Isolated genital annular lichen planus

Annular lichen planus is a rarely reported variant of lichen planus (LP). Although genital lesions are frequent in patients with LP, isolated genital LP is rarely reported. We present a case of a 29-year- -old circumcised man with an asymptomatic annular lesion of the penis. Histopathological features were consistent with LP. Topical clobetasol was prescribed, with clinical improvement. It is important to consider annular LP among the possible diagnoses of individual annular genital lesions.     

环状扁平苔藓一例

本例患者的临床与组织病理表现符合扁平苔藓的诊断,但有其特殊之处：（1）无口腔黏膜损害,皮疹分布于上背部及右侧髋部。（2）无瘙痒症状。（3）两处皮损在临床上形态完全不同。上背部皮损表现为环形堤状隆起,临床上类似于汗孔角化病。右侧髋部皮损为椭圆形,边缘为淡红色隆起性边缘,中央褐色色素沉着,表面附着鳞屑。（4）两处皮损虽然临床表现不同,但组织病理表现相同,均符合扁平苔藓的特征,并且均可见到表皮下疱形成。     

Letter: Isolated annular lichen planus of lower lip

Lichen planus (LP), the prototype of lichenoid dermatoses, is an idiopathic inflammatory disease of the skin and mucous membranes, hair follicles, and nails. It rarely occurs on the lips and usually then in association with oral lesions. We report a 40-year-old man with a 3-month history of an isolated single annular violaceous plaque of the lower lip. The rest of his mucosae, skin, hair and nails were normal. Histopathology confirmed the diagnosis of LP. The patient was advised to use topical tacrolimus 0.03 percent cream twice daily along with multivitamins, but the patient was lost to follow-up. Isolated LP of the lip is unusual, although this condition may be underestimated and therefore under-reported in the literature.     

沿Blaschko线分布的环状萎缩性扁平苔藓一例

患者男,10岁.左侧躯干、左上肢带状皮损9年,于2007年8月7日至我科就诊.9年前无明显诱因左上腹部出现散在紫红色粟粒大小丘疹,无明显鳞屑,皮损逐渐增多,并呈离心性向外扩展,形成边缘隆起而中央萎缩的环状损害,部分融合成片状,沿左侧躯干腹背部带状分布.5年前左上肢、肘关节伸侧出现类似皮疹,亦逐渐增多、扩散,部分融合,并呈不规则沿左上肢纵轴向上下延伸,分别至左侧上胸部和左手指背.     

Successful treatment of psoriatic arthritis and comorbid annular atrophic lichen planus with etanercept

Psoriasis vulgaris and lichen planus are distinct T-cell-driven inflammatory skin diseases. Both present in a variety of clinical subtypes. Mucosal or nail involvement may be present. Here, we report the rare concomitant clinical presentation of psoriatic arthritis and annular atrophic lichen planus on the trunk of a 52-year-old male patient. Treatment with sulfasalazine failed to control inflammatory activity; methotrexate and leflunomide were ceased due to side-effects. After confirmation of both diagnoses, we initiated a tumor necrosis factor (TNF)-α-directed therapy with the fusion protein etanercept resulting in significant improvement of both conditions. This case report aims to highlight the rare colocalization of psoriasis and lichen planus, the rare entity of annular atrophic lichen planus, and to discuss a possible beneficial impact of certain TNF-α inhibitors on subtypes of lichen planus.     

Food allergen‐mediated exacerbations of oral lichen planus

Erosive oral lichen planus (OLP) is a chronic autoimmune condition of unknown aetiology, characterized by periods of exacerbation and quiescence. Many patients with OLP report triggers of flares that overlap with triggers of other oral diseases, including oral allergy syndrome (OAS), an IgE‐mediated food allergy. We report a case that, to our knowledge, is the first reported case of concurrent OLP and OAS diagnoses, which provides insight into the triggers of OLP and the role of trigger avoidance. A woman in her 60s presented with erosive OLP refractory to prednisone and azathioprine. She reported that certain food exposures triggered flares of her OLP. She was subsequently diagnosed with concurrent OAS, and avoidance of food allergens resulted in a clinically significant improvement in her OLP, eventually allowing her to taper off systemic treatment altogether. Further studies are needed to pinpoint common triggers and examine the role of trigger avoidance as a management strategy for OLP.