共查询到20条相似文献,搜索用时 15 毫秒
1.
Bernhard D. Klumpp Joern Sandstede Klaus P. Lodemann Achim Seeger Tobias Hoevelborn Michael Fenchel Ulrich Kramer Claus D. Claussen Stephan Miller 《European radiology》2009,19(5):1124-1131
For contrast-enhanced imaging techniques relying on strong T1 weighting, 3 T provides increased contrast compared with 1.5 T.
The aim of our study was the intraindividual comparison of delayed enhancement MR imaging at 1.5 T and at 3 T. Twenty patients
with myocardial infarction were examined at 1.5 T and 3 T. Fifteen minutes after injection of contrast agent (0.1 mmol gadobenate
dimeglumine per kg body weight), inversion recovery gradient recalled echo (IR-GRE) sequences were acquired (1.5 T/3 T: TR
11.0/9.9 ms, TE 4.4/4.9 ms, flip 30°/30°, slice thickness 6/6 mm) to assess myocardial viability. Two observers rated image
quality (Wilcoxon signed rank test). Quantification of hyperenhanced myocardium and standardized SNR/CNR measurements were
performed (Student’s t test). There was no significant difference with respect to image quality (1.5 T/3 T: 3.5/3.3, p = 0.34, reader 1; 2.4/2.7, p = 0.12, reader 2) and infarction size (760 ± 566/828 ± 677 mm2 at 1.5 T, 808 ± 639/826 ± 726 mm2 at 3 T, reader 1/reader 2, p > 0.05). Mean SNR in hyperenhanced/normal myocardium was 19.2/6.2 at 1.5 T and 29.5/8.8 at 3 T (p < 0.05). Mean CNR was 14.3 at 1.5 T and 26.0 at 3 T (p < 0.05). Delayed enhancement MR imaging at 3 T is a robust procedure yielding superior tissue contrast at 3 T compared with
1.5 T which is, however, not reflected by increased image quality. 相似文献
2.
Winterer JT Moske-Eick O Markl M Frydrychowicz A Bley TA Langer M 《European radiology》2008,18(4):658-664
The purpose of this study was to determine the benefit of bilateral contrast-enhanced MR angiography (ce-MRA) of the hands
at 3.0 Tesla (T) compared with an established 1.5-T technique in healthy volunteers. Intraindividual bilateral ce-MRA of the
hands was performed at 1.5 T and 3.0 T in 14 healthy volunteers using a timed ultra-fast GRE sequence featuring parallel acquisition.
The evaluation comprised measurement of the vessel signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR), rating of
the image quality and the assessment of artefacts and venous contamination. At 3.0 T, SNR improved up to 95% and CNR up to
129%. The image quality of the larger inflow arteries, the palm arches and common digital arteries was good or sufficient
at either magnetic field strengths. However, 3.0-T MRA was clearly superior in the depiction of the digital arteries. Ce-MRA
of the hand clearly profits from the use of 3.0 T. Compared with 1.5 T, a substantial increase of CNR is found resulting in
a significantly better delineation of the small digital arteries. Saturation affects more the SNR of the perivascular tissue
than the contrast-enhanced blood, and thus leads to a marked increase of CNR at 3.0. 相似文献
3.
Bernhard D. Klumpp Achim Seeger Christina Doesch Joerg Doering Tobias Hoevelborn Ulrich Kramer Michael Fenchel Meinrad P. Gawaz Claus D. Claussen Stephan Miller 《European radiology》2010,20(3):533-541
Objective
Stress perfusion magnetic resonance imaging (MSPMRI) is an established technique for the assessment of myocardial perfusion. Shortcomings at 1.5 T are low signal to noise ratio (SNR) and contrast to noise ratio (CNR). One approach to overcome these shortcomings is to increase field strength and contrast concentration. The aim of our study was to investigate the diagnostic capability of high resolution MSPMRI at 3-T field strength using a 1 M contrast agent.Material and methods
Fifty-seven patients (62.3?±?11.0 years) with symptoms of coronary artery disease (CAD) were examined at 3 T. MMRSPI was assessed using a 2D saturation recovery gradient echo (SR GRE) sequence in short axis orientation (TR 1.9 ms, TE 1.0 ms, flip 12°, 0.1 mmol gadobutrol/kg body weight (bw), 140 µg adenosine/kg bw/min). Perfusion images were assessed visually and semiquantitatively (upslope, peak signal intensity (SI), and myocardial perfusion reserve index (MPRI)). Standard of reference was invasive coronary angiography.Results
Stress-induced hypoperfusion was found in 43 patients. Sensitivity for hemodynamically relevant CAD (stenoses greater than 70%) was 95%/98%, specificity 80%/87%, diagnostic accuracy 91%/95% (reader 1/reader 2). The MPRI was significantly lower in hypoperfused myocardium (1.3?±?0.2) compared with normal myocardium (2.6?±?0.7).Conclusion
High resolution MMRSPI at 3 T using 1 M contrast agent under daily routine conditions provides reliable detection of stress-induced myocardial hypoperfusion with higher diagnostic accuracy than 1.5-T conditions. 相似文献4.
J. M. Theysohn O. Kraff S. Maderwald P. C. Kokulinsky M. E. Ladd J. Barkhausen S. C. Ladd 《Skeletal radiology》2013,42(2):261-267
Objective
To present imaging characteristics of the ankle at 7.0 T and to investigate the appearance and image quality of presumed pathologies of ankles without physical strain as well as of ankles after a marathon run in comparison to 1.5 T.Materials and methods
Appearance of presumed pathologic findings and image quality of TSE (PD, T2, and STIR) and GRE sequences (MEDIC, DESS, and/or CISS) at 7.0 T and 1.5 T MRI were compared by two senior radiologists in consensus in two healthy controls without strain and in six marathon runners after a full-length marathon (eight males, mean age 49.1 years).Results
Overall, 7.0 T MRI allowed for higher resolution images for most of the sequences while requiring comparable acquisition times and achieving high contrast images mainly in gradient echo sequences. Bursal or presumed peritendineal fluid and/or edematous tissue, which were found in seven of eight subjects, could be best appreciated with 7.0 T MEDIC. Other findings with sharper delineation at 7.0 T included cartilage defects (best: CISS), osseous avulsions, and osteophytes (best: DESS). Nevertheless, 1.5 T STIR imaging enabled assessment of a tibiotalar bone edema-like lesion in two runners, which was barely visible at 7.0 T using STIR, but not with any other sequence at 7.0 T including MEDIC (with frequency selective fat suppression). 7.0 T showed larger image quality variations with challenges especially in the TSE sequences.Conclusion
Our initial results of ultra-high-field ankle joint imaging demonstrate the improved depiction of ankle anatomy, fluid depositions, and cartilage defects. However imaging of edema-like bone lesions remains challenging at ultra-high magnetic field strength, and TSE coverage in particular is limited by the specific absorption rate. 相似文献5.
Hisato Nakazawa Yuta Shibamoto Takahiko Tsugawa Yoshimasa Mori Masami Nishio Tomohiro Takami Masataka Komori Chisa Hashizume Tatsuya Kobayashi 《Japanese journal of radiology》2014,32(1):22-29
Purpose
The objective of this study was to determine the value of high-field magnetic resonance imaging and to clarify the characteristics of each image among three-dimensional gradient echo (3D-GRE), two-dimensional spin echo (2D-SE) and inversion recovery (2D-IR) sequences used as contrast-enhanced T1-weighted images for stereotactic irradiation treatment planning of sellar lesions.Materials and methods
Pulse sequences of 2D-SE and 3D-spoiled gradient recalled acquisition in the steady state (3D-SPGR) using GRE at 1.5 T and 2D-IR and 3D-fast SPGR (3D-FSPGR) at 3 T after injection of contrast material were acquired for 14 small pituitary tumors. As quantitative methods, signal-to-noise ratios (SNR) and contrast-to-noise ratios (CNR) were evaluated using a region-of-interest analysis.Results
There was no significant difference in SNR between 1.5-T SPGR and 3-T FSPGR, while 3-T IR was superior to 1.5-T SE. The 2D-SE and -IR provided significantly better CNR than 3D-GRE between tumor and normal structures.Conclusions
Three Tesla was found to be superior to 1.5 T in distinguishing tumors from the normal sellar structure. Optimal dose planning will utilize each advantage of imaging; 3D-GRE allows high-resolution acquisition and 2D-SE and -IR can offer better tissue contrast. 相似文献6.
Fushimi Y Miki Y Urayama S Okada T Mori N Hanakawa T Fukuyama H Togashi K 《European radiology》2007,17(11):2921-2925
Discrepancies exist in the literature regarding contrast between gray and white matter on spin-echo (SE) T1-weighted MR imaging
at 3 T. The present study quantitatively assessed differences in gray matter-white matter contrast on both single- and multi-slice
SE T1-weighted imaging between 3 and 1.5 T. SE T1-weighted sequences with the same parameters at both 3 and 1.5 T were used.
Contrast-to-noise ratio (CNR) between gray and white matter (CNRGM-WM) was evaluated for both frontal lobes. To assess the effects of interslice gap, multi-slice images were obtained with both
0 and 25% interslice gap. Single-slice CNRGM-WM was higher at 3 T (17.66 ± 2.68) than at 1.5 T (13.09 ± 2.35; P < 0.001). No significant difference in CNRGM-WM of multi-slice images with 0% gap was noted between 3 and 1.5 T (3T, 8.61 ± 2.55; 1.5T, 7.43 ± 1.20; P > 0.05). Multi-slice CNRGM-WM with 25% gap was higher at 3T (12.47 ± 3.31) than at 1.5 T (9.73 ± 1.37; P < 0.001). CNRGM-WM reduction rate of multi-slice images with 0% gap compared with single-slice images was higher at 3T (0.47 ± 0.13) than at
1.5 T (0.38 ± 0.09; P = 0.02). CNRGM-WM on single-slice SE T1-weighted imaging and CNRGM-WM on multi-slice images with 25% interslice gap were better at 3 T than at 1.5 T. The influence of multi-slice imaging on CNRGM-WM was significantly larger at 3T than at 1.5 T.
This study was supported in part by a Health and Labour Sciences Research Grant of Japan
Yasutaka Fushimi and Yukio Miki equally contributed to the study. 相似文献
7.
Bernd Bittersohl Falk R. Miese Christin Dekkers Hüseyin Senyurt Jörn Kircher Hans-Jörg Wittsack Gerald Antoch Rüdiger Krauspe Christoph Zilkens 《European radiology》2013,23(5):1367-1374
Objectives
To establish baseline T2* and T1Gd values of glenohumeral cartilage at 3 T.Methods
Forty asymptomatic volunteers (mean age: 24.8?±?2.2 years) without shoulder abnormalities were included. The MRI protocol comprised a double-echo steady-state (DESS) sequence for morphological cartilage evaluation, a gradient-echo multiecho sequence for T2* assessment, and a gradient-echo dual-flip-angle sequence for T1Gd mapping. Statistical assessment involved a one-way analysis of variance (ANOVA) to identify the differences between various regions of the glenohumeral joint and intraclass correlation (ICC) analysis comparing repetitive T2* and T1Gd measures to assess intra- and interobserver reliability.Results
Both techniques revealed significant differences between superior and inferior glenohumeral cartilage demonstrating higher T2* (26.2 ms vs. 23.2 ms, P value?<?0.001) and T1Gd (750.1 ms vs. 720.2 ms, P value?=?0.014) values in the superior regions. No trend was observed in the anterior-posterior measurement (P value range: 0.279–1.000). High intra- and interobserver agreement (ICC value range: 0.895–0.983) was noted for both T2* and T1Gd mapping.Conclusions
T2* and T1Gd mapping are reliable in the assessment of glenohumeral cartilage. The values from this study can be used for comparison to identify cartilage degeneration in patients suffering from shoulder joint abnormalities.Key Points
? T2* mapping and dGEMRIC are sensitive to collagen degeneration and proteoglycan depletion. ? This study aimed to establish baseline T2*/dGEMRIC values of glenohumeral cartilage. ? Both techniques revealed significant differences between superior and inferior glenohumeral cartilage. ? High intra-/interreader agreement was noted for both T2* mapping and dGEMRIC. ? These baseline normal values should be useful when identifying potential degeneration. 相似文献8.
Wei Yang Feifei Zhang Haipeng Tang Xiaoliang Shao Jianfeng Wang Xiaosong Wang Xiaonan Shao Wenchong Xin Ling Yang Weihua Zhou Yuetao Wang 《Journal of nuclear cardiology》2018,25(3):742-753
Background
Left ventricular (LV) remodeling has adverse effects on the prognosis of patients with myocardial infarction (MI). The aim of this study is to identify the risk factors of LV remodeling in MI patients by radionuclide myocardial imaging.Methods and Results
This retrospective study consisted of 92 patients who had a history of definite prior MI on ECG and underwent both resting gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) and positron emission tomography (PET) myocardial metabolism imaging. LV remodeling was defined as > mean + 2SD of LV end-diastolic volume index (LVEDVi) in the normal database. LV enlargement, cardiac dysfunction, wall thickening abnormalities expressed as summed thickening score (STS) were more severe in the old MI patients as compared to those with subacute MI. STS (Odds ratio, 1.296; P = .004) and the proportion of segments with reduced wall thickening in segments with normal perfusion (Odds ratio, 1.110; P = .001) were identified as the independent factors of LV remodeling in subacute and old MI patients in the multivariate binary regression model. Total perfusion deficit (TPD), viable myocardium, scar, and the proportion of segments with reduced wall thickening in segments with decreased perfusion showed strong correlation with LV remodeling in the univariate regression model as well.Conclusions
LV remodeling in old MI patients is more extensive and severe than that in subacute MI patients. LV wall thickening abnormalities as expressed by STS and the proportion of segments with reduced wall thickening in segments with normal perfusion are the independent risk factors of LV remodeling in MI patients.9.
10.
Catherine Roy Guillaume Bierry Andrea Matau Gauthier Bazille Rémy Pasquali 《European radiology》2010,20(8):1803-1811
Objective
To investigate the usefulness of diffusion-weighted imaging (DWI) to discriminate between metastatic and non-metastatic small lymph nodes in pelvic carcinoma.Materials and Methods
A total of 259 patients (180 normal, 79 metastatic) prospectively underwent DWI at 3 T. We measured the short-axis diameter and the mean apparent diffusion coefficient (ADC) value. Lymph nodes with a short-axis diameter larger than 8 mm were recorded as being suspected metastatic lymph nodes. Imaging data were correlated station by station with histopathological results.Results
A total of 140 metastatic nodes were accurately matched with histology. On T2w, the short-axis diameter for non-metastatic and metastatic lymph nodes was 6.4 mm?±?2.5 mm and 8.3 mm?±?4.5 mm, respectively. Almost all metastatic or non-metastatic nodes had similar high signal intensity on DWI (except in 5 cases) with a homogeneous pattern. The mean ADC values (10?3 mm3/s ± standard deviation) of involved lymph nodes, control iliac nodes and control inguinal nodes were 924?±?217, 968?±?182 and 1,036?±?181, respectively. There were no statistically significant differences in the ADC of metastatic and non-metastatic nodes.Conclusion
Isolated measurement of mean ADC values in a suspected station does not contribute to the diagnosis of metastatic nodes, in patients with small ambiguous nodes. 相似文献11.
Bernd Bittersohl Harish S. Hosalkar Malte Sondern Falk R. Miese Gerald Antoch Rüdiger Krauspe Christoph Zilkens 《Skeletal radiology》2014,43(4):443-452
Objective
To establish baseline T2* values in healthy knee joint cartilage at 3 T.Materials and Methods
Thirty-four volunteers (mean age: 24.6?±?2.7 years) with no history or clinical findings indicative of any knee joint disease were enrolled. The protocol included a double-echo steady-state (DESS) sequence for morphological cartilage evaluation and a gradient-echo multi-echo sequence for T2* assessment. Bulk and zonal T2* values were assessed in eight regions: posterior lateral femoral condyle; central lateral femoral condyle; trochlea; patella; lateral tibial plateau; posterior medial femoral condyle; central medial femoral condyle; and medial tibial plateau. Statistical evaluation comprised a two-tailed t test and a one-way analysis of variance to identify zonal and regional differences.Results
T2* mapping revealed higher T2* values in the superficial zone in all regions (P values?≤?0.001) except for the posterior medial femur condyle (P?=?0.087), and substantial regional differences demonstrating superior values in trochlear cartilage, intermediate values in patellar and central femoral condylar cartilage, and low T2* values in posterior femoral condylar cartilage and tibial plateau cartilage.Conclusion
Substantial regional differences in T2* measures should be taken into consideration when conducting T2* mapping of knee joint cartilage. 相似文献12.
13.
Magnetic resonance imaging (MRI) using 3.0 T scanners in the clinical environment is in its infancy and is only available
at a limited number of sites worldwide. There is great interest amongst radiologists about the perceived benefits of clinical
imaging at 3.0 T; however, it remains to be seen whether the theoretical advantages will bring real gains. MRI in patients
with non-traumatic intracranial hemorrhage (ICH) is difficult, yet, these patients benefit from non-invasive angiography.
Conventional catheter angiography (CCA) remains the reference standard for excluding/confirming the presence of intracranial
vascular abnormalities, but MR angiography at 3.0 T may offer opportunities for significant changes in patient management.
We present our experiences of using 3.0 T MR angiography in 27 patients with acute or early subacute ICH. 相似文献
14.
Chen F Suzuki Y Nagai N Sun X Coudyzer W Yu J Marchal G Ni Y 《European journal of radiology》2007,61(1):70-78
INTRODUCTION: Delayed perfusion (DP) sign at MR imaging was reported in stroke patients. We sought to experimentally elucidate its relation to spontaneous reperfusion and ischemic penumbra. METHODS: Stroke was induced by photothrombotic occlusion of middle cerebral artery in eight rats and studied up to 72 h using a 1.5 T MR scanner with T2 weighted imaging (T2WI), diffusion weighted imaging (DWI), and dynamic susceptibility contrast-enhanced perfusion weighted imaging (DSC-PWI). Relative signal intensity (rSI), relative lesion volume (rLV), relative cerebral blood flow (rCBF), PWI(rLV)-DWI(rLV) mismatch (penumbra) and DP(rLV) were quantified and correlated with neurological deficit score (NDS), triphenyl tetrazolium chloride (TTC) staining, microangiography (MA) and histopathology. RESULTS: The rSI and rLV characterized this stroke model on different MRI sequences and time points. DSC-PWI reproduced cortical DP in all rats, where rCBF evolved from 88.9% at 1 h through 64.9% at 6 h to 136.3% at 72 h. The PWI(rLV)-DWI(rLV) mismatch reached 10+/-5.4% at 1 h, remained positive through 12 h and decreased to -3.3+/-4.5% at 72 h. The incidence and rLV of the DP were well correlated with those of the penumbra (p<0.01, r(2)=0.85 and p<0.0001, r(2)=0.96, respectively). Shorter DP durations and more collateral arterioles occurred in rats without (n=4) than with (n=4) cortex involvement (p<0.05). Rats without cortex involvement tended to earlier reperfusion and a lower NDS. Microscopy confirmed MRI, MA and TTC findings. CONCLUSIONS: In this rat stroke model, we reproduced clinically observed DP on DSC-PWI, confirmed spontaneous reperfusion, and identified the penumbra extending to 12h post-ischemia, which appeared interrelated. 相似文献
15.
16.
Wieners G Detert J Streitparth F Pech M Fischbach F Burmester G Ricke J Backhaus M Bruhn H 《European radiology》2007,17(8):2176-2182
The goal of this study was to compare magnetic resonance (MR) image quality at different field strengths for evaluating lesions
in wrist and finger joints of patients with rheumatoid arthritis (RA) in order to determine whether the higher field strength
provides diagnostic gain. The hand mainly affected in 17 RA patients was examined at 1.5 Tesla (T) and 3.0 T with comparable
MR imaging (MRI) protocols. MR images were reviewed twice by two experienced radiologists using the Rheumatoid Arthritis MRI
Scoring System (RAMRIS) of the OMERACT (Outcome Measures in Rheumatoid Arthritis Clinical Trials) group. Image quality was
rated on a five-point scale using Friedmann’s test and Kendall’s W-test for statistical analysis. Image comparison revealed better image quality at higher field strength. Image quality of
T1-weighted images was rated 14–22% better at 3.0 T compared with 1.5 T by both readers. Moreover, the rating for the T2-weighted-images
acquired at 3.0 T was one point better in the five-point scale used. Inter-reader correlation for image quality, bone erosions/defects,
edema and synovitis ranged between 0.6 and 0.9 at 3.0 T and between 0.6 and 0.8 at 1.5 T. Intra-reader correlation for these
parameters was high at 0.8–1.0. MRI image quality of RA hands is superior at 3.0 T, while an acceptable image quality is achieved
at 1.5 T, which improves the evaluation of extent of bone edema, synovitis and identification of small bone erosions. 相似文献
17.
Rui Wang Songlin Yu Jeffry R. Alger Zhentao Zuo Juan Chen Rong Wang Jing An Bo Wang Jizong Zhao Rong Xue Danny J. J. Wang 《European radiology》2014,24(5):1135-1144
Objectives
To present a multi-delay pseudo-continuous ASL (pCASL) protocol that offers simultaneous measurements of cerebral blood flow (CBF) and arterial transit time (ATT), and to study correlations between multi-delay pCASL and CT perfusion in moyamoya disease.Methods
A 4 post-labeling delay (PLD) pCASL protocol was applied on 17 patients with moyamoya disease who also underwent CT perfusion imaging. ATT was estimated using the multi-delay protocol and included in the calculation of CBF. ASL and CT perfusion images were rated for lesion severity/conspicuity. Pearson correlation coefficients were calculated across voxels between the two modalities in grey and white matter of each subject respectively and between normalized mean values of ASL and CT perfusion measures in major vascular territories.Results
Significant associations between ASL and CT perfusion were detected using subjective ratings, voxel-wise analysis in grey and white matter and region of interest (ROI)-based analysis of normalized mean perfusion. The correlation between ASL CBF and CT perfusion was improved using the multi-delay pCASL protocol compared to CBF acquired at a single PLD of 2 s (P?<?0.05).Conclusions
There is a correlation between perfusion data from ASL and CT perfusion imaging in patients with moyamoya disease. Multi-delay ASL can improve CBF quantification, which could be a prognostic imaging biomarker in patients with moyamoya disease.Key Points
? Simultaneous measurements of CBF and ATT can be achieved using multi-delay pCASL. ? Multi-delay ASL was compared with CT perfusion in patients with moyamoya disease. ? Statistical analyses showed significant associations between multi-delay ASL and CT perfusion. ? Multi-delay ASL can improve CBF quantification in moyamoya disease. 相似文献18.
The purpose of this study was to investigate if functional activity with spinal cord somatosensory stimulation can be visualized using BOLD fMRI. We investigated nine healthy volunteers using a somatosensory stimulus generator. The stimuli were applied in three different runs at the first, third, and fifth finger tip of the right hand, respectively, corresponding to dermatomes c6, c7, and c8. The stimuli gave an increase of BOLD signal (activation) in three different locations of the spinal cord and brain stem. First, activations could be seen in the spinal segment corresponding to the stimulated dermatome in seven out of nine volunteers for c6 stimulation, two out of eight for c7, and three out of eight for c8. These activations were located close to the posterior margin of the spinal cord, presumably reflecting synaptic transmission to dorsal horn interneurons. Second, activation in the medulla oblongata was evident in four subjects, most likely corresponding to the location of the nucleus cuneatus. The third location of activation, which was the strongest and most reliable observed was inside the spinal cord in the c3 and c4 segments. Activation at these spinal levels was almost invariably observed independently of the dermatome stimulated (9/9 for c6, 8/8 for c7, and 7/8 for c8 stimulation). These activations may pertain to an interneuronal system at this spinal level. The results are discussed in relation to neurophysiological studies on cervical spinal interneuronal pathways in animals and humans. 相似文献
19.
Lenka?Minarikova Wolfgang?Bogner Katja?Pinker Ladislav?Valkovi? Zsuzsanna?Bago-Horvath Rupert?Bartsch Thomas?H.?Helbich Siegfried?Trattnig Stephan?Gruber
Objective
To explore the predictive value of parameters derived from diffusion-weighted imaging (DWI) and contrast-enhanced (CE)-MRI at different time-points during neoadjuvant chemotherapy (NACT) in breast cancer.Methods
Institutional review board approval and written, informed consent from 42 breast cancer patients were obtained. The patients were investigated before and at three different time-points during neoadjuvant chemotherapy (NACT) using tumour diameter and volume from CE-MRI and ADC values obtained from drawn 2D and segmented 3D regions of interest. Prediction of pathologic complete response (pCR) was evaluated using the area under the curve (AUC) of receiver operating characteristic analysis.Results
There was no significant difference between pathologic complete response and non-pCR in baseline size measures (p?>?0.39). Diameter change was significantly different in pCR (p?<?0.02) before the mid-therapy point. The best predictor was lesion diameter change observed before mid-therapy (AUC?=?0.93). Segmented volume was not able to differentiate between pCR and non-pCR at any time-point. The ADC values from 3D-ROI were not significantly different from 2D data (p?=?0.06). The best AUC (0.79) for pCR prediction using DWI was median ADC measured before mid-therapy of NACT.Conclusions
The results of this study should be considered in NACT monitoring planning, especially in MRI protocol designing and time point selection.Key Points
? Mid-therapy diameter changes are the best predictors of pCR in neoadjuvant chemotherapy. ? Volumetric measures are not strictly superior in therapy monitoring to lesion diameter. ? Size measures perform as a better predictor than ADC values.20.
Jérôme Jehl Alexandre Comte Sébastien Aubry Nicolas Meneveau François Schiele Bruno Kastler 《European radiology》2009,19(12):2913-2918
The purpose of this study was to prospectively evaluate the safety of cardiac magnetic resonance (CMR) imaging at 3 T performed
early (less than 14 days) after bare metal or drug-eluting coronary stent implantation in patients with acute myocardial infarction
(AMI). Seventy-two consecutive patients with AMI treated by percutaneous revascularisation with a stent underwent CMR examination
with a median delay of 6 days. Patients were followed-up for major adverse cardiac events, during hospitalisation and at 6 months.
After CMR imaging, no acute stent thrombosis, death or repeated AMI were recorded at 6-month follow-up. Two symptomatic in-stent
restenoses and two silent in-stent restenoses were recorded, at a mean delay of 106 days. In our population, we found a target
revascularisation rate of 5.6%. This is consistent with the 6-month event rates after coronary artery stent (CAS) placement
for AMI, evaluated by several studies. This preliminary clinical study supports the safety of 3-T CMR imaging performed early
after coronary stent placement. 相似文献