3M液体敷料和长效抗菌材料洁悠神在失禁性皮炎中的联合应用

目的探讨3M液体敷料联合长效抗菌材料洁悠神(JUC)对于妇产科患者失禁性皮炎的治疗作用。方法选择入院期间出现失禁性皮炎的94例妇产科患者,进行病情严重程度评估,随机分为实验组48例和对照组46例。实验组采用3M液体敷料联合JUC专门护理皮肤,对照组则采用既往护理手段,比较2组皮炎改善情况以及愈合时间。结果实验组患者相关治疗效果优于对照组,差异有统计学意义(P0.05),尤其对于重度患者差异更显著(P0.01)。结论 3M液体敷料联合长效抗菌材料洁悠神治疗因大小便失禁引起的妇产科患者会阴部失禁性皮炎,能提高治疗效果,减轻患者痛苦,缩短病程,减少费用,有一定推广价值。     

洁悠神长效抗菌材料治疗急性头面部创伤的效果

目的观察洁悠神长效抗菌材料治疗急性头面部创伤的疗效。方法将81例创伤患者,随机分为两组,实验组采用洁悠神长效抗菌材料治疗创面,对照组采用传统的清创、抗感染治疗创面。观察两组治疗效果。结果两组患者创面完全愈合时闻比较,差异具有统计学意义（t=7．191,P〈0．05）;两组患者换药时疼痛情况比较,差异有统计学意义（t=21．443,P〈0．05）。结论洁悠神长效抗菌材料治疗急性头面部创伤,具有创面完全愈合时间短、患者疼痛缓解明显、依从性好等优点,值得临床上推广应用。     

“洁悠神”对留置尿管伴随性尿路感染的临床观察

目的：探讨＂洁悠神＂对留置尿管伴随性尿路感染的临床疗效。方法：选择需留置导尿的男性患者60例,随机分为对照组和观察组各30例。对照组按常规嘱患者或家属用温水清洁会阴部及尿管表面,每日2次,再用生理盐水棉球擦净尿道口、龟头、包皮周围皮肤和尿管表面分泌物,每日2次;观察组按常规嘱患者或家属用温水清洁会阴部及尿管表面,每日2次,选用长效抗菌材料＂洁悠神＂喷洒导尿管表面和尿道口。观察两组置管期间尿液细菌培养结果。结果：观察组置管期间尿培养阳性例数显著低于对照组（P〈0.01）。结论：对留置导尿管患者使用长效抗菌材料＂洁悠神＂进行导尿管表面和尿道口喷洒能有效降低尿路感染的发生。     

洁悠神与氟康唑治疗小儿鹅口疮93例临床疗效对比

目的:比较洁悠神长效抗菌材料(洁悠神)与氟康唑治疗小儿鹅口疮的临床疗效.方法:将93例鹅口疮患儿随机分洁悠神组48例与氟康唑组45例.洁悠神组用温水清洁口腔后喷洒洁悠神,氟康唑组予口服氟康唑胶囊,比较两组患儿口腔体征的改善情况,观察不良反应.结果:洁悠神组与氟康唑组治疗小儿鹅口疮疗效相近(P＞0.05).两组均无发生严重不良反应.结论:洁悠神与氟康唑治疗鹅口疮疗效相近,只需喷洒,无需涂抹,操作简便,安全性高,依从性好.     

洁悠神配合湿敷治疗急性湿疹糜烂渗出创面的效果

目的探讨长效抗菌材料洁悠神配合湿敷治疗急性湿疹糜烂渗出创面的效果。方法将130例急性湿疹糜烂渗出创面病人随机分为两组。在常规治疗和护理基础上，对照组采用乳酸依沙丫啶溶液湿敷糜烂渗出创面；观察组使用乳酸依沙丫啶溶液湿敷创面后，配合使用洁悠神，将其均匀喷洒于糜烂渗出创面上，共治疗2个疗程。结果观察组疗效明显优于对照组（Z=2．32，P〈0．05）。观察组治愈时间较对照组短，自觉症状较对照组轻，差异有显著性（t=2．26，X^2=7．15，P〈0．05）。结论洁悠神配合乳酸依沙、r啶溶液湿敷治疗急性湿疹糜烂渗出创面效果显著，值得临床推广。     

洁悠神联合红光治疗在失禁性皮炎中的应用

目的探讨洁悠神联合红光治疗失禁性皮炎的临床效果。方法将本院收治的62例失禁性皮炎患者采用随机数字表法分为观察组和对照组,每组各31例;对照组使用常规治疗方法,观察组采用洁悠神外用,同时联合红光照射;比较两组的治疗效果。结果观察组组的治疗总有效率为96.77%,高于对照组的70.97%,差异有统计学意义(P0.05)。结论洁悠神联合红光治疗失禁性皮炎的效果良好,且起效快、疗程短,能促进伤口愈合,减轻患者疼痛。     

不同方法处理危重病人腹泻致肛周皮炎的效果观察

目的探讨危重病人腹泻引起肛周皮炎的更好处理方法，减少压疮的发生。方法将2011年9月～2013年2月入住ICU、因腹泻引起肛周皮炎的63例危重病人，按随机数字法分为两组。对照组采用造口护肤粉进行肛周皮炎的处理；实验组采用洁悠神（长效抗菌材料）进行肛周皮炎的处理。两组病人均由护理组长查房后开具相应护嘱，交由责任护士落实各项护嘱要求，护理组长督导落实效果，每天跟踪各组肛周皮炎病人的治疗效果，收集两组病人2d、5d和7d的治愈人数，以及Ⅱ期压疮发生人数等指标。结果实验组较对照组2d、5d、7d治愈人数多，未发生Ⅱ期压疮。结论造口护肤粉与长效抗菌材料均能治愈危重病人的肛周皮炎，但长效抗菌材料比造口护肤粉治疗时间更短，效果更佳。     

留置导尿管患者应用新型抗菌材料的尿道护理分析

目的研究留置导尿管患者在尿道护理中应用新型抗菌材料的价值。方法选择2014年3月~2017年5月我院接受手术治疗并留置导尿管的患者320例,随机为对照组和观察组,各160例。对照组采用常规的尿道护理,并使用抗感染药物静滴预防感染;观察组在对照组的基础上使用新型抗菌材料喷洒(对导尿管和尿道口喷洒洁悠神)。比较两组术后尿路感染发生率。结果观察组术后3d、7d、14d尿路感染发生率分别为1.88%、3.75%、4.38%;对照组分别为6.25%、9.38%、11.88%;两组比较差异有统计学意义(P0.05);两组均未出现明显的护理不良反应。结论在留置导尿管患者的尿道护理中应用新型抗菌材料洁悠神对尿道口、导尿管及与之接触到的衣物、被褥喷洒,能有效保证尿路的清洁无菌,在尿道口、导尿管壁形成一层抗菌分子膜,预防细菌的繁殖,防止尿路感染,促进患者术后康复,且应用方法简单、安全性高。     

激光仪、抗菌材料用于失禁性皮炎的观察及护理

目的探讨激光仪、抗菌材料用于失禁性皮炎的效果。方法将123例失禁性皮炎患者随机分成观察组和对照组,对照级采用常规护理,涂抹护臂膏;观察组用花椒油、长效抗菌材料、激光机照射、保护材料。结果观察组失禁性皮炎的疗效优于对照组(P0.05)。结论花椒油、长效抗菌材料、激光机照射、保护材料用于失禁性皮炎效果好,值得在临床上推广。     

洁悠神在PICC皮肤护理中的应用

目的探讨洁悠神喷雾剂预防PICC置管后局部感染及皮肤过敏的疗效。方法选择44例PICC置管术后使用3M透明敷料覆盖穿刺点患者作为对照组,44例PICC置管术后使用3M透明敷料覆盖穿刺点前喷洒洁悠神长效抗菌剂的患者作为实验组,比较两组的使用效果。结果实验组局部感染发生率为2.3%,对照组为12%;实验组皮肤过敏比率为2.3%,对照组为16%,2组比较差异有统计学意义(P<0.05)。结论洁悠神长效抗菌剂预防PICC穿刺局部感染及皮肤过敏均具有良好效果。     

洁悠神长效喷雾剂治疗鼻咽癌放疗中放射性口腔黏膜炎的疗效观察

目的评价洁悠神长效喷雾剂预防及治疗放射性口腔黏膜炎的临床疗效。方法 94例鼻咽癌放射治疗患者随机分为2组,实验组47例用洁悠神长效喷雾剂联用氯乙定含漱剂含漱,对照组47例用氯乙定含漱剂(洗必泰)含漱进行治疗,观察放射性口腔黏膜炎的发生程度。结果实验组放射性口腔黏膜炎的发生率明显低于对照组。结论洁悠神长效喷雾剂作为一种治疗口腔黏膜炎的口腔用药,可以减少或减轻放射性口腔黏膜的损伤。     

儿童特应性皮炎患者过敏原检测及氯雷他定联合他克莫司的疗效观察

目的检测儿童特应性皮炎的过敏原及观察氯雷他定联合他克莫司治疗儿童特应性皮炎的临床疗效。方法对78例特应性皮炎患儿采用BICOM生物共振体外过敏原检测系统检测过敏原;选用氯雷他定联合他克莫司治疗,并进行临床观察比较。结果特应性皮炎患儿过敏原检测中以食物组过敏原最常见（χ^2=6．24,P〈0．05）;食物组过敏原中以食品添加剂包括防腐剂、香精、香料、甜味剂、食用色素等所占比例最高,达42．4％,其次是鱼类、鸡蛋、牛奶等食物。氯雷他定联合他克莫司治疗儿童特应性皮炎效果明显。结论食品添加剂是儿童特应性皮炎主要的过敏原,氯雷他定联合他克莫司治疗儿童特应性皮炎有效。     

IL-10 is critical for Th2 responses in a murine model of allergic dermatitis

We found that mechanical injury to mouse skin, which can be caused by tape stripping, results in rapid induction of IL-10 mRNA. IL-10-/- mice were used to examine the role of IL-10 in a mouse model of allergic dermatitis induced by epicutaneous (EC) sensitization with OVA on tape-stripped skin. Skin infiltration by eosinophils and expression of eotaxin, IL-4, and IL-5 mRNA in OVA-sensitized skin sites were severely diminished in IL-10-/- mice. Following in vitro stimulation with OVA, splenocytes from EC-sensitized IL-10-/- mice secreted significantly less IL-4, but significantly more IFN-gamma, than splenocytes from WT controls. A similar skewing in cytokine secretion profile was observed in the splenocytes of IL-10-/- mice immunized intraperitoneally with OVA. IL-10-/- APCs skewed the in vitro response of OVA T cell receptor (TCR) transgenic T cells towards Th1. Examination of the Th response of WT and IL-10-/- mice immunized with OVA-pulsed WT or IL-10-/- DCs revealed that both DCs and T cells participate in IL-10 skewing of the Th2 response in vivo. These results suggest that IL-10 plays an important role in the Th2 response to antigen and in the development of skin eosinophilia in a murine model of allergic dermatitis.     

Potential of atelocollagen-mediated systemic antisense therapeutics for inflammatory disease

To study the possibility of using atelocollagen as an oligonucleotide (ODN) delivery carrier in vivo, the activity of formulated antisense ODN targeted against the intercellular adhesion molecule-1 (ICAM-1) mRNA was investigated in an allergic dermatitis model in mice. The allergic dermatitis was elicited in one ear of animals sensitized by treatment with 2,4-dinitrofluorobenzene. Antisense ODN was given to the animals as a single intravenous injection of formulation containing atelocollagen. Antisense activity was determined by measurement of ear thickness, histopathology, and immunohistochemistry 24 hr after the initiation of the dermatitis. Antisense activity was found to increase according to the concentration of atelocollagen in the formulation. The effect mediated by the ODN formulated with 0.05% atelocollagen was more than 50 times greater than that provided by ODN infusion, although the levels of ODN formulated with atelocollagen dropped below that of the 24-hr infusion group within 30 min. The formulated ODN could suppress inflammatory progression by treatment at 8 hr after the ear challenge when inflammation had already commenced at the challenged site. Moreover, antisense activity was noted even when the formulated ODN was injected 3 days before the initiation of inflammation. These data demonstrate that atelocollagen can enhance antisense activity remarkably and that the sustainable antisense activity mediated by the formulation of ODN with atelocollagen could completely change the strategy of antisense therapeutics.     

气囊填堵联合壳聚糖抗菌成膜喷剂治疗肠造口周围皮炎的效果观察

目的探讨气囊填堵联合壳聚糖抗菌成膜喷剂治疗肠造口周围粪水性皮炎的方法及效果。方法将60例肠造口4级粪水性皮炎患者随机分为试验组和对照组,试验组运用气囊填堵肠造口收集管理粪水后,再用壳聚糖抗菌成膜喷剂外喷相结合的方法护理;对照组给予常规护肤粉护理。结果治疗后第1天两组效果比较无差异(P>0.05),治疗后第3天、第5天试验组治疗效果优于对照组(P<0.05)。结论气囊导尿管填堵联合壳聚糖抗菌成膜喷剂应用于肠造口周围粪水性皮炎护理,能有效促进粪水性皮炎的愈合,可尝试在临床推广。     

Chitosan hydrogel for topical delivery of ebastine loaded solid lipid nanoparticles for alleviation of allergic contact dermatitis

Ebastine, is an antihistamine drug that exerts its effect upon oral administration in humans for the treatment of allergic contact dermatitis (ACD), it also has some systemic side effects like gastric distress, headache, drowsiness, and epistaxis. Moreover, topical corticosteroids are used for treatment of ACD, which causes the human skin to lose its thickness and elasticity. Hence, ebastine-loaded solid lipid nanoparticles (E-SLNs) were prepared and their topical efficacy against allergic contact dermatitis was determined. Compritol 888 ATO and tween 80 were used to prepare E-SLNs by cold dilution of the hot micro-emulsion. E-SLNs were optimized statistically by employing a central composite design using Design-Expert® version 11.0. Optimized E-SLNs showed spherical surface morphology, zeta potential of −15.6 ± 2.4 mV, PDI of 0.256 ± 0.03, and particle sizes of 155.2 ± 1.5 nm and th eentrapment efficiency of ebastine was more than 78%. Nanoparticles were characterized using FT-IR, XRD, and TEM. An E-SLNs loaded hydrogel was prepared using chitosan as a gelling agent and glutaraldehyde as a crosslinker. In vitro drug release studies performed for 24 hours on the E-SLNs dispersion and E-SLNs loaded hydrogel showed a sustained release of maximum 82.9% and 73.7% respectively. In vivo studies were conducted on BALB/c mice to evaluate the topical efficacy of the E-SLNs loaded hydrogel for allergic contact dermatitis. ACD was induced on the ear using picryl chloride solution. After induction, ears were treated daily with the E-SLNs loaded hydrogel for 15 days. Swelling behavior, mast cell count, and histopathological studies of the ear confirmed that the hydrogel alleviated the symptoms of allergic contact dermatitis.

Ebastine exerts its effect upon oral administration in humans for the treatment of allergic contact dermatitis (ACD), but it has some systemic side effects. Hence, ebastine-SLNs loaded hydrogel was prepared to increase topical efficacy of ebastine.     

Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease

IgE induced by type 2 immune responses in atopic dermatitis is implicated in the progression of atopic dermatitis to other allergic diseases, including food allergies, allergic rhinitis, and asthma. However, the keratinocyte-derived signals that promote IgE and ensuing allergic diseases remain unclear. Herein, in a mouse model of atopic dermatitis–like skin inflammation induced by epicutaneous Staphylococcus aureus exposure, keratinocyte release of IL‑36α along with IL-4 triggered B cell IgE class-switching, plasma cell differentiation, and increased serum IgE levels—all of which were abrogated in IL-36R–deficient mice or anti-IL‑36R–blocking antibody–treated mice. Moreover, skin allergen sensitization during S. aureus epicutaneous exposure-induced IL-36 responses was required for the development of allergen-specific lung inflammation. In translating these findings, elevated IL‑36 cytokines in human atopic dermatitis skin and in IL‑36 receptor antagonist–deficiency patients coincided with increased serum IgE levels. Collectively, keratinocyte-initiated IL‑36 responses represent a key mechanism and potential therapeutic target against allergic diseases.     

洁悠神在会阴切开术后切口中的应用效果观察

目的探讨洁悠神（JUC）在会阴切开术后切口中的应用效果观察。方法随机将300例在本院行会阴切开术的初产妇分为两组,每组各150例。实验组产妇在会阴切开术中缝合前给予洁悠神喷雾喷射切口缘,对照组则不使用任何药物,术后两组均应用0.5%碘伏消毒液切口,每日2次。比较两组产妇术后切口疼痛、炎性反应、愈合情况。结果两组患者术后切口疼痛、炎性反应、愈合情况比较,均P＜0.05,差异具有统计学意义,实验组患者明显优于对照组。结论会阴切开术后应用洁悠神喷雾能长效抗菌,有效降低术后产妇切口疼痛程度及炎症反应,提高切口甲级愈合率,值得临床推广应用。     

新生儿红臀与局部微生物感染的关系

选择新生儿科2001年8月-2002年8月收治的日龄1-9 d的40例红臀患儿与对照组新生儿进行观察。红臀病例组检出6例白色念珠菌(15％),其中5例为男性,而对照组中仅在1例男性儿检出(2.5％),两组比较有显著性差异(P相似文献   

过敏性皮炎野苋菜花粉皮试与总IgE的相关性研究

目的 了解野苋菜花粉在南昌地区过敏性皮炎中的作用情况。方法 选择170例临床诊断为过敏性皮炎的病人，用野苋菜花粉及春、夏、秋三季花粉的提取液做皮试，并测定它们的血清总IgE。结果 发现野苋菜花粉是南昌地区过敏性皮炎的重要变应原，野苋菜花粉皮试阳性和阴性的患者间的总IgE有明显的差异（P＜0．01）。结论 野苋菜花粉皮试应作为南昌及其周围地区过敏性皮炎的常规检验。