健康中年人血清炎症标志物与骨密度的相关性研究

目的探讨健康中年人血清C反应蛋白(CRP、脂联素、肿瘤坏死因子-α(TNF-α)与骨密度之间相关性。方法我们测量了76名成人的血清CRP、脂联素、TNF-α以及腰椎和股骨颈骨密度(BMD)并分析之间相关性。结果按照BMD检测结果将76名参与者分为两组:BMD正常组(40,52. 6%),和BMD降低组(36,47. 4%)。BMD降低组CRP较BMD正常组水平显著升高,差异有统计学差异(P0. 05)。BMD降低组的脂联素水平较低,但差异无统计学意义(P0. 05)。BMD降低组的TNF-α水平较高,差异无统计学意义(P0. 05)。Pearson相关系数分析显示BMD降低组的BMD与CRP呈负相关性。结论健康中年人血清CRP与BMD呈负相关性。     

绝经后妇女血清鸢尾素与骨密度和骨代谢的相关性研究

目的观察绝经后女性血清鸢尾素与骨密度和骨代谢的相关性。方法选取年龄大于45岁的绝经后女性作为研究对象,按照其绝经时间的长短分为绝经后早期组(绝经后10年内)和绝经后晚期组(绝经后10年以上);获取所有受试者的一般临床资料、血清学指标和骨密度(bone mineral density,BMD);使用ELISA试剂盒检测受试者血清鸢尾素和骨代谢指标;使用统计软件分析之间的相关性。结果 P1NP和β-CTX结果提示,患有骨质疏松症受试者的骨转换速度显著提高(P0. 05);高BMD的受试者年龄较大(P0. 05);此外,BMD高的受试者其体重和身高均高于BMD低的受试者。在具有高BMD的受试者中观察到了更高水平的血糖(P0. 05)。BMD较高的受试者,其鸢尾素水平也较高(P0. 05)。然而,在BMD不同的受试者中没有观察到总胆固醇和甘油三酯之间的差异(P0. 05)。据Spearman相关分析显示,血清鸢尾素水平与BMD和P1NP、β-CTX水平呈正相关,但与甘油三酯、血糖和总胆固醇不相关。结论绝经后妇女血清鸢尾素与骨密度和P1NP、β-CTX水平呈正相关。     

围绝经期女性肾功能与骨密度的相关性研究

目的观察围绝经期女性肾功能与骨密度的相关性。方法选取2014年3月至2017年12月在我院接受健康检查的710名40～55岁汉族女性作为研究对象。通过双能X线吸收法测量受试者腰椎(L1～4)和左侧股骨颈的骨密度(bone mineral density,BMD),根据测量结果将受试者分为高BMD组和低BMD组。使用肾小球滤过率(estimated glomerular filtration rate,eGFR)和肌酸酐清除率(creatinine clearance rate,CCr)来评估肾功能。运用多变量逻辑回归和一般线性模型评估肾功能和BMD之间的相关性。结果 eGFR与BMD、体重和尿酸呈负相关(P 0. 05); CCr与BMD、体重、高血压、LDL-C、空腹血糖、碱性磷酸酶、尿酸和eGFR呈正相关(P0. 05);低eGFR对低BMD有保护作用(P0. 05);低CCr水平与低BMD显著相关[校正比值(AOR)=1. 42,95%置信区间(CI)=1. 05～1. 95]。在绝经前妇女(AOR=1. 46,95%CI=1. 11～1. 96)中观察到这种关联。结论围绝经期女性肾功能与骨密度密切关联,且绝经状态会影响这种关联。     

血清胃饥饿素、脂肪因子与膝骨关节炎患者骨密度的相关性研究

目的探讨血清胃饥饿素、脂肪因子水平与膝骨关节炎(knee osteoarthritis)患者骨密度(bone mineral density,BMD)之间的相关性。方法本研究选取了164例有症状的膝骨关节炎患者和100位健康人群(对照组)。使用酶联免疫吸附试验(ELISA)测量受试者血清胃饥饿素、脂联素和抵抗素水平。通过双能X线吸收测定法(DXA)测量受试者全身、腰椎、髋部和股骨的BMD。结果膝骨关节炎受试者的全身、腰椎、髋关节、股骨的BMD水平低于对照组(P均<0.05);但脂联素及胃饥饿素水平明显高于对照组(P均<0.05);在单因素分析中,血清胃饥饿素水平与所测量各个部位的骨密度之间有显著的负相关性(P<0.05);脂联素与股骨干骨密度和总股骨骨密度呈显著负相关(P<0.05)。进一步调整年龄、性别、体质量指数(body mass index,BMI)和骨关节炎(osteoarthritis,OA)后,胃饥饿素水平与各个部位的骨密度之间仍然存在显著负相关(P<0.05);脂联素与股骨干、股骨的骨密度之间有显著的相关性(P<0.05)。而血清抵抗素与各部位骨密度在混杂因素调整前后未发现显著相关性。结论血清胃饥饿素和脂联素水平与BMD呈显著负相关,提示胃饥饿素和脂联素对膝骨关节炎患者BMD有潜在的不利影响。     

血清Asprosin水平与绝经后女性骨密度、平衡能力和骨折发生率的相关性

目的 探讨血清Asprosin(白脂素)水平与绝经后女性骨密度(bone mineral density,BMD)、平衡能力和骨折发生率的相关性.方法 回顾性分析海南医学院第一附属医院收治的164例绝经后女性骨质疏松症(osteoporosis,OP)患者的临床资料.记录患者一般临床资料以及骨折发生率、髋部骨密度、平衡...     

绝经后骨质疏松患者血清脂联素与瘦素和炎性细胞因子的相关性研究

目的探讨绝经后骨质疏松患者血清脂联素与瘦素和炎性细胞因子的相关性及其发病机制。方法测定80例绝经后骨质疏松患者（实验组）和80例绝经后健康妇女（对照组）的血清脂联素、瘦素、肿瘤坏死因子-α（TNF-α）、白细胞介素石（IL-6）和骨密度（BMD）等指标。结果实验组患者的血清脂联素、瘦素、TNF-α、IL-6显著高于对照组（P〈0．01）,腰椎BMD、髋部BMD、前臂BMD显著低于对照组（P〈0．05）。绝经后骨质疏松症患者的血清脂联素与瘦素（r=0．592）、TNF—α（r=0．553）和IL-6（r=0．388）呈显著正相关,与髋部BMD（r=-0．477）、腰椎BMD（r=-0．391）、前臂BMD（r=-0．329）呈显著负相关。结论绝经后骨质疏松的发生发展过程是脂联素、瘦素和炎性反府等名冈素综合作用的结果．     

血清维生素K1水平与绝经后女性腰椎骨密度相关性分析

目的探讨绝经后女性骨密度与血清维生素K1水平之间的相关性。方法使用标准化的酶联免疫吸附试验(ELISA)试剂盒测量46例绝经后骨质疏松女性和30名绝经后健康对照女性的血清维生素K1水平。检测腰椎(1～4)的骨密度(bone mineral density, BMD)。结果绝经后骨质疏松女性组血清维生素K1水平明显低于正常对照组(P0.05),绝经后骨质疏松女性血清维生素K1浓度与腰椎BMD呈正相关(R=0.545,P=0.003);绝经后正常对照组血清维生素K1浓度与腰椎BMD呈正相关(R=0.513,P=0.009)。维生素K1对骨质疏松症的诊断敏感性和特异性分别为91%和98%(截止值:0.853 ng/mL);维生素K1的ROC曲线下面积(AUC)为0.985,奇数比为18.88。结论维生素K1与诊断绝经后骨质疏松症呈负相关。     

肌肉强度和肌肉质量与绝经后女性骨密度的相关性研究

目的探索绝经后女性肌肉强度和肌肉质量与骨密度相关性。方法分析了2014年3月至2017年8月在我院就诊的340名绝经后妇女。使用双能量X射线吸收测定法检测股骨颈和腰椎骨密度(bone mineral density,BMD)、全身骨密度和附肢骨骼肌肌肉量(appendicular skeletal muscle,ASM)。ASM指数(ASMI,kg/m~2)按照ASM(kg)除以高度的平方(m~2)计算。测量握力(kg)作为肌肉力量的指标。结果调整ASMI和年龄后(股骨颈标准化偏回归系数β=0. 105,腰椎=0. 116),握力强度与几个骨骼部位BMD呈显著性正相关(P0. 05)。股骨颈和腰椎骨密度的调整平均值显示出握力强度从最低到最高三分位数的显著增加趋势。本研究结果表明肌肉强度与绝经后妇女肌肉量的几个位点的BMD密切相关。无论肌肉大小如何,肌力强健的绝经后妇女都有健康的骨骼状态。结论绝经后女性骨密度和肌肉强度密切相关,与肌肉质量无明显相关性。     

绝经后女性骨密度与骨代谢生化指标的相关性分析

目的分析绝经后女性骨密度(bone mineral density,BMD)与骨代谢生化指标的相关性。方法选取西南医科大学附属医院2017年1月至2018年12月收治的绝经后女性患者151例。根据骨密度T值将患者分为骨质疏松组(83例)、骨量低下组(47例)和骨量正常组(21例),比较三组患者骨代谢生化指标的差异,并对各项指标与BMD进行相关性分析。结果骨质疏松组甲状旁腺素(PTH)、Ⅰ型前胶原氨基末端前肽(P1NP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)显著高于骨量低下组和骨量正常组(P0. 05),骨量低下组显著高于骨量正常组(P0. 05)。骨质疏松组体质量指数(bone mass index,BMI)、25(OH) D_3显著低于骨量低下组和骨量正常组(P0. 05),骨量低下组显著低于骨量正常组(P0. 05)。血钙、血磷、骨钙素(BGP)、血清的骨特异性碱性磷酸酶(BALP)在三组之间比较,差异无明显统计学意义(P0. 05)。Spearman相关分析显示,PTH、P1NP、β-CTX与骨密度呈负相关(r=-0. 538,-0. 520,-0. 462,P 0. 05),25(OH) D_3与骨密度呈正相关(r=0. 517,P0. 05),血钙、血磷、BALP、BGP与骨密度无相关性(P0. 05)。结论血清25(OH) D_3、PTH、P1NP、β-CTX与骨密度存在显著相关性,骨代谢生化指标监测有助于绝经后女性骨质疏松的早期诊断。     

围绝经期女性骨密度特点分析

目的总结并分析围绝经期女性腰椎1-4、股骨颈及髋关节部位的骨密度(bone mineral density,BMD)及其临床特点。方法收集2017年12月至2018年6月在我院住院部住院并进行双能X线吸收法骨密度检测的183例围绝经期女性,分别测定其腰椎1-4总体BMD、左侧股骨颈及左髋关节全部BMD,同时分析比较年龄、体质量指数(body mass index,BMI)与骨质疏松的关系。结果 183例患者中,检出骨质疏松39例(21. 3%),其中腰椎1-4、左股骨颈和左髋关节BMD各检出骨质疏松33例(18. 0%)、20例(10. 9%)、13例(7. 1%)。腰椎总体骨质情况与股骨颈、髋关节检查结果相符的各有129例(70. 5%)、119例(65. 0%),股骨颈总体骨质情况与髋关节检查结果相符的有137例(74. 9%)。在骨质疏松组、骨量减少组和骨量正常组,同一组病人腰椎1-4骨密度左髋关节骨密度左侧股骨颈骨密度,组间差异均有统计学意义。年龄、BMI与骨质疏松的发生均相关。骨质疏松与年龄呈正相关,与BMI、腰椎1-4总BMD、左股骨颈BMD、左髋关节BMD负相关,腰椎1-4 BMD与骨质疏松相关程度最高。结论腰椎整体骨密度呈现虚假升高趋势,腰椎1-4 BMD诊断骨质疏松的敏感性和特异性分别为84. 6%、100%,股骨颈分别为51. 3%、100%,髋关节分别为33. 3%、100%;年龄增长、BMI偏低会增加围绝经期妇女罹患骨质疏松的风险。     

甘肃省兰州地区中老年女性骨密度现状调查及危险因素分析

目的调查研究甘肃省兰州地区中老年女性的骨密度情况,并分析体重指数与骨质疏松的相关性。方法选取2019年5月1日至2019年10月30日期间于甘肃省妇幼保健院行健康体检的女性。详细记录其年龄、绝经状态、身高及体重,采用双能X线吸收骨密度仪进行检测。结果共纳入2 078名研究对象。其中绝经前组204名,占9.82%,平均年龄(41.10±3.19)岁;围绝经期组443名,占21.32%,平均年龄(49.29±2.18)岁;绝经后组1 431名,占68.86%,平均年龄(56.25±7.59)岁。围绝经期组及绝经后组平均绝经年龄分别为(50.43±1.30)岁、(48.42±3.06)岁。三组平均身高、体重及体重指数分别为(1.59±0.05) m、(59.58±7.78) kg及(23.71±3.11) kg/m2。左侧股骨颈的平均骨密度分别为:绝经前组(0.85±0.14) g/cm2、围绝经期组(0.91±0.15) g/cm2、绝经后组(0.82±0.12) g/cm2;左侧全部髋关节的平均骨密度分别为:绝经前组(0.99±0.16)g/cm2、围绝经期组(0.97±0.17) g/cm2、绝经后组(0.88±0.13) g/cm2。腰1～4全部椎体的平均骨密度分别为:绝经前组(1.13±0.22) g/cm2、围绝经期组(1.10±0.20) g/cm2、绝经后组(0.97±0.15) g/cm2。所有绝经前女性的骨密度均正常;围绝经期女性中,正常骨密度占45.15%,骨量减少占32.28%,骨质疏松占22.57%;绝经后女性中,正常骨密度占19.57%,骨量减少占33.54%,骨质疏松占46.89%。Spearman等级相关分析结果示BMI与骨质疏松的发病率呈正向显著相关。结论甘肃省兰州地区中老年女性的骨质疏松发病率随年龄的增长而明显增高,尤其是绝经后及肥胖者,定期监测骨密度成为其不可或缺的体检项目。     

The Beneficial Effect of Leisure-Time Physical Activity on Bone Mineral Density in Pre- and Postmenopausal Women

Regular exercise and physical activity (PA) are known to be protective factors for maintaining bone mineral density (BMD) and preventing osteoporotic fracture. We investigated the associations between leisure-time PA and BMD in 2,903 premenopausal and 2,267 postmenopausal women in Korea. BMDs of the lumbar spine and femur were measured using dual-energy X-ray absorptiometry. Leisure-time PA levels were assessed by a self-administrated questionnaire, and a total metabolic equivalent (MET) score was obtained. Regardless of menopausal status, performing more than moderate levels of leisure-time PA or total MET score had a significant positive association with BMD at both the lumbar spine and femur. In the premenopausal group, women whose total MET score was 1,050-1,500 (MET-min/week) appeared to have the highest lumbar spine and femoral BMD (p?相似文献   

Bone mass after long-term euthyroidism in former hyperthyroid women treated with (131)I influence of menopausal status.

The objective of this study was to assess bone mineral density (BMD) and bone markers in former hyperthyroid females after long-term euthyroidism (>4 yr) following (131)I therapy, as well as the potential influence of the timing of menopause. Twenty-six females ages 57 +/- 8 yr previously diagnosed with hyperthyroidism and treated with (131)I who were euthyroid for a minimum of the last 4 yr (10 +/- 5 yr) were studied. Eighteen patients (69%) were on levothyroxine (LT(4)) replacement therapy for 9 +/- 4 yr. BMD (g/cm(2) and Z-score) was measured by dual X-ray absorptiometry in the lumbar spine, femoral neck, and Ward's triangle. BMD (Z-score) was lower than the normal reference values for the Spanish population in all sites (lumbar spine: -0.65 +/- 1.13; femoral neck: -0.47 +/- 0.95; Ward's triangle: -0.37 +/- 0.88). No differences were found between BMD values according to the etiology of the hyperthyroidism or current LT(4) therapy. Current postmenopausal patients (n = 21) showed lower BMD than current premenopausal patients in the lumbar spine and femoral neck (p < 0.05). Those women who were postmenopausal at the time of the (131)I therapy (n = 15) also had lower lumbar spine BMD than premenopausal patients (p = 0.01), while no significant difference in BMD was seen according to the menopausal status when hyperthyroidism was diagnosed. Former hyperthyroid patients after long-term euthyroidism following (131)I therapy showed reduced BMD at the lumbar spine and proximal femur. Menopausal women showed a greater reduction in bone density. The menopausal status at the time of diagnosis did not seem to have long-term effects in bone density; nevertheless, an early therapeutic intervention in premenopause is suggested to reduce bone loss.     

凝溶胶蛋白与绝经后女性股骨颈及腰椎骨密度的相关性研究

目的探讨凝溶胶蛋白(GSN)在绝经后女性血浆中的水平并分析与股骨颈及腰椎骨密度(BMD)的相关性。方法选取我院2015年1月至2019年5月期间在我院正常体检人员。纳入绝经后女性110名。与此同时,在我院体检中心选择非绝经期女性110例。采用Hologic?QDR-4500 DXA骨密度仪测定股骨颈、腰椎(L_1-L_4)的BMD。BMD数据以g/cm~2和T评分表示。T评分-2.5定义为骨质疏松症,T评分在-1～-2.5间定义为骨量减少,T评分-1定义为骨密度正常(正常BMD组)。骨质疏松症或骨量减少定义为低BMD组,骨密度正常定义为正常BMD组。采用酶联免疫吸附试验(ELISA)测定GSN水平。结果绝经后女性年龄、SBP、DBP、TC、FBS高于绝经前女性(P0.05);而股骨颈-BMD、腰椎(L_1-L_4)-BMD、GSN低于绝经前女性(P0.05)。股骨颈-BMD组中,低BMD组的年龄、吸烟比例、TC、FBS、GSN高于正常BMD组(P0.05);而BMI、HDL低于正常BMD组(P0.05)。腰椎(L_1-L_4)-BMD组中,低BMD组的年龄、TC、FBS、GSN高于正常BMD组(P0.05);而BMI、HDL低于正常BMD组(P0.05)。股骨颈-BMD与年龄、吸烟、FBS、pGSN呈负相关(r=-0.435、-0.301、-0.243、-0.609),与HDL、BMI呈正相关(r=0.395、0.365)。腰椎(L_1-L_4)-BMD与年龄、p GSN呈负相关(r=-0.463、-0.433),与BMI呈正相关(r=0.398)。年龄、BMI、GSN是股骨颈-BMD独立影响因素;年龄、GSN是腰椎(L1-L4)-BMD独立影响因素。结论 GSN是股骨颈-BMD、腰椎(L_1-L_4)-BMD的独立影响因素。因此,GSN水平升高可能预测绝经后女性骨质疏松症的发生及进展。     

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

The bone and fat interface is implicated in the pathogenesis of postmenopausal osteoporosis. The association between circulating omentin-1 levels and bone mineral density (BMD) in postmenopausal women has never been assessed. A total of 382 healthy postmenopausal women were randomly selected. Omentin-1, visfatin, adiponectin, the receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin, high sensitivity C-reactive protein, degradation products of C-terminal telopeptides of type I collagen, and osteocalcin were measured by highly specific enzyme-linked immunosorbent assay methods. BMD was determined for the lumbar spine (L2-L4) and the proximal femur using dual-energy X-ray absorptiometry. In multivariable-adjusted linear regression, serum omentin-1 levels were inversely correlated with BMD at the lumbar spine (β=-0.11, p=0.020). In multiple regression analyses, serum visfatin and adiponectin levels were not significantly correlated with BMD at different skeletal sites after controlling for age, body mass index, and bone-related markers. However, the highest quartile of adiponectin compared to the lowest quartile, after adjusting for potential confounders, revealed an inverse association with BMD in the lumbar spine (β=-0.19, p=0.010). In conclusion, circulating omentin-1 levels had an inverse correlation with BMD at the lumbar spine in Iranian postmenopausal women. To further understand the role of omentin-1 in bone and mineral metabolism, large-scale longitudinal studies focusing on BMD and osteoporotic fractures are warranted.     

The relationship between endogenous estrogen,sex hormone-binding globulin,and bone loss in female residents of a rural Japanese community: the Taiji Study

 The aim of this study was to clarify the relationship between endogenous estrogen, sex hormone-binding globulin (SHBG), and bone loss in pre-, peri-, and postmenopausal female residents of Taiji, a rural Japanese community. From a list of inhabitants aged 40 to 79 years, 200 participants—50 women in each of four age decades—were randomly selected, and baseline bone mineral density (BMD) at the lumbar spine and proximal femur were measured by dual-energy X-ray absorptiometry in 1993. Total estradiol (total E2) and SHBG were measured, and SHBG-unbound E2 (UBE2) was calculated using SHBG and the percent SHBG-unbound fraction ratio. BMD was measured again 3 years later, in 1996. Participants with ovariectomy or hysterectomy were excluded, and the remaining participants were categorized into four groups: premenopausal (n= 38), perimenopausal (n= 14), postmenopausal group 1 (5 years or less since menopause; n= 18), and postmenopausal group 2 (6 years or more since menopause; n= 74). The mean value of total E2 was highest in the premenopausal group (49.1 pg/ml), followed by the perimenopausal group (26.4 pg/ml), and the postmenopausal groups (0.83 pg/ml in postmenopausal group 1 and 0.96 pg/ml in postmenopausal group 2). The means for UBE2 showed the same pattern across the groups. After the multiple regression analysis of BMD at follow-up and endogenous estrogens, in premenopausal women, there were no significant associations between BMD at follow-up and serum total E2 and UBE2. In perimenopausal women, however, serum total E2 and UBE2 were significantly correlated with trochanteric BMD at follow-up (P < 0.05); and in postmenopausal group 2, they were significantly correlated with lumbar spine and Ward's triangle BMD at follow-up (P < 0.001 at lumbar spine, P < 0.05 at Ward's triangle). Concerning the association between BMD at follow-up and SHBG, in the premenopausal group, serum levels of SHBG were negatively correlated with BMD at the femoral neck (P < 0.05). In regard to partial regression coefficients for the change rates of BMD over 3 years and serum estrogens and SHBG concentrations, in perimenopausal women, UBE2 was correlated with the change rate of BMD at Ward's triangle (P < 0.05), and in postmenopausal group 1, serum levels of SHBG were significantly negatively related to change in BMD at the trochanter (P < 0.01). No other relationships with change in BMD were observed at any sites. These findings suggest that serum E2, UBE2, and SHBG levels differentially predict BMD levels in groups of differing menstrual status. It would, however, be difficult to predict bone loss in middle-aged and elderly Japanese women over a 3-year period using these indices alone. Received: November 29, 2001 / Accepted: February 28, 2002     

绝经后女性骨密度与冠状动脉钙化的相关性研究

目的评估绝经后妇女骨密度(bone mineral density,BMD)与冠状动脉钙化(coronary calcification,CAC)之间的相关性。方法本研究纳入120名年龄超过55岁的绝经后妇女作为研究对象。所有对象均收集一般临床资料;同时检测三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平、空腹血糖(FBG)、血清钙和血清磷。髋部和腰椎(L1～4) BMD使用双能X线骨密度仪检测。CAC采用高清计算机断层扫描技术进行测量。结果年龄与左股骨颈及腰椎L1～4的骨密度呈显著负相关(均P0. 05)。CAC的钙化积分、体积积分和质量积分与年龄呈正相关。66%的受试者中发现有CAC。各种CAC评分(钙化、体积、质量积分)和所有身体扫描部位(L1～4、股骨颈)的BMD之间没有显著的相关性(P0. 05)。此外,在多元线性回归分析中,CAC评分与BMD之间的关系不存在统计学意义(P0. 05)。结论年龄是高清计算机断层扫描技术检测到的BMD降低和CAC发展的重要因素。     

Bone mass status in different degrees of chronic renal failure.

Bone mineral density (BMD) was evaluated in 69 patients with chronic renal failure (CRF) and in healthy controls matched for age, sex, and, for women, menopausal status. Both appendicular (predominantly cortical) and axial (predominantly trabecular) bone mass were measured. Appendicular BMD was measured by single photon absorptiometry on the distal forearm and axial BMD was measured by dual photon absorptiometry on the lumbar spine. Patients were divided into three groups on the basis of creatinine clearance: group 1, 58 to 36 ml/min; group 2, 30 to 18 ml/min; group 3, 15 to 9 ml/min. Both appendicular and axial BMD decreased with the worsening of renal failure. Parathyroid hormone levels were inversely correlated with the values of appendicular BMD. BMD values were significantly lower in postmenopausal than in premenopausal women. Months of menopause were inversely correlated with axial BMD values. Appendicular BMD was lower in CRF patients than in controls, and both appendicular and axial BMD were significantly lower in postmenopausal uremic women than in postmenopausal healthy women.     

CD38 is associated with premenopausal and postmenopausal bone mineral density and postmenopausal bone loss

One goal of osteoporosis research is to identify the genes and environmental factors that contribute to low bone mineral density (BMD) and fracture. Linkage analyses have identified quantitative trait loci (QTLs), however, the genes contributing to low BMD are largely unknown. We examined the potential association of an intronic polymorphism in CD38 with BMD and postmenopausal bone loss. CD38 resides in 4p15, where a QTL for BMD has been described. CD38−/− mice display an osteoporotic phenotype at 3 months, with normalization of BMD by 5 months. The CD38 polymorphism was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 457 postmenopausal and 173 premenopausal Caucasian women whose spine and hip BMD was measured by dual energy X-ray absorptiometry (DXA). Influence of the CD38 polymorphism on bone loss was analyzed in 273 postmenopausal women over a follow-up of 2.94 ± 1.50 years. The CD38-PvuII polymorphism was significantly associated with premenopausal and postmenopausal (P = 0.001) lumbar spine BMD. Women homozygous for the G allele had >14% lower spinal BMD than women with GC/CC genotypes. An allele dose effect was observed at the spine in premenopausal (P = 0.002) and postmenopausal (P < 0.001) cohorts. The CD38-PvuII polymorphism was significantly associated with femoral neck BMD in pre- and postmenopausal women (P = 0.002 and P = 0.011, respectively). However, significance was lost following adjustment of hip BMD for covariates in the postmenopausal cohort (P = 0.081). The CD38-PvuII polymorphism was weakly associated with bone loss at the spine (P = 0.024), in postmenopausal women not taking hormone replacement therapy. We suggest that the CD38-PvuII polymorphism may influence the attainment and maintenance of peak BMD and postmenopausal bone loss.     

绝经后妇女腰椎和髋部骨密度分布特点的分析研究

目的 绝经后妇女年龄、绝经年限、绝经年龄与腰椎和骨密度的关系.方法 采用双能X线骨密度仪对500例健康绝经后妇女进行骨密度检测,并且分析绝经年龄、绝经年限对腰椎(L2-L4)和髋部骨密度分布特点的影响.结果 随着绝经年龄的增长,腰椎和髋部骨密度均逐渐降低,单因素相关分析表明,年龄、绝经年限与腰椎和髋部各部位的骨密度呈负相关(P＜0.05),绝经年龄与腰椎和髋部各部位的骨密度无显著相关性(P＞0.05).结论 年龄、绝经年限与腰椎和髋部骨密度有关联,而绝经年龄与腰椎和髋部骨密度关联性不显著.