Effect of Rigid Gas Permeable Contact Lenses on Nystagmus and Visual Function in Hyperopic Patients with Infantile Nystagmus Syndrome

Purpose: To determine the effect of rigid gas permeable contact lenses (RGPCL) on involuntary eye movements and visual function in hyperopic patients with infantile nystagmus syndrome. Methods: This prospective interventional case series was conducted on 16 patients with infantile nystagmus and hyperopia equal or more than +0.5 D and astigmatism more than -1 D over a 2-year period. A complete ophthalmological examination including determination of best corrected visual acuity (BCVA), contrast sensitivity, and videonystagmography was performed for all patients before and after at least 3 months of RGPCL use, and the outcomes were compared. Results: Thirty-two eyes of 16 patients with mean age of 18.6±4.9 years were enrolled. Mean spherical equivalent refractive error was +1.5±2.35 (range +1 to +6.25) diopters (D); corresponding values were +2.45±2.44 D (range +0.5 to +7.5) for spherical error and +1.90±0.83 D (range +1 to +4) for astigmatism. Monocular BCVA improved from 0.56±0.23 to 0.51±0.23 Log MAR (P=0.007), and binocular BCVA improved from 0.54±0.25 to 0.48±0.24 Log MAR (P=0.01) after fitting RGPCL. Following the use of RGPCL, contrast sensitivity was significantly improved at low (P=0.02) and intermediate (P< 0.001) frequencies but not at high frequencies (P=0.6). The frequency, amplitude, and intensity of nystagmus were decreased significantly after RGPCL use (P<0.001). Conclusion: RGPCL improved monocular and binocular BCVA and contrast sensitivity in hyperopic patients with infantile nystagmus syndrome. Motor indices of nystagmus (frequency, amplitude, and intensity) were also significantly improved after RGPCL use.     

扫描电镜法评价护理液对软性接触镜上蛋白的清除效果

目的：通过扫描电镜观察并结合图像计算机统计分析法评价护理液对软性接触镜上吸附蛋白的清除效果。方法：实验研究。将软性接触镜镜片浸泡在人工泪液中65 h,模拟蛋白吸附,再分别用隐形眼镜护理液和PBS对镜片进行揉搓、冲洗和浸泡处理（6 h）操作;然后镜片经戊二醛水溶液固定后干燥,通过扫描电镜观察镜片表面的蛋白形态及数量,最后通过图像计算机统计分析法对镜片表面的蛋白数量进行定量分析,吸附蛋白的软性接触镜经护理液处理前后蛋白数量减少值占镜片处理前表面蛋白的百分比,即为清除率。采用Tukey多重比较法对不同护理液处理的镜片表面蛋白清除数据进行单因素方差分析。结果：隐形眼镜护理液对镜片表面吸附的蛋白有显著清除效果,100 倍放大倍数下,PBS对镜片表面蛋白的清除率为89.58%,2 个不同厂家的隐形眼镜护理液对镜片表面蛋白的清除率分别为98.18%和98.38%;1 500 倍放大倍数下,PBS对镜片表面蛋白的清除率为89.76%,2 个不同厂家的隐形眼镜护理液对镜片表面蛋白的清除率分别为98.42%和98.27%。结论：扫描电镜观察并结合图像计算机统计分析法可对隐形眼镜护理液的蛋白清除效果进行评价。隐形眼镜护理液对镜片表面吸附的蛋白有显著清除效果。     

Case Report: A Procedure for the Clinical Management of Giant Papillary Conjunctivitis in a Patient Wearing Contact Lenses

ABSTRACT The successful clinical management of a patient with giant papillary conjunctivitis is reported. The patient was a 50 year old man.