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Miguel Carro-Juárez Juan Francisco Rodríguez-Landa María de Lourdes Rodríguez-Peña María de Jesús Rovirosa-Hernández Francisco García-Orduña 《Journal of ethnopharmacology》2012
Ethnopharmacological relevance
Cihuapatli is the Nahuatl name assigned to some medicinal plants grouped in the genus Montanoa, where Montanoa frutescens (Family: Asteraceae, Tribe: Heliantheae) is included. The crude extract from these plants has been used for centuries in the Mexican traditional medicine as a remedy for reproductive impairments and mood disorders. Experimental studies have systematically corroborated the traditional use of cihuapatli on reproductive impairments and sexual motivation, however, the effect on mood and “nervous” disorders, remains to be explored.Materials and methods
The anxiolytic-like effect of aqueous crude extract of M. frutescens (25, 50 and 75 mg/kg) was investigated in male Wistar rats evaluated in the elevated plus-maze and compared with several doses of diazepam (1, 2 and 4 mg/kg) as a reference anxiolytic drug. Picrotoxin (1 mg/kg), a noncompetitive antagonist of the GABAA receptor, was used in experimental procedures to evaluate if this receptor could be involved in the anxiolytic-like effects produced by M. frutescens. To discard hypoactivity, hyperactivity, or no changes associated with treatments, which could interfere with the behavioral activity in the elevated plus-maze, rats were subjected to the open field test.Results
M. frutescens at 50 mg/kg showed anxiolytic-like activity similarly to 2 mg/kg of diazepam, without disrupts in general motor activity. The anxiolytic-like effect of M. frutescens detected in the elevated plus-maze was blocked by picrotoxin, indicating that GABAA receptors are involved in the modulation of this effect.Conclusions
The results corroborate the use of M. frutescens in folk Mexican ethnomedicine as a potential anxiolytic agent and suggest that this effect is mediated by the GABAA receptors. Additionally, some sedative effects with high doses of M. frutescens were detected in the present study. 相似文献2.
E. T. Venâncio N. F. M. Rocha E. R. V. Rios M. L. Feitosa M. I. Linhares F. H. C. Melo M. S. Matias F. N. Fonseca F. C. F. Sousa L. K. A. M. Leal M. M. F. Fonteles 《Phytotherapy research : PTR》2011,25(3):444-450
Justicia pectoralis (Acanthaceae) is used as an antiinflammatory, antimicrobial and bronchodilator, and its extract exerts an anxiolytic‐like effect profile in animal models. This work presents the behavioral effects of an aqueous standardized extract of Justicia pectoralis (SEJP) in animal models, such as the elevated plus maze (EPM), light/dark, open field, rota rod and pentobarbital sleep time. The extract was administered intragastrically to male mice at single doses of 50, 100 and 200 mg/kg, while diazepam 1 or 2 mg/kg was used as a standard drug and flumazenil 2.5 mg/kg was used to evaluate the participation of benzodiazepinic receptors. The results showed that, similar to diazepam (1 mg/kg), SEJP significantly modified all the observed parameters in the EPM test, without altering the general motor activity in the open field, rota rod and pentobarbital sleep time tests. Flumazenil reversed not only the diazepam effect but also the SEJP effect. In the same way, all doses of SEJP increased the time of permanence in the light box in the light/dark test. The results showed that SEJP presented an anxiolytic‐like effect, disproving sedative effects. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
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David Wing-Shing Cheung Chi-Man Koon Chun-Fai Ng Ping-Chung Leung Kwok-Pui Fung Simon Kar-Sing Poon Clara Bik-San Lau 《Journal of ethnopharmacology》2012