Low serum albumin may predict poor efficacy in patients with perforated peptic ulcer treated nonoperatively

BACKGROUNDNonoperative management (NOM) is a promising therapeutic modality for patients with perforated peptic ulcer (PPU). However, the risk factors for poor efficacy and adverse events of NOM are a concern. AIMTo investigate the factors predictive of poor efficacy and adverse events in patients with PPU treated by NOM.METHODSThis retrospective case-control study enrolled 272 patients who were diagnosed with PPU and initially managed nonoperatively from January 2014 to December 2018. Of these 272 patients, 50 converted to emergency surgery due to a lack of improvement (surgical group) and 222 patients were included in the NOM group. The clinical data of these patients were collected. Baseline patient characteristics and adverse outcomes were compared between the two groups. Logistic regression analysis and receiver operating characteristic curve analyses were conducted to investigate the factors predictive of poor efficacy of NOM and adverse outcomes in patients with PPU.RESULTSAdverse outcomes were observed in 71 patients (32.0%). Multivariate analyses revealed that low serum albumin level was an independent predictor for poor efficacy of NOM and adverse outcomes in patients with PPU.CONCLUSIONLow serum albumin level may be used as an indicator to help predict the poor efficacy of NOM and adverse outcomes, and can be used for risk stratification in patients with PPU.     

Laparoscopic repair of perforated peptic ulcer: a meta-analysis

Background Laparoscopic repair of perforated peptic ulcer has been gaining popularity in recent years, but few data exist to support the superiority of the laparoscopic approach over open repair. The objective of the current study was to compare the safety and efficacy of open and laparoscopic repair of perforated peptic ulcer in an evidence-based approach using meta-analytical techniques.Methods A search of electronic databases, including MEDLINE and EMBASE, was conducted to identify relevant articles published between January 1990 and December 2002. Only studies in the English language comparing the outcomes of laparoscopic and open repair of perforated peptic ulcer were recruited. All reports were critically appraised with respect to their methodology and outcome. Data from all included studies were extracted using standardized data extraction forms developed a priori. Both qualitative and quantitative statistical analyses were performed. The effect size of outcome parameters was estimated by odds ratio where feasible and appropriate.Results A total of 13 publications comprising 658 patients met the inclusion criteria. The overall success rate of laparoscopic repair was 84.7% (n = 249). Postoperative pain was lower after laparoscopic repair than after open repair, supported by a significant reduction in postoperative analgesic requirement after laparoscopic repair. Meta-analyses demonstrated a significant reduction in the wound infection rate after laparoscopic repair, as compared with open repair, but a significantly higher reoperation rate was observed after laparoscopic repair.Conclusions Evidence suggests that laparoscopic repair of perforated peptic ulcer confers superior short-term benefits in terms of postoperative pain and wound morbidity. This approach is as safe and effective as open repair. Laparoscopic Graham–Steele patch repair of perforated duodenal or justapyloric ulcer is beneficial for patients without Boeys risk factors.     

Laparoscopic suture closure of perforated peptic ulcer

Background: Laparoscopic vs open suture in the surgical treatment of perforated peptic ulcer were compared in a retrospective study. Methods: The outcome of 10 patients having the laparoscopic procedure was compared with the outcome of 17 patients treated with suture via laparotomy during the same time period. Results: The mortality rate and the complication rate were comparable. The laparoscopic procedure was more time consuming; hospital stay did not differ. Conclusions: The results indicate that surgery for perforated peptic ulcer can be performed with the laparoscopic technique with an outcome comparable to open surgery. No obvious advantages to the patient were noted with the laparoscopic method.This study has been presented as an abstract at the EAES meeting in Madrid, September 1994     

腹腔镜与开腹手术治疗老年消化性溃疡急性穿孔的对比研究

目的:比较腹腔镜与开腹手术治疗老年患者消化性溃疡急性穿孔的临床效果。方法:比较腹腔镜与开腹两种手术治疗52例老年患者消化性溃疡穿孔的疗效,两种术式的手术时间、术后下床活动时间、术后排气时间、术后止痛药使用率、术后并发症发生率、住院时间等影响因素。结果:两种手术的各项指标均有显著差异(P<0.05或P<0.01)。结论:腹腔镜手术修补具有患者创伤小、康复快、并发症少、住院时间短等优点,是治疗老年消化性溃疡急性穿孔较为理想的手术方式。     

改良五孔法腹腔镜胃十二指肠溃疡穿孔修补术的应用价值

目的:探讨改良五孔法在困难腹腔镜胃十二指肠溃疡穿孔修补术中的临床应用价值.方法:根据病例纳入与排除标准,筛选2017年12月至2020年5月收治的50例胃十二指肠溃疡穿孔患者,研究组(n=25)行改良五孔法腹腔镜穿孔修补术,对照组(n=25)行非改良五孔法腹腔镜穿孔修补术,对比分析两组临床疗效.结果:研究组与对照组手术...     

经验性临床诊断胃十二指肠溃疡穿孔合理性的评价

目的探讨临床诊断（急诊时尚无影像学确诊依据者）PGDU的合理性及其对非手术治疗方式的影响。方法对本院急诊入院时临床诊断PGDU,并采用行非手术治疗的117例患者,在根据临床指标认定穿孔闭合后经住院期间胃镜检查,以及中转手术探查,明确其穿孔病因诊断及其病理改变。结果入选者经非手术治愈114例,其中,确诊穿孔病因为胃十二指肠溃疡（GDU）111例,占受检者97.3%;胃癌2例,占1.8%;十二指肠憩室1例,占0.9%。中转急诊手术3例,均为十二指肠溃疡（DU）。结论在急诊的特定情况下,临床诊断PGDU有其合理性,但其中非溃疡因素应引起重视,PGD非手术治疗后早期胃镜检查对确定病因诊断及后续治疗的选择具有重要意义。     

腹腔镜消化性溃疡穿孔修补术的临床应用

目的:探讨腹腔镜手术治疗消化性溃疡穿孔的可行性。方法:自2006年初,对上消化道溃疡穿孔患者进行前瞻性随机对照研究,按照手术方式分为开腹手术组和腹腔镜手术组,至2010年末,有效病例160例。对比分析两组患者术后疼痛指数、住院时间及术后并发症发生率。结果:腹腔镜组术后疼痛指数、住院时间低于开腹组(P<0.05),两组术后并发症发生率无明显差异,术后随访半年均无复发。结论:腹腔镜上消化道溃疡穿孔修补术是安全有效的微创术式,在一定程度上优于传统开腹手术。     

腹腔镜与开腹消化性溃疡穿孔修补术比较的Meta分析

目的评价腹腔镜修补手术治疗消化性溃疡穿孔的安全性和有效性。方法收集1990－2011年公开发表的腹腔镜和开腹消化性溃疡穿孔修补术的中文和英文文献．对腹腔镜组和开腹组的术中情况、术后恢复情况及术后并发症情况进行Meta分析。结果筛选出符合纳入标准的研究19项,共1507例,腹腔镜组673例,开腹组834例。与开腹组相比,腹腔镜组患者术中出血量更少,术后排气时间更快、住院时间更短、术后切口感染率和围手术期死亡率更低（均P〈O．05）。两组患者手术时间和术后败血症、肺部感染、腹腔脓肿、修补处瘘发生率的差异则无统计学意义（均P〉O．05）。结论腹腔镜修补手术治疗消化性溃疡穿孔具有出血少、恢复快、切口感染和死亡率低的优势．安全可行。     

腹腔镜高选择性迷走神经离断术治疗上消化道溃疡穿孔的临床研究

目的:评价腹腔镜穿孔修补术联合高选择性迷走神经离断术治疗胃十二指肠溃疡穿孔的疗效.方法:回顾分析2003年1月至2007年1月273例胃十二指肠溃疡穿孔患者的临床资料,其中胃穿孔149例,十二指肠穿孔124例.134例行腹腔镜穿孔修补加高选择性迷走神经切断术(研究组),139例行剖腹穿孔修补加高选择性迷走神经切断术(对...     

腹腔镜胃十二指肠溃疡穿孔修补术28例报告

目的:探讨腹腔镜手术在胃十二指肠溃疡穿孔修补术中的应用价值。方法:2003年1月~2006年8月我院为28例胃十二指肠溃疡穿孔患者行腹腔镜穿孔修补术。结果:27例成功完成腹腔镜手术,1例中转开腹。手术时间30~100m in,平均45m in,术后住院时间5~10d,平均7.8d,术后并发症少,无一例死亡。结论:腹腔镜胃十二指肠溃疡穿孔修补术具有痛苦小,恢复快,并发症少,住院时间短等优点,疗效确切,操作简单易行,值得在临床工作中推广应用。     

消化性溃疡患者的骨密度变化

目的　为探讨消化性溃疡（溃疡病）对患者骨密度（ＢＭＤ）的影响。方法本文采用双能Ｘ 线骨密度仪（ＤＥＸＡ）测定了１１４ 例溃疡病患者腰椎及右股骨上端（Ｎｅｃｋ、Ｗ ａｒｄ 三角、Ｔｒｏｃｈ）的骨密度。结果　从疾病、性别、年龄、体重指数（ＢＭＩ）等方面将溃疡病患者ＢＭＤ 的变化与相匹配的正常对照组ＢＭＤ 进行分析比较,发现溃疡病患者ＢＭＤ 广泛低于对照组,以腰椎改变具有显著差异（Ｐ＜０．０１）。结论　溃疡病患者存在明显骨丢失,其骨质疏松症（ＯＰ）患病率为男３１．０３％ 、女４２．８６％ 。     

重新评估非手术治疗十二指肠溃疡穿孔的地位

目的 重新评估幽门螺杆菌时代非手术治疗十二指肠溃疡穿孔的地位。方法 回顾性分析过去8年间54例十二指肠溃疡穿孔患者非手术治疗的临床资料。结果 43例(79.6％)经过非手术治疗成功(含1例并发肠袢间脓肿);11例中转开腹手术,其中死亡1例,并发胃瘫1例;全组病死率1.9％,并发症发生率3.7％。非手术治疗组与中转开腹手术组间年龄、溃疡病史、穿孔时间和有无膈下游离气体等方面差异无显著性意义(均P>0.05);而是否空腹穿孔、腹膜炎的范围、腹穿结果和泛影葡胺造影结果组间差异有显著性意义(均P<0.05)。31例非手术治疗成功者获得1～8年的随访,有28例治愈,1例死于溃疡无关的内科疾病,2例因内科治疗效果不佳而进行了外科治疗。结论 合理掌握适应证,非手术治疗是处理十二指肠溃疡穿孔安全有效的重要治疗方法之一。     

腹腔镜消化性溃疡穿孔修补术23例

目的探讨腹腔镜消化性溃疡穿孔修补术的方法和治疗效果. 方法应用腹腔镜对23例消化性溃疡穿孔(十二指肠穿孔17例,胃窦部前壁穿孔5例,胃体部小弯侧穿孔1例)行穿孔修补﹑腹腔引流术. 结果手术均获成功,无手术并发症.3个月后胃镜复查,13例使用丝线者均有缝线外露,10例使用可吸收外科缝线者无缝线外露.随访6～27个月,平均18个月,3例十二指肠球部穿孔者仍有轻度嗳气,返酸,余无明显症状,无再穿孔. 结论腹腔镜消化性溃疡穿孔修补术安全可靠,术后继续正规内科治疗,效果满意.     

Prognostic scoring systems in burns: a review

Survival after burn has steadily improved over the last few decades. Patient mortality is, however, still the primary outcome measure for burn care. Scoring systems aim to use the most predictive premorbid and injury factors to yield an expected likelihood of death for a given patient. Age, burn surface area and inhalational injury remain the mainstays of burn prognostication, but their relative weighting varies between scoring systems. Biochemical markers may hold the key to predicting outcomes in burns. Alternatively, the incorporation of global scales such as those used in the general intensive care unit may have relevance in burn patients. Outcomes other than mortality are increasingly relevant, especially as mortality after burns continues to improve.The evolution of prognostic scoring in burns is reviewed with specific reference to the more widely regarded measures. Alternative approaches to burn prognostication are reviewed along with evidence for the use of outcomes other than mortality. The purpose and utility of prognostic scoring in general is discussed with relevance to its potential uses in audit, research and at the bedside.     

青少年十二指肠溃疡穿孔的处理

目的：探讨青少年十二指肠溃疡急性穿孔的治疗方法。方法：回顾性分析45例青少年十二指肠溃疡急性穿孔的治疗，其中行单纯修补术24例，胃大部切除术13例，迷走神经切除加胃部分切除3例，修补加高选择性迷走神经切除5例。单纯修补组术后国洛赛克治疗3个月。结果：随讠年，全组无死亡。单纯修补组并发症发生率（8％）与手术切除组（38％）相比差异有显著意义（P＜0．05）；修补组治愈率明显高于手术切除组（P＜0．05）；2组溃疡复发率相比差异无意义（P＞0．05）；修补组体重增加较手术切除组差异有显著意义（P＜0．05）。结论：应用单纯修补加洛赛克治疗青少年十二指肠溃疡穿孔是一种既符合青少年生理特征又有效和可靠的方法。     

Treatment of Helicobacter pylori infection in patients with peptic ulcer disease

Helicobacter pylori is an organism that is thought to be important in the pathophysiology of peptic ulcer disease and gastritis. Eradication of the organism is useful in clinical cure of infected patients. Efficacious regimens generally include an antisecretory agent combined with two to three antimicrobials. The main determinant of overall cost of treatment is the rate of eradication of the organism. Impediments to patient compliance include intensive dosage schedules and drug side effects. Resistance can occur to the commonly used antibiotics but can usually be overcome with an altered regimen.     

消化性溃疡穿孔治疗方法的选择

目的探讨损伤控制在胃十二指肠溃疡穿孔手术治疗中的应用。根据损伤控制理论合理选择胃十二指肠溃疡穿孔的手术方式。方法回顾性分析我院1996年1月-2006年12月收治的胃十二指肠溃疡穿孔98例的临床资料。结果行单纯溃疡修补术84例,治愈81例,死亡3例;行胃大部切除术12例,治愈11例,死亡1例;保守治疗2例,均治愈。结论胃十二指肠溃疡穿孔病人诊断一旦明确,在损伤控制理论的指导下,在进行体液复苏,抗感染,纠正水、电解质和酸碱平衡紊乱的前提下,以抢救生命为首要治疗目的,选择损伤小、简单、快捷且能阻断病情发展的穿孔修补手术,术后进行规范的抗溃疡及根除幽门螺杆菌治疗,能有效治愈溃疡,预防复发。     

腹腔镜治疗上消化道溃疡穿孔的应用体会

目的:探讨腹腔镜治疗上消化道溃疡穿孔的应用价值及优越性。方法:回顾分析2005年1月至2008年12月我院应用腹腔镜手术治疗上消化道穿孔30例患者的临床资料。结果:30例中胃十二指肠溃疡穿孔28例,胃癌穿孔2例。28例腹腔镜手术成功,2例胃癌穿孔患者中转开腹。手术时间60～80min,平均(68.2±15.5)min。术后住院4～10d,平均6.2d。本组无并发症发生及死亡病例。结论:腹腔镜手术治疗上消化道溃疡穿孔具有患者痛苦小、损伤轻、康复快、并发症少、住院时间短等优点,疗效满意,值得临床推广应用。     

Comparative study of postoperative complications after open and laparoscopic surgery of the perforated peptic ulcer: Advantages of the laparoscopic approach

BackgroundDespite the acceptance of the laparoscopic approach for the treatment of perforated peptic ulcers, its definitive implantation is still a matter of discussion. We performed a comparative study between the open and laparoscopic approach focused on postoperative surgical complications.MethodsRetrospective observational study in which patients operated on for perforated peptic ulcus in our center between 2001 and 2017 were analyzed. Only those in whom suture and/or omentoplasty had been performed were selected, either for open or laparoscopic approach. Demographic, clinical, and intraoperative variables, complications, mortality and length of stay were collected. Both groups, open and laparoscopic surgery patients, were compared.ResultsThe final study sample was 250 patients, 190 (76%) men and 60 (24%) women, mean age 54 years (SD ± 16.7). In 129 cases (52%), the surgical approach was open, and in 121 (48%) it was laparoscopic. Grades III-V complications of the Clavien-Dindo Classification occurred in 23 cases (9%). Operative mortality was 1.2% (3 patients). Laparoscopically operated patients had significantly fewer complications (p = 0.001) and shorter hospital stay (p < 0.001). In multivariate analysis, laparoscopic approach (p = 0.025; OR:0.45–95%CI: 0.22–0.91), age (p = 0.003; OR:1.03–95%CI: 1.01–1.06), and Boey score (p = 0.024 – OR:1.71 – CI95%: 1.07–2.72), were independent prognostic factors for postoperative surgical complications.ConclusionLaparoscopic surgery should be considered the first-choice approach for patients with perforated peptic ulcer. It is significantly associated with fewer postoperative complications and a shorter hospital stay than the open approach.