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1.

Objective

In midst of the overdose crisis, the clinical features of opioid overdoses seem to be changing. Understanding of the adverse effects of synthetic opioids such as fentanyl is currently limited to clinical settings. Insite, a supervised injection site in Vancouver, Canada, provides an opportunity to better understand illicit drug overdose presentations.

Methods

A review of clinical records at Insite for October 2016 to April 2017 was undertaken to quantify atypical overdose presentations. Overdose reports were reviewed for the number of atypical opioid overdose presentations, temporal trends over the study period, concurrent symptoms, and interventions employed by staff.

Results

Insite staff responded to 1581 overdoses during the study period, including 497 (31.4%) that did not fit a typical presentation for opioid overdoses. Of these, 485 fit into five categories of atypical features: muscle rigidity, dyskinesia, slow or irregular heart rate, confusion, and anisocoria. Muscle rigidity was the most common atypical presentation, observed in 240 (15.2%) of the overdose cases, followed by dyskinesia, observed in 150 (9.2%). Slow or irregular heart rate was observed in 69 (4.4%) cases, confusion in 24 (1.5%), and anisocoria in 2 (0.1%) of overall overdose cases.

Discussion

The similarity of atypical overdose cases at Insite with anesthesiology case reports supports the understanding that the illicit drug supply is contaminated by fentanyl and other synthetic opioids. Atypical overdose presentations can affect clinical overdose response. The experience at Insite highlights the potential for supervised consumption sites to be innovative spaces for community learning and knowledge translation.
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2.

Aim

Lymphatic filariasis is an important public health problem that causes economic loss and poverty in many endemic regions of India. This study explores the influence of socioeconomic factors on filariasis prevalence in the Chittoor district of Andhra Pradesh.

Subjects and methods

To understand the influence of socioeconomic variables on lymphatic filariasis, a pilot-scale epidemiological and socioeconomic study was conducted in 30 villages of Chittoor district, Andhra Pradesh, India, from 2004 to 2007. Data were analyzed statistically by frequency distribution, multivariate logistic regression and principal component analysis (PCA).

Results

A total of 5133 blood samples were collected and screened for microfilaria; 77 were found to be positive (1.52 %). The multivariate analysis showed that variables such as age (OR?=?2.4, 95 % CI: 1.47–4.01), income [Indian rupees (INR): <1000: OR?=?4.2, 95 % CI: 1.48–11.76; INR: 1000–3000: OR?=?3.84, 95 % CI:1.92–7.68], drainage system (OR?=?3.5, 95 % CI: 1.62–7.5), mosquito avoidance (OR?=?1.41, 95 % CI: 0.69–2.87) and participation in mass drug administration (MDA) programs (OR?=?1.33, 95 % CI:0.74–2.38) were risk factors for filariasis. The socioeconomic index derived from the PCA was categorized into low (1.7 %), medium (1.7 %) and high (1.3 %) in relation to the percentage of parasite prevalence.

Conclusion

This study reveals that filariasis is largely associated with various socioeconomic factors. Hence, health officials should focus on improving the quality of life to minimize the filarial incidence in the endemic villages by considering the socioeconomic index as a marker for targeting low and medium socioeconomic level groups for disease control programs.
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3.

Background

Occupational exposure is known to play a role in the aetiology of lymphomas. The aim of the present work was to explore the occupational risk of the major B-cell lymphoma subtypes using a case–control study design.

Methods

From 2009 to 2014, we recruited 158 lymphoma cases and 76 controls in the provinces of Bari and Taranto (Apulia, Southern Italy). A retrospective assessment of occupational exposure based on complete work histories and the Carcinogen Exposure (CAREX) job-exposure matrix was performed.

Results

After adjusting for major confounding factors, farmers showed an increased risk of diffuse large B-cell lymphoma (DLBCL) [odds ratio (OR)?=?10.9 (2.3–51.6)] and multiple myeloma (MM) [OR?=?16.5 (1.4–195.7)]; exposure to the fungicide Captafol was significantly associated with risk of non-Hodgkin lymphoma (NHL) [OR?=?2.6 (1.1–8.2)], particularly with the risk of DLBCL [OR?=?5.3 (1.6–17.3)].

Conclusions

Agricultural activity seems to be a risk factor for developing lymphoma subtypes, particularly DLBCL, in the provinces of Bari and Taranto (Apulia Region, Southern Italy). Exposure to the pesticides Captafol, Paraquat and Radon might be implicated.

Trial registration

Protocol number UNIBA 2207WEJLZB_004 registered 22/09/2008.
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4.

Objectives

We conducted a meta-analysis to determine the association between Chlamydia trachomatis and adverse perinatal outcomes.

Methods

Electronic databases were searched between 1970 and 2013. Included studies reported perinatal outcomes in women with and without chlamydia. Summary odds ratios were calculated using fixed- and random-effects models. Study bias was assessed using a Funnel Plot and Begg’s test.

Results

Of 129 articles identified, 56 studies met the inclusion criteria encompassing 614,892 subjects. Chlamydia infection in pregnancy was associated with preterm birth (OR?=?1.27, 95% CI 1.05, 1.54) with a large quantity of heterogeneity (I2?=?61%). This association lost significance when limiting the analysis to high-quality studies based on the Newcastle–Ottawa Scale. Chlamydia infection in pregnancy was also associated with preterm premature rupture of membranes (OR?=?1.81, 95% CI 1.0, 3.29), endometritis (OR 1.69, 95% CI 1.20, 2.38), low birthweight (OR 1.34, 95% CI 1.21, 1.48), small for gestational age (OR 1.14, 95% CI 1.05, 1.25) and intrauterine fetal demise (OR 1.44, 95% CI 1.06, 1.94).

Conclusions

This review provides evidence that chlamydia in pregnancy is associated with a small increase in the odds of multiple adverse pregnancy outcomes. The literature is complicated by heterogeneity and the fact that the association may not hold in higher quality and prospective studies or those that use more contemporary nucleic acid testing.
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5.

Background

This study aims to evaluate variation in somatic symptoms by age using patient health questionnaire-9 (PHQ) depression scores, which may be helpful in identifying depression.

Methods

The study evaluated a nationally representative cross-sectional sample of community-dwelling adults in Japan in 2013. We utilized the PHQ to identify risk for depression, with PHQ?≥?10 defining at least moderate depression. Bivariate and factor analyses were used to capture underlying patterns in self-reported symptoms over a 30?day period; aged-stratified multivariate logistic regression was performed to further explore associations between age, symptoms, and depression.

Results

Of 3753 respondents, 296 (8, 95% CI 7.0–8.8) reported a PHQ?≥?10; 42% of these were male and mean age was 51.7?years old (SD?=?18.6). Multivariate analysis showed that presence of fatigue and malaise (OR?=?1.7, 95% CI 1.3–2.4) was significantly associated with PHQ?≥?10. After stratification by age, PHQ?≥?10 was associated with gastrointestinal complaints among 18–39?year olds (OR?=?1.7, 95% CI 1.0–2.9); fatigue and malaise (OR?=?1.8, 95% CI 1.1–3.1) among 40–64?year olds; and fatigue and malaise (OR?=?1.8, 95% CI 1.1–3.0) as well as extremity pain (OR?=?1.7, 95% CI 1.0–2.8) in over 65?year olds.

Conclusion

Age-related somatic symptom correlates of PHQ?≥?10 differ across the lifespan. Predominantly gastrointestinal symptoms in younger patients, and generalized fatigue, malaise, and musculoskeletal pain in older groups were observed. In order for screening physicians to proactively identify depression, awareness of age-related somatic symptoms is warranted.
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6.

Background

Return to work (RTW) is a key parameter of outcome quality that ensures social participation. Therefore, this study analyses the sociodemographic and disease-related determinants of RTW among newly diagnosed breast cancer patients.

Methods

In a prospective, multicentre cohort study, breast cancer patients were surveyed three times: directly after surgery, after 10?weeks, and after 40?weeks. Logistic regression analysis was applied to estimate the association of RTW at 40?weeks following discharge with sociodemographic and disease-related characteristics (n =?577).

Results

The sociodemographic variables “entrance certificate at a university of applied science” compared to “university entrance certificate” (OR?=?3.1, 95%-CI?=?1.2–8.1), age group “55–59?years” compared to “18–44?years” (OR?=?3.2, 95%-CI?=?1.2–8.4) and “having children” (OR?=?2.8, 95%-CI?=?1.2–6.2) as well as the disease-related variables “rehabilitation” (OR?=?0.5, 95%-CI?=?0.3–0.9), self-rated health “good” and “excellent” compared to “bad” (OR?=?2.7, 95%-CI?=?1.4–5.5; OR?=?11.6, 95%-CI?=?4.2–31.8) and the UICC-classification “stage II” and “stage III/IV” in comparison to “stage 0/I” (OR?=?0.5, 95%-CI?=?0.3–0.8; OR?=?0.2, 95%-CI?=?0.1–0.5) significantly affect RTW among breast cancer patients (Nagelkerke’s Pseudo-R2 =?0.275).

Conclusions

The findings show that significant differences in RTW exist between patient groups and suggest that RTW issues must be addressed more effectively before, during and after treatment. For future research on RTW in Germany, longitudinal studies with a follow-up of several years are necessary. Information and support deficits should be tackled by social services or breast care nurses.

Trial registration

Database Health Services Research, VfD_PIAT_12_001630, registered 01.03.2012
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7.

Background

This paper will determine whether expanding Insite (North America’s first and only supervised injection facility) to more locations in Canada such as Montreal, cost less than the health care consequences of not having such expanded programs for injection drug users.

Methods

By analyzing secondary data gathered in 2012, this paper relies on mathematical models to estimate the number of new HIV and Hepatitis C (HCV) infections prevented as a result of additional SIF locations in Montreal.

Results

With very conservative estimates, it is predicted that the addition of each supervised injection facility (up-to a maximum of three) in Montreal will on average prevent 11 cases of HIV and 65 cases of HCV each year. As a result, there is a net cost saving of CDN$0.686 million (HIV) and CDN$0.8 million (HCV) for each additional supervised injection site each year. This translates into a net average benefit-cost ratio of 1.21: 1 for both HIV and HCV.

Conclusions

Funding supervised injection facilities in Montreal appears to be an efficient and effective use of financial resources in the public health domain.
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8.

Aim

Problematic mobile phone use (PMPU) is defined as an inability to regulate one’s use of the mobile phone, including excessive use, gradual increase in use to get the gratification, interference with school and other personal activities, and the need to avoid emotional alterations when mobile phone use is impeded. The potential health risks of PMPU have attracted increasing research attention. This study investigated the proportion of PMPU and the interactive effect of PMPU and depressive symptoms with alcohol use among college students in Anhui Province, China.

Subjects and methods

A cross-sectional study was conducted among 2,376 college students between May and June 2012. PMPU, depressive symptoms and alcohol use were measured by self-reported validated instruments. Multivariable logistic regression models were used to examine the independent and interactive effects of PMPU and depressive symptoms with alcohol use.

Results

Results revealed the proportion of PMPU was 27.9 %, while the prevalence of depressive symptoms and alcohol use was 18.9 and 37.5 %, respectively. PMPU was significantly associated with alcohol use independently (OR?=?1.30, 95 % CI?=?1.04–1.61), and there was no significant increase with alcohol use in students with depressive symptoms (OR?=?1.18, 95 % CI?=?0.93–1.50). There was a multiplicative interaction between PMPU and depressive symptoms with alcohol use (OR?=?1.46, 95 % CI?=?1.04–2.03).

Conclusion

We conclude that there is a significant relationship between PMPU and alcohol use, and a significant multiplicative interactive effect of PMPU and depressive symptoms with alcohol use among college students, in Anhui, China. These findings may have important implications for designing and implementing mental health programs at universities.
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9.

Background

Tuberculosis is a major disease worldwide and most research focus on risk factors for adults, although there is a marked adolescent peak in incidence. The objective of this study was to identify risk factors for tuberculosis in children aged 7 to 19.

Methods

A case control study matched by age with 169 cases and 477 controls. The study population consisted of adolescents and older children from Recife, Brazil. Cases were individuals diagnosed with tuberculosis in the control programme and controls were selected in the neighborhood of cases. Conditional logistic regression was used to identify risk factors.

Results

Cigarette smoking increased by 50% the risk of tuberculosis but that this was not statistically significant (OR?=?1.6). Other risk factors were sleeping in the same house as a case of tuberculosis (OR?=?31.6), living in a house with no piped water (OR?=?7.7) (probably as a proxy for bad living conditions), illiteracy (OR?=?3.7) and male sex (OR?=?1.8). The increase in risk with living in houses with no piped water was much more marked in males. The proportion of cases of tuberculosis attributed to contact with someone with TB was 38% and to illiteracy, lack of piped water and smoking, 20%.

Conclusion

Household contact with tuberculosis, social factors and male sex play the biggest role in determining risk of TB disease among children and adolescents in the study. We recommend further research on the relationship of cigarette smoking on tuberculosis in adolescents, and on whether the sex differentials are more marked in bad living conditions. Separate studies should be conducted in older children and in adolescents.
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10.

Background

The quality of life for childhood cancer patients is impaired by this disease and its treatment. Knowing the factors that contribute most to this framework allows identifying the greatest needs, subsidized preventive strategies. The objective of the study was assessing the factors associated with health-related quality of life among children with cancer from the standpoint of patients and caregivers.

Methods

A cross-sectional study was conducted with sample consisted of 71 patients between the ages of 5 and 18 as well as their caregivers. Two forms (clinical examination and interview) from the National Oral Health Survey, the Modified Oral Assessment Guide and the Pediatric Quality of Life Inventory (PedsQLTM) version 3.0 were used as data collection instruments.

Results

From the standpoint of the caregivers, having fewer cognitive difficulties (OR?=?0.92), fewer pain symptoms and hurt (OR?=?0.94) and lower procedure anxiety (OR?=?0.93) were associated with higher quality of life scores; by contrast, being female (OR?=?9.49), the number of household members (OR?=?1.94) and smiling with embarrassment (OR?=?13.82) were associated with lower quality of life score. From the standpoint of patients, having fewer cognitive difficulties (OR?=?0.94) and positive perception of physical appearance (OR?=?0.94) were associated with higher quality of life scores; by contrast, smiling with embarrassment (OR?=?11.56) and toothaches (OR?=?7.37) were associated with lower quality of life score.

Conclusions

The patient and caregiver symptom reports yielded distinct results, although cognitive difficulties and smiling with embarrassment were significantly associated with impaired quality of life on both types of reports.
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11.

Aim

The objective of this study was to determine risk factors for non-communicable diseases (NCDs) on the basis of socio-demographic characteristics, lifestyle-related determinants, environmental and psychological characteristics, and individual and family disease history among university students in Bangladesh.

Study design

Cross-sectional survey.

Methods

Using the WHO STEPwise approach for NCDs, a cross-sectional study was conducted among 1,140 students. The collected data were analyzed using the Statistical Package for Social Sciences (SPSS) software, version 22.

Results

In all, 29.2% of the respondents (BMI?≥?23.00 kg/m2) were overweight and/or obese, and almost two-thirds (65%) of them did not take part in any physical activity (PA). A third (33.3%, p?=?0.002) of male smokers reported health problems and it was found that environmental tobacco smoke (ETS) was significantly responsible for developing asthma (OR?=?0.55; CI?=?0.33–0.93). Individual and family history of NCDs was statistically significant for obesity and asthma and considerably increased the odds ratio for heart disease.

Conclusion

This study shows that the number of students suffering from different types of NCDs is not negligible. Their lifestyle and family history of NCDs are responsible for this to a significant extent. Urgent initiatives should be taken to rein in the spread of NCDs among the youth of Bangladesh.
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12.

Objective

This study aimed to examine perceptions of shopping difficulty, and the relationships with satisfaction with state of health and meals, physical condition, food diversity and health behavior in older people living alone in Japan.

Design

A cross-sectional, multilevel survey was designed. The questionnaire was distributed by mail and self-completed by participants.

Setting

The sample was drawn from seven towns and cities across Japan.

Participants

A geographic information system was used to select the sample of older people living alone, by proximity to a supermarket. In total, 2,346 older people (827 men and 1,519 women) completed the questionnaire.

Measurements

The dependent variable was whether shopping was easy or difficult. A logistic regression analysis was performed, adjusting for age, socioeconomic status and proximity of residence to a supermarket using stepwise variable analyses.

Results

The response rate was 67.8%. Overall, 14.5% of men and 21.7% of women considered shopping difficult. The stepwise logistic analysis showed that the factors most strongly related to shopping difficulty were a subjective feeling of poor health (men: OR = 3.01, women: OR = 2.16) and lack of satisfaction with meals (men: OR = 2.82, women: OR = 3.69). Other related physical condition and dietary factors were requiring nursing care (men: OR = 3.69, women: OR = 1.54), a high level of frailty, measured using the frailty index score (women: OR = 0.36) and low food diversity score (men: OR = 1.84, women: OR = 1.36).

Conclusion

The study found that older people’s assessment of their shopping difficulty was related to satisfaction aspects, including a subjective feeling of poor health, and lack of satisfaction with meals, as well as physical condition. These have a greater influence on shopping difficulty than income in both sexes, and proximity to a supermarket in women.
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13.

Purpose

Little is known about specific concerns facing long-term melanoma survivors. The goal of this study was to compare quality of life (QOL) and mental health between long-term melanoma survivors and population controls.

Methods

Participants from a previously conducted case-control study of risk factors for melanoma were recruited for a cross-sectional survey. Generic QOL and emotional health were measured using the SF-36 and Hospital Anxiety and Depression Scale questionnaires. A total of 724 melanoma survivors and 660 controls participated. Most melanoma survivors had stage I disease (85.6%); mean time from diagnosis was 9.6?±?1.0 years. Comparisons of QOL measures between melanoma survivors and controls were conducted using regression models, adjusting for potential confounders.

Results

Melanoma survivors, compared to controls, reported statistically significant but only slightly higher physical functioning and bodily pain QOL subscale scores than controls and otherwise similar QOL as measured by the remaining six SF-36 subscale scores. Prevalence of anxiety (18.1% vs. 19.3%, adjusted OR?=?1.00 (0.74, 1.36); p?=?1.00) and depression (7.2% vs. 9.8%, adjusted OR?=?0.74 (0.48, 1.16); p?=?1.00) were similar between melanoma survivors and controls.

Conclusion

Long-term early stage melanoma survivors report similar general QOL and mental health compared to population controls. Further research is needed to identify concerns more specific to melanoma.
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14.
15.

Background

The prevalence of HIV in Malawi is one of the highest in sub-Saharan Africa, and misconceptions about its mode of transmission are considered a major contributor to the continued spread of the virus.

Methods

Using the 2010 Malawi Demographic and Health Survey, the current study explored factors associated with misconceptions about HIV transmission among males and females.

Results

We found that higher levels of ABC prevention knowledge were associated with lower likelihood of endorsing misconceptions among females and males (OR?=?0.85, p?<?0.001; OR?=?0.85, p?<?0.001, respectively). Compared to those in the Northern region, both females and males in the Central (OR?=?0.54, p?<?0.001; OR?=?0.53, p?<?0.001, respectively) and Southern regions (OR?=?0.49, p?<?0.001; OR?=?0.43, p?<?0.001, respectively) were less likely to endorse misconceptions about HIV transmission. Moreover, marital status and ethnicity were significant predictors of HIV transmission misconceptions among females but not among males. Also, household wealth quintiles, education, religion, and urban–rural residence were significantly associated with endorsing misconceptions about HIV transmission.

Conclusion

Based on our findings, we recommend that education on HIV transmission in Malawi should integrate cultural and ethnic considerations of HIV/AIDS.
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16.
17.

Background

In 2001, the National Health Interview Survey (NHIS) commenced in Taiwan. This survey, conducted on a sample of the whole Taiwanese population, is nationally representative and has a high response rate (>80 %). As a result, the four already completed surveys from 2001 to 2013 can be used to investigate the time trend of smoking prevalence, the rate of cessation, and exposure to secondhand smoking.

Methods

There were 72918 adults combined from the 2001, 2005, 2009 and 2013 National Health Interview Surveys (NHIS). Smoking status, exposure to secondhand smoking, and smoking cessation were asked, as well as demographic characteristics and other variables. Statistical analyses with sampling weights were carried out using SAS and SUDAAN.

Results

In males, the prevalence of smoking significantly decreased (rates in 4 surveys were 44.4 %, 44.6 %, 38.9 %, and 34.2 %, respectively). Since 2005 the rate of smoking cessation increased significantly (p?=?0.033). The odd ratio (OR) exposure of secondhand among non-smokes (OR) in 2009 and 2013 were 0.96 (CI?=?0.85–1.08) and 0.78 (CI?=?0.70–0.88) comparing to 2005. In females, the prevalence of smoking was stable over time. The rate of smoking cessation only appeared significantly high in the older age group. The OR for exposure to secondhand smoking were 0.81 (CI?=?0.74–0.89) and 0.68 (CI?=?0.62–0.74), for 2009 and 2013 comparing to 2005, respectively.

Conclusion

Early anti-smoking legislation in Taiwan might have raised the awareness of the harm of smoking. However, the implementation of the Tobacco Hazards Prevention Act (THPA) in 2009 had great contribution to the reduction of smoking rate, especially in males.
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18.

Aim

Socioeconomic status (SES) is one of the most important determinants of health. Subjective social status (SSS) is a popular SES indicator. The objective of this study is to compare the associations between health and various SES indicators in order to examine whether SSS is a proper SES indicator.

Subject and methods

In this 2013 cross-sectional study, 1,995 Tehrani residents were selected through multi-stage random sampling. The questionnaires included items on subjective and objective SES, self-rated health (SRH) and objective health status. The crude and adjusted associations between health and SES indicators were assessed using bivariate and multiple logistic regressions.

Results

The crude associations between SSS and all assessed health outcomes were significant. After adjustment of the wealth index, consumption, education and occupation, the associations between SSS and SRH (OR?=?0.69, CI 95 %: 0.55–0.86) and having cardiovascular (OR?=?0.73, CI 95 %: 0.58–0.92), musculoskeletal (OR?=?0.81, CI 95 %: 0.70–0.94), asthma and other respiratory diseases (OR?=?0.71, CI 95 %: 0.54–0.92) still remained significant. The adjusted associations between SSS and having hypertension and diabetes were not significant. SSS had a stronger correlation with the wealth index (Spearman r?=?0.42) compared to other SES indicators.

Conclusion

SSS showed a significant association with most of the health outcomes, independent of other SES indicators; therefore, it can be used in health research, though it is not an exact alternative for other objective SES indicators.
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19.

Objectives

In older adults, nutritional health is essential for good quality of life and living independently at home. Especially in cancer patients, malnutrition is common and known to complicate treatment. This study aims to evaluate the nutritional status and its associated factors in community-dwelling older adults with and without cancer.

Design

This is an observational study.

Setting

This study focuses on older community-dwelling people.

Participants

This study included older people with and without cancer (≥70 years). Cancer patients included patients with a new diagnosis of breast, lung, prostate, or colorectal cancer.

Measurements

Data collection included measures of nutritional status, quality of life, depression, fatigue, distress and functional status. We used multivariate logistic regression analysis to assess the association between personal characteristics and malnutrition.

Results

Data were available for 657 people; 383 people without cancer and 274 with a cancer diagnosis. Overall, malnutrition was detected in 245 (37.5%) people; in cancer patients this was 66.1%. Multivariate analysis showed that having cancer (OR 14.4, 95% CI: 8.01 - 23.3), being male (OR 2.38, 95% CI: 1.49–3.70), having depression (OR 13.5, 95% CI: 6.02-30.0), distress (OR 2.60, 95% CI: 1.55–4.37) and impaired instrumental activities of daily living (IADL) (OR 2.63, 95% CI: 1.63–4.24) were associated with a higher risk of malnutrition.

Conclusion

The prevalence of malnutrition in community-dwelling older people is high, particularly in patients with cancer. Benchmarking and routine screening of older patients may be helpful strategies to increase awareness of (risk of) malnutrition among professionals.
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20.

Background

Numerous studies reported that dyslipidemia was associated with cancer risk. However, few studies investigated the associations between dyslipidemia and non-small cell lung cancer (NSCLC).

Methods

Four hundred twenty-four histologically confirmed NSCLC cases and 414 controls, matched for age and sex, were enrolled to examine the relationship between dyslipidemia and NSCLC. Demographic and clinical data were obtained from patients’ medical records and telephone interviews. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression.

Results

Abnormal triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels showed statistically significant coexistence with NSCLC compared with controls. Higher levels of TG were associated with a higher risk of NSCLC (OR?=?1.541, 95% CI, (1.072–2.215)). The odds ratios (ORs) for NSCLC for normal and high levels of HDL-C versus those with a low level of HDL-C were 0.337(95% CI, (0.242–0.468)) and 0.288(95% CI, (0.185–0.448)), respectively. After adjustment for age, sex, smoking status, hypertension, body mass index, diabetes and lipid profiles, the adjusted OR for normal and high levels of HDL-C were 0.320(95% CI, (0.218–0.470)) and 0.233(95% CI, (0.134–0.407)), respectively. However, after adjustment, high levels of TG increased the risk of NSCLC but not significantly (OR?=?1.052, 95% CI (0.671–1.649)).

Conclusions

This study provided evidence that dyslipidemia increased the risk of NSCLC in Chinese population.
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