口服特比萘芬联合外用治疗32例头癣

特比萘芬［Ｔｅｒｂｉｎａｆｉｎｅ，商品名疗霉舒（Ｌａｍｉｓｉｌ）］由瑞士诺华公司（原名山德士药厂）生产，为丙烯胺类抗真菌药物，已被广泛应用于临床治疗体股癣、手足癣和甲癣等真菌感染，疗效显著，安全可靠。我们于１９９５年７月使用口服疗霉舒结合外用治疗３２...     

特比萘芬口服联合外用治疗足癣疗效观察

足癣是皮肤癣菌侵犯足部所引起的浅部真菌感染性疾病,因其顽固易复发,外用给药患者的依从性差,难以达到预期疗效,因此笔者于2006年6月-2007年6月采用特比萘芬(商品名:兰美抒,北京诺华公司)口服联合特比萘芬乳膏(天津中美史克制药)外用治疗足癣94例,获得较好的疗效,现将结果报告如下.     

特比萘芬片口服联合特比萘芬凝胶外用治疗足癣疗效观察

目的探讨口服特比萘芬联合外用特比萘芬凝胶治疗足癣的疗效。方法将足癣患者124例随机分成两组,治疗组64例,口服特比萘芬1次/d,同时外用1%特比萘芬凝胶2次/d,疗程2周。对照组60例,局部外用1%特比萘芬凝胶2次/d,疗程4周。结果治疗组治愈率为96.9%,真菌清除率为90.6%;对照组分别为91.7%和86.7%。结论联合疗法和单一外用药物治疗足癣均有效,但联合疗法起效快、效果较好。     

口服特比萘芬治疗儿童头癣的开放性研究

将符合人选标准的52例儿童头癣患者进行真菌培养，经鉴定以亲动物性犬小孢子菌为主要致病菌。采用特比萘芬口服治疗4周后临床和真菌学治愈率分别为68.9%和83.1%；治疗6周后分别为82.9%和97.4%；停药后4周则分别为90.2%和100%。治疗期间无明显副作用。     

口服及外用特比萘芬治疗头癣10例

头癣好发于儿童，是由真菌感染头皮毛发所致。以往常口服灰黄霉素或酮康唑治疗，虽然具有一定的疗效，但治疗时间较长，且具有较明显的副作用，不易为患儿家长所接受。我们于１９９６年４月－１９９７年８月采用瑞士山德士药厂生产的特比萘芬片剂及其１％霜剂治疗头癣１０...     

特比萘芬治疗儿童头癣13例

近年来头癣的发病率有所增加 ,我们用齐鲁制药厂研制的特比萘芬治疗儿童头癣 ,取得满意效果 ,现将 13例总结如下。一般资料　 13例头癣病人中男 8例 ,女 5例 ;年龄 5～ 14岁 ;病程 2 0天～ 1年 ,白癣 12例 ,脓癣 1例 ,损害呈蚕豆大至拳头大 ,数目 1～ 14个。 13例头癣病人经流行病学调查 ,家中饲养猫、狗等小动物 9例 ,2例家中虽未饲养 ,但经常到邻居家玩耍猫、狗。 13例病人 ,农村 9例 ,城市 4例。所有病例真菌直接镜检均阳性 ;真菌培养鉴定为犬小孢子菌 12株 ,紫色毛癣菌 1株。治疗方法　体重 <18.5ｋｇ的病儿每日特比萘芬 [山东齐鲁制药…     

口服和外用特比萘芬治疗体癣和股癣疗效观察

笔者于2000年10月—2003年12月，采用特比萘芬片和1％特比萘芬软膏(丁克软膏)治疗体、股癣患者，观察两药的疗效，现报告如下。     

特比萘芬治疗甲癣疗效观察

我们从 1999年 3月～ 2 0 0 0年 1月应用山东齐鲁制药厂生产的特比萘芬治疗 36例甲癣病人 ,取得满意效果 ,现报告如下。临床资料　 36例均为门诊病人 ,其中男 15例 ,女 2 1例 ;病程 3月～ 15年 ;36例患者中共有病指甲 82个 ,病趾甲 195个 ;其中合并手癣、足癣或股癣的病人共 2 0例 ,全部病例治疗前直接镜检均阳性 ,且 2周内未曾内服或外用过其它抗真菌药。治疗方法　特比萘芬第 1周每日 1次 ,每次 2 5 0ｍｇ ;自第 2周开始 ,隔日 1次 ,每次 2 5 0ｍｇ,指甲癣共服 7周 ,趾甲癣共服 11周 ,服完全部药物 4周后观察治疗结果。疗效判断标准　痊愈…     

特比萘芬的临床应用研究进展

特比萘芬是一种有效的抗真菌药物 ,对于头癣、手足癣、体股癣、甲真菌病等浅部真菌病具有较好的疗效 ,并且耐受良好 ,不良反应轻 ,最常见的不良反应是胃肠道反应和皮疹 ,然而在临床应用过程中仍须注意其可能发生的少见的严重不良反应 ,如超敏反应综合征和急性肝坏死。关于特比萘芬在深部真菌病的应用 ,临床资料十分有限 ,仍需进一步积累经验     

特比萘芬治疗甲真菌病75例

笔者于2001年8月～2004年2月对75例甲真菌病患者采用特比萘芬（山东齐鲁制药厂生产）进行治疗，获得满意疗效，现报告如下：     

皮肤肥大细胞瘤4例

报告4例皮肤肥大细胞瘤.4例患儿中男女各2例,年龄5.5～20个月.2例皮损单发,另外2例皮损多发,Darier征均阳性.皮损组织病理改变为真皮全层和(或)皮下脂肪组织有大量肥大细胞浸润.其中2例患儿还有散在的嗜酸性粒细胞浸润.4例患儿的皮损均随年龄增大而逐渐减轻或消退,局部遗留色素沉着和色素减退斑.     

Usefulness of TrichoScan professional in the evaluation of hair loss in females. Report of 180 cases

Background TrichoScan Professional is a computerized program used for digital measurement of hair growth and hair loss. The aim of our study was to undertake an evaluation with TrichoScan Professional of female patients consulting at our hospitals for hair loss. The purpose of our study was to determine whether TrichoScan was able to identify differences in hair parameters that would correlate with the pattern of alopecia or according to the age of the patients evaluated. Material and methods One hundred‐eighty women that consulted consecutively for loss of hair were included. Patients were aged between 8 and 85 years (mean age 36 years). Data including age, the number of hairs, hair density per square centimetre, anagen and telogen percentage and percentage of terminal and miniaturized hair were analysed. Results Results observed with TrichoScan were as below: number of hairs (mean 154.9; range 34–316). Hair density per square centimetre (mean 239; range 52–486). Hair in anagen phase (mean 62.4%; range 9–93%). Hair in telogen phase (mean 37.4%; range 7–91%). Terminal hair (mean 95.2%; range 82–100%). Vellus hair (mean 4.7%; range 0–17%). Pearson′s correlation test was used to measure the strength of the association of age with the rest of parameters. The statistical analysis showed a significant correlation between age and both the number of hairs and the hair density per square centimetre. However, no significant correlation between age and rest of the parameters was observed. Conclusions TrichoScan Professional may help to quantify hair density and in our sample, this was the only parameter showing a significant decrease according to age in various types of alopecia affecting the females.     

多发性皮肤平滑肌瘤4例

报道4例多发性皮肤平滑肌瘤，均与典型的临床和病理改变，其中1例伴有子宫肌瘤，另1例伴有Becker's痣，3例经心痛定治疗后疼痛明显减轻。     

发疹型汗管瘤4例

1临床资料病例1,男,24岁。躯干、四肢泛发皮色丘疹15年。患者9岁时胸部出现散在米粒大皮色丘疹,持续不退,无自觉症状,未治疗,皮疹缓慢增多。5年后波及腹部。10年后波及四肢,皮疹增至数百个。曾外用多种药物,疗效不佳。皮肤科查体:胸、腹、四肢皮肤广泛分布米粒大坚实丘疹,皮色、淡红     

毛囊型白癜风四例

例1 女，12岁，因头顶部白发3周、白斑1周就诊。患儿家长数周前发现患儿头顶散在数十根毛发变白，未见头皮白斑，未予重视，近1周发现头皮白斑。否认恶性贫血等内科疾病，无早年白发及白癜风家族史……     

富于细胞性血管纤维瘤四例

富于细胞性血管纤维瘤（cellular angiofibroma,CAF）是一种较为罕见的良性间叶性肿瘤,最早被Nucci等［1］于1997年命名并报道,现报道我科诊治的4例CAF病例……     

Paracoccidioidomycosis (South American blastomycosis) successfully treated with terbinafine: first case report

We describe a 63-year-old man who presented with painful malodorous lesions in the perianal, perineal and scrotal regions. Following definitive diagnosis of paracoccidioidomycosis, he was treated initially with trimethoprim/sulphamethoxazole, but there was no clinical improvement. He then received terbinafine (Lamisil) 250 mg twice daily for 6 months. There was rapid resolution of all lesions and complete relief of symptoms, without any associated side-effects. The patient remains clinically well and without any evidence of infection 2 years after discontinuation of terbinafine treatment.     

A case of black dot ringworm with a review of Japanese cases

Black dot ringworm (BDR), caused by Trichophyton violaceum var. glabrum (T. glabrum), was observed in a 28-year-old Japanese female who had been treated with prednisolone (22.5 mg/day) for systemic lupus erythematosus. It was successfully treated with oral terbinafine (125 mg/day) for 12 weeks. The causative fungus was identified by molecular analysis as well as morphological and biochemical examination. The chitin synthase 1 (CHS1) gene cleavage pattern of the clinical isolate with restricted enzyme HinfI was identical to that of T. violaceum. We reviewed previous reports of BDR to determine the historical trend of this infection in Japan. Since 1974, 93 Japanese cases have been reported. The age distribution was bi-modal: the higher peak consisted of children (aged 0-15 years), and the lower peak was composed of the elderly (aged 60-75 years). In the elderly group, females were predominant (M:F=1:22, p<0.001). T. violaceum, including T. glabrum, was identified as the most common causative fungus of BDR (75.3%). Sixty percent of cases showed slight erythema. In 8 families, 16 cases were found to be intrafamilial infections. A history of previous steroid treatment was described in about 40%.