第四军医大学口腔修复网的开发与应用

随着信息化社会的发展，专业信息资源建设和服务的网络化促进了学科信息门户的开发与应用，使学科信息门户成为专业信息资源共建共享、网络服务以及提升学科影响力的重要模式，用以完成本学科网络资源内容的高度组织集成和网络应用程序的聚集。     

国内外学科信息门户中的医学资源类型研究

选取4个与生命科学或医学有关的学科信息门户,即"Intute-health and life sci- ences:Medicine"、"Health Web"、"CSDL生命科学学科信息门户"和"CALIS重点学科网络资源导航数据库",对其组织的医学资源类型进行调查,发现这些学科信息门户中的医学资源类型存在类型不全面、医学特色不突出、资源名称不规范等问题。针对这些问题,提出合理设计医学资源类型表的几点建议。     

我国信息组织相关文献计量分析

目的:全面了解我国信息组织的研究现状及发展趋势,从而更好地把握其研究方向。方法:利用文献计量学方法,运用NoteExpress和TDA两种信息分析软件,对万方数据资源系统1982-2009年收录的国内信息组织相关文献的时间、著者、期刊、机构进行了分析。利用关键词词频分析法,对国内信息组织的研究热点和发展趋势进行了研究。结果:1982-2009年,万方数据资源系统共收录信息组织研究文献952篇。武汉大学发文量最多,是开展信息组织相关研究的核心机构。知识组织、数字图书馆、情报检索语言等是当前研究的热点,竞争情报、学科信息门户及神经网络等领域是未来的发展趋势。结论:现阶段我国信息组织相关研究的总体发展趋势良好,基础理论研究与应用研究并重,涉及多个学科领域,并逐步向一些热门领域发展,其潜在价值仍有待进一步研究。     

基于信息门户面向重点领域的信息跟踪与推送服务

介绍信息门户的定义、类型及信息管理、学科导航、信息筛选与加工等功能,着重描述NSTL重点领域信息门户的内容及建设依据,包括语料建设及信息跟踪与推送服务功能。     

基于Web2.0的高校图书馆学科服务平台建设

学科馆员制度是国际图书馆界推行的一种先进的办馆理念和服务方式,它以用户为中心,按照学科开展针对性服务,自开展以来,受到了用户的普遍欢迎,目前已在国内高校图书馆中得到了快速发展.Web2.0作为一种全新的信息服务模式,是以用户为核心,强调开放、共享、参与、互动、创造的信息资源组织与管理体系,使信息的创造、获取、交流方式和服务都发生了重大的变化,其服务理念与技术已经得到了广泛传播和应用.利用Web2.0技术可以有效弥补传统学科服务平台用户间缺乏交流、用户与门户间的交互性差等问题,进而提高信息服务的质量,更好地为学科用户服务.     

NSTL艾滋病预防与控制热点门户建设思路

阐述学科门户的定义，艾滋病预防与控制热点门户建设的背景和目标以及建设思路和 步骤，包括建立热点门户平台，制定热点门户资源的采选标准，形成规范的指导性工作文档，确定艾滋 病防控热点门户主题分类体系，确定门户收录的资源类型，提出数据采集和加工的质量控制方法和 “资源发现”的策略。     

基于用户信息需求和信息行为的医学院校药学信息资源建设研究

通过浏览网站和实地问卷调查的方式了解安徽省医学院校药学信息资源建设现状和药学科研人员的信息需求及信息行为,为建设针对性强、实用性强的药学学科信息门户网站提供参考。指出目前医学院校主动提供科研信息的意识薄弱,专业信息资源匮乏,高校间资源共享亟待加强,药学学科门户建设十分必要。     

数字化医院信息门户集成的设计与实现

医院需要一个统一的信息集成平台,将医院内部各自为政的业务应用系统、千变万化的行政管理系统集成在一个统一的浏览器门户。江苏省人民医院利用iOffice.net对医院原有系统的有机集成,改造及重构医院门户系统,建立统一的用户管理和权限配置体系;设立分级门户和虚拟门户,为各个科室、分院实现个性化门户;建立统一的流程管理,实现工作流平台;通过数据挖掘、分析与展现,最终成为医院综合办公、信息传递、统计与分析平台。     

E-Learning环境下信息资源组织发展趋势

根据E-Learning环境注重用户个性化需求的新特点、新技术,分析了E-Learning环境下信息资源组织的重要性,指出应用Web 2.0及可视化的理念和技术进行信息资源组织、以开放教育资源的形式进行信息资源组织和发布、以门户的方式进行资源整合是信息资源组织的发展趋势。     

高校实现网络信息资源效用最大化的探讨

概述了高校网络信息资源的内容、组织形式及评价标准,网络信息资源效用低下的原因在于传统观念的阻碍,技术层面的水平不高及管理层面的内容缺少,主要表现为对网络信息资源的重视程度不高,信息整合技术水平低下,没有对应评价体系而导致竞争因素的缺失,无法建立有效的反馈渠道。提出高校图书馆要注意转变传统观念,运用先进的信息整合技术建立信息门户,完善信息管理中的评价体系与反馈机制,建立统一的外部标准以及加强自身特色化的建设。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.