首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 62 毫秒
1.
目的 探讨生长停滞特异性蛋白6(GAS6)基因多态性及血浆水平与昆明地区汉族2型糖尿病合并动脉粥样硬化(T2DM AS)的相关性。方法 收集181例单纯T2DM患者、171例T2DM AS患者和186例正常对照(NC)者,运用 PCR和单向基因测序检测GAS6基因多态性,ELISA检测血浆GAS6水平,并分析其基因型及等位基因频率、血浆GAS6水平和相关临床指标。结果 T2DM组分别与NC组、T2DM AS组相比,三种基因型频率的分布无差异(2=8031,P=0018;2=1762,P=0414);T2DM AS组GG基因型频率高于NC组,GA、AA基因型频率低于NC组,差异有统计学意义 (2=9286,P=0010)。T2DM组和T2DM AS组的A等位基因频率低于NC组,G等位基因频率高于NC组,差异有统计学意义 (2=7493,P=0006;2=8718,P=0003);T2DM AS组和T2DM组相比,等位基因频率的分布无差异(2=0069,P=0793)。T2DM组和T2DM AS组的体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL C)、空腹血糖(FBG)均高于NC组(P<001),而高密度脂蛋白胆固醇(HDL C)和GAS6水平低于NC组(P<001);T2DM AS组的病程、SBP和血管内中膜厚度(IMT)均高于T2DM组,差异有统计学意义(P<001),而GAS6水平与T2DM组相比无差异(P>0.05)。T2DM病程、饮酒、SBP是AS发生的危险因素(OR: 1072、2625、1019;95% CI:1024 1122、1241 5552、1003 1035)。HDL C是AS的保护性因素(OR=0253;95% CI:0071 0902);而GAS6基因rs8191974多态性及其血浆水平可能与AS无关联。结论 本研究尚未发现GAS6基因rs8191974多态性及其血浆水平与昆明地区汉族AS之间的关联。T2DM病程、饮酒、高血压是AS发生的危险因素,HDL C是AS的保护性因素。  相似文献   

2.
目的:研究巨噬细胞移动抑制因子(MIF)启动子上游的rs2012133G/C、rs4822443A/G和rs4822446G/A位点基因多态性与剖宫产术后腹壁子宫内膜异位症易感性的关系。方法:收集60例经病理确诊的剖宫产术后腹壁子宫内膜异位症患者作为病例组,同期选取109例健康志愿者作为对照组,采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法对MIF基因多态性进行分析,分析基因型的分布及其与剖宫产术后腹壁子宫内膜异位症发病风险的关系。结果:rs2012133G/C SNP的CC、CG、GG基因型频率在病例组和对照组2组中比较差异有统计学意义(P=0.032);C、G等位基因频率分布2组比较差异有统计学意义(P= 0.031)。与CG+CC基因型相比,携带GG基因型可明显增加子宫内膜异位症的发病风险(OR=2.284,95%CI:1.200~4.345)。而rs4822443A/G、rs4822446G/A SNP的基因型频率在病例组和对照组中的比较,差异无统计学意义(P>0.05)。结论:MIF rs2012133G/C位点基因多态性与剖宫产术后腹壁子宫内膜异位症发生的易感性有关,GG基因型是子宫内膜异位症的易感基因型。  相似文献   

3.
江舟 《西部医学》2018,30(6):794-797+802
【摘要】目的探讨近日钟基因Clock单核苷酸多态性与心肌缺血的关系。方法 收集临床确诊的心肌缺血患者120例为心肌缺血组;同时收集临床体检健康人群78例为健康对照组。采用普通PCR、凝胶电泳、单碱基引物延伸法基因分型(SnapShot)等方法检测Clock基因单核苷酸多态性位点(rs3840267, rs3749474和 rs1402963)在心肌缺血组和健康对照组中的基因型及等位基因频率分布,并分析其与心肌缺血的关系。 结果 Clock基因rs3840267位点的基因型及等位基因频率分布在心肌缺血组和健康对照组中差异有统计学意义(P<005);而rs3749474和rs1402963位点基因型及等位基因频率分布在心肌缺血组和健康对照组比较差异无统计学意义(P>005)。结论 Clock基因rs3840267位点多态性与心肌缺血存在关联。  相似文献   

4.
目的微小RNA(microRNA,miRNA)基因多态性与肿瘤的关系密切。文中探讨rs11614913(miRNA-196a2)及rs3746444(miRNA-499)的基因多态性与膀胱癌及其病理参数的相关性。方法选取膀胱癌患者283人作为膀胱癌组,正常体检者283人作为正常对照组。利用Massarray单核苷酸多态性检测技术对膀胱癌组和正常对照组的rs11614913(miRNA-196a2)及rs3746444(miRNA-499)基因多态性进行分析;采用Logistic回归模型分析各基因型与膀胱癌发生的关系并比较不同基因型与膀胱癌及其病理参数的关系。结果 rs11614913位点的各基因型在2组中分布差异有统计学意义(χ2=15.077,P<0.001),其中TT基因型在膀胱癌组中的频率(19.08%)显著低于对照组(33.95%),差异有统计学意义(P<0.05);TT基因型发生膀胱癌的风险是CC基因型的0.45倍(ORadjusted=0.45,95%CI:0.28~0.73)。rs3746444位点的各基因型在2组中分布差异无统计学意义(χ2=5.107,P=0.078),但GG基因型在膀胱癌组中分布频率(7.77%)显著高于对照组(3.56%),差异有统计学意义(P<0.05);GG基因型发生膀胱癌的风险是AA的2.39倍(ORadjusted=2.39,95%CI:1.10~5.17)。rs11614913及rs3746444位点的基因型分布频数在不同肿瘤分期、周围淋巴结转移、远端淋巴结转移组间的差异无统计学意义(P>0.05)。然而,在不同分化程度的肿瘤分组中2个位点的基因型分布频数差异有统计学意义(rs11614913:χ2=15.066,P=0.005;rs3746444:χ2=11.120,P=0.025)。结论 rs11614913(miRNA-196a2)及rs3746444(miRNA-499)基因多态性与膀胱癌的发生相关,2个位点的基因多态性与肿瘤的分化程度相关。  相似文献   

5.
目的: 研究中国汉族人群中乙醛脱氢酶2(aldehyde dehydrogenase 2,ALDH2)和乙醇脱氢酶1B(alcohol dehydrogenase 1B,ADH1B)基因多态性与食管癌淋巴结转移风险性的关系。方法: 采用基质辅助激光解吸电离飞行时间质谱(matrix assisted laser desorption/ ionization time of flight mass spectrometry, MALDI TOF MS)技术分析85例有淋巴结转移的食管癌和270例无淋巴结转移的食管癌标本ALDH2 rs671和ADH1B rs1229984基因多态性,计算各种基因型与食管癌淋巴结转移的相对风险度及其95%可信区间。结果: ALDH2 rs671 G>A3种多态基因型GG,GA,AA在食管癌淋巴结转移组和无淋巴结转移组的频率分别为58.8%(GG),38.8%(GA),2.4%(AA)和59.3%(GG),37.4%(GA),3.3%(AA)(χ2 =0.237, P=0.888);以ALDH2 rs671 GG基因型作参照,ALDH2 rs671 AA基因型食管癌淋巴结转移发生的风险降低(调整年龄、性别、吸烟及饮酒状态OR=0.70, 95% CI=0.14 ~3.45), 但相关性未达到明显统计学意义。ADH1B rs1229984 A>G3种多态基因型AA, AG, GG在食管癌淋巴结转移组和无淋巴结转移组的频率分别为38.8%(AA), 50.6%(AG), 10.6%(GG)和42.8%(AA), 41.6%(AG), 15.6%(GG)(χ2=2.553, P=0.279),以ADH1B rs1229984 AA基因型作参照,ADH1B rs1229984 GG基因型食管癌淋巴结转移发生的风险降低(调整年龄、性别、吸烟及饮酒状态OR=0.66, 95% CI=0.29 ~1.53), 但相关性未达到明显统计学意义。结论: ALDH2 rs671 G>A和ADH1B rs1229984 A>G基因多态性可能与食管癌淋巴结转移的风险无明显相关,需进一步研究证实。  相似文献   

6.
【摘要】 目的 探讨乳腺癌癌性疲乏(CRF)与肾上腺素水平、α2 肾上腺受体(α2AR)单核苷酸多态性(SNP)的相关性。方法 抽样法抽取2016年02月~2018年3月在陕西省肿瘤医院及西安交通大学第一、第二附属医院确诊并符合抽样标准的乳腺癌患者240例,分为手术组、化疗组和放疗组,每组各80例,测评其疲乏状况(轻、中、重度疲乏),并取外周静脉血,采用酶联免疫法测定其肾上腺素浓度,分析不同治疗期肾上腺素水平与癌性疲乏的关系。并将化疗组重度疲乏的59例患者设为病例组,选取同期59例健康人设为对照组,采用PCR RELP方法检测两组受试者的基因型,应用SPSS200统计软件分析α2A 肾上腺受体单核苷酸多态性位点与癌性疲乏程度的关联性。结果 不同治疗期内,乳腺癌患者的疲乏程度均与血液中的肾上腺素水平呈正相关(P<0.05 )。同等疲乏程度的患者在不同治疗时期内,血液中的肾上腺素水平并不一致:重度疲乏者中,手术组肾上腺素水平显著高于放疗组 (t=237,P<0.05),化疗组显著高于放疗组 (t=315,P<0.01);中度疲乏者中,手术组肾上腺素水平显著高于化疗组(t=231,P<0.01)和放疗组 (t=604,P<0.05);轻度疲乏者中,手术组、化疗组和放疗组的肾上腺素水平差异无统计学意义(P<0.05)。病例组和对照组α2A AR 1296位点的基因频数分布均符合Hardy Weinberg平衡定律(P>0.05),两组α2A AR的基因型频数分布比较差异无统计学意义(2=1161,P>0.05)。结论 乳腺癌癌性疲乏程度与肾上腺素水平呈正相关,但可能与α2A AR 1296位点基因多态性无关。  相似文献   

7.
目的探讨聚腺苷二磷酸核糖聚合酶1(PARP1)单核苷酸多态性对转移性食管鳞癌(ESCC)患者化疗反应及生存预后的影响。方法选择2016年7月至2020年1月该院收治的175例转移性ESCC患者,给予顺铂联合卡培他滨化疗,首次化疗前采集静脉血5 mL用于提取DNA,采用TaqMan探针法鉴别PARP1基因rs907187C/G、rs8679T/C和rs1136410T/C单核苷酸多态性位点的基因型,研究各多态性与化疗反应率及总生存期(OS)的关联性。结果 rs907187C/G单核苷酸多态性与转移性ESCC化疗反应密切相关,变异等位基因G携带者的化疗有效率明显升高(CC 22.6%、CG 40.7%、GG 56.1%,χ2=11.116,P=0.004)。杂合基因型CG化疗反应率为CC基因型的2.337倍(95%CI:1.068~5.113,χ2=4.516,P=0.034);纯合变异基因型GG化疗反应率为CC基因型的4.326倍(95%CI:1.771~10.565,χ2=10.334,P=0.001);CG+GG基因型...  相似文献   

8.
目的 探讨SLC22A3-LPAL2-LPA基因多态性与冠状动脉粥样硬化性心脏病(coronary artery disease,CAD)的相关性.方法 用聚合酶链反应-单链构象多态性(PCR-SSCP)方法和核苷酸测序技术检测165例CAD患者和166例对照的SLC22A3-LPAL2-LPA基因多态性.结果 CAD组和对照组中rs2048327位点均检测出AA、AG基因型,GG基因型未检出,G等位基因频率组间有统计学差异(19.7% vs 11.1%,P=0.002);rs3127599位点均检测出AG、GG基因型,AA基因型未检出,A等位基因频率组间有统计学差异(7.6% vs 13.2%,P=0.017);rs7767084位点均检测出CC、CT、TT 3种基因型,C等位基因频率组间差异有统计学意义(16.4% vs 30.7%,P=0.000);rs10755578位点均检测出CG、GG基因型,CC基因型未检出,C等位基因频率组间有统计学差异(18.5% vs 12.7%,P=0.038);使用Logistic回归分析排除年龄、吸烟、高血压等因素的影响后,除rs10755578位点外(P=0.077),其余各位点等位基因频率组间差异依然有统计学意义(P<0.05);单倍型AGC、AGT、GGC、GGT组间分布有统计学差异(P<0.05);分别比较各位点不同基因型的血脂水平,并未发现有统计学差异的指标(P>0.05).结论 SLC22A3-LPAL2-LPA基因rs2048327、rs3127599、rs7767084多态性位点可能与CAD发病相关,携带AGT、GGC、GGT单倍型的人群罹患CAD的风险性可能较正常人高,各位点基因多态性可能与血脂水平无关.  相似文献   

9.
姚佳欣  陈诗言  刘青松  苏敏  张大鹏 《西部医学》2018,30(7):1051-1054,1059
目的 探究精子细胞X射线交叉互补修复基因(XRCC1)rs25487位点的多态性及与少弱精的相关性。方法 收集182例男性少弱精患者和73例正常男性的精液,进行精液常规分析,包括精液量、液化时间、精液浓度及精子活力,然后采用聚合酶链反应 限制性段长度多态性(PCR RFLP)方法对精子细胞中的XRCC1基因进行分型。检测XRCC1基因rs25487位点的基因分型和等位基因频率,分析其与少弱精症的相关性。结果 少弱精患者的精子浓度和精子活力显著降低,液化时间显著延长。与GG基因型相比,携带AA基因型个体患少弱精症的风险是GG基因型的7.84倍(95%CI:1.019~60.365)。结论 精子细胞XRCC1基因rs25487位点AA基因型是男性患少弱精症的危险因素。  相似文献   

10.
黄娜  罗杨坤  冯玺  李勇  彭新皓  王宇  梁黎  秦远 《西部医学》2020,32(11):1620-1625+1629
【摘要】目的 探讨淋巴结外侵犯(ENE)在鼻咽癌(NPC)患者中的预后价值。方法 纳入2004年1月~2011年1月在我院初治的,并经病理学证实为非转移性鼻咽癌并接受调强放疗(IMRT)的294例NPC患者,搜集所有患者的临床资料。根据是否有ENE分为有ENE组(n=153)和无ENE组(n=141),采用倾向性评分匹配方法对两组患者进行匹配。生存分析采用Kaplan Meier法,log rank以及Cox回归分析。结果 ENE的发生率为52.0%。ENE常伴有的特征是淋巴结坏死的发生率更高,淋巴结直径更大以及N分期更晚。在初始队列中,ENE与较差的5年远处无转移生存率(DMFS),无进展生存率(PFS),总生存率(OS)相关(654% vs 76.9%,P=0020;575% vs 723%,P=0006;713% vs 839%,P=0028)。倾向匹配后的队列中,两组生存比较无差异[局部无复发生存率(LRFS):920% vs 924%,P=0656;区域无复发生存率(RRFS):973% vs 955%,P=0474; DMFS:710% vs 706%,P= 0801; PFS:659% vs 628%,P=0907;OS:757% vs 800%,P=0558]。多因素COX回归分析确认ENE不是鼻咽癌患者生存的独立预后因素。结论 ENE不是接受IMRT治疗NPC患者的独立预后因素。  相似文献   

11.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

12.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

13.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

14.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

15.
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.  相似文献   

16.
Objective:To investigate the gene expression of osteoprotegerin(OPG) and osteoclast differentiation factor(ODF) in the bone tissue of patients with hip fracture due to osteoporosis. Methods:OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers(over 50 years old) with hip fracture(Observer Group) and 30 cases of hip facture sufferers with no osteoporosis(Control group) were analyzed with the Semi-Quantitative RT-PCR method. Results:The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion:Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.  相似文献   

17.
Objective:To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas(SPTP). Methods:Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin(HE) staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results:Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin(9/9 cases), AAT(9/9 cases), NSE(9/9 cases), ACT(7/9 cases), CK20(2/9 cases), CgA(1/9 cases), S-100(3/gcases), PR(4/gcases), Syn(3/9 cases) and CD56(5/9cases), negative in CEA and ER. Conclusion:SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.  相似文献   

18.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

19.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

20.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号