颈动脉粥样硬化斑块MSCTA特点与脑梗死的关系研究

目的：观察颈动脉粥样硬化斑块多层螺旋CT血管造影（Multislice spiral CT angiography,MSCTA）特点,探讨颈动脉硬化斑块与脑梗死的关系。方法：对342例怀疑脑部缺血或颈动脉病变患者进行颈动脉多层螺旋CT血管造影检测和颅脑扫描。调查样本分为脑梗死组（98例）和非脑梗死组（244例）,分析比较两样本颈动脉粥样硬化斑块的发病部位、性质及动脉狭窄程度的关系。结果：脑梗死组患者颈动脉狭窄以颈内动脉虹吸段、颈内动脉颈段最多见,且颈内动脉虹吸段和颈内动脉颈段斑块的出现与脑梗死发生有统计学意义（P〈O．05）。结论：脑梗死患者颈动脉狭窄以颈内动脉虹吸段、颈动脉膨大最多见;颈动脉狭窄发生在颈内动脉虹吸段、颈内动脉颈部与脑梗死有联系。     

颈动脉粥样硬化与急性脑梗死关系的研究

目的 探讨颈动脉粥样硬化与急性脑梗死的关系.方法 入选急性脑梗死患者(脑梗死组)80例及非急性脑梗死患者(对照组)80例,均进行颈部血管彩超检查,比较两组间颈动脉粥样硬化程度、粥样斑块性质及相关危险因素的差异.结果 两组颈动脉斑块均以颈总动脉分叉处(BIF)最为多见,脑梗死组双侧颈动脉分叉处、颈内动脉起始段发生率明显高于对照组,两组比较有显著性差异(P＜0.05).与对照组比较,脑梗死组颈动脉内膜厚度明显增加,两组差异有显著性(P＜0.01).两组颈动脉粥样硬化斑块均以混合斑最多,脑梗死组混合斑、软斑发生率明显高于对照组,两组比较有显著性差异(P＜0.05).脑梗死组与对照组颈内动脉狭窄率比较显示两组中均以轻度狭窄比例最高,脑梗死组中度、重度狭窄率明显高于非梗死组,两组比较有显著性差异(P＜0.05,P＜0.01).本研究发现所有患者中合并有高血压、糖尿病、冠心病等疾病者颈动脉粥样硬化发生率明显高于非合并症患者.结论 颈动脉粥样硬化是导致缺血性脑血管病的重要原因,因此对缺血性脑血管病和有脑血管病危险因素的患者应行常规颈动脉超声检查,及早发现颈动脉狭窄和斑块,尤其是不稳定性斑块的患者,应早期制定治疗方案,并定期随访和追踪观察,以减少心脑血管事件的发生.     

颈动脉血管超声及头颈CTA在脑梗死并颈动脉狭窄患者血流动力学状态评估中的应用观察

目的探究颈动脉血管超声及头颈电子计算机断层扫描血管造影(CTA)在脑梗死并颈动脉狭窄患者血流动力学状态评估中的应用。方法回顾性分析52例于我院接受颈动脉血管超声检查提示存在颈动脉狭窄的脑梗死患者临床资料,超声检查3d内均完成头颈CTA及CT灌注扫描检查(CTP),另选择30例健康体检者为对照组,进行CTA及CTP检查,分析患者和健康体检者检查结果及不同颈动脉狭窄患者血流动力学指标差异。结果52例患者经颈动脉血管超声、头颈CTA共检查119支颈内动脉,对应显示46支和43支颈内动脉正常,73支和76支颈内动脉狭窄,颈动脉狭窄对应包括轻度11支和16支、中度13支和11支、重度29支和25支、闭塞20支和24支,颈动脉血管超声与头颈TCA评价颈动脉狭窄程度的一致性评价Kappa=0.788,具有极高一致性(P<0.05);颈动脉血管超声显示,轻、中、重度狭窄及闭塞患者颈内动脉收缩期峰值流速(PSV)、舒张期末流速(EDV)水平均显著高于对照组(P<0.05),重度狭窄和闭塞患者大脑中动脉搏动指数(PI)、平均血流速度(Vm)水平显著低于对照组(P<0.05);脑梗死并颈动脉狭窄患者颈内动脉PSV、EDV水平由低到高依次为轻度、中度、重度狭窄和闭塞(P<0.05),重度狭窄及闭塞患者大脑中动脉PI、Vm水平显著低于轻度和中度狭窄患者(P<0.05),重度狭窄及闭塞患者侧肢循环开放率大于轻、中度狭窄患者(P<0.05),闭塞患者侧肢循环开放率大于重度狭窄患者(P<0.05);对照组和轻度、中度狭窄患者额叶、颞叶、基底节区脑血流动力学参数比较差异无统计学意义(P>0.05);重度狭窄、闭塞患者额叶、颞叶、基底节区脑血流量低于对照组体检者及轻度、中度狭窄患者(P<0.05),脑血容量、平均通过时间、达峰时间高于对照组体检者及轻度、中度狭窄患者(P<0.05)。结论颈动脉血管超声配合头颈CTA及CTP检查能够了解脑梗死伴颈动脉狭窄患者血流动力学状态,评价患者颈动脉狭窄程度,为临床诊疗提供有效的影像学信息。     

颅外段颈动脉狭窄及粥样硬化的MSCT血管造影的临床应用

目的探讨MSCT血管造影诊断颈动脉狭窄及粥样硬化的准确性以及影像学价值。方法对20例颈动脉病变的血管成像作回顾性分析,行MPR、CPR、MIP及VRT并综合比对各种重建技术。结果狭窄:颈内、外动脉起始部轻度狭窄8例,中度狭窄3例,呈弧形或半月状。重度狭窄2例。颈动脉分叉处轻度狭窄10例,中度狭窄2例。颈内、外动脉远段轻度狭窄5例,中度2例。颈总动脉处轻度狭窄4例,重度1例。粥样硬化斑块:颈内、外动脉起始部10例,其中硬斑块7例,软斑块3例。颈动脉分叉处12例,其中硬斑块9例,软斑块3例。颈内、外动脉远段6例,其中硬斑块4例,软斑块2例。颈总动脉硬斑块3例。闭塞:2例左侧颈内动脉起始段闭塞。结论CT血管造影检查对颈动脉狭窄程度及粥样硬化斑块具有较高的直观性和准确性。     

急性缺血性脑卒中患者颈部动脉双源CT血管造影分析

目的 探讨急性缺血性脑卒中患者颈部动脉双源CT血管造影的改变特点.方法 71例急性缺血性脑卒中患者经磁共振检查在弥散加权像上呈高信号,分析该组患者在双源CT血管造影上颈动脉粥样硬化斑块分布特点、斑块性质及血管狭窄程度等,并与45例非缺血性脑卒中患者(对照组)相比较.结果 71例急性缺血性脑卒中患者中51例检出颈动脉粥样硬化斑块196个,其中最好发的部位为颈总动脉分叉处和主干,分别占52.0%及20.4%;斑块性质以混合斑块和软斑块为主,分别占52.0%(102/196)和27.0%(53/196);中到重度血管狭窄约占54例患者中的86.3%.与对照组比较,斑块检出率、斑块分布、斑块性质及血管狭窄程度两组差异具有统计学意义(P<0.05).结论 急性缺血性脑卒中患者颈动脉粥样硬化斑块性质以混合斑块和软斑块为主,其动脉狭窄常为中到重度.     

MRI评价颈动脉斑块与脑梗死相关性研究

目的 利用血管壁MR高分辨成像技术,探讨颈动脉硬化斑块、狭窄程度与脑梗死的关系.方法 回顾性分析74例脑梗死患者(卒中组)和86例健康检查者(对照组)的颈动脉MRI,比较两组间的颈动脉斑块性质和狭窄程度的差异.结果 卒中组患者中52例(70.3%)共检出各种类型斑块138处,其中易损斑块88处,稳定斑块50处,易损斑块占63.8%;斑块最好发部位为颈动脉分叉处;47例可见动脉狭窄125处,轻度狭窄35处,中度狭窄50处,重度狭窄或闭塞40处.对照组共26例(30%)患者检出各种类型斑块74处,其中易损斑块32处,稳定斑块42处,易损斑块占43.2%;20例可见颈动脉狭窄58处,其中轻度狭窄31处,中度狭窄25处,重度狭窄或闭塞2处.卒中组颈动脉易损斑块和狭窄均明显高于对照组,两组间比较差异具有统计学意义(P<0.05).结论 颈动脉斑块性质和狭窄程度与脑梗死具有明显相关性.颈动脉MRI高分辨成像有助于判断颈动脉斑块性质及狭窄程度,为临床评估脑梗死风险提供重要帮助.     

颈动脉粥样硬化与脑梗死亚型的相关性研究

近年来对于颈动脉粥样硬化与脑血管病的关系已有大量研究。颈内动脉颅外段粥样硬化是发生缺血性脑血管病的主要原因之一，因此尽早明确有症状患者颈内动脉狭窄的程度、脑血流动力学的变化对脑梗死的治疗和预防具有重要意义。颈动脉粥样硬化的检测方法包括血管超声、数字血管减影造影（DSA）、CT、血管造影（CTA）和磁共振血管造影（MRA）等。本文对颈动脉粥样硬化与脑梗死亚型的相关性综述如下。     

颈动脉斑块与冠状动脉粥样硬化相关性研究

目的 通过超声检查判定颈动脉斑块性质,并分析其与冠心病(CHD)冠脉病变的关系.方法 选取2016年1月至2017年1月张家口市建国医院心内科收治的CHD患者214例,经冠脉造影检查显示:冠脉轻度狭窄患者36例(轻度组),中度狭窄患者72例(中度组),重度狭窄患者106例(重度组),采用彩色多普勒超声诊断仪对入选患者颈动脉粥样硬化斑块类型及形态进行检查,并分析其与冠脉病变之间的关系;同时设置同期来院体检正常者30例(对照组)进行对照观察.结果 CHD3个亚组患者颈动脉内中膜厚度(IMT)、斑块数量、体积均明显高于对照组,差异有统计学意义(P<0.05);重度组IMT、斑块数量均明显高于轻、中度组,差异有统计学意义(P<0.05);中度组IMT、斑块数量明显高于轻度组,差异有统计学意义(P<0.05);重度组患者颈动脉不稳定斑块检出率明显高于中、轻度组,差异有统计学意义(P<0.05);中度组患者颈动脉不稳定斑块检出率明显高于轻度组,差异有统计学意义(P<0.05);重度组、中度组患者颈动脉稳定斑块检出率均明显高于轻度组,差异有统计学意义(P<0.05);重度组及中度组患者中颈动脉稳定斑块检出率比较,差异无统计学意义(P>0.05).Logistic相关性分析显示,颈动脉Crouse积分与冠脉Gensini评分均具有相关性(P<0.05).结论 CHD患者颈动脉不稳定斑块检出率越高,预示CHD患者冠脉硬化程度越重,颈动脉斑块性质与CHD患者冠脉病变程度密切相关.     

颈动脉粥样硬化与冠状动脉狭窄相关性探讨

目的探讨颈动脉粥样硬化病变的性质、程度与冠状动脉狭窄程度之间的关系。方法选择265例经过冠状动脉造影的冠心病患者,常规做颈动脉超声检查。依据冠状动脉造影结果分为冠脉狭窄组和未狭窄组。按冠状动脉狭窄程度分为3个亚组,即轻度、中度、重度狭窄组。结果冠脉狭窄组颈动脉粥样硬化斑块检出率、内膜病变率和粥样斑块性质与未狭窄组比较,差异有统计学意义(P<0.01),且随着冠状动脉狭窄程度加重,颈动脉粥样斑块检出率明显增加(P<0.01)。经相关性分析,冠状动脉狭窄程度与颈动脉内膜增厚、斑块检出率和病变性质均呈正相关。结论颈动脉粥样硬化病变与冠状动脉狭窄病变有显著的相关性;对于冠心病高危人群常规颈动脉超声检查可用于估计冠状动脉粥样硬化病变的状况。     

缺血性脑血管病患者颈动脉粥样硬化斑块稳定性与颈动脉狭窄度检测

目的 :检测缺血性脑血管病患者颈动脉粥样硬化斑块稳定性和颈动脉狭窄度。方法 :1 1 2例缺血性脑血管病患者按颈动脉超声表现分为 3组 :颈动脉正常组、稳定性斑块组、不稳定性斑块组 ;3组患者均行颅脑CT平扫记录颈动脉的梗死灶数 ;以超声测算患者动脉管腔狭窄度 ,分为轻、中、重度狭窄 3组。结果 :颈动脉正常组 33例 ,稳定性斑块组 38例 ,不稳定性斑块组 4 1例 ,3组患者颈内动脉分布区梗死灶数经统计学处理差异有统计学意义 (P<0 .0 5 ) ;稳定性斑块和不稳定性斑块组中 ,重度狭窄 7例 ,中度狭窄 1 6例 ,轻度狭窄 5 6例。结论 :基于颅脑CT平扫的颈内动脉分布区梗死灶数可以反映颈动脉斑块不稳定性 ;稳定斑块和不稳定斑块缺血性脑血管病患者颈动脉狭窄以轻度为主 ,其构成以为 70 .89%。     

Evaluating non-invasive medical imaging for diagnosis of carotid artery stenosis with ischemic cerebrovascular disease

Objectives To assess the value of non-invasive medical imaging for diagnosis of carotid artery stenosis and to study the relationship between stenosis and brain infarction.Methods Thirty-one patients with a total of 62 carotid arteries were studied using Doppler ultrasound (DUS)and magnetic resonance angiography(MRA),Eleven of the 31 patients were studied using CT angiography(CTA).CT and MRI of the brain were also done in all patients.The imaging results in 5 patients were compared with those of digital subtraction angiography(DSA).Eight patients with severe stenosis received carotid endarterectomy.The comparisons between the imaging results and pathological data were conducted in 2 patients. Results Of the 62 carotid arteries,mild stenosis was seen in 11,moderate in 14,severe in 21,obstructed in 4 and normal in 12.In 25 patients with severe stenosis or occlusion of carotid arteries,there were a total of 35 focal or multifocal infarcts on the ipsilateral cerebral hemisphere,and 15 infarcts on the contrary side.Compared with the results of the operations,DUS correctly diagnosed 6 stenoses,while MRA identified 7 correctly and CTA 8.Agreement on location of stenosis as performed by endarterectomy,DUS,MRA and CTA occurred in all patients.Histologically,areas of calcification and fibrousness were related to high densities on CTA,strong echoes on DUS,and low signal intensities on MRA.Relatively large amounts of necrotic material and foam cells filled with lipolytic materials on the intimal surface of arteries were observed during pathologically,corresponding to low and iso-densities of CTA.low echoes on DUS,and inhomogeneous signal intensities on MRA.Conclusions A strong link exists between carotid stenosis and brain infarction.The combined use of DUS,MRA and CTA can improve diagnostic accuracy for the assessment of carotid artery stenosis,as well as assist in ascertaining the nature of the plaque.     

128层螺旋CT头颈部血管成像评估急性脑梗死患者颈动脉狭窄的临床价值

目的研究128层螺旋CT头颈部血管成像评估急性脑梗死患者颈动脉狭窄的临床价值。方法选取我院2010年3月至2013年3月急性脑梗死患者58例为观察组,同时选取同期就诊的非急性脑梗死患者58例为对照组,两组均采用128层螺旋CT头颈部血管成像技术进行诊断。根据检测所获得的图像比较两组颈动脉狭窄程度和双侧颈动脉斑块的分布情况。结果观察组二次诊断81.03%的患者出现颈动脉狭窄,较对照组48.28%显著较高(P0.05),其中轻度狭窄44.83%、中度狭窄24.14%,与对照组的25.86%、10.34比较显著较高(P0.05);观察组斑块总检出率为71.78%较对照组的54.45%均显著较高(P0.05)。结论临床上应用128层螺旋CT头颈部血管成像技术可更有效的评估急性脑梗死患者劲动脉狭窄情况,其双侧颈动脉斑块检出率更高,对诊断急性脑梗死有重要作用,有应用推广价值。     

彩色多普勒超声联合CTA检查对脑梗死患者颅外颈动脉斑块性质的诊断价值

目的研究彩色多普勒超声联合电子计算机断层扫描血管造影(CTA)检查对脑梗死患者颅外颈动脉斑块性质的诊断价值。方法选择2016年8月至2018年8月我院收治的98例有颈动脉斑块的脑梗死患者作为研究对象。所有患者均在发病一周内进行彩色多普勒超声及CTA检查,同时随机选择40例患者进行数字减影血管造影(DSA)检查,比较彩色多普勒超声及CTA检查颈动脉狭窄程度、斑块检出及斑块位置检出情况,并与DSA检查对比。结果 98例进行彩色多普勒超声及CTA检查的患者共检查血管数588根,同时40例进行DSA检查的患者检查血管240根,CTA及DSA检查对不同程度颈动脉狭窄检出率均高于彩色多普勒超声检查,差异具有统计学意义(P<0.05);彩色多普勒超声与CTA检查在轻度与中度颈动脉狭窄的诊断上一致性较低,在重度与完全闭塞颈动脉狭窄的诊断上一致性较强;98例患者中,彩色多普勒超声检出斑块135个,CTA检查检出斑块149个,同时40例进行DSA检查的患者中,检出斑块88个,CTA检查在颈内动脉斑块检出率明显高于彩色多普勒超声检查,差异具有统计学意义(P<0.05);彩色多普勒超声与CTA检查在软斑、扁平斑、硬斑及溃疡性混合斑的检出上一致性较强;彩色多普勒超声与CTA检查在颈总动脉及颈总动脉分叉处的斑块检出上一致性较强。结论通过与DSA检查结果比较,彩色多普勒超声与CTA检查在诊断脑梗死患者颅外颈动脉斑块性质、发生部位及颈动脉狭窄程度上各具优势,结果一致性良好,联合检测具有较高的诊断价值,值得临床推广应用。     

脑卒中患者的颈动脉粥样硬化病变比较研究

这了探讨颈动脉粥样硬化程度、性质特点和及卒中的关系，对１４例脑卒中病例（脑出血７例，脑梗塞７例）的颈动脉进行了病理观察及形态定量分析。结果显示：脑出血病灶例颈动脉存在明显粥样硬化性狭窄，Ｐ〈０．０５，脑梗塞患者的颈动脉粥样硬化程度重于脑出血，尤以颈内动脉表现为著，Ｐ〈０．０５，脑梗塞患者的颈动脉粥样硬化斑块具备不稳定的组织学特性，为夹层动脉瘤，动脉内膜溃疡，附壁血栓或质地松散，密度不均易脱落的斑块     

CT血管成像评估颈动脉粥样硬化与远期卒中的临床研究

目的：探讨CT血管成像评估颈动脉粥样硬化与远期卒中的临床价值。方法选取颈动脉粥样硬化患者120例作为观察组,同期选择除外颈动脉粥样硬化的120例患者作为对照组,2组都进行CT血管成像评估、临床资料的调查与远期随访。结果观察组的颈动脉狭窄程度多为重度与闭塞,而对照组多为中度与轻度;观察组的颈动脉斑块类型多为易损斑块,而对照组多为稳定斑块,对比差异有统计学意义(P<0.05)。观察组与对照组随访6个月的卒中发生率分别为26.7%和5.0%,观察组明显高于对照组(P<0.05);同时多因素Logistic回归分析,结果显示颈动脉狭窄程度(OR=3.327,95%CI：1.211～9.145)、颈动脉斑块形态(OR=3.699,95%CI：1.292～10.589)都为远期卒中的主要独立危险因素。结论 CT血管成像能有效评估颈动脉粥样硬化的狭窄程度与斑块形态,远期卒中的发生率也比较高,而狭窄程度与斑块形态与远期卒中密切相关,为此CT血管成像对判断预后具有重要的指导意义。     

Gadolinium-enhanced magnetic resonance angiography in renal artery stenosis: comparison with digital subtraction angiography.

OBJECTIVES: To evaluate the accuracy of gadolinium-enhanced magnetic resonance angiography in assessing renal artery stenosis compared to catheter digital subtraction angiography. DESIGN: Retrospective study. SETTING: Singapore General Hospital. PATIENTS: Records of patients who underwent magnetic resonance angiography as well as digital subtraction angiography for assessment of renal artery stenosis from January 2003 to December 2005 were reviewed. RESULTS: There were 27 patients (14 male, 13 female) with a mean age of 62 (range, 44-77) years. There were 10 patients with renal transplants; their native renal arteries were not evaluated. Each of the two experienced interventional and body magnetic resonance radiologists, who were blinded to the results, reviewed the digital subtraction angiography and magnetic resonance angiography images respectively. Digital subtraction angiography was used as the standard of reference. A total of 39 renal arteries from these 27 patients were evaluated. One of the arteries was previously stented and could not be assessed with magnetic resonance angiography due to severe artefacts. Of the remaining 38 renal arteries, two were graded as normal, seven as having mild stenosis (<50%), eight as having moderate stenosis (> or =50% but <75%), and 21 as having severe stenosis (> or =75%). Magnetic resonance angiography and digital subtraction angiography were concordant in 89% of the arteries; magnetic resonance angiography overestimated the degree of stenosis in 8% and underestimated it in 3% of them. In the evaluation of clinically significant renal artery stenosis (> or =50%) with magnetic resonance angiography, the overall sensitivity, specificity, positive predictive value, and negative predictive value were 97%, 67%, 90%, and 86% respectively. The sensitivity and specificity of magnetic resonance angiography in transplant renal artery stenosis was 100%. CONCLUSION. Our experience suggested that gadolinium-enhanced magnetic resonance angiography is a sensitive non-invasive modality useful in the assessment of clinically significant renal artery stenosis.     

颈动脉粥样斑块形成与非心源性缺血性卒中相关性探讨

目的:探讨缺血性卒中部位及严重性与颈动脉彩超所示部位及严重性是否存在明显相关性。方法:回顾性收集急性缺血性脑卒中患者400例,排除心源性卒中,行美国国立研究院卒中量表(NIHSS)评分及颈动脉彩超检查。结果:脑梗死病灶同侧斑块为204例,占51%,病灶对侧斑块为108例,占27%,斑块中均以软斑及混合斑所占比例为高;NIHSS评分轻度者狭窄占58例(24%),中度者狭窄占61例(49.2%),重度及极重度者狭窄占27例(79.4%),且评分重者斑块多发。结论:颈动脉粥样斑块形成与脑梗死密切相关,且病变血管与梗死部位存在相关性,病变严重性与脑血管病严重性亦明显相关。     

脑梗死患者颅内外动脉粥样硬化性狭窄及影响因素分析

目的 分析脑梗死患者颅内外动脉粥样硬化性狭窄的分布情况,探讨动脉粥样硬化危险因素与病变部位的关系.方法 搜集2008年7月至2010年6月间在北京大学人民医院神经内科住院的由经颅多普勒、颈动脉彩色超声、颅内磁共振血管成像和数字减影血管造影诊断存在颅内和(或)颅外动脉粥样硬化性狭窄的428例脑梗死患者资料,根据血管病变部位分组,比较各组间动脉粥样硬化危险因子的差别.结果 颅内动脉病变组199例(46.5%),颅外动脉病变组129例(30.1%),颅内合并颅外动脉病变组100例(23.4%);颅内动脉病变组总胆固醇(TC)、低密度脂蛋白胆固醇酯(LDL-C)水平高于其他两组(TC:P1=0.001,P2=0.000;LDL-C:P1=0.004,P2=0.039),颅内合并颅外动脉病变组男性比例高于颅内动脉病变组(P=0.003).结论 脑梗死患者颅内动脉粥样硬化性狭窄多于颅外,单纯颅内动脉狭窄组血脂控制欠佳,大多数传统的动脉粥样硬化危险因素并不是动脉狭窄发生部位的决定因子.

Abstract：

Objective To investigate the distribution of atherosclerotic stenosis of cerebral arteries in Chinese patients suffered from cerebral infarction,and to determine if there are any factors correlating with intracranial and extracranial atherosclerosis.Methods For this study,we enrolled 428 consecutive inpatients with cerebral infarction,All patients were examined with transcranial Doppler ultrasonography (TCD) and carotid duplex ultrasound to detect atherosclerotic lesions in intracranial and extracranial cerebral arteries,some also were examined by magnetic resonance angiography (MRA) and/or digital subtraction angiography(DSA),they were all diagnosed as atherosclerotic cerebral artery stenosis.The patients were divided into three groups according to the different location of lesions,the frequency of risk factors of atherosclerosis and the demographic parameters were compared among these groups.Results 199 cases (46.5%) had only intracranial artery stenosis,129 cases (30.1%) had only extracranial artery stenosis,100 cases (23.4%) had both intracranial and extracranial stenosis (combine group).Compared with the other two groups,the levels of total cholesterol and low density lipoprotein-cholesterol of the intracranial artery group are both significantly higher(TC:P1 = 0.001,P2 = 0.000;LDL-C:P1 = 0.004,P2 = 0.039),the combine group had a significant higher ratio of male than that of the intracranial artery group (P =0.003),there were no any other atherosclerosis risk factors had association with the location of cerebral artery stenosis.Conclusion The occurrence of stenosis in intracranial arteries is more frequent than that in extracranil arteries in Chinese patients with cerebral infarction,and the lipid level is higher in the intracranial artery group,most risk factors of atherosclerosis may not be major determinants of location for cerebral atherosclerosis.