. METHODS: We inserted 204 primary Souter-Strathclyde total elbow prostheses for rheumatoid arthritis. Two groups could be distinguished: group A with previous synovectomy 3.9 yr (mean) before the elbow replacement (n = 33) and group B without previous synovectomy (n = 171). The mean follow-up was 5.8 yr for group A and 6.3 yr for group B. All patients were assessed clinically and radiologically before the operation, 1 and 2 years later and then at regular intervals. The effect of previous synovectomy was analysed via a Cox model and a generalized linear mixed model for binomial data with multivariate normal random effects. RESULTS: No statistically significant effect of previous synovectomy on pain, function or complaints of the ulnar nerve could be found post-operatively. The post-operative flexion was significantly higher in group B than in group A. The complication-rates were similar for both groups. The overall survival rate for respectively group A and B with revision as endpoint was 66.9% (s.e. 13.4) versus 79.6 (s.e. 4.3) after 10 yr. CONCLUSIONS: Previous synovectomy does not diminish the outcome after total elbow prosthesis in this series and could therefore be considered in early, painful stages of rheumatoid destruction of the elbow joint.     

氟中毒大鼠不同系统损害的超微结构观察

目的观察氟中毒大鼠不同系统损害的超微结构改变。方法用高氟水(100.0mg/L)复制氟中毒大鼠模型,用透射电镜观察了高氟对大鼠不同系统损害程度。结果大鼠饮用高氟水以后,多个脏器和组织超微结构受损,牙齿、骨骼、尺神经、肾脏损害重,血管、肌肉轻微。结论高氟可导致大鼠多个系统损害,并严重影响其超微结构的改变。     

大骨节病病例罹患氟骨症的流行病学调查

目的证实大骨节病与饮茶型氟中毒重叠病区中存在大骨节病病例罹患氟骨症的特征性病例,为诊断、预防和控制同患此两种疾病提供科学依据。方法 （1）按大骨节病诊断标准进行临床和X线检查,筛选出大骨节病病例人群做为研究对象;（2）每个研究对象进行调查日饮茶量等信息并采集所饮砖茶水和尿液,用氟离子选择电极法测定茶水和尿氟含量,计算人群摄氟量、人群尿氟值,并就大骨节病病例罹患氟骨症人群（氟骨症人群组）与大骨节病病例未患氟骨症人群（大骨节病人群组）进行比较;（3）每个研究对象拍摄前臂（包括肘关节）X线片,按氟骨症X线诊断标准诊断氟骨症,并就氟骨症人群组与大骨节病人群组掌指、前臂的临床体征以及X线影像进行比较。结果 （1）40-78岁之间的自愿受试者共61人中确诊大骨节病病例45人,其中Ⅰ度病例检出34例、Ⅱ度病例检出5例、Ⅲ度病例检出6例;（2）45例大骨节病病例共确诊氟骨症19人,其中Ⅰ度病例检出4人、Ⅱ度病例检出2人、Ⅲ度病例检出13人;（3）氟骨症人群组摄氟量人均日为7.69 mg,是大骨节病人群组人均日摄氟量的2倍,也是人群总摄氟量卫生标准的2倍;氟骨症人群组尿氟含量几何均值为3.03 mg/L,是大骨节病人群组尿氟值的1.5倍,是人群尿氟正常值的2倍。（4）氟骨症人群组与大骨节病人群组掌指、前臂的临床体征以及X线影像进行比较,掌指临床体征及其X线影像基本无差异;氟骨症人群肘关节（被动）后伸10-70度的为84.21%（16/19）,大骨节病人群组肘关节（被动）后伸10-30度的为30.77%（7/26）,卡方检验,χ^2=4.89〉χ^20.05（1）=3.84,P〈0.05两者之间有显著统计学差异,并且,大骨节病人群组肘关节后伸曲度均在30度以内,而氟骨症人群组大于30度的达到56.25%（9/16）;X线影像上大骨节病人群组除无桡尺骨间膜骨化外,表现为肘关节退变和骨质增生,而氟骨症人群组表现为肘关节退变、骨质增生并伴有膨大、变形以及肌腱韧带附着点和关节囊骨化。结论 （1）证实了大骨节病与饮茶型氟中毒重叠病区中存在大骨节病病例罹患氟骨症的特征性病例;（2）大骨节病发病在前,氟骨症发病在后;（3）掌指临床体征和X线影像基本无差异;（4）氟骨症人群组的肘关节损害体征重于大骨节病人群组,X线影像具有双重性。     

Cubital tunnel syndrome in patients with haemophilia

Summary. Elbow is the second most common joint involved in patients with haemophilia; however, there is little data about the involvement of ulnar nerve at elbow in patients with haemophilic arthropathy. The purpose of this study was to address this problem in the elbow and evaluate the results of anterior subcutaneous transposition of the ulnar nerve in a small group of patients with haemophilia who had been managed in two institutions. Information on six patients who were diagnosed with tardy ulnar nerve palsy in two institutions was retrospectively collected. All patients suffered form severe haemophilia A. Anterior subcutaneous transposition of the ulnar nerve had been performed in all except one. The mean age of the patients at the time of procedure was 45.8 years and the mean duration of follow‐up was 60.2 months. No postoperative complication or recurrence was observed. No additional surgery was required in operated patients. Evaluation was performed using subjective and objective measures, and a modified Bishop score. After operation, subjective sensory and motor disturbances were improved or resolved in all of the operated patients, while objective measures improved less well. Ulnar nerve can be involved in cubital tunnel in patients with haemophilia. Anterior subcutaneous transposition of the ulnar nerve is an effective procedure for improving patients’ symptoms, with low risk of complications.