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本研究对63例心,脑血管疾病患者进行了服药后3h及(或)1周的临床观察,发现穿心莲(APN)对1及5min血小板聚集率均有明显抑制作用(P<0.001),且随用药时间延长(1周后)疗效更显著。通过20名志愿者服药前后血浆及血小板5-叛色(5-HT)测定证明APN能显著抑制血小板释放5-HT(P<0.01)。透射电镜观察到无论体外加药还是服药后APN均能明显抑制ADP诱聚所致的血小板管导系统扩张及颗 相似文献
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补阳还五汤注射液对PAF诱导的家兔血小板聚集功能的影响 总被引:9,自引:2,他引:7
观察补阳还五汤注射液体外给药对血小板活化因子诱导的家兔血小板聚集功能的影响。方法应用体外血小板聚集功能测定法;结果补阳还五汤注射液体外给药可明显抑制家兔洗涤血小板和未洗涤血小板的聚集功能,对洗涤血小板聚集功能的抑制作用强于未洗涤血小板,且有一定的量效关系。 相似文献
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白灵片显著抑制ADP诱发的家兔体外、体内血小板聚集,对抗家兔体外血栓形成,显著降低家兔全血粘度。 相似文献
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川芎口服液对兔血小板聚集的作用 总被引:19,自引:0,他引:19
用比浊法测得川芎口服液对胶原、花生四烯酸(AA)、ADP诱导的兔体外血小板聚集抑制作用IC50值分别为14.4g/L、21.1g/L、19.8g/L。 相似文献
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鬼针草肠溶胶囊对体外血小板聚集的影响 总被引:1,自引:0,他引:1
目的实验观察鬼针草肠溶胶囊对体外血小析聚集的影响。方法以比浊法观察鬼针草肠溶胶囊对家兔体外血小板聚集的影响。结果鬼针草肠溶胶囊0.13 g生药/m l可明显抑制ADP诱导的家兔体外血小板聚集,未观察到鬼针草肠溶胶囊0.063,0.025,0.005 g生药/m l对ADP诱导的家兔体外血小板聚集有明显的抑制作用。结论鬼针草肠溶胶囊只有在高浓度下有明显的抗血小板聚集的作用。 相似文献
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银杏叶提取物对兔血小板聚集的影响 总被引:32,自引:0,他引:32
目的 探讨银杏叶提取物 (GBE)对兔血小板聚集作用的影响。方法 进行体内、体外实验观察银杏叶提取物 (GBE)对由花生四烯酸 (AA)、二磷酸腺苷 (ADP)及血小板活化因子 (PAF)诱导的兔血小板聚集作用的影响 ,并对其作用的特点进行了初步分析。结果 GBE体外选择性地抑制PAF诱导兔血小板聚集 (比浊法 )及 5 HT的释放 (荧光法 ) ,其抗血小板聚集和 5 HT释放的IC50 分别为 (4 7.5± 9.5 )mg·L-1和 (176 .3± 2 5 .5 )mg·L-1;银杏苦内酯B(BN5 2 0 2 1)体外抗聚集的IC50 为 (5 .5 6×10 -3 ± 1.0 1× 10 -3 )mg·L-1。体内试验GBE也选择性地抑制PAF诱导的兔血小板聚集 :静注GBE 5 0 ,10 0mg·kg-1的作用时间分别可持续 6 0 ,2 40min以上 ;灌胃 10 0 ,2 0 0mg·kg-1的作用持续时间分别可达 180 ,2 40min以上 ;静注和灌胃作用高峰时最大抑制率分别为 (96 .5± 6 .1) %,(83.3± 17.2 ) %。结论 GBE对由PAF ,ADP诱导的体内、体外兔血小板聚集有抑制作用 ,但对由AA诱导的聚集无影响。可见GBE是一种有效的、选择性较高的抗血小板聚集药物。 相似文献
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通过异种移植物抗宿主反应(XGVHR)的动物模型筛选出黄芪促免疫的有效成份 F3。该成份在体外 XGVHR 试验中显示对癌症患者淋巴细胞功能有完全性免疫恢复作用(反应结节从57.80±16.44mm~3到148.95±40.84mm~3),在体内动物模型试验中可显示出全部逆转因环磷酰胺而造成的免疫抑制现象,提示黄芪成份在免疫治疗中可能是一个很有希望的生物反应调节剂。 相似文献
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本研究将麻疹活疫苗注入家兔主胰管及耳缘静脉,14及48小时血清淀粉酶明显升高,血小板聚集率显著增强,与两个对照组相比均有显著差异(P<0.05~0.01)。胰腺可见明显瘀血及点片状出血。大黄治疗组24及48小时血清淀粉酶及血小板聚集升高均受到阻抑,胰腺瘀血、出血亦减轻。结果提示病毒对胰腺的侵袭是发生出血型胰腺炎的因素之一;大黄是治疗出血型胰腺炎的有效药物。 相似文献
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钩吻素子对兔血小板聚集的影响 总被引:4,自引:2,他引:4
钩吻素子在体外实验中,对由花生四烯酸(AA)、凝血酶(Thr)、Ca2+诱导的兔血小板聚集抑制作用的IC50分别为0.45g/L、0.22g/L、0.0015g/L,并在一定浓度范围内呈剂量依赖关系。钩吻素子在静注后不同时间内,其抑制血小板聚集作用呈现良好曲线变化,以AA、Thr为诱导剂,其最大抑制作用的时间分别为静注后56min、78min处 相似文献
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The antiplatelet and antithrombotic activities of a methanol extract of a medicinal lichen, Usnea longissima, were investigated on platelet aggregation in vitro and on pulmonary thrombosis in vivo. The extract showed concentration dependent inhibitory effects on ADP-induced platelet aggregation, with an IC50 value of 3.6 mg/mL. Using an in vivo mouse thrombotic model in which mice were challenged with an intravenous injection of collagen and epinephrine mixture, oral administration of the extract prior to the injection produced a significant inhibition of thrombotic death or paralysis at 100-200 mg/kg body weight. Aspirin, a representative antiplatelet drug, produced a significant inhibition of thrombotic death at 10-20 mg/kg body weight. The mouse tail bleeding time was significantly prolonged by the addition of the extract. On the other hand, the extract did not show any fibrinolytic activity or alter the coagulation parameters such as activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) in rat platelets in vitro. These results suggested that the antithrombotic activity of U. longissima extract might be due to antiplatelet activity rather than anticoagulant activity. 相似文献
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本文用放免法测定了一次静脉给药参芪液60ml 前后对冠心病心气虚或心阴虚患者血小板环核苷酸含量的变化。结果表明用药后一小时,血小板内 cAMP 含量由20.89±3.7增至30.0±3.0pm/10~9血小板(P<0.02),cGMP 含量由3.33±1.0增至5.4±1.2pm/10~9血小板(P<0.05)。心阴虚者用药后环核苷酸含量有下降趋势。用参芪后血小板环核苷酸含量增加可能为参芪抑制血小板聚集的机理之一。环核苷酸含量增加与参芪抑制磷酸二酯酶活性有关。 相似文献
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孕康口服液对针刺和缩宫素所致的大鼠和小鼠实验性流产模型有明显的保胎作用,其疗效与黄体酮无差异;对大鼠,小鼠的离体子宫和家兔在体子宫平滑肌均有明显的松驰作用,并能损坏抗缩宫素和乙酰胆碱收缩动物离体和在体子宫平滑肌的作用,毒性试验结果:小鼠和大鼠灌胃的最大耐受量分别大于240g/kg和96g/kg,小鼠腹腔注射的LD50=61.56±5.29g/kg(P=0.95);大鼠长期毒性试验未见明显毒性;致突 相似文献
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The antiinflammatory and platelet aggregation inhibiting activities of the methanol extract of Pleurotus florida Eger, an edible and commercially grown mushroom, were investigated. The extract showed significant activity in ameliorating acute inflammation induced by carrageenan and chronic inflammation by formalin at 500 and 1000 mg/kg body weight. The effect was comparable to the standard reference drug, diclofenac. The extract also showed significant platelet aggregation inhibiting activity of washed human platelets. Adenosine 5'-diphosphate (ADP) induced platelet aggregation was inhibited by 88% to 95% at a concentration of 500 microg/mL of the extract after a preincubation time of 5, 10 and 20 min. The marked antiinflammatory and platelet aggregation inhibiting properties of this mushroom suggest its potential therapeutic use against vascular disorders. 相似文献
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El Haouari M Bnouham M Bendahou M Aziz M Ziyyat A Legssyer A Mekhfi H 《Phytotherapy research : PTR》2006,20(7):568-572
Platelet hyperactivity plays an important role in arterial thrombosis and atherosclerosis. The present study was undertaken to investigate the effects of different extracts of Urtica dioica leaves on platelet aggregation. Rat platelets were prepared and incubated in vitro with different concentrations of the tested extracts and aggregation was induced by different agonists including thrombin (0.5 U/mL), ADP (10 microm), epinephrine (100 microm) and collagen (5 mg/mL). The crude aqueous extract inhibited thrombin-induced platelet aggregation in a dose-dependent manner. At 1 mg/mL, the percent inhibition was 17.1 +/- 4.2%. Soxhlet extraction of the plant leaves with different successive solvents showed that the ethyl acetate extract exhibited the most antiaggregant effect with an inhibition of 76.8 +/- 6.1% at 1 mg/mL. Flavonoids isolated from the plant leaves, produced a strong inhibitory effect on thrombin-induced platelet aggregation with an IC(50) of 0.25 +/- 0.05 and 0.40 +/- 0.04 mg/mL for genins and heterosidic flavonoids, respectively. Flavonoids also markedly inhibited platelet aggregation induced by ADP, collagen and epinephrine. It is concluded that Urtica dioica has an antiplatelet action in which flavonoids are mainly implicated. These results support the traditional use of Urtica dioica in the treatment and/or prevention of cardiovascular disease. 相似文献