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1.
Dejin Yang Hongyi Shao Yixin Zhou Hao Tang Shengjie Guo 《The Journal of arthroplasty》2017,32(11):3539-3543
Background
Lateral soft-tissue release can jeopardize the common peroneal nerve (CPN) in total knee arthroplasty for valgus knees. Previous studies reporting safe zones to protect the CPN were based on well-aligned knees. We conducted this study to compare the localization of the CPN in well-aligned knees and in valgus knees.Methods
We conducted a consecutive 3-dimensional radiographic study on magnetic resonance images of 58 well-aligned knees and 39 valgus knees. We measured the distance between the CPN and the tibia, as well as the mediolateral, anteroposterior, and angular location of the CPN. We compared the results between well-aligned knees and valgus knees.Results
We found that there is an increased distance between the CPN and the tibia at the level of the tibial cut, but not at the joint line in valgus knees. It is safer to release the posterolateral capsule at the tibial side than at the level above this. The angular location and the mediolateral or anteroposterior location of the CPN in valgus knees are similar to those of well-aligned knees.Conclusion
The location of the CPN in valgus knees is similar to that in well-aligned knees. The previously reported safe zone in well-aligned knees is applicable in valgus knees to protect the CPN. 相似文献2.
Daisuke Chiba Eiichi Tsuda Harehiko Tsukada Kohei Iio Yasuyuki Ishibashi 《Journal of orthopaedic science》2017,22(5):892-897
Objectives
There are not many chances to arthroscopically reassess how graft tunnel malpositions in primary anterior cruciate ligament reconstruction (ACLR) associate with intra-articular degeneration in revision ACLR. This study was aimed to evaluate whether radiographic tunnel position in primary ACLR affect cartilaginous changes and bucket-handle meniscus tears in revision ACLR.Methods
Thirty-five patients who underwent revision ACLR were recruited; their primary surgeries were single-bundle reconstructions. Tunnel positions were evaluated using the plain radiographs after primary surgery. The sagittal tunnel positions of the femur (FP) and tibia (TP) were determined on the lateral view. The articular cartilage was evaluated arthroscopically at primary and revision surgery using the International Cartilage Repair Society (ICRS) score. A progression of two grades was considered as cartilaginous changes. Meniscal tears were evaluated with an arthroscopic probe. Logistic regression analysis was conducted using the prevalence of cartilaginous changes or bucket-handle meniscus tears as the dependent variable; tunnel parameters were used as the independent variables.Results
Seven patients (20.0%) had cartilaginous changes and nine patients (25.7%) had bucket-handle tears in the medial meniscus. In logistic regression analysis, %FP [odds ratio (OR): 1.212; P = 0.007] and the cut-off of 60% in the FP (OR: 22.000; P = 0.008) were correlated with cartilaginous changes. %TP (OR: 1.126; P = 0.036) was correlated with the prevalence of bucket-handle meniscus tears.Conclusions
Anterior femoral tunnel malposition in the femur was associated with the cartilaginous changes, and posterior tibial tunnel malposition with the development of bucket-handle meniscus tears. 相似文献3.
Pieter-Jan T.K. Vandekerckhove Matthew G. Teeter Douglas D.R. Naudie James L. Howard Steven J. MacDonald Brent A. Lanting 《The Journal of arthroplasty》2017,32(6):2012-2016
Background
Coronal plane alignment is one of the contributing factors to polyethylene wear in total knee arthroplasty.Methods
Based on 95 retrieved polyethylene inserts, wear and damage patterns were analyzed in relationship to the overall mechanical alignment and to the position of the tibial component.Results
A progression of wear was observed with progressively mechanical varus alignment. However, there was significantly more damage in the lateral compartment in the mild and moderate varus group compared to the valgus group. No difference in damage was seen between all groups for tibial component positioning in valgus or varus.Conclusion
Progressive wear was observed with progressively varus alignment with more damage at the lateral side. This observation is unique and might be explained by lateral condylar lift-off inducing impact and shear loading in the varus group. 相似文献4.
Nobutake Ozeki Takeshi Muneta Kenichi Kawabata Hideyuki Koga Yusuke Nakagawa Ryusuke Saito Mio Udo Katsuaki Yanagisawa Toshiyuki Ohara Tomoyuki Mochizuki Kunikazu Tsuji Tomoyuki Saito Ichiro Sekiya 《Journal of orthopaedic science》2017,22(3):542-548
Background
Meniscus extrusion often observed in knee osteoarthritis has a strong correlation with the progression of cartilage degeneration and symptom in the patients. We recently reported a novel procedure “arthroscopic centralization” in which the capsule was sutured to the edge of the tibial plateau to reduce meniscus extrusion in the human knee. However, there is no animal model to study the efficacy of this procedure. The purposes of this study were [1] to establish a model of centralization for the extruded medial meniscus in a rat model; and [2] to investigate the chondroprotective effect of this procedure.Methods
Medial meniscus extrusion was induced by the release of the anterior synovial capsule and the transection of the meniscotibial ligament. Centralization was performed by the pulled-out suture technique. Alternatively, control rats had only the medial meniscus extrusion surgery. Medial meniscus extrusion was evaluated by micro-CT and macroscopic findings. Cartilage degeneration of the medial tibial plateau was evaluated macroscopically and histologically.Results
By micro-CT analysis, the medial meniscus extrusion was significantly improved in the centralization group in comparison to the extrusion group throughout the study. Both macroscopically and histologically, the cartilage lesion of the medial tibial plateau was prevented in the centralization group but was apparent in the control group.Conclusions
We developed medial meniscus extrusion in a rat model, and centralization of the extruded medial meniscus by the pull-out suture technique improved the medial meniscus extrusion and delayed cartilage degeneration, though the effect was limited. Centralization is a promising treatment to prevent the progression of osteoarthritis. 相似文献5.
Yijie Zhang Yanxi Chen Minfei Qiang Kun Zhang Haobo Li Yuchen Jiang Xiaoyang Jia 《The Journal of arthroplasty》2017,32(8):2563-2567
Background
We aim to make an anthropometric analysis of tibial plateau at the surface level and the resected level and analyze the correlation in lengths between 2 levels. We hypothesized that lengths at the surface level were longer than those at the resected level, which brought soft tissue tolerance for tibial component to overhang.Methods
Anthropometric data were measured using three-dimensional structures reconstructed from tibial plateaus of 100 knees in 100 Chinese subjects (50 men and 50 women). Mediolateral, medial anteroposterior, and lateral anteroposterior lengths at the surface level and the resected level were measured, and the Pearson's correlation coefficients of these data were calculated.Results
Mediolateral and medial anteroposterior lengths at the surface level were longer than those at the resected level by a mean 2.38 ± 1.29 and 1.99 ± 1.76 mm, respectively. Lateral anteroposterior length at the surface level was shorter than that at the resected level by a mean 1.54 ± 2.49 mm. All these differences between 2 levels had no gender difference.Conclusion
Our findings suggest that tibial overhang could be better tolerated in the medial compared to the lateral compartment but this hypothesis has to be further investigated in a clinical study. 相似文献6.
Arata Yuuki Takeshi Muneta Toshiyuki Ohara Ichiro Sekiya Hideyuki Koga 《Journal of orthopaedic science》2017,22(2):300-305
Background
Associations of lateral/medial knee instability with anterior cruciate ligament (ACL) injury have not been thoroughly investigated. The purposes of this study were to investigate whether lateral/medial knee instability is associated with ACL injury, and to clarify relevant factors for lateral/medial knee instability in ACL-injured knees.Methods
One hundred and nineteen patients with unilateral ACL-injured knees were included. Lateral/medial knee instability was assessed with varus/valgus stress X-ray examination for both injured and uninjured knees by measuring varus/valgus angle, lateral/medial joint opening, and lateral/medial joint opening index. Manual knee instability tests for ACL were evaluated to investigate associations between lateral/medial knee instability and anterior and/or rotational instabilities. Patients' backgrounds were evaluated to identify relevant factors for lateral/medial knee instability. Damage on the lateral collateral ligament (LCL) on MRI was also evaluated.Results
All parameters regarding lateral knee instability in injured knees were significantly greater than in uninjured knees. There were significant correlations between lateral knee instability and the Lachman test as well as the pivot shift test. Patients with LCL damage had significantly greater lateral joint opening than those without LCL damage on MRI. Sensitivity of LCL damage on MRI to lateral joint opening was 100%, while its specificity was 36%. No other relevant factors were identified. In medial knee instability, there were also correlations between medial knee instability and the Lachman test/pivot shift test. However, the correlations were weak and other parameters were not significant.Conclusions
Lateral knee instability was greater in ACL-deficient knees than in uninjured knees. Lateral knee instability was associated with ACL-related instabilities as well as LCL damage on MRI, whereas MRI had low specificity to lateral knee instability. On the other hand, the association of medial knee instability on ACL-related instability was less than that of lateral knee instability.Levels of evidence
Level IV, case series with no comparison group. 相似文献7.
Tomoharu Mochizuki Osamu Tanifuji Yoshio Koga Ryosuke Hata Takahiro Mori Katsutoshi Nishino Takashi Sato Koichi Kobayashi Go Omori Makoto Sakamoto Yuji Tanabe Naoto Endo 《Journal of orthopaedic science》2017,22(3):501-505
Introduction
The relative torsional angle of the distal tibia is dependent on a deformity of the proximal tibia, and it is a commonly used torsional parameter to describe deformities of the tibia; however, this parameter cannot show the location and direction of the torsional deformity in the entire tibia. This study aimed to identify the detailed deformity in the entire tibia via a coordinate system based on the diaphysis of the tibia by comparing varus osteoarthritic knees to healthy knees.Methods
In total, 61 limbs in 58 healthy subjects (age: 54 ± 18 years) and 55 limbs in 50 varus osteoarthritis (OA) subjects (age: 72 ± 7 years) were evaluated. The original coordinate system based on anatomic points only from the tibial diaphysis was established. The evaluation parameters were 1) the relative torsion in the distal tibia to the proximal tibia, 2) the proximal tibial torsion relative to the tibial diaphysis, and 3) the distal tibial torsion relative to the tibial diaphysis.Results
The relative torsion in the distal tibia to the proximal tibia showed external torsion in both groups, while the external torsion was lower in the OA group than in the healthy group (p < 0.0001). The proximal tibial torsion relative to the tibial diaphysis had a higher external torsion in the OA group (p = 0.012), and the distal tibial torsion relative to the tibial diaphysis had a higher internal torsion in the OA group (p = 0.004) in comparison to the healthy group.Conclusion
The reverse torsional deformity, showing a higher external torsion in the proximal tibia and a higher internal torsion in the distal tibia, occurred independently in the OA group in comparison to the healthy group. Clinically, this finding may prove to be a pathogenic factor in varus osteoarthritic knees.Level of evidence
Level Ⅲ. 相似文献8.
Douglas S. Weinberg Jeremy J. Gebhart Glenn D. Wera 《The Journal of arthroplasty》2017,32(5):1659-1664.e1
Background
Posterior condylar offset (PCO) and posterior tibial slope (PTS) have critical consequences in total knee arthroplasty, especially with regards to sagittal plane balancing. However, there has only been limited investigation into the functional consequences of each, and there have only been anecdotal observations regarding any associations between PCO and PTS.Methods
In a large osteological study of 1138 knees, standardized measurements of PCO and PTS were taken using previously described techniques on specimens of different age, race, and gender. Multiple linear regression was performed to determine the independent predictors of medial and lateral PTS.Results
Mean standardized medial PCO was greater than lateral PCO (1.22 ± 0.16 vs 1.15 ± 0.19 mm, P < .001) and medial PTS was greater than lateral PTS (7.3 ± 3.8° vs 5.7 ± 3.7°, P < .001). Decreasing PCO, female gender, and African-American race were associated with both increased medial and lateral PTS. Neither age nor femoral length correlated with medial or lateral PTS.Conclusion
These data are the first to quantify that an inverse correlation between PCO and PTS exists. This relationship represents an important area for future biomechanical and clinical studies. 相似文献9.
Background
Potential advantages combined with lower cost have prompted a renewed interest in modern all-polyethylene tibial designs.Methods
A total of 317 Natural Knee total knee arthroplasties with an all-polyethylene tibial component that was performed since 1993 were retrospectively reviewed to confirm that cost savings were not associated with inferior clinical results. They were primarily used in elderly, low-demand patients. The average age at the time of surgery was 80.8 years.Results
227 knees with a minimum of 2-year follow-up were identified. The average follow-up was 5.6 years (range, 2-20 years). Clinical and radiographic outcomes were evaluated. At the latest follow-up, the average Knee Society and functional score was 94.2 and 57.2. The average postoperative range of motion was 1.6°-115.4°. No patient required a revision for aseptic or septic loosening, wear, or instability. Only 5 knees had a partial nonprogressive cement/bone radiolucency. There was an approximate 33% cost savings for the implants when the all-polyethylene component was used.Conclusion
An all-polyethylene tibial component of this design provides excellent results in the elderly population along with a significant cost savings. 相似文献10.
Tetsuro Ushio Hideki Mizu-uchi Ken Okazaki Yuan Ma Umito Kuwashima Yukihide Iwamoto 《The Journal of arthroplasty》2017,32(3):1006-1012
Background
We evaluated the effect of cutting surface on the anteroposterior (AP) axis of the proximal tibia using a 3-dimensional (3D) bone model to ensure proper tibial rotational alignment in total knee arthroplasty.Methods
3D bone models were reconstructed from the preoperative computed tomography data of 93 Japanese osteoarthritis knees with varus deformity. The AP axis was defined as the perpendicular bisector of the medial and lateral condylar centers in a 3D coordinate system. Bone cutting of the proximal tibia was performed with various tibial posterior slopes (0°, 3°, 7°) to the mechanical axis, and we compared the AP axes before and after bone cutting.Results
The AP axis before bone cutting crossed a point at about 16% (one-sixth) of the distance from the medial edge of the patellar tendon at its tibial attachment. The AP axis after bone cutting was significantly internally rotated at all posterior slopes: 4.1° at slope 0°, 3.0° at slope 3°, and 2.1° at slope 7°. The percentages of cases with differences of more than 3° or 5° were 66.7% and 34.4% at slope 0°, 53.8% and 24.7% at slope 3°, and 38.3% and 11.8% at slope 7°, respectively.Conclusion
The AP axis of the proximal tibia may be rotated internally after resection of the proximal tibia in total knee arthroplasty. Hence, surgeons should recognize the effect of changes in the cutting surface on rotational alignment of the proximal tibia. 相似文献11.
Tatsuo Mae Konsei Shino Ryo Iuchi Kazutaka Kinugasa Ryohei Uchida Shigeto Nakagawa Hideki Yoshikawa Ken Nakata 《Journal of orthopaedic science》2017,22(5):886-891
Purpose
To clarify 1) the force sharing between two portions of BTB graft in anatomic rectangular tunnel (ART) reconstruction and 2) the knee stability in ART technique under anterior tibial load.Methods
Eleven fresh cadaveric knees were used. First, anterior-posterior (A-P) laxity was measured with Knee Laxity Tester® in response to 134 N of A-P tibial load at 20° on the normal knees. Then ART ACL reconstruction was performed with a BTB graft. For graft, the patellar bone plug and tendon portion was longitudinally cut into half as AM and PL portions. After the tibial bone plug was fixed at femoral aperture, AM/PL portions were connected to the tension-adjustable force gauges at tibial tubercle, and were fixed with 10 N to each portion at 20°. Then the tension was measured 1) under anterior tibial load of 134 N at 0, 30, 60, and 90°, and 2) during passive knee extension from 120 to 0°. Next the graft tension was set at 0, 10, 20, 30, or 40 N at 20°, and the A-P laxity was measured by applying A-P load of 134 N. By comparing the laxity for the normal knee, the tension to restore the normal A-P laxity (LMP) was estimated.Results
The AM force was significantly smaller at 0° and larger at 90° than the PL force under anterior load, while the force sharing showed a reciprocal pattern. During knee extension motion, the tension of both portions gradually increased from around 5 N to 20–30 N with knee extended. And the LMP was 1.6 ± 1.0 N with a range from 0.3 to 3.5 N.Conclusion
The pattern of force sharing was similar to that in the normal ACL in response to anterior tibial load and during passive knee extension motion. LMP in this procedure was close to the tension in the normal ACL.Level of evidence
Level IV, a controlled-laboratory study. 相似文献12.
Wenzel Waldstein Tom Schmidt-Braekling Giorgio Perino Maximilian F. Kasparek Reinhard Windhager Friedrich Boettner 《The Journal of arthroplasty》2017,32(3):788-792
Background
Intact cartilage in the lateral compartment is an important requirement for medial unicompartmental knee arthroplasty. This study sought to determine how measurements of joint space width in the lateral compartment on valgus stress radiographs compare to cartilage thickness as measured with a precise needle test, and whether cartilage thickness is a predictor of cartilage degeneration.Methods
A consecutive series of 100 knees undergoing total knee arthroplasty for end-stage varus osteoarthritis was studied. Twenty-eight knees were retrospectively excluded because not all data were available, leaving 72 knees (61 patients; mean age, 67 years [49-87]). On calibrated valgus stress radiographs, lateral-compartment joint space width was measured. During surgery, osteochondral samples of the distal lateral femur and the lateral tibia plateau were harvested. Cartilage thickness and histology were assessed. Cartilage thickness of tibia and femur was defined as lateral-compartment cartilage thickness.Results
Lateral-compartment joint space width on valgus stress radiographs and lateral-compartment cartilage thickness correlated well (rs = 0.671, P < .001). However, no correlation of cartilage histology according to the osteoarthritis cartilage histopathology assessment system, and cartilage thickness on the lateral tibia plateau (rs = ?0.060, P = .614) and cartilage thickness on the distal lateral femur (rs = ?0.128, P = .282) was observed.Conclusion
Valgus stress radiographs can assess combined cartilage thickness in the lateral compartment of the knee. Cartilage thickness, however, is a poor predictor of cartilage degeneration. 相似文献13.
Vincent V.G. An Brahman S. Sivakumar Kevin Phan Yadin David Levy Warwick J.M. Bruce 《Journal of orthopaedic science》2017,22(1):116-120
Introduction
The technical objective of total knee arthroplasty (TKA) is to restore normal mechanical parameters to the knee. Patient-specific instrumentation (PSI) was developed to streamline the operative process and improve accuracy. PSI produces individualized cutting guides based on three-dimensional models of the patient's anatomy acquired from computed-tomography (CT) or magnetic-resonance imaging (MRI). However, the superiority of one modality over the other remains unclear. Therefore, we aimed to compare the accuracy of patient-specific cutting guides produced from MRI or CT imaging methods in TKA.Methods
Electronic databases were systematically searched using relevant keywords and MeSH terms for original-data English-language publications comparing the accuracy of CT and MRI-based PSI cutting guides in TKA. Data was extracted from the text, tables and figures of studies and meta-analysed.Results
MRI-based PSI cutting guides produced a lower proportion of coronal plane outliers (>3°) with regard to overall limb mechanical axis (OR 2.75, p = 0.01). There were no significant differences between the two in terms of sagittal femoral and tibial component placement, or coronal femoral and tibial placement, or femoral component axial rotation. Tibial rotation was not analysed in the literature.Conclusions
MRI-based patient-specific cutting guides produced a lower proportion of outliers in the overall coronal alignment of the limb compared to CT, with no significant difference between the two in terms of femoral or tibial component placement. Future studies should investigate the differences in resource usage and operative time between the two to inform surgeons' decision making when choosing an ideal imaging modality for PSI TKA.Study design
Meta-analysis.Level of evidence
III, systematic review of cohort and comparative studies. 相似文献14.
Qian-Li Ma Joseph D. Lipman Cheng-Kung Cheng Xiao-Nan Wang Yi-Yuan Zhang Bin You 《The Journal of arthroplasty》2017,32(9):2878-2886
Background
The bone morphologies of intact knees were measured and compared between Chinese and Caucasian populations. However, to assess if distinct designs of implants are necessary for the Chinese population owing to different morphologies and sizes, the knee measurements after osteotomy performed in total knee arthroplasty were evaluated.Methods
Thirty-seven Caucasian and 50 Chinese patients' knees were examined using computed tomography scans. Mimics were applied to reconstruct 3-dimensional bone models. Dimensions of the 3-dimensional knee models and simulated bone resections during total knee arthroplasty were measured using Geomagic Studio and Pro/ENGINEER. The morphologic measurements of the native and resected femur and tibia included the anteroposterior (AP) depth, mediolateral (ML) width, notch width, knee physical valgus angle, tibial slope angle, and the ML-to-AP ratio of the femur, tibia, and resected femur. Statistical analysis was performed using the independent samples t test and the Pearson correlation coefficient in SPSS for Windows. Values of P < .05 were considered significant.Results
No measurements were significantly different between the Chinese and Caucasian knees. However, the Chinese female showed significant differences compared with the Chinese male on distal femoral measurements both presimulated and postsimulated osteotomy such as a smaller mean ML-to-AP ratio in presimulated (1.3 ± 0.1) and postsimulated (1.3 ± 0.1) osteotomy.Conclusion
The necessity of designing a full set of total knee components specifically for the Chinese population is still undetermined. However, we suggest designing femoral components specific for the Chinese females because of different postosteotomy distal femoral ML-to-AP ratio between the Chinese males and the Chinese females. 相似文献15.
Cheng Jin Eun-Kyoo Song Jatin Prakash Sung-Kyu Kim Chee Ken Chan Jong-Keun Seon 《The Journal of arthroplasty》2017,32(6):1829-1833
Background
Recently, anatomical designs in total knee arthroplasty are introduced to address asymmetry of the resected tibia cutting surface. It is still not well known how much improvement would be achieved in total knee arthroplasty, especially in Asian knees.Methods
We evaluated the bony coverage of 4 commercially available posterior-stabilized tibial designs (3 symmetrical: NexGen, Attune, and Vega; 1 anatomical: Persona) by measuring uncovered areas over 3 different regions: lateroposterior (LP), medioposterior (MP), and mediolateral (ML) areas. The implant size was chosen based on lateral anteroposterior dimension of the implant that most closely matched the corresponding surface of tibia. The knee with over coverage <1 mm and under coverage <2 mm was regarded as having optimal fit.Results
The optimal fit of anatomical design in LP dimension was achieved in 76% of the cases, which was not significantly different from other symmetrical designs (P > .05). The anatomical tibial implant had a more optimal fit in MP and ML dimensions (48% and 42%, respectively) compared to all symmetric designs (P < .05). All symmetrical tibial designs had significant absolute underhang in MP (62%-78%) and ML (24%-34%) areas without difference. The anatomical tibial design had significant improvement for posteromedial coverage by about 69.8%-74.3% compared with the symmetrical designs.Conclusion
Recently introduced anatomical tibial design improves surface coverage at the medioposterior dimension in Asian knees. Moreover, there is small improvement in ML fit compared with the symmetrical designs. 相似文献16.
Jade Pei Yuik Ho Azhar M. Merican Muhammad Sufian Hashim Azlina A. Abbas Chee Ken Chan Jamal A. Mohamad 《The Journal of arthroplasty》2017,32(10):3176-3183
Background
The posterior tibial slope (PTS) is an important consideration in knee arthroplasty. However, there is still no consensus for the optimal slope. The objectives of this study were (1) to reliably determine the native PTS in this population using 3-dimensional computed tomography scans and (2) to determine the normal reference range for PTS in this population.Methods
One hundred computed tomography scans of disease-free knees were analyzed. A 3-dimensional reconstructed image of the tibia was generated and aligned to its anatomic axis in the coronal and sagittal planes. The tibia was then rotationally aligned to the tibial plateau (tibial centroid axis) and PTS was measured from best-fit planes on the surface of the proximal tibia and individually for the medial and lateral plateaus. This was then repeated with the tibia rotationally aligned to the ankle (transmalleolar axis).Results
When rotationally aligned to the tibial plateau, the mean PTS, medial PTS, and lateral PTS were 11.2° ± 3.0 (range, 4.7°-17.7°), 11.3° ± 3.2 (range, 2.7°-19.7°), and 10.9° ± 3.7 (range, 3.5°-19.4°), respectively. When rotationally aligned to the ankle, the mean PTS, medial PTS, and lateral PTS were 11.4° ± 3.0 (range, 5.3°-19.3°), 13.9° ± 3.7 (range, 3.1°-24.4°), and 9.7° ± 3.6 (range, 0.8°-17.7°), respectively.Conclusion
The PTS in the normal Asian knee is on average 11° (mean) with a reference range of 5°-17° (mean ± 2 standard deviation). This has implications to surgery and implant design. 相似文献17.
The distribution of vascular endothelial growth factor in human meniscus and a meniscal injury model
Zhichao Lu Takayuki Furumatsu Masataka Fujii Ami Maehara Toshifumi Ozaki 《Journal of orthopaedic science》2017,22(4):715-721
Background
The meniscus plays an important role in controlling the complex biomechanics of the knee. Meniscus injury is common in the knee joint. The perimeniscal capillary plexus supplies the outer meniscus, whereas the inner meniscus is composed of avascular tissue. Angiogenesis factors, such as vascular endothelial growth factor (VEGF), have important roles in promoting vascularization of various tissues. VEGF-mediated neovascularization is beneficial to the healing of injured tissues. However, the distribution and angiogenic role of VEGF remains unclear in the meniscus and injured meniscus. We hypothesized that VEGF could affect meniscus cells and modulate the meniscus healing process.Methods
Menisci were obtained from total knee arthroplasty patients. Meniscal injury was created ex vivo by a microsurgical blade. VEGF mRNA and protein expression were detected by the polymerase chain reaction and immunohistochemical analyses, respectively.Results
In native meniscal tissue, the expression of VEGF and HIF-1α mRNAs could not be detected. However, VEGF and HIF-1α mRNAs were found in cultured meniscal cells (VEGF: outer > inner; HIF-1α: outer = inner). Injury increased mRNA levels of both VEGF and HIF-1α, with the increase being greatest in the outer area. Immunohistochemical analyses revealed that VEGF protein was detected mainly in the outer region and around injured areas of the meniscus. However, VEGF concentrations were similar between inner and outer menisci-derived media.Conclusions
This study demonstrated that both the inner and outer regions of the meniscus contained VEGF. HIF-1α expression and VEGF deposition were high in injured meniscal tissue. Our results suggest that injury stimulates the expression of HIF-1α and VEGF that may be preserved in the extracellular matrix as the healing stimulator of damaged meniscus, especially in the outer meniscus. 相似文献18.
Background
De novo gastric cancer is a rare complication of liver transplantation.Methods
Surgical treatments of 16 cases with different outcomes were reported in the English literature.Results
De novo gastric cancer (stage II) was diagnosed as the result of epi-gastric discomfort in a recipient 10 years after liver transplantation. The patient received chemotherapy alone and remained well for 26 months.Conclusions
De novo gastric cancer of liver transplantation recipients is a severe complication; early detection and relevant intervention will benefit these recipients. 相似文献19.
Background
The purpose of our prospective, randomized, long-term investigation is to compare the aseptic loosening rate of the femoral component of the total knee prosthesis and clinical and radiographic results of high-flexion posterior cruciate-substituting knee prosthesis or standard posterior cruciate-substituting knee prosthesis in the same patients.Methods
There were 960 patients (mean age 71.3 years). The mean follow-up period was 13.2 years (range 10-14). The patients were assessed clinically and radiographically with rating systems of the Knee Society. Furthermore, Western Ontario and McMaster Universities Osteoarthritis questionnaire and ranges of knee motion were determined in both groups.Results
In the high-flexion knee group, 2 knees (0.2%) had aseptic loosening of both femoral and tibial components. In the standard knee group, 2 knees (0.2%) had aseptic loosening of the femoral component only. The mean postoperative knee scores (97 vs 97 points), Western Ontario and McMaster Universities Osteoarthritis scores (19 vs 19 points), and range of knee motion (128° vs 129°) were not significantly different between the 2 groups. Two knees (0.2%) in the high-flexion knee group underwent a revision of both femoral and tibial components and 2 knees (0.2%) in the standard knee group had a revision of the femoral component only.Conclusion
After a mean of 13.2 years of follow-up, this study did not show increased incidence of femoral component loosening in the high-flexion knee group. Furthermore, we found no significant differences between the 2 groups with regard to clinical or radiographic parameters or range of knee motion. 相似文献20.
Takayuki Furumatsu Masataka Fujii Yuya Kodama Toshifumi Ozaki 《Journal of orthopaedic science》2017,22(4):731-736