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Predictive validity of clinical AUDIT‐C alcohol screening scores and changes in scores for three objective alcohol‐related outcomes in a Veterans Affairs population 下载免费PDF全文
Katharine A. Bradley Anna D. Rubinsky Gwen T. Lapham Douglas Berger Christopher Bryson Carol Achtmeyer Eric J. Hawkins Laura J. Chavez Emily C. Williams Daniel R. Kivlahan 《Addiction (Abingdon, England)》2016,111(11):1975-1984
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Christian Homann Thomas Lars Benfield Niels Albert Graudal Peter Garred 《Liver international》2000,20(6):442-449
Abstract: Background: Neutrophil cytotoxity and activated macrophages have been implicated in the pathogenesis of alcohol‐induced liver disease. The aim of this study was to relate plasma levels of neopterin, a marker of activation of the cellular immune system, and IL‐8, a neutrophil chemotactic factor, with severity of liver disease and prognosis in patients with alcohol‐induced cirrhosis. Methods: Plasma concentrations of neopterin and IL‐8 were assessed in 81 patients with alcohol‐induced cirrhosis admitted to the Department of Medicine B, Bispebjerg Hospital, Copenhagen, Denmark, and in 16 healthy controls. After a median follow‐up period of 5 years, mortality and death causes were registered. The patients were divided into groups according to the major contributing cause of death: infection, upper gastrointestinal bleeding or hepatic coma. Results: Neopterin and IL‐8 levels were increased in the cirrhosis patients, but not significantly related to Child‐Pugh classification. Five‐year mortality was 67%. High neopterin levels (>upper quartile) were an independent predictor of death (p=0.01, Log rank and p<0.02, Cox). High IL‐8 levels (>upper quartile) were of no significant prognostic value for overall mortality. Causes of death related mortality were as follows (Log rank): Neopterin; p=0.009, p=0.84 and p=0.94, and IL‐8; p=0.36, p=0.002 and p=0.27, respectively, according to infection, bleeding and coma as causes of death. Conclusions: Neopterin and IL‐8 plasma levels are raised in patients with alcohol‐induced cirrhosis, and are predictive of mortality associated with infections and upper gastrointestinal bleeding, respectively. 相似文献
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Understanding the alcohol harm paradox: an analysis of sex‐ and condition‐specific hospital admissions by socio‐economic group for alcohol‐associated conditions in England 下载免费PDF全文
Susannah Sadler Colin Angus Lucy Gavens Duncan Gillespie John Holmes Jean Hamilton Alan Brennan Petra Meier 《Addiction (Abingdon, England)》2017,112(5):808-817
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José M. Sahuquillo‐Arce Rosario Menéndez Raúl Méndez Isabel Amara‐Elori Rafael Zalacain Alberto Capelastegui Javier Aspa Luis Borderías Juan J. Martín‐Villasclaras Salvador Bello Inmaculada Alfageme Felipe Rodriguez de Castro Jordi Rello Luis Molinos Juan Ruiz‐Manzano Antoni Torres 《Respirology (Carlton, Vic.)》2016,21(8):1472-1479