秃发性毛发角化症

报告1例秃发性毛发角化症。患者女,22岁。因全身泛发毛囊性红色丘疹8年,头皮瘢痕性秃发伴瘙痒4年就诊。临床表现为头部毛发稀疏,部分秃发区可见毛囊萎缩。面颊部毛细血管扩张,密集毛囊性粉刺样丘疹,四肢、躯干泛发粟米大毛囊性丘疹。枕部头皮组织病理检查：表皮角化过度,表皮突局灶性延长,毛囊口有角质栓,毛囊内外根鞘灶性萎缩或消失,局部多核巨细胞反应性增生,毛囊周围及真皮血管周围见较多淋巴细胞浸润。诊断：秃发性毛发角化症。     

棘状秃发性毛囊炎

报告1例棘状秃发性毛囊炎.患者男,27岁.因头皮起毛囊性丘疹伴脱发7年就诊.皮肤科检查:头皮片状不规则脱发.有萎缩性瘢痕,头皮、面部、颈部、躯干、四肢广泛分布粟粒大毛囊性丘疹.组织病理检查可见角化过度,表皮萎缩变薄,真皮内胶原纤维增生,呈瘢痕样改变,部分毛囊破坏,周围淋巴细胞、浆细胞及多核巨细胞浸润,符合棘状秃发性毛囊炎改变.     

棘状秃发性毛囊炎

报告1例棘状秃发性毛囊炎.患者男,41岁.头面部反复出现红色脓疱性丘疹伴疼痛、脱发近41年.家族中其大姐有类似疾病.毛囊性丘疹和脓疱在青春期加重,并伴有畏光、结膜干燥、睑缘炎.皮肤科检查:头皮弥漫性秃发,可见网状瘢痕形成和色素脱失.眉弓、上唇和下颌散在分布许多红色丘疹,有的丘疹顶端有脓疱.双侧眉毛、腋毛和阴毛大部分缺失,局部可见散在毛囊角化性丘疹.皮损组织病理检查:表皮萎缩,真皮可见毛囊,其周围有较多淋巴细胞、组织细胞浸润,并有纤维组织增生.结合临床和组织病理表现,符合棘状秃发性毛囊炎的诊断.     

毛发移植治疗瘢痕性秃发的研究进展

瘢痕性秃发是一组毛囊被结缔组织取代的疾病,分为原发性和继发性。原发性瘢痕性秃发病情隐匿反复,早期以控制原发病为主,晚期病情稳定可考虑外科修复,术后需长期随诊、药物维持治疗。继发性瘢痕性秃发多继发于烧伤、手术,瘢痕稳定后可考虑手术治疗。本文就毛发移植治疗瘢痕性秃发的研究进展进行综述。     

毛发移植术治疗秃发疗效分析

目的应用自体毛发移植术对秃发进行治疗并观察中、远期疗效。方法选择本院2000年2月~2005年7月的638例患者,其中雄激素源性秃发522例,瘢痕性秃发116例,均采用自体毛发移植术治疗,并定期随访。结果移植毛囊成活率分别为96.83%(男性雄激素源型秃发),95.73%(女性雄激素源型秃发),90.52%(瘢痕性秃发)。随访6~68个月未见移植毛发再次脱落。医生满意度为95.14%(607/638),患者满意度为97.49%(622/638)。结论毛发移植技术是一项安全、可靠、有效的治疗方法。可用于雄激素源性秃发和瘢痕性秃发的治疗,远期疗效较好。     

伴牙齿异常棘状秃发性毛囊炎一例

患者男,24岁.因头皮脓疱、萎缩性瘢痕伴脱发6年.皮肤科检查:头皮弥漫性秃发伴萎缩性瘢痕.头顶仅残留少数头发,发根处有角化性丘疹、脓疱或黑色痂,前额、颞、枕部近发际处尚有部分头发,枕部头发成小簇,发根处见角化性丘疹.眉弓有红斑、鳞屑及毛囊角化性丘疹,眉毛稀疏、脱落.腋毛也稀疏.两颊、腋、胸、腹、后背、四肢均有明显毛囊角化性丘疹.口腔科检查:上下前牙排列间隙过大,上前牙前倾,(+1)先天性缺失,前牙深覆(牙合),深覆盖.沟纹舌,丝状乳头消失.皮损组织病理:表皮棘层增厚,毛囊周围可见大量浆细胞、中性粒细胞及多核巨细胞浸润.结合临床及组织病理表现,符合棘状秃发性毛囊炎的诊断.     

自体显微毛发移植治疗永久性秃发146例

目的观察自体显微毛发移植治疗永久性秃发的效果。方法应用毛发移植术对146例秃顶患者进行手术治疗。结果术后平均3个月生长出新发,移植毛发成活率大于90%,经过1～2次毛发移植手术,秃发区头发密度、发型等较为理想。结论应用自体显微毛发移植治疗永久性秃发的手术效果满意。     

棘状角皮病

报告1例棘状角皮病。患者女,41岁。掌跖多发棘状凸起5年。皮肤科检查：双侧掌跖多发棘状凸起,触之粗糙。皮损组织病理检查：角化过度,柱状角化不全。诊断：棘状角皮病。治疗：予0.025%维A酸乳膏及0.3%尿囊素乳膏外用,每日2次,随访半年,皮损无复发。     

89例常见秃发的毛发结构检查分析

目的:探讨毛发结构异常与常见秃发类型的相关性。方法:收集89例常见秃发患者的头发每人次100根,于光镜及电镜下观察其结构是否异常。结果:经统计斑秃(AA)的生长期脱发是以感叹号样发为主,伴断发时可见有羽状脆发、偶见粗细段发、结节状脆发或伴有毛小皮损伤;男性型秃发(MPA)、女性型秃发(FPA)的休止期脱发是以杵(棒)状发为主;另外女性秃发患者经常伴有管状发鞘(毛管型)。26例进行治疗前后的毛发结构检查,经有效治疗后所有秃发病例感叹号样发减少,而杵状发都不同程度增加。结论:毛发的结构异常与常见秃发类型相关。毛发结构检查的静态及动态观察,对秃发的诊断、疗效判断具有重要临床意义。     

小棘状毛壅病1例

患者男 ,5 0岁。无明显诱因背部出现黑点状丘疹 1年 ,无自觉症状 ,皮疹逐渐增多。家族无类似病史。体检 :Ｔ 36 .0℃ ,Ｐ 76次 /ｍｉｎ ,Ｂｐ 16 .0 / 10 .0ｋＰａ。系统检查无异常。皮肤科情况 :背部可见与毛囊一致帽针头大小、灰黑色丘疹 ,丘疹周围可见色素沉着。皮肤组织病理 :表皮大致正常 ,真皮内毛囊漏斗部可见多根毛发 ,被包绕在一个角质的鞘内 (见图 1)。图 1　皮损组织病理ＨＥ× 10诊断为小棘状毛壅病。给予维生素Ａ口服 ,维Ａ酸软膏外用。讨论　本病又称为毳毛黑头粉刺 ,Ｎｏｂｌ于 1915年首先报道 ,病因尚不清楚 ,多见于青年男…     

Keratosis follicularis spinulosa decalvans

The case findings in a 22-year-old male patient of keratosis follicularis spinulosa decalvans are described. In addition to the characteristic cutaneous, occular and histological features, he had striking angular stomatitis and fissuring of the tongue simulating vitamin B-complex deficiency. This is an unreported feature to our knowledge. The mode of inheritance suggested X-linked trait.     

Keratosis follicularis spinulosa decalvans

Keratosis follicularis spinulosa decalvans is a rare, X-linked disorder of keratinization of the hair follicle with inflammation and atrophy associated with corneal dystrophy and other symptoms. A family with several affected members is reported. The unaffected parents were related. A 12-year-old girl and her 5-year-old brother had follicular spiny hyperkeratoses on the trunk and extremities. The girl had thinning of the eyelashes and eyebrows as well as scarring alopecia of the scalp as additional features of the disease. Both the girl and her brother had corneal dystrophy and photophobia. Two sisters aged 8 and 10 years did not show similar skin or eye findings.     

Keratosis follicularis spinulosa decalvans

Ohne Zusammenfassung Eingegangen am 1. April 1997 Angenommen am 9. Mai 1997     

Keratosis follicularis spinulosa decalvans

Ohne Zusammenfassung     

Keratosis follicularis spinulosa decalvans: report of a new pedigree

Summary Keratosis follicularis spinulosa decalvans is a rare, X-linked genodermatosis characterized by follicular hyperkeratosis, scarring alopecia of the scalp, eyebrows and eyelashes, corneal dystrophy and photophobia. We describe two cases from a large family, the first with keratosis follicularis spinulosa decalvans to be reported in the U.K.     

Keratosis follicularis spinulosa decalvans in a female

Keratosis follicularis spinulosa decalvans (KFSD), is a rare follicular syndrome associated with widespread keratosis pilaris and progressive scarring alopecia. This genodermatoses often starts at infancy or early childhood with an X-linked mode of inheritance. Males are predominantly affected and females frequently show no disease or only a mild form. We describe this not so common entity of KFSD in a nine year old female child.     

Keratosis follicularis spinulosa decalvans in a family

Keratosis follicularis spinulosa decalvans (KFSD) is a rare condition characterized by diffuse keratosis pilaris with a scarring alopecia of the scalp and associated photophobia, facial erythema, and palmoplantar keratoderma. Although initially described as a sex-linked disorder, several different inheritance patterns have been observed. We describe a patient whose father and sister were also affected with this condition, consistent with an autosomal dominant genetic transmission. Multiple topical and systemic treatments have been unsuccessful in this patient, attesting to the treatment refractoriness typically seen in KFSD.     

Keratosis follicularis spinulosa decalvans and acne keloidalis nuchae

A 27-year-old man presented with a 10-year history of scarring alopecia on the vertex of the scalp associated with follicular crusting and pustule formation, and a papular eruption on the posterior neck. Additionally, there was keratosis pilaris on the cheeks, eyebrows and thighs. Histology from the vertex showed scarring with a mixed perifollicular inflammatory infiltrate and foci of acute suppurative folliculitis. With clinical correlation, the diagnosis of keratosis follicularis spinulosa decalvans and concurrent acne keloidalis nuchae was made. The association of keratosis follicularis spinulosa decalvans with acne keloidalis nuchae has not previously been described. The patient responded to treatment with oral isotretinoin 20 mg (0.25 mg/kg) daily for 12 months.