一种减肥食品的动物试验研究

肥胖与健康的关系越来越受到人们的关注,膳食不平衡及营养过剩是引起肥胖的重要因素,由此所产生的一些慢性代谢性疾病也随之形成,对人民健康造成相当程度的影响。     

Cigarette smoking and self-reported health problems among U.S. high school seniors, 1982-1989

PURPOSE: To estimate the independent effect of cigarette smoking on respiratory tract symptoms and health status indicators among high school seniors. DESIGN: Consolidated data sets from one-time cross-sectional survey designs. SETTING: High schools in the United States, 1982-1989. SAMPLE: A total of 26,504 high school seniors, with an 83% response rate. MEASURES: Odds ratios for respiratory tract symptoms and health status indicators for cigarette smokers compared with nonsmokers, while controlling for sex, socioeconomic status, and use of other drugs. RESULTS: High school seniors who were regular cigarette smokers and who began smoking by grade nine were significantly more likely than never smokers to report shortness of breath when not exercising (adjusted odds ratio [OR] = 2.7), coughing spells (OR = 2.1), productive cough (OR = 2.4), and wheezing or gasping (OR = 2.6). These smokers were also more likely to have seen a doctor or other health professional for an emotional or psychologic complaint (OR = 3.0) and to rate their overall health as poorer than average (OR = 2.4). We found strong dose-response relationships for most outcome measures. CONCLUSIONS: Cigarette smoking among high school seniors is associated with respiratory tract symptoms and poorer overall physical health and may be a marker for underlying mental health problems. Smoking prevention activities directed at adolescents should include information on the early adverse health consequences of cigarette smoking.     

Nutritional elements in U.S. diets: results from the Total Diet Study, 1982 to 1986

Through the Food and Drug Administration's Total Diet Study, the levels of 11 nutritional elements (sodium, potassium, calcium, phosphorus, magnesium, iron, zinc, copper, manganese, selenium, and iodine) in the diets of eight age-sex groups were determined for the 4 years between 1982 and 1986. The 234 Total Diet Study foods, which are representative of the U.S. food supply, were purchased, prepared for consumption, and analyzed for the elements four times each year. The results were combined with national food consumption data to estimate intakes for 6- to 11-month-old infants, 2-year-old children, 14- to 16-year-old boys and girls, 25- to 30-year-old men and women, and 60- to 65-year-old men and women. Six elements (calcium, magnesium, iron, zinc, copper, and manganese) were low (less than 80% of the Recommended Dietary Allowance or below the low end of the Estimated Safe and Adequate Daily Dietary Intake range) for three or more of the age-sex groups. Six elements were of concern for teenage girls and adult women, five for older women, three for 2-year-old children, two for teenage boys and older men, and only one for infants and adult men. Sodium levels (which did not include discretionary salt) were elevated for 2-year-old children and teenage boys, and iodine was elevated for all age-sex groups. A significant trend was noted only for iodine, the intake of which decreased during the 4-year period.(ABSTRACT TRUNCATED AT 250 WORDS)     

An industry-wide epidemiologic study of vinyl chloride workers, 1942-1982

The cohort consisted of 10,173 men who had worked for at least one year in jobs involving exposure to vinyl chloride prior to 1 January 1973. These men were employed at 37 plants in the U.S., belonging to 17 companies. Observation of the mortality experience of the cohort was updated from 31 December 1972 to 31 December 1982 (the study now covering 1942-1982). A total of 1,536 cohort members were identified as having died. The observed mortality, by cause, was compared with the expected based on U.S. mortality rates, standardized for age, race, and calendar time. Analyses by length of exposure, latency, age at first exposure, calendar year of first exposure, and type of products were performed. The study confirmed that the vinyl chloride workers experience a significant mortality excesses in angiosarcoma (15 deaths), cancer of the liver and biliary tract (SMR = 641), and cancer of the brain and other central nervous system (SMR = 180). In addition, the study also found a significant mortality excess in emphysema/chronic obstructive pulmonary disease (COPD) (SMR = 179). On the other hand, the study did not find any excess in either respiratory cancer or lymphatic and hematopoietic cancer. This study also found an increase in biliary tract cancers, independent from liver cancer.     

Waterborne-disease outbreaks, 1989-1990.

For the 2-year period 1989-1990, 16 states reported 26 outbreaks due to water intended for drinking; an estimated total of 4,288 persons became ill in these outbreaks. Giardia lamblia was implicated as the etiologic agent for seven of the 12 outbreaks in which an agent was identified. The outbreaks of giardiasis were all associated with ingestion of unfiltered surface water or surface-influenced groundwater. An outbreak with four deaths was attributed to Escherichia coli O157:H7, the only bacterial pathogen implicated in any of the outbreak investigations. An outbreak of remitting, relapsing diarrhea was associated with cyanobacteria (blue-green algae)-like bodies, whose role in causing diarrheal illness is being studied. Two outbreaks due to hepatitis A and one due to a Norwalk-like agent were associated with use of well water. Eighteen states reported a total of 30 outbreaks due to the use of recreational water, which resulted in illness for an estimated total of 1,062 persons. These 30 reports comprised 13 outbreaks of whirlpool- or hot tub-associated Pseudomonas folliculitis; 13 outbreaks of swimming-associated gastroenteritis, including five outbreaks of shigellosis; one outbreak of hepatitis A associated with a swimming pool; and three cases of primary amebic meningoencephalitis caused by Naegleria. The national surveillance of outbreaks of waterborne diseases, which has proceeded for 2 decades, continues to be a useful means for characterizing the epidemiology of waterborne diseases.     

Hungarian diet and nutritional status survey - The OTAP2009 study I. Nutritional status of the Hungarian population

Obesity is a leading public health problem, but representative data on measured prevalence among Hungarian adults has been missing since the late eighties. Aim and method: Joining in European Health Interview Survey the aim of the OTAP2009 study was to provide data representative by age and gender on the prevalence of obesity and abdominal obesity among Hungarian adults based on their measured anthropometric data. Results: Participation rate was 35% (n = 1165). Data shows that nearly two-thirds of adults are overweight or obese. 26.2% of men and 30.4% of women are obese. Prevalence of morbid obesity is 3.1% and 2.6% in men and women, respectively. Abdominal obesity is more prevalent among women than men (51.0% vs. 33.2%), and rate is increasing parallel with age in both gender. In elderly, 55% of men and almost 80% of women are abdominally obese. Conclusions: Besides interventions of population level for tackling obesity, individual preventive measures are indispensable. Orv. Hetil., 2012, 153, 1023-1030.     

Kidney disease mortality--Michigan, 1989-2005

Kidney disease was the ninth leading cause of death in Michigan in 2005 and in the United States in 2004. In 2004, the incidence rate for kidney failure (i.e., end-stage renal disease) was higher in Michigan than in the United States (365 versus 353 per 1 million population). A total of 3,695 Michigan residents started treatment (i.e., dialysis or transplant) for kidney failure in 2004; by the end of that year, 11,002 Michigan residents were receiving dialysis, and 614 had received a transplant. Many of these persons had a diagnosis of diabetes (40%) or hypertension (30%) as the primary cause of kidney failure. To examine recent trends in kidney disease mortality, the Michigan Department of Community Health (MDCH) analyzed vital statistics data from the period 1989--2005. This report describes the results of that analysis, which indicated that kidney disease mortality is a growing public health problem in Michigan and that blacks were more likely than whites to die from kidney disease. Continued disease-prevention and health-promotion activities, including targeted interventions among populations at greatest risk, are needed by MDCH and other organizations to reduce the burden of kidney disease in Michigan.     

The Pelotas birth cohort study, Rio Grande do Sul, Brazil, 1982-2001

Given the growing recognition of the importance of the life course approach for the determination of chronic diseases, birth cohort studies are becoming increasingly important. This paper describes the methods used in the 1982 Pelotas (Brazil) birth cohort study, one of the largest and longest studies of this type in developing countries. All 5,914 hospital births occurring in Pelotas in 1982 (over 99% of all deliveries) were studied prospectively. The main stages of the study took place in 1983, 1984, 1986, 1995, 1997, 2000, and 2001. More than two thousand variables are available for each subject who participated in all stages of the study. Recent phases of the study included the examination of 2,250 males when presenting for the army recruitment exam in 2000, the study of a 27% sample of men and women in 2001 through household visits, and the study of over 400 children born to the cohort women. Follow-up rates in the recent stages of the cohort were 78.9% for the army examination and 69.0% for the household visits. Ethnographic and oral health studies were conducted in sub-samples. Some recent results on blood pressure, adolescent pregnancy, and asthma are presented as examples of utilization of the data. Suggestions on lessons learned for other cohort studies are proposed.     

Review of poliomyelitis in Bombay (1982-1989): observations on the improved immunisation coverage

In Bombay, the immunization coverage with 3 doses of oral polio vaccine in children below 2 years of age has reached 80%. As a result, the high incidence of over 11/100,000 population prevailing in the 6 year period (1982-1987) has declined to around 6 in 1988 and 1989. The decline was observed both in the slum and in the "non-slum" population. The incidence in the slum population has reduced from over 22/100,000 population to around 11. In the morbidity, a subtle "age shift" to older children was noticed in 1988-1989. Average age-specific incidence (for age group below 1 year) was found to be 1.04/1000 children in 1988-89 as against 2.47 in the preceding 6 years. The proportion of "Non-Immunized" cases gradually declined from 65.8% in 1982 to 49.7% in 1989 and conversely, the proportion of fully immunized cases increased from 14.5% in 1982 to 22.7% in 1989. The attack rates per 1000 children below 1 year of age in the inadequately/"Non-Immunized" and the fully immunized children were found to be 2.822 and 0.224 respectively. The sharp peak in the morbidity observed in the 3rd quarter of an year (July to September) has been replaced by almost even distribution of cases in all the quarters of an year. All the three polioviruses were encountered through out the year. Although, poliovirus type 1 was the most predominant of viruses, its proportion was on decline. The portion of isolation of "Non-Polio" viruses has increased from 6.8% in 1982 to 16.2% in 1989.(ABSTRACT TRUNCATED AT 250 WORDS)     

Food consumption,energy and nutrient intake and nutritional status in rural Bangladesh: changes from 1981-1982 to 1995-96

OBJECTIVE: To determine and evaluate changes in nutritional status, food consumption, energy and nutrient intake in rural Bangladesh, using appropriate statistical analyses. DESIGN: Repeated cross-sectional surveys. Two seasons in 1981-1982 and 1995-1996. SETTING: Two villages with different production patterns. SUBJECTS: Anthropometric measurements of 1883 individuals, food consumption data of 404 households. METHODS: Repeated measurements of one-day food weighing and anthropometry in two seasons in 1981-1982 and 1995-1996. Mixed model analyses were used to evaluate and quantify temporal changes and their interactions with determinants. RESULTS: Prevalence of underweight children decreased from 82 to 70% (P=0.015), wasted children from 34% to 18% (P=0.009) and chronic energy deficient adults decreased from 78 to 64% (P<0.0001). Intake of fish and green leafy vegetables increased from (l.s. mean+/-s.e.) 23+/-3.0 to 40+/-1.8 g/person/day (P<0.001) and from 28+/-4.5 to 41+/-2.7 g/person/day (P=0.019), respectively. Rice intake remained unchanged: 463+/-12 g raw/person/day in 1981-1982 and 450+/-7.3 g raw/person/day in 1995-1996 (P=0.355). Calcium and iron intakes increased by 40% (P<0.0001) and 16% (P=0.0002), respectively, whereas vitamin A intake remained unchanged. CONCLUSIONS: Nutritional status improved and intakes of nutrient dense food groups, fat, iron and calcium increased from 1981-1982 to 1995-1996.     

Preterm singleton births--United States, 1989-1996

Preterm birth (birth at <37 completed weeks of gestation) is the second leading cause of neonatal mortality in the United States. Preterm birthrates differ by race; in 1996, black infants were 1.8 times more likely than white infants to be preterm. From 1989 through 1996, the overall rate of preterm birth (per 1000 live-born infants) increased 4%, and the rate of multiple births (e.g., twins, triplets, or other higher-order births) increased 19%. Multiple births are associated with preterm birth; trends in preterm births independent of the influence of multiple births have not been fully explored. To characterize race- and ethnicity-specific trends in preterm birth independent of multiple births, data from U.S. birth certificates for 1989-1996 were analyzed for singleton births only. This report summarizes the results of this analysis and indicates that although singleton preterm birthrates are stable overall, substantial changes in rates occurred in some racial/ethnic subgroups.