抗抑郁药的合并使用(英文)

难治性抑郁症是精神科医生面临的一个普遍问题。这些患者往往难以有效治疗。治疗难治性抑郁症患者的策略包括换药、增加另一种抗抑郁药(抗抑郁药联合治疗)以及抗抑郁药以外的增效治疗。     

The use of complementary and alternative therapies to treat anxiety and depression in the United States

OBJECTIVE: This study presents data on the use of complementary and alternative therapies to treat anxiety and depression in the United States. METHOD: The data came from a nationally representative survey of 2,055 respondents (1997-1998) that obtained information on the use of 24 complementary and alternative therapies for the treatment of specific chronic conditions. RESULTS: A total of 9.4% of the respondents reported suffering from "anxiety attacks" in the past 12 months; 7.2% reported "severe depression." A total of 56.7% of those with anxiety attacks and 53.6% of those with severe depression reported using complementary and alternative therapies to treat these conditions during the past 12 months. Only 20.0% of those with anxiety attacks and 19.3% of those with severe depression visited a complementary or alternative therapist. A total of 65.9% of the respondents seen by a conventional provider for anxiety attacks and 66.7% of those seen by a conventional provider for severe depression also used complementary and alternative therapies to treat these conditions. The perceived helpfulness of these therapies in treating anxiety and depression was similar to that of conventional therapies. CONCLUSIONS: Complementary and alternative therapies are used more than conventional therapies by people with self-defined anxiety attacks and severe depression. Most patients visiting conventional mental health providers for these problems also use complementary and alternative therapies. Use of these therapies will likely increase as insurance coverage expands. Asking patients about their use could prevent adverse effects and maximize the usefulness of therapies subsequently proven to be effective.     

A survey of psychiatrists' practices related to the use of tricyclic antidepressants

Four groups of psychiatrists were surveyed about their clinical practices in relation to the use of tricyclic antidepressants to determine if there is any unanimity about procedures. The four groups were U.S. experts in the pharmacotherapy of depression, faculty who taught the pharmacotherapy of depression in accredited departments of psychiatry, general psychiatrists in Virginia who treated depressions with drugs, and non-U.S. experts. The authors report on practices related to dosage buildup, side effects, concurrent medical conditions, blood level information, and maintenance on tricyclics. They found moderate to high consensus on most issues; exceptions were treatment of a patient with chronic hypertension and maintenance dosage and duration.     

Discrepancy between opinion and attitude on the practice of ECT by psychiatrists specializing in old age in the Netherlands

BACKGROUND: Current guidelines consider electroconvulsive therapy (ECT) in the Netherlands a treatment of choice for a depressive disorder with psychotic features, severe suicidal behavior, severe physical exhaustion, or resistance to treatment with antidepressants (consecutively SSRIs, TCAs, lithium, MAO inhibitors). It is advised to use ECT early on in the treatment of depressed elderly patients. In practice, ECT is applied to only a minority of depressed elderly patients in the Netherlands. This situation dates back to the 1970s, in which strong aversive opinions toward ECT grew in the Netherlands, largely as a reaction to the malpractice of ECT in that time and influenced by social-cultural opinions toward psychiatry. Negative attitudes among professionals and lack of knowledge may contribute to the under use in depressed elderly patients. METHODS: A postal questionnaire was sent to 152 psychiatrists who specialize in old age to assess their opinions and attitudes toward ECT. RESULTS: Only a small minority thought ECT was a treatment of choice in a depressive disorder with psychotic features (4%), severe suicidal risk (2%), or physical exhaustion (5%). The majority of the psychiatrists had strongly reserved opinions in considering ECT as a treatment of first, second or third choice in depressed elderly patients, even in treatment-resistant depressive disorders. CONCLUSIONS: Many psychiatrists who specialize in old age in the Netherlands divert from the current guidelines and are reluctant toward using ECT as a treatment of choice in a number of specific, clinical situations. This might be a major contributing factor to the present and past underuse of ECT in depressed elderly patients in the Netherlands.     

Psychiatrists' attitudes towards autonomy, best interests and compulsory treatment in anorexia nervosa: a questionnaire survey

Background

The compulsory treatment of anorexia nervosa is a contentious issue. Research suggests that psychiatrists have a range of attitudes towards patients suffering from anorexia nervosa, and towards the use of compulsory treatment for the disorder.

Methods

A postal self-completed attitudinal questionnaire was sent to senior psychiatrists in the United Kingdom who were mostly general adult psychiatrists, child and adolescent psychiatrists, or psychiatrists with an interest in eating disorders.

Results

Respondents generally supported a role for compulsory measures under mental health legislation in the treatment of patients with anorexia nervosa. Compared to 'mild' anorexia nervosa, respondents generally were less likely to feel that patients with 'severe' anorexia nervosa were intentionally engaging in weight loss behaviours, were able to control their behaviours, wanted to get better, or were able to reason properly. However, eating disorder specialists were less likely than other psychiatrists to think that patients with 'mild' anorexia nervosa were choosing to engage in their behaviours or able to control their behaviours. Child and adolescent psychiatrists were more likely to have a positive view of the use of parental consent and compulsory treatment for an adolescent with anorexia nervosa. Three factors emerged from factor analysis of the responses named: 'Support for the powers of the Mental Health Act to protect from harm'; 'Primacy of best interests'; and 'Autonomy viewed as being preserved in anorexia nervosa'. Different scores on these factor scales were given in terms of type of specialist and gender.

Conclusion

In general, senior psychiatrists tend to support the use of compulsory treatment to protect the health of patients at risk and also to protect the welfare of patients in their best interests. In particular, eating disorder specialists tend to support the compulsory treatment of patients with anorexia nervosa independently of views about their decision-making capacity, while child and adolescent psychiatrists tend to support the treatment of patients with anorexia nervosa in their best interests where decision-making is impaired.     

Treatment of depression in the elderly: a Canadian view

1. Between 10 and 15% of people over the age of 65 have a potentially treatable depression. 2. The commonest antidepressants used in Canada, the tertiary-amine tricyclics, are potentially problematic when used with geriatric patients. 3. It is current practice in geriatric psychiatry to use secondary-amine tricyclics as "first choice" drugs for elderly depressed patients. 4. Electroconvulsive therapy can be effectively used to deal with severely depressed elderly patients, particularly if there are also features of dementia. 5. Although "better drugs" are needed for the elderly, people over the age of 65 are typically excluded from treatment outcome research.     

The pharmacotherapy-psychotherapy triangle: psychiatrist, nonmedical psychotherapist, and patient

Members of the Washington State Psychiatric Association (N = 387) were sent a questionnaire asking about their experience with providing adjunctive medicinal treatment to patients in psychotherapy with someone else. Of the 202 respondents, 63% acknowledged such "therapeutic triangles." Younger psychiatrists, psychiatrists working in clinic and/or public settings, and non-psychoanalytic psychiatrists were more likely to participate in such arrangements. It is estimated that between 7200 and 21,000 U.S. psychiatrists participate in such arrangements, with 72,000-210,000 patients seen each month. More extensive study of all aspects of this phenomenon is urged.     

Psychiatrists' self-reported adherence to evidence-based prescribing practices in the treatment of schizophrenia

OBJECTIVE: This study sought to identify relationships between psychiatrists' characteristics and their self-reported adherence to evidence-based recommendations regarding antipsychotic use in the treatment of schizophrenia. METHODS: Surveys were sent to 1,757 psychiatrists affiliated with the Veterans Health Administration. Respondents (N=696) reported their own adherence to two recommended prescribing practices for using antipsychotics. RESULTS: Several psychiatrists' characteristics were associated with greater adherence, including midcareer status, male sex, a caseload with a larger proportion of patients with schizophrenia, and use of current information from scientific literature or from drug company detailing. CONCLUSIONS: This study identified several characteristics of psychiatrists that may affect their adherence to evidence-based prescribing practices for patients with schizophrenia.     

Psychiatric opinion and antipsychotic selection in the management of schizophrenia

OBJECTIVES: This study examined psychiatrists' opinions regarding the use of second-generation antipsychotics for treatment-resistant schizophrenia. It then sought to identify factors associated with these opinions. METHODS: A national survey was conducted (September 2003-January 2004) of psychiatrists engaged in the management of patients with schizophrenia. RESULTS: Among survey respondents (N=431), most psychiatrists (88%) believed that one or more of the five currently available second-generation antipsychotics could improve treatment-resistant positive symptoms after a failed trial of optimal oral haloperidol treatment. Psychiatrists who reported familiarity with schizophrenia practice guidelines were more likely to have high levels of optimism that these medications improve positive symptoms (odds ratio [OR]=3.6, 95% confidence interval [CI]=1.4-9.3, p=.009). Psychiatrists who met with a pharmaceutical representative at least once a week were also more likely to have high levels of optimism toward second-generation antipsychotics (OR=2.3, CI=1.4-3.9, p=.001). CONCLUSIONS: Reported familiarity with treatment guidelines and frequent contact with pharmaceutical representatives appear to be associated with optimism toward second-generation antipsychotics.     

A UK national survey of the management of depression by geriatricians and old age psychiatrists

A national postal questionnaire on the management of depression in the elderly was completed by 89 geriatricians and 72 old age psychiatrists. Significant differences were noted in intended choice of antidepressant drugs (using case vignettes), knowledge of antidepressant drugs and knowledge of psychological treatments. Geriatricians were more likely to suggest dose ranges which were subtherapeutic and were not confident in prescribing newer antidepressants. Very few doctors had overtly negative attitudes towards ageing and depression. However, a need for more training was clearly identified, particularly for geriatricians and for older doctors of both groups. Doctors who were confident about their own abilities tended to also have a more positive approach to therapy and regarded depression as less difficult to treat. Older doctors, geriatricians and those who felt they needed more training in how to treat depression were more likely to use low doses or discontinue treatment too soon after recovery. The results suggest a need for training which focuses on these areas.     

IPA survey of brief cognitive screening instruments

BACKGROUND AND OBJECTIVES: Cognitive screening is a "first step" in detecting dementia and other neuropsychiatric syndromes and hence represents an important public health and clinical initiative. A plethora of cognitive screening instruments has been advocated in recent years, but the extent to which these instruments are used or their effectiveness is not well known. An International Psychogeriatric Association (IPA) survey was designed to determine which cognitive screening instruments were used most frequently by clinicians with special expertise in the neuropsychiatric aspects of old age and also to determine the ones considered most useful by these specialists. METHOD: Under the auspices of the IPA, the survey was mailed in the fall of 2004 to all IPA members as well as members of the American and Canadian Associations of Geriatric Psychiatry. The survey inquired about demographic information, the frequency of use of cognitive screening instruments, and the value attributed to the cognitive screening instruments. Participants also had an opportunity to provide written commentary. RESULTS: A total of 334 completed surveys were processed. The majority of respondents were geriatric psychiatrists (58%). Of the 20 different instruments that were listed on the survey, only six were selected as "routinely" or "often used" by the survey respondents. These instruments in declining order were: (1) the Folstein Mini-mental State Examination; (2) the Clock Drawing Test; (3) Delayed Word Recall; (4) the Verbal Fluency Test; (5) Similarities; and (6) the Trail Making Test. "Effectiveness" and "ease of administration" were the test characteristics most highly predictive of frequency of use. Open-ended comments highlighted patient factors that continue to provide challenges, including ethnicity/culture, language, education/literacy, and sensory impairment. Respondents concluded that "no single test is adequate." CONCLUSIONS: Psychogeriatricians worldwide routinely use a relatively small number of brief cognitive screening instruments. Further evaluation is necessary as the need increases for cognitive screening guidelines that inform public health initiatives related to dementia and neuropsychiatric syndromes.     

Mental health service use in a nationally representative Canadian survey.

BACKGROUND: Previous Canadian surveys have noted a wide range of prevalence rates for mental health service use and found no consistent relation between type of contact with mental health professionals and severity of illness. This study is the first investigation to examine the prevalence and correlates of mental health service use in a nationally representative Canadian survey. METHODS: The Canadian Community Health Survey Cycle 1.1 was conducted between 2000 and 2001 (n = 125,493; respondent age 12 years and over; response rate; 84.7%). Respondents were asked whether they had contacted a professional because of emotional symptoms in the past year and about their experience of barriers to treatment. DSM-IV major depression and alcohol dependence diagnoses were assessed with the Composite International Diagnostic Interview Short Form. The relation between a range of measures of clinical severity and the type of professional contacted for emotional symptoms was examined. RESULTS: The prevalence of 12-month help seeking for emotional symptoms was 8.3% (99%CI, 8.10 to 8.55); an additional 0.6% (99%CI, 0.49 to 0.62) of the sample perceived a need for treatment without seeking care. Respondents endorsing contact with multiple professionals or with psychiatrists only had higher levels of severity than those who had contact with family doctors only or nonphysician professionals only. CONCLUSIONS: Although untreated depression remains a significant problem in Canada, more severe illness was more likely to be associated with seeing a psychiatrist (or multiple professionals), indicating a relation between greater severity of mental illness and receiving more specialized care.     

Old age psychiatrists' views on the use of ECT

Two hundred and five practising old age psychiatrists completed a questionnaire regarding their opinions and use of electroconvulsive therapy (ECT). Details of the psychiatrists and their jobs were recorded, their opinions were sought on ECT and they were asked their views regarding physical problems in association with treatment, as well as the treatment procedure they employed. The majority of respondents reported that they would consider using ECT for appropriate patients, but opinion diverged concerning who this might be. Agreement was greatest regarding when ECT would never be appropriate. Depressive psychosis was the condition where ECT was felt most often to be useful. Most respondents used bilateral ECT, and most commonly administered it twice weekly. There was broad agreement over when ECT might be the treatment of choice and whether certain psychotropic drugs should be discontinued during treatment. All respondents regarded physical examination as routinely necessary prior to treatment, but opinion diverged regarding other investigations. Similarly, views diverged regarding which physical conditions might constitute absolute or partial contraindications to ECT. ECT is regarded as useful by most old age psychiatrists, and age itself is not a contraindication to treatment.     

Adherence to guidelines by French psychiatrists in their real world of clinical practice

The treatment modalities of bipolar disorder and adherence to international guidelines recommendations in France were investigated. We conducted an observational survey among 210 French psychiatrists concerning their prescribing practice in bipolar disorder, and whether they use guidelines or not. Simple mania is mainly treated with valproate, whereas second-generation antipsychotics are preferred for delusional mania. Lithium is mostly used as second-line treatment by "young psychiatrists." Personal experience appears in the foreground (41% of psychiatrists) in the choice of therapy. Young psychiatrists refer more to guidelines (32% of responders) as compared with other psychiatrists. The main reason for the lack of use of guidelines is because they refer mostly to an Anglo-Saxon medical practice, which is considered different from the French practice. Guidelines for treatment of bipolar disorder are not frequently used. French psychiatrists' age and practice type are the most important variables correlated to the level of use of guidelines.     

Physician attitudes toward treatment of depression in older medical inpatients

Objectives: To better understand low treatment (<50%) and psychiatry referral rates (<10%) of depressed older medical patients, we examined medical physicians’ characteristics, attitudes and practices regarding treatment.

Methods: Physicians caring for a consecutive series of 1000 depressed older patients during medical hospitalization and/or after discharge were asked about their general attitudes and behaviors related to the treatment of depression in older patients. Results: Of 422 physicians responding to questionnaires, less than half (48%) usually started more than two patients a month on antidepressants. Even fewer (14%) referred more than two patients a month for counseling; 37% usually referred none. Only 11% referred more than two patients a month to psychiatrists; nearly 40% usually referred none. Antidepressants, counseling, and psychiatric referral were seldom thought very effective. Physicians out of their training and those in primary care specialties (especially family practice) were more likely to treat patients. Common reasons for not treating these patients were perceived resistance to treatment (62.3%), lack of time (61.1%), uncertainty of depression diagnosis (56.2%), belief that patients couldn’t afford treatment (50.5%), and concern about medication/disease interactions (58.8%). One-third (33.5%) emphasized that they were unsure about treatment effectiveness and one-third (34.4%) that they were poorly prepared to treat depression in older patients. Non-white physicians were more likely to refer to psychiatrists. Conclusions: Many older depressed patients in medical settings are not treated or referred. Physician experience and specialty may affect the decision to treat, and physician race may affect the decision to seek consultation. Therapeutic nihilism may be influential.     

The impact of treatment-resistant depression on health care utilization and costs

BACKGROUND: Approximately 50% of patients diagnosed with major depressive disorder will experience a recurrent or chronic course of illness for which long-term treatment is recommended. Moreover, at least 20% of patients diagnosed with depression do not respond satisfactorily to several traditional antidepressant medication treatment trials. Very little is known about the health care costs of patients with treatment-resistant depression. METHOD: Based on medical claims data (MarketScan Research Database, The MEDSTAT Group, Cambridge, Mass.) from January 1, 1995, to June 30, 2000, a naturalistic, retrospective analysis was conducted to study the characteristics and health care utilization of patients with treatment-resistant depression. All patients having an International Classification of Diseases, Ninth Revision (ICD-9), diagnosis code for unipolar or bipolar depression with specified antidepressant dosing and treatment durations were initially selected. Patients were then classified as "treatment resistant" if either they switched from or augmented initial antidepressant medication with other antidepressants at least twice (outpatient treatment-resistant group) or they switched from or augmented their initial antidepressant medication and also had a claim for either a depression-related hospitalization or suicide attempt (hospitalized treatment-resistant group). Those meeting the initial medication and diagnosis selection criteria but not meeting the treatment-resistance criteria constituted the comparison group. Members of the comparison group had comparatively stable antidepressant medication use patterns, consistent with an acceptable response to treatment. Patients were followed for a minimum of 9 months. Resource utilization was calculated from index date to last available claims data point and then annualized. RESULTS: Treatment-resistant patients were more likely to be diagnosed with bipolar disorder or concurrent substance abuse or anxiety disorders than the comparison group (p <.001). Treatment-resistant patients were at least twice as likely to be hospitalized (general medical and depression related) and had at least 12% more outpatient visits (p <.02). Treatment resistance was also associated with use of 1.4 to 3 times more psychotropic medications (including antidepressants) (p <.001). Patients in the hospitalized treatment-resistant group had over 6 times the mean total medical costs of non-treatment-resistant depressed patients ($42,344 vs. $6512) (p <.001) and their total depression-related costs were 19 times greater than those of patients in the comparison group ($28,001 vs. $1455) (p <.001). CONCLUSION: Treatment-resistant depression is costly and associated with extensive use of depression-related and general medical services. These findings underscore the need for early identification and effective long-term maintenance treatment for treatment-resistant depression.     

Awareness of metabolic concerns in patients with bipolar disorder: a survey of European psychiatrists.

PURPOSE: An online survey of European psychiatrists assessed awareness of the metabolic syndrome and its influence on the management of bipolar disorder. MATERIALS AND METHODS: Psychiatrists in the United Kingdom, France, Germany, Spain, and Italy were surveyed from April to June 2006. Eligibility criteria w ere 4-30 years in practice, >or=50% of time in direct patient care, had seen >or=10 bipolar patients in the preceding month. Aggregate data were weighted to represent the practicing physician population per country. RESULTS: Of 718 respondents, 56% had diagnosed metabolic syndrome. Respondents reported that metabolic syndrome prevalence was higher in bipolar patients (25%) than in the general population (20%). Seventy-two percent felt that metabolic syndrome poses significant health risks, warranting monitoring/treatment, and were most concerned with the bipolar medication adverse effects of weight gain, cognitive impairment, and glucose intolerance. Survey respondents recognized clear differences among psychotropic agents in the propensity to induce metabolic adverse effects. Sixty-five percent of respondents indicated that they had made interviewing and monitoring changes in the past three years as a result of metabolic concerns. CONCLUSIONS: European psychiatrists view metabolic syndrome as highly prevalent in the general population and in bipolar patients; two-thirds have changed their management of bipolar patients because of metabolic health concerns.     

Survey of forensic psychiatrists on evaluation and treatment of prisoners on death row

Psychiatrists have debated their role in evaluating prisoners accused of capital crimes and in treating prisoners on death row when restoration of competence would result in execution. Despite debate, there are no previous surveys of psychiatrists' opinions on this issue. We sent an anonymous questionnaire to all board-certified forensic psychiatrists in the United States. Of the 456 forensic psychiatrists identified, 290 (64%) returned the survey. Most respondents supported a role, in at least some cases, for psychiatric evaluation of prisoners accused of capital crimes. Respondents were divided on whether or not psychiatrists should treat incompetent death row prisoners if restoration of competence would result in execution. Attitudes about the ethical acceptability of capital punishment were associated with views about the psychiatrists' role but were not determinative in every case.     

Observer bias in the assessment of anxiety and depression

Summary Two studies are described here. In the first, an attempt is made to examine the relationship between the complaints of anxiety and depression using the results of a survey of a dermatology clinic. The Hospital Anxiety and Depression scale (HAD) and Clinical Interview Schedule (CIS) were both used in 117 unselected clinic attenders. The results showed that the self-report scales (HAD and first section of CIS) showed a closer relationship between anxiety and depression than the second section of the CIS that requires clinical judgement. In the second study, an attempt was made to distinguish between two possible explanations for this phenomenon; that psychiatrists use the constructs of anxiety and depression more carefully than patients, or alternatively that psychiatrists show an observer bias. A sample of psychiatrists were asked to complete symptom profiles for anxiety and depression; both for an imaginary patient and for their own emotions, allowing psychiatrists' beliefs concerning the relationship between anxiety and depression to be studied. The results indicated that the psychiatrists thought there was a negative correlation between anxiety and depression in patients in contrast to the consistent empirical finding that anxiety and depression are positively correlated. Psychiatrists also thought anxiety and depression were less closely related in patients than in themselves. It is likely that psychiatric assessments of anxiety and depression requiring clinical judgement on the part of the interviewer are subject to observer bias. It is argued that self-report measures of psychiatric symptoms will provide more convincing evidence to resolve diagnostic disputes.