利塞膦酸钠对非骨水泥型全髓关节置换术后早期股骨假体周围骨密度的影响

目的 探讨利塞膦酸钠对非骨水泥型全髋关节置换术后早期股骨假体周围骨密度的影响及治疗作用,以其为临床提供防止假体周围骨丢失和松动的预防措施和处理方法.方法 2011年3月～2012年5月于本院行非骨水泥型人工全髋关节置换术中符合纳入标准的患者共26例随机分成利塞膦酸钠组与对照组;试验组术后每日口服利塞膦酸钠5 mg+钙剂600 mg,而对照组仅服用钙剂600 mg;分别于术后1周、3、6个月测定股骨近端各感兴趣区(ROI)的骨密度.结果 获得完整病例24例,术后3、6个月各区骨密度均呈持续下降趋势,和对照组相比,术后3个月利塞膦酸钠组股骨假体(ROI1、ROI7)的差异有统计学意义(P＜0.01),其余各测量区骨密度2组相比差异无统计学意义(P＞0.05).与对照组相比,术后6个月利塞膦酸钠组股骨假体(ROI1、ROI7)的差异有统计学意义(P＜0.01),其余各测量区骨密度2组相比差异无统计学意义(P＞0.05).结论 利塞膦酸钠能够有效的减少非骨水泥型全髋关节置换术后假体周围的骨丢失,从而减缓假体松动,延长假体使用寿命.     

短柄股骨假体全髋关节置换术后股骨近端骨改建及有限元分析

目的通过观察股骨假体周围骨密度改变情况来分析短柄股骨假体全髋关节置换术后股骨近端骨改建情况。方法纳入自2011-06—2016-06完成的71例全髋关节置换术,35例(37髋)采用短柄股骨假体(短柄组),36例(37髋)采用常规股骨假体(常规组)。比较两组术后1年疼痛VAS评分、髋关节功能Harris评分、股骨假体周围骨密度。采用有限元法分析两种股骨假体置入后的应力遮挡情况。结果 71例均获得随访,随访时间13～15(13.2±0.8)个月。短柄组与常规组术后1年疼痛VAS评分、髋关节功能Harris评分差异无统计学意义(P0.05)。与术后1周比较,术后1年短柄组股骨假体周围Gruen 1区和5区骨密度无明显变化,Gruen 4区骨密度降低,而Gruen 2、3、6、7区骨密度增加;常规组术后1年股骨假体周围Gruen 1、2、3、5、6、7区骨密度降低,而Gruen 4区骨密度升高。术后1年短柄组股骨假体周围所有Gruen分区骨密度均高于常规组,差异有统计学意义(P0.05)。有限元分析结果显示常规组股骨近端内侧与外侧均出现应力遮挡,而短柄组仅在股骨近端外侧出现应力遮挡。结论短柄股骨假体具有良好的力学传导特性,全髋关节置换术中使用短柄股骨假体可促进股骨近端骨改建并减少应力遮挡。     

全髋关节置换术联合阿仑磷酸钠片对老年股骨颈骨折的关节功能及骨密度的影响

目的:探讨全髋关节置换术联合阿仑磷酸钠片对老年股骨颈骨折的关节功能及骨密度水平的影响。方法:选取股骨颈骨折行全髋关节置换术老年患者100例,随机分成观察组和对照组各50例。对照组全髋关节置换术后7 d给予钙尔奇D片(1片/次,1次/d)、骨化三醇胶丸(25μg/次,2次/d)口服,行常规抗骨质疏松治疗;观察组在对照组治疗基础上口服阿仑磷酸钠片(10 mg/次,1次/d)联合治疗,连续治疗3个月。观察两组术后7 d、术后3个月和术后6个月时间点的髋关节功能优良率和假体周围7个兴趣区(ROI 1～7)的骨密度水平。结果:术后7 d,观察组髋关节优良率为18.00%(9/50),对照组为16.00%(8/50),二组比较无差异;术后3个月及6个月,观察组髋关节优良率分别为74.00%(37/50)、90.00%(45/50),对照组分别为42.00(21/50)、72.00%(36/50),观察组明显优于对照组(P0.05)。术后7 d,两组假体周围7个兴趣区的骨密度水平比较无差异;术后3个月,两组假体周围骨密度较术后7 d时均有不同程度下降,观察组ROI 1和ROI 7区骨密度下降水平明显低于对照组(P0.05);术后6个月,观察组除ROI 4区外,其他各兴趣区骨密度水平均明显高于对照组(P0.05)。结论:全髋关节置换术联合阿仑磷酸钠片治疗股骨颈骨折,能明显提高患者术后关节功能和假体周围骨密度水平,临床应用效果明显。     

生物固定C2型股骨柄对股骨近端应力遮挡影响的临床研究

目的 探讨生物固定C2型股骨柄人工全髋关节对股骨近端假体周围骨丢失方面的影响。方法31例C2型股骨柄全髋关节置换术（THA）后患者得到完整随访，包括X线片、Harris评分以及双能X线骨密度仪（DEXA）测量股骨近端假体周围骨密度，采用Gruen七区法，非手术侧作为对照。结果31例患者HHS评分优秀22例，良好8例，一般1例。X线显示所有柄都是稳定的，X线上未见明显假体周围骨密度改变。DEXA测量结果表明手术侧骨密度较非手术侧均出现下降，范围在2．42％～27．4％，平均6．67％，其中Gruen 4区和7区的骨密度下降有统计学意义（t值分别是-5．52和-7．08，P〈0．01）。结论 C2型股骨柄术后2年临床疗效较好，DEXA在评估THA的术后假体周围骨密度方面比普通平片更敏感，THA术后股骨近端假体周围的骨丢失是存在的，尤其在股骨距区下降明显。假体周围骨丢失与假体设计存在关系。     

骨水泥型单髋和全髋关节置换治疗老年股骨颈骨折的疗效比较

目的比较骨水泥型单髋和全髋关节置换治疗老年股骨颈骨折的疗效。方法将41例股骨颈骨折患者分为A组(采用单髋关节置换治疗,n=23)和B组(采用全髋关节置换治疗,n=18)。比较两组手术时间和术中出血量;术后6、12、24个月采用髋关节Harris评分评价疗效。结果患者均获得24个月随访。手术时间和术中出血量B组均多于A组(P 0. 05)。术后6、12、24个月Harris评分优良率B组均高于A组(P 0. 05)。结论治疗老年股骨颈骨折,单髋关节置换术具有手术时间短、出血量少等优点;而全髋关节置换患者术后功能恢复较好。     

全髋关节置换与人工股骨头置换术治疗老年不稳定股骨颈骨折的疗效比较

目的探讨全髋关节置换与人工股骨头置换术治疗老年不稳定股骨颈骨折对患者髋关节功能恢复及术后并发症的影响。方法回顾性分析自2013-04—2015-04诊治的110例老年不稳定股骨颈骨折,55例采用全髋关节置换术治疗(全髋置换组),55例采用人工股骨头置换术治疗(股骨头置换组)。比较2组手术时间、术中出血量、术后引流量及住院总时间,术后12、24个月髋关节功能Harris评分,以及随访期间并发症情况。结果 110例均获得至少2年随访。股骨头置换组手术时间、术中出血量及术后引流量明显少于全髋置换组,而全髋置换组术后24个月髋关节功能Harris评分优于股骨头置换组,术后并发症发生率低于股骨头置换组,差异有统计学意义(P0.05)。2组住院总时间、术后12个月髋关节功能Harris评分比较差异无统计学意义(P0.05)。结论全髋关节置换与人工股骨头置换术治疗老年不稳定股骨颈骨折临床应用广泛,人工股骨头置换术具有创伤小、操作简便的优点,而全髋关节置换术能更有效维持患者远期良好的髋关节功能,并降低术后远期并发症发生的风险。     

全髋与半髋关节置换术治疗老年人股骨颈骨折结果比较

目的 比较全髋关节置换术与半髋关节置换术治疗老年人完全移位股骨颈骨折的疗效。方法 将1995～2001年在我院治疗的262例60岁以上有移位的股骨颈骨折患者分为两组，A组为全髋关节置换术，B组为人工股骨头置换术。随访12～78个月，平均37个月。结果 按Harris评分标准，A组术后优良率达到93.8％；B组术后优良率达78.4％，单极与双极股骨头置换组之间结果没有明显的差别；人工股骨头置换后有5例需行全髋翻修手术；双极人工股骨头置换中有2例发生双极之间脱位，7例出现假体周围骨溶解。结论 人工股骨头或全髋关节置换术是治疗老年股骨颈骨折的有效方法，可提高老年人的生活质量，减少并发症。全髋关节置换结果优于人工股骨头置换。     

全髋关节表面置换术治疗髋关节发育不良继发骨关节炎的早期疗效观察

目的 探讨全髋关节表面置换术(total hip resurfacing arthroplasty,THRA)治疗成人髋关节发育不良(developmental dysplasia of the hip,DDH)继发骨关节炎的早期疗效.方法 2005年3月至2006年6月,采用THRA治疗25位(26髋)DDH患者,女18例,男7例;年龄30～59岁,平均48岁.根据Hartofilakidis分型,半脱位22髋,低位脱位4髋.临床随访主要采用Harris评分,影像学测量指标包括CE角、Sharp角/臼杯外展角、股骨颈干角/柄干角、髋关节旋转中心、偏心距比值、髋臼假体覆盖率,记录髋臼假体周围透亮线及骨溶解,检测手术前后股骨颈及股骨近端的骨密度.结果 所有患者平均随访3.5年(3～5年),截至随访终点无翻修或影像学松动病例,Harris评分由术前平均(46.1±6.57)分提高到术后平均(92.1±2.59)分,优良率100%.臼杯外展角平均为41.6°±5.5°,柄干角平均为146.4°±3.2°,髋关节旋转中心位置平均下移3.9 mm,内移12.7 mm,宿主骨对臼杯的平均覆盖率为94.4%±4.2%.1髋宿主骨与臼杯界面在Deice 2区出现透亮线,宿主骨与股骨假体柄界面无1例出现透亮线.Gruen 1～6区术后6个月骨密度比率降低,术后6～36个月骨密度比率均有不同程度的增加;术后6个月时股骨颈外上区、股骨颈内下区和Gruen 7区骨密度比率已恢复至术前水平,术后36个月时上述三区的骨密度比率均高于术前.结论 THRA治疗半脱位型及低位脱位型DDH继发骨关节炎患者具有良好的临床疗效,THRA术后股骨近端骨量可以得到有效保存和恢复.     

股骨颈骨折内固定术失败原因分析及其治疗对策

目的探讨空心螺钉及股骨近端解剖板内固定治疗股骨颈骨折失败的原因,评价改行全髋关节置换术后的疗效。方法对23例股骨颈骨折内固定失败后行全髋关节置换术,根据术前、术后X线片及髋关节功能恢复情况,评价治疗效果。结果术后随访6~13个月,平均9个月,髋关节功能根据Harris评分标准:优20例,良3例。结论全髋关节置换术能有效挽救股骨颈骨折内固定失败后髋关节功能,解除疼痛,恢复下肢功能。     

唑来膦酸对骨质疏松患者全髋关节置换术后假体周围骨密度的影响

目的：探讨注射用唑来膦酸5 mg对骨质疏松患者全髋关节置换术后假体周围骨密度的影响。方法选取2012年3月至2013年2月期间因骨质疏松性髋部骨折行全髋关节置换术的患者31例,所有患者初次诊断均为原发性骨质疏松症合并髋部骨折,入院前未曾行任何抗骨质疏松治疗,根据随机数字表分为两组：治疗组（16例,平均年龄73.8岁）,全髋关节置换术后5～7 d给予唑来膦酸5 mg,静脉滴注30 min,同时口服钙尔奇600 mg/d及阿尔法D30.25 ug/d;对照组（15例,平均年龄74.1岁）,术后仅给予口服钙尔奇600 mg/d及阿尔法D30.25 ug/d。分别于术后1周、3个月、6个月、12个月使用双能X线骨密度仪（ DEXA）测定两组患者假体周围各感兴趣区的骨密度值。结果两组患者术后3个月、6个月、12个月与术后1周（基线）股骨近端假体周围骨密度除Gruen1区外,2～7区骨密度均呈不同程度下降。治疗组与对照组骨密度变化值相比,术后3个月Gruen 4区（0.84％vs -3.34％, t＝3.5805）、7区（-3.61％vs -16.7, t＝4.0455）组间差异有统计学意义（P＜0.05）;术后6个月Gruen 1区（9.96％vs 1.17％, t＝2.1293）、4区（1.21 vs -2.96, t＝2.0892）、6区（-0.56 vs -6.16, t＝2.9500）、7区（-5.71 vs -22.8, t＝4.3959）组间差异有统计学意义（ P＜0.05）;术后12个月Gruen 1区（13.83 vs 1.39, t＝2.1795）、4区（0.81 vs -3.68, t＝2.1805）、6区（0.14 vs -6.04, t＝0.0247）、7区（-8.39 vs -25.4, t ＝3.8959）组间差异有统计学意义（ P＜0.05）。术后使用唑来膦酸3个月即表现出明显抑制骨量丢失的作用,并且于6个月、12个月时唑来膦酸对Gruen 1、4、6、7区骨量有持续的正向影响;Gruen 7个区中对1、7区的影响最大,治疗组1区骨密度增幅是对照组的9.95倍,7区骨密度减幅是对照组的1/3。结论唑来膦酸注射液5 mg能有效减少股骨假体周围骨密度的丢失,潜在的增加假体生物学稳定性,减少假体无菌性松动的概率,延长假体使用寿命。     

Changes in Bone Mineral Density of the Acetabulum and Proximal Femur After Total Hip Resurfacing Arthroplasty

Our aim was to investigate the changes in bone mineral density (BMD) of acetabulum and proximal femur after total hip resurfacing arthroplasty. A comparative study was carried out on 51 hips in 48 patients. Group A consisted of 25 patients (26 hips) who had undergone total hip resurfacing and group B consisted of 23 patients (25 hips) who had had large-diameter metal-on-metal total hip arthroplasty (THA). BMDs around the acetabulum and proximal femur were measured using dual-energy x-ray absorptiometry (DEXA) at 2 weeks, 6 months, 1 year and annually thereafter during the 3 years after surgery. At final follow-up, the acetabular net mean BMD decreased by 11% in group A and 10% in group B with no differences between two groups (P = .35). For the femoral side, in Gruen zone 1, the mean BMD increased by 4% in group A, whereas it decreased by 11% in group B (P = .029). In Gruen zone 7, the mean BMD increased by 8% at the final follow-up in group A, whereas it decreased by 13% in group B (P = .02). In both groups the mean BMD increased by 3% in Gruen zones 3, 4, 5, and 6. Stress-related bone loss of the acetabulum was comparable for MOM THA and resurfacing devices, but proximal femoral bone density increased in the resurfacing group and decreased in the THA group.     

Preservation of the bone mineral density of the femur after surface replacement of the hip

We investigated the effect of the Birmingham hip resurfacing (BHR) arthroplasty on the bone mineral density (BMD) of the femur. A comparative study was carried out on 26 hips in 25 patients. Group A consisted of 13 patients (13 hips) who had undergone resurfacing hip arthroplasty with the BHR system and group B of 12 patients (13 hips) who had had cementless total hip arthroplasty with a proximal circumferential plasma-spray titanium-coated anatomic Ti6A14V stem. Patients were matched for gender, state of disease and age at the time of surgery. The periprosthetic BMD of the femur was measured using dual-energy x-ray absorptiomentry of the Gruen zones at two years in patients in groups A and B. The median values of the BMD in zones 1 and 7 were 99% and 111%, respectively. The post-operative loss of the BMD in the proximal femur was significantly greater in group B than in group A. These findings show that the BHR system preserves the bone stock of the proximal femur after surgery.     

Proximal femoral bone mineral density after resurfacing total hip arthroplasty and after standard stem-type cementless total hip arthroplasty, both having similar neck preservation and the same articulation type

To examine whether the Freeman cementless total hip arthroplasty (THA), with femoral neck preservation and a large metal head, can prevent stress shielding in a manner similar to resurfacing THA, we compared femoral bone mineral density (BMD) change in 10 resurfacing THA patients (group A) and 16 cementless THA patients (group B). Six and twelve months postoperatively, the mean BMD ratio in zone 1 was significantly higher in group A (97% +/- 10%, 95% +/- 11%) than in group B (79% +/- 15%, 77% +/- 20%); at 12 months, the mean BMD ratio in zone 7 was significantly higher in group A (104% +/- 15%) than in group B (84% +/- 21%). The cementless THA might not be a substitute for the resurfacing THA with respect to prevention of proximal femoral bone loss at the femoral neck, although it may prevent some major complications after resurfacing THA such as neck fracture and avascular necrosis of the femoral head.     

Changes of the bone mineral density in proximal femur following total hip resurfacing arthroplasty in osteonecrosis of femoral head

Total hip resurfacing arthroplasty (THRA) is being performed with increasing frequency for osteonecrosis of femoral head (ONFH). To evaluate femoral bone remodeling in ONFH after THRA and determine the impact of stem‐neck angle (SNA) of inserted femoral component on bone remodeling, we monitored the changes in BMD in proximal femur in 23 patients with ONFH after surgery. Patients were divided into group A (SNA ≥ 5°) and group B (SNA < 5°). The BMD was measured in seven Gruen zones and two neck zones using dual‐energy X‐ray absorptiometry preoperatively, then at 3, 6, 12, and 24 months after surgery. At all ROIs, the BMD decreased significantly by 3 months postoperatively. The BMD ceased to decrease and reversed by 6 months. The BMD in neck increased significantly in group A, compared with group B at 24 months. The BMD increased 2% at ROI1 at 24 months in both groups, and at ROI7, the BMD in group A reversed to baseline value by 6 months and increased 5.81% at 24 months. These findings implied that the bone stock of proximal femur in ONFH can be well reserved after total hip resurfacing arthroplasty with valgus positioning of the femoral component. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:453–459, 2008     

Femoral neck bone mineral density after resurfacing hip arthroplasty

Introduction: Resurfacing hip arthroplasty (RHA) has been suggested to provide an alternative to conventional total hip arthroplasty in younger, active patients. It seems to have an ability to conserve the bone mass on the femoral side. Some controversy exists regarding to the possible disadvantages of RHA and some of them are connected to poor femoral bone quality after surgery. Hence we wanted to study the bone mineral density changes 3 and 12 months after RHA. Materials and Methods: A total of 26 patients (22 men and 4 women, 28 hips) underwent a hip resurfacing arthroplasty. The mean age of the patients was 55,2 (range 38-69) years. Bone mineral density (BMD) of the proximal femur was measured by using the dual-energy X-ray absorptiometry (DXA) postoperatively and within 3 and 12 months from surgery. For analysis, we divided the femoral neck area into four equal-sized regions of interest ranging from the prosthesis to the trochanter level. Results: At three months follow-up the BMD changes varied between -5.1% (ROI C) and + 1.9% (ROI A), as compared with the immediate postoperative values. After one year follow-up the BMD changes were + 1.1% in the ROI A, + 5.4% in the ROI B, -3.9% in the ROI C and + 1.3% in the ROI D. The changes in BMD were not statistically significant. Discussion: While there is still much debate and room for additional research in this topic, the results suggest that BMD is conserved in the femoral neck one year after hip resurfacing arthroplasty.     

A Reliable Femoral Osteotomy in Total Hip Arthroplasty for Hartofilakidis Type C Developmental Dysplasia of the Hip: Proximal Femoral Reconstruction

BackgroundProcedure of the femur is extremely challenging during total hip arthroplasty (THA) for Hartofilakidis type C developmental dysplasia of the hip. The main purpose of this study is to compare the clinical effectiveness of proximal femoral reconstruction (PFR) with subtrochanteric transverse osteotomy (STO).MethodsBetween 2006 and 2015, 33 primary THAs in 26 patients were performed with PFR and 16 hips in 13 patients underwent STO. The mean follow-up was 4.2 (range, 2.2-10.8) years in PFR group and 5.9 (range, 3.5-11.3) years in STO group. At the final follow-up, clinical scores and radiographic results were evaluated for 33 hips in PFR group and 15 hips in STO group.ResultsPostoperative Harris hip scores and implant position did not differ between the treatment groups. The mean length of the oblique osteotomy line at proximal femur was 6.9 cm (range, 5.8-7.6 cm) in PFR group. The amount of bone union occurred within 6 months after surgery was 24 (72.7%) hips in PFR group and 9 (60.0%) in STO group. Three major postoperative complications occurred in PFR group, and medial femoral calcar erosion was noted in 1 hip in STO group.ConclusionSimilar with STO, the clinical results of PFR technique are a reliable solution for femoral procedure during THA in patients with Hartofilakidis type C developmental dysplasia of the hip.     

全髋表面置换术治疗股骨头坏死短期随访研究

目的：研究全髋表面置换术治疗股骨头坏死的短期疗效,探讨表面置换术治疗股骨头坏死技术要求和手术指征。方法：对2006年12月至2009年12月37例（43髋）行全髋表面置换术的股骨头缺血坏死患者进行随访,男25例,女12例;年龄21～67岁,平均44.5岁。按照ARCO进行分期：3A期3髋,3B期6髋,3C期16髋,4期18髋。根据Harris评分系统对手术前后关节疼痛、活动度、畸形矫正及功能的改善进行对比,用Charnley法比较术后假体松动X线改变。结果：失访3例,34例（40髋）获得随访,37髋疼痛完全缓解,3髋行走后有酸痛不适。随访时间16～53个月,平均32.4个月。术前Harris平均评分（51.5±1.7）分,术后32.4个月平均（94.3±1.4）分,较术前提高。优37髋,良3髋,差0髋。34例都恢复了正常生活或工作,术后疼痛明显缓解,其中3例（髋）长距离行走后有轻度酸痛不适,休息后缓解。1例异位骨化BrookerⅢ型,无疼痛,不影响正常行走和生活。无术后股骨颈骨折,无脱位,无松动和翻修。结论：经过适当患者选择、术中的精细操作,全髋表面置换术治疗股骨头缺血坏死可以获得满意的短期疗效。     

Resurfacing hip arthroplasty. A 3 to 5-year matched pair study of two different implant designs

We compared the 3 to 5 year clinical and radiological results of two different hybrid metal-on-metal resurfacing hip arthroplasty designs in 28 patients who had undergone bilateral hip resurfacing with ReCap implants on one side and BHR implants on the other side. Both hips were compared in each patient, to specifically evaluate the bone response to the cemented femoral component. Post operative function was measured with the Harris Hip Score and University of California at Los Angeles (UCLA) Activity Score, and was excellent in these patients. Mean cup inclination was 43.3 degrees +/- 7 degrees (43.3 degrees +/- 7 degrees for the BHR and 43.4 +/- 6 degrees for the Recap). The inclination angle was greater than 45 degrees in 15 patients: 7 with a BHR, 8 with a Recap; eight patients showed inclination angles greater than 50 degrees (4 patients in each group). All acetabular monoblock cups were well fixed. One patient (1.8%) had radiographs showing bone changes of uncertain significance around the stem of the femoral component. Three percent had femoral bone resorption in the BHR hip and two percent showed bone resorption in the ReCap hip. There was no evidence of migration of the femoral components. The dual energy X-ray absorptiometry (DEXA) scans identified no real reduction in bone density in these resurfacing hip arthroplasties. None of these hips showed any other adverse features. The biological response showed no difference for the two different designs of resurfacing hip arthroplasties.     

大头金对金全髋关节置换治疗老年人股骨颈骨折近期疗效

目的 探讨大头金对金全髋关节置换术治疗老年人股骨颈骨折的近期疗效.方法 55例老年股骨颈骨折患者(55髋)中,26髋采用大头金对金全髋关节置换(观察组),29髋采用常规小头金属对聚乙烯全髋关节置换(对照组),比较两组的临床疗效,对并发症进行分析.结果 55例门诊随访12~23(18.3±5.4)个月.术后对照组发生脱位1例2次;观察组无脱位发生.观察组术后6、12周的髋关节活动范围和术后12个月的Harris评分优秀率均优于对照组,差异有统计学意义(P<0.05).结论 大头金对金全髋关节置换术治疗老年股骨颈骨折,具有术后脱位率低、关节活动范围大等优点,近期临床疗效满意.     

Factors influencing bone mineral density around the femoral stem after cementless total hip arthroplasty]

Factors influencing bone mineral density around the femoral stem after PM cementless total hip arthroplasty were evaluated in longitudinal study of 18 hips in 18 patients who had undergone surgery due to unilateral hip osteoarthritis. Bone mineral density in the femoral neck was determined by dualenergy X-ray absorptiometry measurement performed preoperatively and in periprosthetic femoral Gruen's zones prospectively 2 weeks, 3, 6, 12 and 24 months after surgery. The concentrations of calcium, magnesium and fluoride were measured in cortical and trabecular bone samples taken from resected femoral head and neck. At 12 and 24 months after the operation the regional bone mineral density measurement showed significant, maximum decrease but after 12 months bone mineral density appeared to be stabilized. The analysis of preoperative femoral neck density and fluoride content in trabecular bone proved that osteopenia and lower fluoride concentrations correlated significantly with greater bone density decrease after total hip arthroplasty. No other factors (age, sex, weight, calcium and magnesium concentrations in bone and fluoride concentration in cortical bone) showed significant associations.