胃和冲剂对胃溃疡模型大鼠的抗溃疡作用及对其胃？…

目的：研究胃和冲剂１、２号对大鼠胃粘膜损伤程度和实验性大鼠胃液的影响。方法：两实验均将大鼠随机分成生理盐水组,胃和冲剂１、２号组疗雷尼替丁组,每天给药１次。实验１按要求连续给药３ｄ,第３天给药后１ｈ,在大鼠皮下注射消炎痛,７ｈ后将动物处死,观察胃粘膜损伤程度。     

胃康冲剂防治大鼠胃溃疡的作用

目的：探讨胃康冲剂促进溃疡愈合的作用和机制。方法：用乙酸浸渍的滤纸片腐蚀胃壁复制大鼠胃溃疡模型,测定胃粘膜表面粘液厚度,胃液中的表皮生长因子（EGF）,胃组织的一氧化氮（NO）与血浆6－酮－前列腺素F1α（6－K－PGF1α）水平。结果：造模后各组与正常对照组比较,胃粘膜表面粘液厚度显著降低（P＜0．01）,胃液中EGF、胃组织中NO与血浆6－K－PGF1α－水平平均显著降低（均P＜0．01）,胃饲不同剂量胃康冲剂使胃粘膜表面粘液厚度显著增加（P＜0．01）,胃液中EGF、胃组织NO水平,血浆6－K－PGF1α均显著升高（P＜0．05）。结论：胃康冲剂对胃粘膜具有明显的保护作用,其机制是增加胃粘膜表面粘液厚度与提高EGF、NO6－K－PGF1α细胞保护因子的水平。     

胃安冲剂治疗慢性胃炎和消化性溃疡的疗效观察

慢性胃炎、消化性溃疡是常见的上消化道疾病，可引起多种消化不良及疼痛等症状，有些甚至久治不愈，严重影响了病人的生活和工作。为了减轻病人的痛苦，开发利用我国丰富的中药资源，我们应用胃安冲剂治疗上述疾病，获得满意的疗效，现报告如下。     

和胃冲剂对胃肠运动影响的实验研究

[目的] 观察含阳春砂、绿壳砂、缩砂的3种和胃冲剂对胃肠动力的促进作用,筛选出较优组方,探讨剂量反应关系。[方法] 采用营养性半固体灌胃法观察服用3种和胃冲剂前后小肠推进比和胃排空率的变化。[结果]3种和胃冲剂有明显的促胃肠动力作用,与西沙必利相近(P>0. 05),明显高于对照组(P<0 .05)。3种冲剂对胃肠动力的影响差异无统计学意义(P>0 .05),其中含阳春砂和胃冲剂对胃肠促进作用优于另两种;不同剂量和胃冲剂作用比较差异无统计学意义(P>0. 05)。[结论] 和胃冲剂能有效地促进正常小鼠胃肠动力。3 种冲剂作用强度依次为:含阳春砂和胃冲剂>含绿壳砂和胃冲剂>含缩砂和胃冲剂。增大和胃冲剂剂量,促胃肠动力作用无明显改变。     

康尔胃抗消化性溃疡复发的临床研究

据报道,消化性溃疡治愈停药后1年内复发率为70%～90%[1],目前尚无理想的抗复发措施。中医治疗本病具有复发率低、无毒副作用等特点,但迄今为止,尚无中药抗复发的报道。笔者总结多年治疗消化性溃疡经验,制成康尔胃冲剂,自1993年12月～1998年1月应用该药抗溃疡病复发,经过4年的临床研究,取得良好疗效,现将结果报告如下。1　资料与方法1.1　临床资料:选择病例均为经雷尼替丁、法莫替丁及洛赛克等药治疗、未用任何抗幽门螺杆菌(HP)治疗、且1周内经胃镜复查确诊溃疡已愈合者,共计156例,男121例,女35例;年龄17～79岁,平均41岁;病程1～20年,平均5…     

胃苏冲剂治疗胆囊炎36例

1．1一般资料本组36例，其中男19例，女17例；年龄22～58例，平均36岁；发病时间最短3天，最长27个月，平均为58天。     

萎胃冲剂对大鼠慢性萎缩性胃炎治疗作用的研究

[目的]观察萎胃冲剂对大鼠慢性萎缩性胃炎(CAG)的治疗作用.[方法]以自研中药萎胃冲剂对脱氧胆酸造模的复合型CAG大鼠进行治疗,观察其体重、胃液酸度及胃蛋白酶活性,胃黏膜组织病理变化等方面的作用,并以胃苏冲剂作对照.[结果]萎胃冲剂可增加造模大鼠的体重,提高其降低的胃液酸度和胃蛋白酶活性,改善其胃黏膜组织的病理变化,效果明显优于胃苏冲剂.[结论]萎胃冲剂对大鼠CAG具有良好的治疗作用.     

康尔胃治疗难治性溃疡及抗复发作用的临床研究

难治性溃疡是指不能用一般的内科治疗方法治愈、或症状持续不退，或反复发作的消化性溃疡［1我们于1993年12月～1997年12月用康尔胃冲剂治疗本病39例，现将结果报告如下。l资料与方法1．互病例选择：根据江绍基拟定的标准【门，结合临床，诊断标准修订如下：①有典型症状如胃痛、吞酸、呕吐等持续2年以上，或吐血、黑便经常发生者；②经胃镜诊断为胃或十二指肠溃疡，排除胃癌及胃泌素瘤；③系统接受H。受体桔抗剂治疗2个月以上无效者；④排除有明显饮食不节史，或长期服阿斯匹林、消炎痛、激素等药者。按上述方法选择病例39例．其中男27例…     

健脾理气颗粒对大鼠胃溃疡作用的研究

目的：研究健脾理气颗粒对大鼠胃溃疡及胃粘膜损伤的作用。方法：采用水浸应激致胃溃疡及口服乙醇致胃粘膜损伤法制模，再用健脾理气颗粒3个剂量组进行药效评价，并设对照组进行比较。结果：健脾理气颗粒3个剂量组对大鼠应激性胃溃疡的形成有明显的抑制作用（P＜0.05-0.01)，对口服乙醇致胃粘膜损伤也有保护作用，尤以10g/kg、20g/kg组为明显（P＜0.05-0.01)。结论：健脾理气颗粒具有明显地抑制大鼠胃溃疡及保护胃粘膜损伤作用。     

胃灵颗粒对大鼠乙酸胃溃疡愈合质量的影响

目的 :研究胃灵颗粒对大鼠乙酸慢性胃溃疡愈合质量的影响。方法 :用冰醋酸制备大鼠乙酸慢性胃溃疡模型 ,随机分为 5组 ,分别灌服蒸馏水 ,雷尼替丁 ,低、中、高剂量胃灵颗粒 ,用苏木精 -伊红染色对大鼠愈合性胃溃疡再生粘膜进行定量观察 ,并测胃壁结合粘液量、胃酸、胃蛋白酶活性。结果 :胃灵颗粒组改善胃粘膜的组织损伤 ,并提高胃壁结合粘液量 ,减少胃酸的排出。结论 :胃灵颗粒能提高溃疡愈合质量 ,是临床抗消化性溃疡复发的可能机制之一。     

消化性溃疡活动期脾胃湿热证胃液及血前列腺素E2水平的研究

目的 :探讨胃液及血前列腺素 E2 (PGE2 )水平与消化性溃疡活动期脾胃湿热证的关系。方法 :采用放射免疫法对 30例确诊为消化性溃疡活动期 (APU)脾胃湿热型血液及胃液中 PGE2 水平进行检测 ,并与 2 0例非脾胃湿热型和正常对照组比较。结果 :APU患者胃液中 PGE2 低于正常对照组 ,且以脾胃湿热型为最低。而血中 PGE2检测结果刚好与此相反。结论 :PGE2 与 APU脾胃湿热证的形成有一定关系。     

Non-Traumatic Perforation of Gastric Ulcer in a Hiatal Hernia to the Pericardium

ABSTRACT A patient with ulcer in a hiatal hernia with perforation to the pericardial sac is reported. The symptoms and signs of non-traumatic perforation from esophagus or stomach to the pericardium or heart are described on the basis of a brief review of the literature. A prominent feature of our patient was long-standing pain in the left shoulder. We suggest that this symptom may be a warning of threatening pericardial perforation.     

Gastric Emptying of a Liquid Meal in Health and Duodenal Ulcer Disease

In the present investigation an extension of the method of George was used, which allows the rate of emptying of the gastric content (GC) to be assessed. The aim of the study was to find out whether there is any difference in gastric emptying rate of a liquid meal of 750 ml 10% glucose (glucose monohydrate, mol. wt. 198) between healthy subjects and duodenal ulcer patients (DU). The straight numerical volume of GC, the logarithm and the square root of GC were related to time, and these functions were compared. The correlation coefficient for the regression line for these functions showed that data both for healthy subjects and DU gave a better fit to the GC/time and ?GC/time relationship than to a semi-logarithmic function, when the starting point at time zero was excluded. Regardless of the type of transformation of the basic data, there was no difference between healthy controls and DU as regards the regression coefficient, indicating that from 20 min after the installation of the test volume the GC is decreasing at the same rate in the two groups. When the straight numerical volume of GC was used, there was a significant difference in the extrapolated Y-intercept for the regression lines between healthy subjects and the DU, indicating an increased initial emptying in the DU patients. This was further confirmed when the volume emptied during consecutive 20-min periods was estimated. Furthermore, there was a shorter emptying time in patients with duodenal ulcer than in healthy controls.     

Effect of Ranitidine and Cimetidine on Gastric Ulcer Healing and Recurrence

Fifty-eight patients with endoscopically confirmed benign gastric ulceration were randomly allocated to treatment with 150 mg ranitidine twice daily, placebo matching ranitidine twice daily, or 200 mg Cimetidine three times daily and 400 mg at night. Patients were endoscoped at monthly intervals for up to 3 months, the endoscopist being unaware of the treatment. Significantly more ulcers (p < 0.05) had healed after 2 months of ranitidine (14 of 18, 78%) and Cimetidine (17 of 20, 85%) than with placebo (9 of 20, 45%; P < 0.05) and after 3 months of ranitidine (15 of 18, 88%) and Cimetidine (18 of 20, 90%) than with placebo (11 of 20, 55%; p < 0.05). Forty-eight patients with healed ulcers were randomly allocated in a double-blind prophylactic study to recieve 150 mg ranitidine at night or matching placebo. After 6 months recurrent ulcers were found in 2 of 24 (8%) of patients receiving ranitidine and 10 of 24 (42%) of patients receiving placebo (p < 0.05). These data indicate that H₂-receptor antagonists are significantly better than placebo in healing gastric ulceration and that ranitidine and Cimetidine are equally effective. Ranitidine is significantly superior to placebo in preventing gastric ulcer recurrence.     

Changes in Gastric Mucosal Blood Flow during Healing of EMR-Induced Ulcer

Abstract: We used the laser Doppler method to study the difference in gastric mucosal blood flow changes between peptic ulcer (65 cases) and artificial ulcer caused by endoscopic mucosal resection (35 cases) during their respective healing processes. At each endoscopic ulcer stage, blood flow at the ulcer margin and that in the surrounding mucosa were measured. In the artificial ulcer, which heals easily, blood flow at the ulcer margin was still high at the scarring stage as compared with that in the corresponding area of a peptic ulcer, which is prone to relapse. Moreover, the blood flow ratio (blood flow at the ulcer margin/blood flow in the surrounding mucosa) at the S1 stage in artificial ulcers was significantly higher than that in peptic ulcers (p<0.05). These results suggest that blood flow in the SI stage is an important aspect of ulcer healing and relapse.     

胃克星抗消化性溃疡的药理研究

目的：探讨胃克星抗消化性溃疡的药理作用。方法：观察药物对小鼠水浸应激性溃疡，无水乙醇性溃疡，慢性乙酸烧灼性溃疡模型和大鼠胃蛋白酶、胃酸活性的影响。结果：胃克星对小鼠水浸应激性胃溃疡，无水乙醇性溃疡的形成有显著预防作用（P＜0．05，＜0．01）；对乙酸烧灼性溃疡等有显著治疗作用（P＜0．05，＜0．01），并可显著抑制胃酸和胃蛋白酶分泌（P＜0．05，＜0．01）。结论：胃克星具有抗消化性溃疡的作用。     

消化性溃疡和胃癌病人血清可溶性IL－2受体和纤维结合素的观察

用多克隆单克隆夹心ＥＬＩＳＡ法和单向扩散法测定溃疡病和胃癌患者血清可溶性白细胞介素２受体（ｓｏｌｕｂｌｅＩＬ－２ｒｅｃｅｐｔｏｒｓ，ＳＩＬ－２Ｒ）和纤维结合素（ｆｉｂｒｏｎｅｃｔｉｎ，ＦＮ）。结果显示溃疡病血清ＳＩＬ－２Ｒ和ＦＮ分别为２１２．９２±１２２．２７Ｕ／ｍｌ和２９８．０９±３３．４６ｎｇ／ｍｌ，胃癌分别为５５９．２７±２３４．０１Ｕ／ｍｌ和３３６．６５±３９．２１ｎｇ／ｍｌ。与正常人２４０．０±９７．０７Ｕ／ｍｌ和３２３．６４±２８．２１ｎｇ／ｍｌ比较，胃癌患者ＳＩＬ－２Ｒ水平明显升高（Ｐ＜０．００１），其中肿瘤有转移者低于无转移者（Ｐ＜０．０５）。这表明血清ＳＩＬ－２Ｒ和ＦＮ检测可做为胃癌病人病情监测和判断预后的指标，亦可用以签别良性和恶性溃疡。