The Chinese-German Journal of Clinical Oncology

1. Aims and scope The Chinese.German Journal of Clini- cal Oncology is an international profes- sional academic periodical on oncology. The Journal, with the authors from around world, especially from China, is dominated in intro- ducing the clinical experience of diagnosis and treatment as well as leading scientific research achievement in the tumor domain, in addition to report basic theory researches that help instruct the clinical practice of oncol- ogy and closely connect with the discipline.     

Clinicopathological significance and relations of Caspase-3 expression,cell proliferation and apoptosis in gastric cancer and the precancerous lesions

Objective： We investigated the relationship between the expression of Caspase-3, cell proliferation and apoptosis in gastric cancer and their precancerous lesions, to explore the tumorigenesis of the stomach mucosa. Methods： Caspase- 3 expression in 13 normal gastric mucosa, 6 chronic atrophic gastritis （CAG）, 31 intestinal metaplasia （IM）, 114 dysplasia （DYS） and 20 gastric carcinomas were investigated immunohistochemically. Cell proliferation was evaluated with anti-Ki-67 immunostaining and apoptosis was evaluated using DNA fragmentation in situ by TdT-mediated dUTP biotin nick end labeling （TUNEL） method. Results： Caspase-3 mild-moderately positive expression was observed in most of normal superficial epithelia, its positively polar distribution in normal mucosa, CAG, IM, DYS and gastric carcinomas changed as seen in TU- NEL, and so did the positive rate. Caspase-3 protein expression showed significantly positive correlation with the number of apoptotic cells labeled with TUNEL （correlation coefficient r = 0,94; P 〈 0101）. Ki-67 expression showed a negative but not significant correlation trend with Caspase-3 （correlation coefficient r = -0.23; P 〉 0.05）. Conclusion： Caspase-3 protein expression was up-regulated from CAG to IM and mild-moderate atypical dysplasia, but down-regulated in severe dysplasia and gastric carcinoma, indicating that inactivity or reduced expression of Caspase-3 is closely correlated with carcinogenesis of the stomach mucosa.     

《 Chinese-German Journal of Clinical Oncology》发展小史

《中德临床肿瘤学杂志》（英文）是中国教育部主管，华中科技大学主办，华中科技大学同济医学院附属同济医院承办，与德国Springer出版社合作出版的全英文国际性医学学术期刊，并作为中国中德医学协会与德国德中医学协会的联合刊物出版发行。本刊面向国内外公开发行，主要刊登肿瘤学领域的优秀科研成果和临床诊疗经验及基础理论研究方面的论文。     

《Chinese-German Journal of Clinical Oncology》发展小史

《中德临床肿瘤学杂志》（英文）是中国教育部主管，华中科技大学主办，华中科技大学同济医学院附属同济医院承办，与德国Springer出版社合作出版的全英文国际性医学学术期刊，并作为中国中德医学协会与德国德中医学协会的联合刊物出版发行。本刊面向国内外公开发行，主要刊登肿瘤学领域的优秀科研成果和临床诊疗经验及基础理论研究方面的论文。     

~.adiofrequency induction on sodium/iodide symporter expression of thyroid cancer

Objective; The aim of this study was to investigate the effects of radiofrequency treatment on sodium/iodide symporter expression of thyroid cancer ceils. Methods： In 29 thyroid cancer patients with low or no expression of soda ／ iodide symporter, the radio frequency combined 1311 therapy was used, the whole-body scintigraphy and serum Ig were detected before and after the radiofrequency treatment. Results： The whole-body scintigraphy showed that 4 cases （4/29） before radiofrequenc_y treatment had positive iodine uptake, 19 cases （19/29） two weeks after radiofrequency treatment had the positive iodine uptake, 12 cases （12/29） four weeks after radiofrequency treatment had the positive iodine uptake. Four weeks after radiofrequency treatment, 5 cases had increased serum Ig levels, 17 cases had decreased serum Ig levels, 7 cases showed no change. 25 cases （25/29） were effective, 15 cases （15/29） were cured. Conclusion： The radiofrequency induced the non-expressed the sodium/iodide symporter of thyroid cancer cells regain the iodine intake ability, it improved the clinical efficacy of 131I therapy in dedifferentiated thyroid cancer.