Cimetidine increases the pancreatic response to histamine

The effects of histamine alone and histamine plus cimetidine on basal pancreatic exocrine secretion were determined in anaesthetized rabbits with an acute pancreatic cannula. Intravenous histamine administration (0.2–0.8n mol/kg/min) increased pancreatic enzyme secretion. A much greater stimulative effect on pancreatic (cimetidine 4 mol/kg/min). The results indicate that in the rabbit pancreas the stimulatory effect of histamine is mediated by H1 receptors.     

Cimetidine does not influence cellular immunity in patients with chronic renal insufficiency

Numerical and functional markers of peripheral lymphocytes were adopted to study the influence of cimetidine on the immune response in immunocompromized patients.Twenty-three patients on regular dialysis treatment, who had been given cimetidine (400 mg daily) for peptic ulcer, were studied during a follow-up of 3 months. Thirty healthy people served as controls for the study of the immunological parameters, i.e. DNCB and PPD skin tests, E-rosetting assays, monoclonal antibodies to T-cells, membrane immunoglobulins for the B-cells, serum immunoglobulins and complement.Before therapy was started CMI was impaired in all patients, with a significant reduction in the E-rosette count (P < 0.01) and depressed DTH (DNCB, PPD). The number of active E-rosettes and OKT4 subsets increased slightly during the period of treatment, though this finding was not confirmed by functional in vivo tests. No change was observed in the B-lymphocyte count and in serum immunoglobulins or complement.The fact that treatment with cimetidine does not seem to influence the immune response in patients on RDT, may suggest that this therapy does not restore the principal immunopathological disorder of these patients, and further justifies its use in patients awaiting renal transplantation or in those who have been given transplant.     

西咪替丁治疗过敏性紫癜甲襞微循环观察

本文对用西咪替丁治疗的过敏性紫癜35例临床及甲襞微循环改变进行了观察.有效率100%,与对照组比较有显著差异(x=8.17 P相似文献   

^131I治疗36例Graves病伴白细胞减少患者的临床疗效观察

为探讨^131I治疗对Graves病（GD）伴白细胞（WBC）减少患者或服用ATD后出现白细胞减少的GD患者的疗效,给予36例GD伴白细胞减少的患者^131I治疗,并分别测定患者治疗前和治疗后1个月、3个月、6个月的血常规、甲状腺激素水平等相关指标。结果显示^131I治疗3个月后,FT3、FT4水平明显降低,TSH升高,与治疗前比较有显著性差异（P〈0.05）;^131I治疗后3个月,外周血白细胞水平逐渐恢复,与治疗前比较有显著性差异（P〈0.05）。^131I治疗GD伴白细胞减少是一种安全可靠、疗效肯定的治疗方法,应尽早选用。     

Cimetidine as an Organic Cation Transporter Antagonist

This Correspondence relates to “Organic transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions” (Am J Pathol 2010, 176:1169–1180).     

Cimetidine and delirium: Assessment and management

A number of reports have appeared of possible cimetidine- induced delirium. In many cases it appears that this delirium may have resulted from inadvertently overdosing the patient with cimetidine. The author briefly reviews the drug's pharmacokinetics and interactions with other drugs. He then explains the use of a formula and a nomogram for accurate dosage adjustment in patients with cimetidine-induced delirium.     

Cimetidine in the treatment of refractory anaphylaxis

After preoperative intubation and administration of intravenous cefuroxime, a 48-year-old white female developed anaphylactic shock that was refractory to the usual therapeutic measures but was responsive to treatment with intravenous cimetidine. Beta-lactam sensitivity was subsequently confirmed by skin testing. Cimetidine, which antagonizes arterial H2 receptors, may be useful in the treatment of anaphylaxis refractory to the usual resuscitative measures.     

Cimetidine and stress ulcer in aged rats

Male Sprague-Dawley rats, 2, 6, 11, 18, and 26 months old, were subdivided into four drug treatment groups and received either 25, 50, 100 mg/kg of cimetidine or a placebo control before being exposed to restraint plus cold stress for 3 hr. Cimetidine, at all dose levels, significantly reduced ulcer severity in all age groups except the 18- and 26-month-old rats. Senescent rats were not more susceptible to restraint ulcer and cimetidine had the least anti-ulcer effect with the senescent 26-month-old rats.     

Cimetidine and postprandial pancreatic exocrine secretion in dogs

In dogs fitted with a pancreatic cannula and a duodenal cannula the intake of a standard meal induced a significant increase in the flow of pancreatic secretion and in the output of amylase, total protein, bicarbonate and chloride.The oral administration (200 mg/day) of cimetidine to dogs was seen to elicit a marked decrease in postprandial flow increase and bicarbonate output, coinciding with a significant increase in amylase and total protein output. At the same time the postprandial duodenal pH remained at levels similar to those obtained in basal periods. The implications of secretin, gastrin and cholecystokinin (CCK) on these effects are discussed.     

Cimetidine abrogates suppressor T cell function in vitro

Cimetidine increased the [3H] thymidine incorporation of normal human mononuclear cells in culture both when unstimulated or when under the stimulus of phytohemagglutinin or pokeweed mitogen (PWM). It also increased their supernatant immunoglobulin production under PWM stimulus. These effects were higher when the cells were preincubated with cimetidine than when it was added simultaneously. To determine if this effect of cimetidine reflects an abrogation of suppression we studied concanavalin-A-induced suppressor function of normal mononuclear cells using both [3H] thymidine incorporation and immunoglobulin synthesis as indicator systems and found that preincubation with cimetidine caused significant decrease in suppressor cell function in both systems.     

奥司他韦和利巴韦林治疗白细胞减少的肺炎比较(附40例分析)

目的 探讨奥司他韦和利巴韦林治疗白细胞减少的肺炎疗效.方法 选择40例白细胞减少的肺炎患者,随机选择20例白细胞减少的肺炎患者予以奥司他韦加抗生素治疗.另外随机选择20例患者予以利巴韦林加抗生素治疗作为对照组,来比较两组的白细胞恢复时间、肺炎的总疗程、治愈率.结果 实验组白细胞恢复时间提前,肺炎的总疗程缩短,经统计学分析,差异有明显的统计学意义.结论 奥司他韦治疗白细胞减少的肺炎有显著疗效,可以缩短病程,而且预后良好.