共查询到20条相似文献,搜索用时 15 毫秒
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B. J. Levvey M. Harkess P. Hopkins D. Chambers C. Merry A. R. Glanville G. I. Snell 《American journal of transplantation》2012,12(9):2406-2413
Donation‐after‐Determination‐of‐Cardiac‐Death (DDCD) donor lungs can potentially increase the pool of lungs available for Lung Transplantation (LTx). This paper presents the 5‐year results for Maastricht category III DDCD LTx undertaken by the multicenter Australian National DDCD LTx Collaborative. The Collaborative was developed to facilitate interaction with the Australian Organ Donation Authority, standardization of definitions, guidelines, education and audit processes. Between 2006 and 2011 there were 174 actual DDCD category III donors (with an additional 37 potentially suitable donors who did not arrest in the mandated 90 min postwithdrawal window), of whom 71 donated lungs for 70 bilateral LTx and two single LTx. In 2010 this equated to an “extra” 28% of donors utilized for LTx. Withdrawal to pulmonary arterial flush was a mean of 35.2 ± 4.0 min (range 18–89). At 24 h, the incidence of grade 3 primary graft dysfunction was 8.5%[median PaO2/FiO2 ratio 315 (range 50–507)]. Overall the incidence of grade 3 chronic rejections was 5%. One‐ and 5‐year actuarial survival was 97% and 90%, versus 90% and 61%, respectively, for 503 contemporaneous brain‐dead donor lung transplants. Category III DDCD LTx therefore provides a significant, practical, additional quality source of transplantable lungs. 相似文献
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N‐acetyl‐seryl‐aspartyl‐lysyl‐proline mediates the anti‐fibrotic properties of captopril in unilateral ureteric obstructed BALB/C mice 下载免费PDF全文
Gary C.W. Chan Hao Jia Wu Kam Wa Chan Wai Han Yiu Ailis Zou Xiao Ru Huang Hui Yao Lan Kar Neng Lai Sydney C.W. Tang 《Nephrology (Carlton, Vic.)》2018,23(4):297-307
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Evaluation of Hyphecan (1‐4,2‐acetamide‐deoxy‐B‐D‐glucan polymer) on wound healing in a rodent model
Objective: To evaluate the effect of an artificial skin Hyphecan (1‐4,2‐acetamide‐deoxy‐B ‐D ‐glucan polymer) on wound healing in a rodent model. Materials and Method: The prospective study was conducted at a basic science laboratory at a tertiary teaching hospital. Two 4 cm × 4 cm full‐thickness wounds were created on the dorsal surface of 10 Spraque–Dawley rats and covered with Hyphecan and Kaltostat, respectively. Wounds were examined and measured on days 4, 10, 21 and 28, and would continue after day 28 until healed up completely. Punch biopsies (3 mm) were taken on days 4, 10 and 28 for histological examination of the response of healing and repair. Results: Despite the fact that the wound healing rate was similar for both groups on days 4, 10, 21 and 28, the average healing time for the Hyphecan group (29.1 ± 1.7 days) was significantly shorter statistically (P = 0.03) than the Kaltostat group (30.7 ± 2.8 days). Conversely, the marked healing response elicited by Hyphecan on day 4 persisted on days 10 and 28 in contrast to Kaltostat, which had only a mild degree of healing response on days 10 and 28. The study suggests that wounds treated by Hyphecan heal faster than Kaltostat. Conclusion: The findings provide basic scientific evidence supporting the clinical use of Hyphecan in different wounds and might also reduce the cost of wound management as Hyphecan is cheaper than Kaltostat and requires a shorter treatment time. 相似文献
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Effect of 4‐chloro‐7‐trifluoromethyl‐10H‐benzo[4,5]furo[3,2‐b]indole‐1‐carboxylic acid on the intraurethral pressure in a rat model of benign prostatic hyperplasia 下载免费PDF全文
Bo Ram Choi Kiran Kumar Soni Li Tao Zhang Sung Won Lee Insuk So Hye Kyung Kim Jong Kwan Park 《International journal of urology》2016,23(3):259-265
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Lucia Savarino Giovanni Padovani Massimo Ferretti Michelina Greco Elisabetta Cenni Giorgio Perrone Francesco Greco Nicola Baldini Armando Giunti 《Journal of orthopaedic research》2008,26(12):1569-1576
Alternative bearing surfaces for total hip arthroplasty, such as metal‐on‐metal and ceramic‐on‐ceramic, offer the potential to reduce mechanical wear and osteolysis. In the short and medium term, the second generation of metal‐on‐metal bearings demonstrated high systemic metal ion levels, whereas ceramic‐on‐ceramic bearings showed the lowest ones. We aimed to verify whether the long‐term ion release in metal‐on‐metal subjects was still relevant at a median 10‐year follow‐up, and whether a fretting process at the modular junctions occurred in ceramic‐on‐ceramic patients and induced an ion dissemination. Serum levels were measured in 32 patients with alumina‐on‐alumina implants (group A), in 16 subjects with metal‐on‐metal implants (group B), and in 47 healthy subjects (group C). Group B results were compared with medium‐term findings. Cobalt and chromium levels were significantly higher in metal‐on‐metal implants than in ceramic‐on‐ceramic ones and controls. Nevertheless, ion levels showed a tendency to decrease in comparison with medium‐term content. In ceramic‐on‐ceramic implants, ion values were not significantly different from controls. Both in groups A and B, aluminum and titanium release were not significantly different from controls. In conclusion, negligible serum metal ion content was revealed in ceramic‐on‐ceramic patients. On the contrary, due to the higher ion release, metal‐on‐metal coupling must be prudently considered, especially in young patients, in order to obtain definitive conclusions. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 相似文献
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Investigation of High‐Speed Erythrocyte Flow and Erythrocyte‐Wall Impact in a Lab‐on‐a‐Chip 下载免费PDF全文
To better understand erythrocyte high‐speed motion, collision characteristics, and collision‐induced hemolysis probability in rotary blood pumps, a visual experimental investigation of high‐speed erythrocyte flow and erythrocyte‐wall collision in a lab‐on‐a‐chip was performed. The erythrocyte suspension was driven by a microsyringe pump connected to the microchip, and the erythrocyte flow and erythrocyte‐wall impact process were observed and imaged by an optical microscope and a high‐speed camera. Two types of microchips with different impact surfaces (flat and curved) were employed. The motion and deformation features before and after collision were studied in detail. The results show that erythrocytes not only move along the flow direction in the flow plane but also rotate and roll in three‐dimensional space. Erythrocytes keep discoid shape during the movement in the straight channel, but their deformations during collision are mainly classified into two types: erythrocyte structure is still stable and the erythrocyte performance can be ensured to a certain extent in the TypeA deformation, while the TypeB deformation makes the membrane more likely to fracture on the stretched side, increasing the probability of hemolysis. Furthermore, the movements and deformations of the erythrocytes after collision are analyzed and classified into two types: bouncing and slipping. Moreover, a simulation method for the flow in microchip was performed and validated through a comparison of the streamlines and experimental erythrocytes tracks, which can be further employed to predict the high‐speed blood flow, associated with collision process in mechanical blood pump. 相似文献
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Junmo An Andrew G. Webb Dipan J. Shah Karen Chin Nikolaos V. Tsekos 《The international journal of medical robotics + computer assisted surgery : MRCAS》2018,14(1)
Background
A method for the identification of semi‐active fiducial magnetic resonance (MR) markers is presented based on selectively optically tuning and detuning them.Methods
Four inductively coupled solenoid coils with photoresistors were connected to light sources. A microcontroller timed the optical tuning/detuning of coils and image collection. The markers were tested on an MR manipulator linking the microcontroller to the manipulator control to visibly select the marker subset according to the actuated joint.Results
In closed‐loop control, the average and maximum were 0.76° ± 0.41° and 1.18° errors for a rotational joint, and 0.87 mm ± 0.26 mm and 1.13 mm for the prismatic joint.Conclusions
This technique is suitable for MR‐compatible actuated devices that use semi‐active MR‐compatible markers. 相似文献13.
Lian Zhu Dai Chuanchang Liu Wei Cao Yilin Dong Jiasheng 《Journal of orthopaedic research》2010,28(3):412-418
Segmental defect regeneration is still a clinical challenge. In this study, we investigated the feasibility of bone marrow stromal cells (BMSCs) infected with adenoviral vector containing the bone morphogenetic protein 7 gene (AdBMP7) and load‐bearing to enhance bone regeneration in a critically sized femoral defect in the goat model. The defects were implanted with AdBMP7‐infected BMSCs/coral (BMP7 group) or noninfected BMSCs/coral (control group), respectively, stabilized with an internal fixation rod and interlocking nails. Bridging of the segmental defects was evaluated by radiographs monthly, and confirmed by biomechanical tests. Much callus was found in the BMP7 group, and nails were taken off after 3 months of implantation, indicating that regenerated bone in the defect can be remodeled by load‐bearing, whereas after 6 months in control group. After load‐bearing, it is about 5 months; the mechanical property of newly formed bone in the BMP7 group was restored, but 8 months in control group. Our data suggested that the BMP7 gene‐modified BMSCs and load‐bearing can promote bone regeneration in segmental defects. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:412–418, 2010 相似文献
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N. T. Hu J. S. H. Tsai S. M. Guo L. S. Shieh Y. Chen 《Optimal control applications & methods.》2011,32(4):433-475
This paper presents the low‐order multi‐rate linear time‐invariant decentralized trackers using the new observer‐based sub‐optimal method for a class of unknown sampled‐data nonlinear time‐delay system with closed‐loop decoupling. For the unknown sampled‐data nonlinear time‐delay system, we assume that the inner time delay is clearly known. Under this prerequisite, the appropriate (low‐) order decentralized linear observer for the unknown sampled‐data nonlinear system is determined by the off‐line observer/Kalman filter identification (OKID) method with artificial delay input and actual delay output. Then, the above observer has been further improved based on the proposed new observer‐based sub‐optimal approach. Sequentially, the decentralized tracker with the high gain property is proposed, so that the closed‐loop system has the decoupling property. The proposed approach constructs complete mathematics method including the concept of optimal control theory and state‐matching digital redesign technique and is quite useful for the complicated interconnected large‐scale sampled‐data nonlinear time‐delay system with unknown system equation. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
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A linear optimization problem with unknown parameters from a given finite set is tackled. The problem is to find the robust time‐optimal control transferring a given initial point to a convex terminal compact set M for all unknown parameters in a shortest time. The robust maximum principle for this minimax problem is formulated. It gives a necessary and sufficient condition of robust optimality. Under natural conditions, the existence and uniqueness of robust optimal controls are proven when the resource set is a convex polytope. Several illustrating examples, including a bang–bang robust optimal control, are considered in detail. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
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Jianyu Weng Peilong Lai Suxia Geng Chenwei Luo Suijing Wu Wei Ling Chengxin Deng Xin Huang Zesheng Lu Xin Du 《Clinical transplantation》2015,29(6):547-554
Cutaneous damage is one of the characterized manifestations in chronic graft‐versus‐host disease (cGVHD). When local effective immunity in the skin is altered to a dysimmune reaction, cutaneous injuries occur. Toll‐like receptor 4 signaling is regarded as a central mediator of inflammation and organ injury. In this study, we found that TLR4 mRNA in peripheral blood from patients with cutaneous cGVHD was markedly increased compared with that from non‐GVHD patients and healthy controls. In addition, NF‐κB expression, TLR4 downstream signaling, and TLR4‐mediated cytokines, including IL‐6 and ICAM‐1, were upregulated. Moreover, ICAM‐1 was widely distributed in skin biopsies from patients with cutaneous cGVHD. We also found that LPS induced TLR4‐mediated NF‐κB activation and IL‐6 and ICAM‐1 secretion in human fibroblasts in vitro. Thus, TLR4, NF‐κB, IL‐6, and ICAM‐1 contribute to the inflammatory response that occurs in cutaneous cGVHD, indicating the TLR4 pathway may be a novel target for cutaneous cGVHD therapy. 相似文献
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《Journal of orthopaedic research》2017,35(11):2557-2566