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Transcatheter left atrial appendage occlusion with Amplatzer devices to obviate anticoagulation in patients with atrial fibrillation. 总被引:12,自引:0,他引:12
Bernhard Meier Igor Palacios Stephan Windecker Martin Rotter Qi-Ling Cao David Keane Carlos E Ruiz Ziyad M Hijazi 《Catheterization and cardiovascular interventions》2003,60(3):417-422
It is assumed that over 90% of clinically apparent embolisms in atrial fibrillation originate from the left atrial appendage. Recently, a percutaneous method (PLAATO technique) to occlude the left atrial appendage to the end of preventing thromboembolic complications of atrial fibrillation has been introduced into clinical practice. This technique is quite intricate and requires general anesthesia. The Amplatzer atrial septal occluder lends itself for a more simple approach to this intervention. The first 16 patients treated at four centers are described. Their age varied from 58 to 83 years. All suffered from atrial fibrillation but eight of them were in sinus rhythm at the time of implantation. All but two procedures were done under local anesthesia of the groin only. There was one technical failure (device embolization) requiring surgery. All other patients left the hospital a day after the procedure without complications. There were no problems or embolic events during an overall follow-up of 5 patient-years and all left atrial appendages were completely occluded without evidence of thrombosis at the atrial side of the device at the latest follow-up echocardiography. With the Amplatzer technique, the left atrial appendage can be percutaneously occluded with a venous puncture under local anesthesia, without echocardiographic guidance, and at a reasonable risk. It remains to be evaluated in larger series or randomized trials how the simpler Amplatzer technique compares with the complex PLAATO technique, and whether left atrial appendage closure is competitive with oral anticoagulation with warfarin or the novel ximelagatran to prevent thromboembolism in atrial fibrillation. 相似文献
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Intracardiac versus transesophageal echocardiography for left atrial appendage occlusion with watchman 下载免费PDF全文
Antonio H. Frangieh MD Jasmina Alibegovic MD Christian Templin MD Oliver Gaemperli MD Slayman Obeid MD Robert Manka MD Erik W. Holy MD Willibald Maier MD Thomas F. Lüscher MD Ronald K. Binder MD 《Catheterization and cardiovascular interventions》2017,90(2):331-338
Background: Left atrial appendage occlusion (LAAO) is mostly performed by transesophageal echocardiography (TEE) guidance. Intracardiac echocardiography (ICE) may be an alternative imaging modality for LAAO that precludes the need for general anesthesia or sedation. Methods and Results: All consecutive single center, single operator LAAO candidates were analyzed. Baseline clinical and procedural characteristics and in‐hospital outcomes were compared between patients in whom a Watchman was implanted with ICE vs. TEE guidance. In 76 consecutive patients the Watchman device was deployed under ICE in 32 patients (42%) and under TEE guidance in 44 patients (58%). Baseline characteristics were comparable between groups, except that patients in the TEE group were older (81 [75–85] years vs. 75 [68–80] years, P = 0.007). Total injected contrast media as well as fluoroscopy time were comparable between groups (90 ml [54–140] vs. 85 ml [80–110], P = 0.86 and 7.9 min [6.4–15.5] vs. 9.8 min [7.0–13.2], P = 0.51, for TEE vs. ICE, respectively). However, time from femoral venous puncture to transseptal puncture and to closure was longer in the ICE group (14 min [7.3–20] vs. 6 min [3.3–11], P = 0.007 and 48 min [40–60] vs. 34.5 min [27–44], P = 0.003, respectively). In the TEE group one patient suffered esophageal erosion with bleeding, which was managed conservatively and one non‐LAAO related in‐hospital mortality occurred in an 88‐year‐old patient. Device implantation success rate was 100% in both groups. No device embolization, no significant peri‐device leak, no tamponade, no stroke, and no access site bleeding occurred in any patient. Total hospital stay for stand‐alone LAAO was comparable between groups (2 days [2–2] vs. 2 days [2–3.3], P = 0.17, in ICE vs. TEE, respectively). Conclusions: ICE guidance for LAAO with the Watchman device is feasible and comparable to TEE and may become the preferred imaging modality for LAAO. © 2016 Wiley Periodicals, Inc. 相似文献
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Eric Black‐Maier Jonathan P. Piccini Christopher B. Granger 《Journal of cardiovascular electrophysiology》2019,30(12):2968-2976
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and confers a fivefold increased risk for stroke. Cardioembolic stroke secondary to AF is a devastating event, but is largely preventable with appropriate oral anticoagulation (OAC). The PROTECT and PREVAIL trials demonstrated that the WATCHMAN left atrial appendage closure (LAAC) device in combination with short‐term warfarin therapy is noninferior to long‐term warfarin with respect to a composite endpoint of stroke, cardiovascular death, and systemic embolism. Importantly, the WATCHMAN confers a significant reduction in life‐threatening bleeding compared to OAC. Although direct‐acting oral anticoagulant (DOAC) are superior to warfarin in eligible patients, several important AF populations exist in whom left atrial appendage (LAA) closure may be preferable to DOAC. Populations warranting strong consideration of LAAC include patients with contraindications to DOAC, end‐stage renal disease, prior intracranial hemorrhage, recurrent gastrointestinal bleeding, and patients undergoing transcatheter aortic valve replacement or left atrial electrical isolation. Device‐related thrombosis is an important complication of LAAC, and DOAC may be preferential to warfarin for prevention and treatment of this complication remains unexplored. Prospective clinical trials comparing DOAC to LAAC in these unique populations are either ongoing or needed. 相似文献
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Ignacio Cruz‐Gonzalez MD PhD Jose‐Angel Perez‐Rivera MD PhD Armando Bethencourt MD PhD 《Catheterization and cardiovascular interventions》2015,85(2):E58-E62
We present the case of a 72‐year‐old woman with permanent atrial fibrillation and contraindication to long‐term oral anticoagulant therapy who underwent left atrial appendage (LAA) occlusion. A 24‐mm Amplatzer Cardiac Plug (St Jude Medical) device was deployed. The inferior part of the external disc of the device appeared to be over the posterior leaflet of the mitral valve but no significant mitral stenosis or mitral regurgitation was detected before deployment. After the procedure the patient suffered several syncopes when she tried to stand up. A transesophageal echocardiography (TEE) was performed and no significant differences on the device position were detected, it was not possible to perform the TEE in a stand‐up position due to the patient symptoms (hypotension, tachycardia, dizziness, and loss of consciousness). After discussion with the surgical team, surgical removal of the device and surgical exclusion of LAA was performed. The symptoms disappeared and the patient was discharged. In the best of our knowledge, this is the first time that recurrent syncope has been described as a complication of LAA occlusion. © 2014 Wiley Periodicals, Inc. 相似文献
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Oh‐Hyun Lee Young Dae Kim Jung‐Sun Kim Hui‐Nam Pak Geu‐Ru Hong Chi Young Shim Jae‐Sun Uhm In‐Jeong Cho Boyoung Joung Sung‐Jin Hong Chul‐Min Ahn Byeong‐Keuk Kim Young‐Guk Ko Donghoon Choi Myeong‐Ki Hong Cheol‐Woong Yu Hyun‐Jong Lee Woong‐Chol Kang Eun‐Seok Shin Rak‐kyeong Choi Do‐Sun Lim Xavier Freixa Apostolos Tzikas Ji Hoe Heo Yangsoo Jang Jai‐Wun Park 《Catheterization and cardiovascular interventions》2019,94(1):E23-E29
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Only 50% of patients who would benefit from warfarin therapy for atrial fibrillation (AF) receive treatment because of clinical concerns regarding chronic anti-coagulation. Percutaneous strategies to treat AF, including pulmonary vein isolation with a curative intent or atrioventricular nodal ablation and implantation of a permanent pacemaker for palliative rate control, have not eliminated the need to manage thromboembolic risk. With the development of a percutaneous left atrial appendage (LAA) occlusion device (the WATCHMAN percutaneous left atrial appendage occluder - Atritech Inc., Plymouth, MN, USA) for thromboembolic protection in non-valvular AF a significant therapeutic option for select patients may be available. We present the first case performed in Australia (24 November 2009) and explore this new methodology. 相似文献
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Gian Paolo Ussia MD FSCAI Massimiliano Mulè MD Valeria Cammalleri MD Marilena Scarabelli MD Marco Barbanti MD Sebastiano Immè MD Sarah Mangiafico MD Anna Marchese MD Alfredo Ruggero Galassi MD FESC FACC FSCAI Corrado Tamburino MD PhD FESC FSCAI 《Catheterization and cardiovascular interventions》2009,74(2):217-222
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Francesco Gallo MD Federico Ronco MD Gianpiero D'Amico MD PhD Domenico G. Della Rocca MD PhD Patrizio Mazzone MD Stefano Bordignon MD Gavino Casu MD Francesco Giannini MD Sergio Berti MD Rodney P. Horton MD Giuseppe D'Angelo MD Lukas Urbanek MD Pierluigi Merella MD Rossella Ruggiero MD Maria Rita Romeo ENG Francesco Bosica MD PhD Boris Schmidt MD Enrico Atzori MD Marco Barbierato MD Andrea Natale MD Sakis Themistoclakis MD 《Catheterization and cardiovascular interventions》2023,101(6):1144-1153
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Moniek Maarse MD Lisette I. S. Wintgens MD Andrey Ponomarenko MD Karen P. Phillips MD Aleksandr B. Romanov MD Gabriel Ballesteros MD PhD Martin J. Swaans MD PhD Richard J. Folkeringa MD PhD Ignacio Garcia-Bolao MD PhD Lucas V. A. Boersma MD PhD 《Journal of cardiovascular electrophysiology》2021,32(3):737-744
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S Leal R Moreno M de Sousa Almeida JA Silva JL Lopez-Sendon 《Current Cardiology Reviews》2012,8(1):37-42
Atrial fibrillation is the most common cardiac arrhythmia, and its prevalence is increasing. Cardioembolic stroke, most of the times secondary to thrombus formation in the left atrial appendage, is its most feared and life threatening consequence. Oral anticoagulation with vitamin-K-antagonists is currently the most used prophylaxis for stroke in patients with atrial fibrillation; unfortunately, its benefits are limited by a narrow therapeutic window and an increased risk for bleeding, making it often undesired. Percutaneous occlusion of the left atrial appendage is a novel alternative strategy for cardioembolic stroke prophylaxis in patients with atrial fibrillation at a high risk of stroke but with contraindication for long-term oral anticoagulation therapy. At present, several devices have been developed specifically for percutaneous occlusion of the left atrial appendage. Current results show good feasibility and efficacy for these devices, with a high rate of successful implantation, although also associated with the inherent potential periprocedural complications. This work reviews the current state of the art of percutaneous left atrial appendage closure for stroke prophylaxis in patients with atrial fibrillation. 相似文献
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目的探讨心房颤动"一站式"手术的有效性和安全性。方法回顾性分析临床17例心房纤颤患者通过射频消融联合左心耳封堵"一站式"手术治疗后的临床资料。结果手术后出现肺部感染2例(11.76%),一过性交界性逸搏心律2例(11.76%),食管瘘1例(5.89%),术后3个月经食道超声心动图复查发现,封堵器表面血栓形成1例(5.89%),术后6个月随访无卒中、出血及死亡患者,1例患者心房颤动复发,继续抗凝治疗,其他患者均改为阿司匹林或氯吡格雷单联抗栓治疗。结论对于卒中高危且有抗凝禁忌的非瓣膜性心房颤动患者,射频消融联合左心耳封堵"一站式"手术是可行的、安全的、有效的。 相似文献
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Optimal combination strategy of left atrial appendage closure plus catheter ablation in a single procedure in patients with nonvalvular atrial fibrillation 下载免费PDF全文
Xianfeng Du MD Huimin Chu MD Bin He MD Binhao Wang MD Jing Liu MD Mingjun Feng MD Yibo Yu MD Guohua Fu MD He Jin MD Fang Gao MD Jingjing Zhu MD Xiaomin Chen MD 《Journal of cardiovascular electrophysiology》2018,29(8):1089-1095
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Sapan Bhuta MD Adnan Shaaban MD Nkongho C. Binda MD James Antaki MD Ralph S. Augostini MD Steven J. Kalbfleisch MD Salvatore J. Savona MD Toshimasa Okabe MD Mahmoud Houmsse MD Muhammad R. Afzal MD Emile G. Daoud MD John D. Hummel MD FACC FHRS 《Journal of cardiovascular electrophysiology》2023,34(8):1698-1705
Introduction
Among patients with non-valvular atrial fibrillation (AF) and percutaneous left atrial appendage closure (LAAC) undergoing direct current cardioversion (DCCV), the need for and use of LAA imaging and oral anticoagulation (OAC) is unclear.Objective
The purpose of this study is to evaluate the real-world use of transesophageal echocardiography (TEE) or cardiac computed tomography angiography (CCTA) before DCCV and use of OAC pre- and post-DCCV in patients with AF status post percutaneous LAAC.Methods
This retrospective single center study included all patients who underwent DCCV after percutaneous LAAC from 2016 to 2022. Key measures were completion of TEE or CCTA pre-DCCV, OAC use pre- and post-DCCV, incidence of left atrial thrombus (LAT) or device-related thrombus (DRT), incidence of peri-device leak (PDL), and DCCV-related complications (stroke, systemic embolism, device embolization, major bleeding, or death) within 30 days.Results
A total of 76 patients with AF and LAAC underwent 122 cases of DCCV. LAAC consisted of 47 (62%), 28 (37%), and 1 (1%) case of Watchman 2.5, Watchman FLX, and Lariat, respectively. Among the 122 DCCV cases, 31 (25%) cases were identified as “non-guideline based” due to: (1) no OAC for 3 weeks and no LAA imaging within 48 h before DCCV in 12 (10%) cases, (2) no OAC for 4 weeks following DCCV in 16 (13%) cases, or (3) both in 3 (2%) cases. Among the 70 (57%) cases that underwent TEE or CCTA before DCCV, 16 (23%) cases had a PDL with a mean size of 3.0 ± 1.1 mm, and 4 (6%) cases had a LAT/DRT on TEE resulting in cancellation. There were no DCCV-related complications within 30 days.Discussion
There is a widely varied practice pattern of TEE, CCTA, and OAC use with DCCV after LAAC, with a 6% rate of LAT/DRT. LAA imaging before DCCV appears prudent in all cases, especially within 1 year of LAAC, to assess for device position, PDL, and LAT/DRT. 相似文献20.
Percutaneous left atrial appendage occlusion using different technologies in the United Kingdom: A multicenter registry 下载免费PDF全文
Timothy R. Betts MD Milena Leo MD Sandeep Panikker MD Prapa Kanagaratnam MD PhD Michael Koa‐Wing MD PhD David Wyn Davies MD FHRS David Hildick‐Smith MD Dylan G. Wynne PhD Oliver Ormerod MD Oliver R. Segal MD Anthony W. Chow MD Derick Todd MD Sandra Cabrera Gomez MD Graeme J. Kirkwood PhD David Fox MD Chris Pepper MD John Foran MD Tom Wong MD 《Catheterization and cardiovascular interventions》2017,89(3):484-492