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1.
Jens C. Stollfuss Felix Haas Ichiro Matsunari Jodi Neverve Stephan Nekolla Jan Schneider-Eicke Ullrich Schricke Sybille Ziegler Markus Schwaiger 《European journal of nuclear medicine and molecular imaging》1998,25(5):522-530
We investigated the use of visual and quantitative technetium 99m tetrofosmin ECG-gated single-photon emission tomography
(SPET) for the assessment of regional myocardial wall thickening (WT) and left ventricular (LV) ejection fraction (EF) in
comparison with gated magnetic resonance imaging (MRI) in patients with a low angiographic LVEF. Gated SPET using 99mTc-labelled flow tracers offers potential for simultaneous assessment of myocardial perfusion and LV function. Few data are
available on the use of visual and quantitative gated SPET in patients with low LVEF. In this study 21 patients with low angiographic
LVEF (mean 37%±5%) were studied. Resting gated 99mTc-tetrofosmin SPET and gated MRI were performed within 48 h. WT was assessed by visual interpretation (five point score)
and quantitative analysis based on count increase. There was good agreement for EF measurements by MRI and gated SPET (mean
EF: 33%±12% vs 35%±11%, r = 0.86, P<0.001). Areas under receiver operator characteristic curves (AUC) for differentiation between MRI WT score points ranged
from 0.60 to 0.66 for visual SPET WT analysis, from 0.59 to 0.71 for delta count increase values and from 0.46 to 0.60 for
% WT, indicating substantial overlap between WT categories. Absolute agreement for visual WT between MRI and gated SPET ranged
from 25% to 57% (kappa 0.03–0.25) depending on tracer uptake, and was limited in areas with moderate to severe perfusion defects
(kappa 0.03–0.13). It is concluded that gated SPET provided reliable estimates of regional WT and global function in patients
with low angiographic LVEF.
Received 15 October 1997 and in revised form 31 January 1998 相似文献
2.
Eiji Tadamura Takashi Kudoh Makoto Motooka Masayuki Inubushi Tomohisa Okada Shigeto Kubo Naoya Hattori Tetsuya Matsuda Takaaki Koshiji Kazunobu Nishimura Masashi Komeda Junji Konishi 《European journal of nuclear medicine and molecular imaging》1999,26(7):705-712
In patients who had undergone cardiac surgery (coronary artery bypass graft) and whose hearts showed abnormal movement during
the cardiac cycle, we studied the accuracy of functional assessment using ECG-gated single-photon emission tomography (SPET)
and the automated software developed by Germano et al. by comparing the findings with magnetic resonance (MR) images acquired
three-dimensionally. Sixteen patients who had undergone cardiac surgery underwent 99mTc-sestamibi gated SPET (MIBI-g-SPET) and MRI on the same day. Left ventricular end-diastolic and end-systolic volumes (EDV,
ESV) and ejection fraction (LVEF) were measured using MIBI-g-SPET and the aforementioned algorithm. Regional wall thickening
was assessed using a four-point scale on MIBI-g-SPET and cine MRI. There was a good correlation between MIBI-g-SPET and MRI
in respect of EDV (r=0.89), ESV (r=0.93) and LVEF (r=0.89). A high degree of agreement was found between the wall thickening scores obtained by MIBI-g-SPET and MRI in total segments
(κ=0.62) and in septal segments (κ=0.67). It is concluded that ECG-gated perfusion SPET can provide regional and global functional
information, including absolute volumes, in patients following cardiac surgery.
Received 5 January and in revised form 18 March 1999 相似文献
3.
Zhiming Yao Xiu Jie Liu MD. Rongfang Shi Ruping Dai Shaoxiong Zhang Yunzhong Liu Shengting Li Yueqin Tian Xiaoli Zhang 《European journal of nuclear medicine and molecular imaging》1997,24(9):1115-1120
We compared technetium-99m methoxyisobutylisonitrile (MIBI) myocardial perfusion single-photon emission tomography (SPET) (MPS) and electron beam computed tomography (EBCT) in order to assess their respective value in the detection of coronary artery disease (CAD).99mTc-MIBI SPET (stress-resting) and EBCT studies were performed in 51 patients with suspected CAD who underwent coronary angiography (CAG). CAG showed that of the 51 patients, 36 had coronary stenosis 50% while 15 had normal results. A moderate positive rank correlation was found between coronary calcification detected by EBCT and MPS score (r
s=0.5283,P<0.01). The concordance between EBCT and MPS for the evaluation of CAD was 72.5% (37/51). The sensitivity of EBCT in detecting CAD in 51 patients was comparable to that of MPS (81% vs 94%, NS). However, the accuracy of EBCT was lower than that of MPS (78% vs 94%,P<0.025). As regards the detection of individual coronary artery disease, there was no significant difference in sensitivity between EBCT and MPS (65% vs 75%, NS); however, the specificity and accuracy of EBCT were lower than those of MPS (specificity: 77% vs 95%,P<0.005; accuracy 71% vs 85%,P<0.005). The sensitivity, specificity and accuracy of MPS in detecting single-vessel disease were higher than those of EBCT (sensitivity: 86% vs 42%,P<0.025; specificity: 96% vs 70%,P<0.025; accuracy: 93% vs 61%,P<0.005). However, no significant differences in the sensitivity, specificity and accuracy of MPS and EBCT were found in respect of multivessel disease. In conclusion:99mTc-MIBI myocardial perfusion SPET and EBCT provide different information in the assessment of CAD. The sensitivity of EBCT for the detection of CAD is comparable with that of MPS; however, the specificity and accuracy of EBCT are lower than those of MPS. More reliable results will be obtained if both myocardial perfusion SPET and EBCT are performed. 相似文献
4.
Gated single-photon emission tomography imaging protocol to evaluate myocardial stunning after exercise 总被引:1,自引:1,他引:0
Jun Hashimoto Atsushi Kubo Ryuichiro Iwasaki Shiro Iwanaga Hideo Mitamura Satoshi Ogawa Shigeru Kosuda 《European journal of nuclear medicine and molecular imaging》1999,26(12):1541-1546
This study was designed to apply ECG-gating to stress myocardial perfusion single-photon emission tomography (SPET) for the
evaluation of myocardial stunning after exercise. Technetium-99m sestamibi was selected as the perfusion agent and a rest/exercise
1-day protocol was employed. Fourteen patients without coronary stenosis and 33 patients with coronary stenosis were enrolled
in the study. We carried out three data acquisitions with ECG-gating: a 15-min data acquisition starting 30 min after the
rest injection (AC1), a 5-min acquisition starting 5 min after the stress injection (AC2) and a 15-min acquisition starting
20 min after the stress injection (AC3). Calculation of left ventricular ejection fraction (LVEF) values was performed by
means of automatic determination of the endocardial surface for all gating intervals in the cardiac cycle. Measured global
EF values in 14 patients without coronary stenosis were 52.3%±7.6% (AC1), 60.6%±8.9% (AC2) and 55.6%± 5.6% (AC3), and those
in 11 patients with severe ischaemia were 53.6%±8.0% (AC1), 45.6%±12.1% (AC2) and 49.7%±10.7%. The magnitude of the depression
of post-stress LVEF relative to the rest LVEF correlated with the severity of ischaemia (r=0.594, P=0.002), and segments manifesting post-stress functional depression were associated with ischaemic segments showing reversible
perfusion defects. Stress myocardial perfusion SPET with ECG-gating is a feasible method for the evaluation of myocardial
stunning as well as exercise-induced ischaemia.
Received 13 June and in revised form 19 August 1999 相似文献
5.
Evaluation of global and regional left ventricular function using technetium-99m sestamibi ECG-gated single-photon emission tomography 总被引:3,自引:2,他引:1
Kuang-Tao A. Yang Hon-Der Chen 《European journal of nuclear medicine and molecular imaging》1998,25(5):515-521
We evaluated a method for the assessment of left ventricular (LV) function with technetium-99m sestamibi ECG-gated single-photon
emission tomography (GSPET). GSPET was performed at rest in 21 patients. Images were reconstructed to obtain end-diastolic
(ED) and end-systolic (ES) images. Endocardial and epicardial edges of the left ventricle for the ED and ES images were defined
using the gradient images and the algorithm developed. LV wall thickness was measured for the mid-ventricular slices of ED
and ES images at 10° intervals. The systolic thickening (ST) and the LV ejection fraction [LVEF(GSPECT)] could be determined.
These values were compared with the LV ejection fraction (LVEF) estimated using the gated blood pool method. There was a linear
correlation between LVEF and ST (r=0.79), and LVEF and LVEF(GSPET) (r=0.87). Histograms of LV thicknesses were generated. Agreement for evaluation of regional wall motion between the method using
histograms of LV thicknesses and the gated blood pool study was 92.8% (kappa=0.75). It is concluded that with an appropriate
method for LV edge detection, GSPET with 99mTc-labelled perfusion agents is of use for simultaneous evaluation of myocardial perfusion and assessment of LV function.
Received 1 December 1997 and in revised form 26 January 1998 相似文献
6.
H. Palmedo F. Grünwald H. Bender A. Schomburg P. Mallmann D. Krebs H. J. Biersack 《European journal of nuclear medicine and molecular imaging》1996,23(8):940-946
The aim of the study was to compare the diagnostic accuracy of scintimammography with technetium-99m methoxyisobutylisonitrile (MIBI; SMM) in the detection of primary breast cancer with that of mammography (MM) and magnetic resonance imaging (MRI). Fifty-six patients with suspected lesions detected by palpation or MM were included in the study. Within the 4 weeks preceding excisional biopsy, MM and MRI were performed in all patients. Between 5 and 10 min after the injection of 740 MBq99mTc-MIBI, SMM in the prone position was performed. In the total group of 56 patients, 43 lesions were palpable, while 13 were non-palpable but were detected by MM. Breast cancer was confirmed by histopathology in 27 of the patients (22 palpable and 5 non-palpable carcinomas). The tumour size ranged from 6 to 80 mm in diameter. For non-palpable lesions, the sensitivity of SMM, MM and MRI was 60%, 60% and 100%, respectively, while the specificity was 75%, 25% and 50%, respectively. For palpable breast lesions, all methods showed high sensitivity (SMM 91%, MM 95%, MRI 91%) but SMM demonstrated significantly higher specificity (SMM 62%, MM 10%, MRI 15%). In two mammographically negative tumours (dense tissue), SMM showed a positive result. In comparison to MRI, one additional carcinoma could be diagnosed by SMM. It may be concluded that for palpable breast lesions, the diagnostic accuracy of SMM is superior to that of MM and MRI. Through the complementary use of SMM it is possible to increase the sensitivity for the detection of breast cancer and multicentric disease. In patients in whom the status of a palpable breast mass remains unclear, SMM may help to reduce the amount of unnecessary biopsies. 相似文献
7.
Alice Widding Birger Hesse Niels Gadsbøll 《European journal of nuclear medicine and molecular imaging》1997,24(1):42-45
The aim of this study was to compare technetium-99m labelled tetrofosmin and sestamibi myocardial perfusion single-photon emission tomography (SPET) with one common sestamibi reference file for bull's eye imaging, with quantitation of the extent and severity of perfusion defects. Twenty patients suspected or known to have coronary artery disease participated in the study. Patients first underwent routine sestamibi myocardial SPET over 2 days, receiving doses of 400–600 MBq at stress and 600–800 MBq at rest. Then within the same week a 1-day tetrofosmin myocardial SPET study was performed, with a dose of 300 MBq at stress, followed 2.5 h later by a dose of 750 MBq at rest. Bull's eye images were generated for visual evaluation. Black-out defects according to the Cequal software analysis were only recorded if they comprised more than 10 pixels in men and 20 in women. According to the Cequal program, extent score and severity scores were expressed as number of pixels and deviations below reference limits. Five patients had normal myocardial SPET imaging with both radiotracers, while 15 had reversible, irreversible or partially reversible defects. The concordance of the results was high. The only two significant differences were that one patient had a reversible defect which appeared to be located in different myocardial regions (LAD vs RCA), and another patient had a defect that was partially reversible with sestamibi but irreversible with tetrofosmin. The results showed very high correlation coefficients for the extent and severity scores (linear correlation coefficient values of 0.99 and 0.94, respectively). In conclusion, it appears that changing between sestamibi and tetrofosmin has little influence on the interpretation of bull's eye images from the data file of a common reference population using one of the tracers. 相似文献
8.
Sciagrà R 《European journal of nuclear medicine and molecular imaging》2007,34(7):1107-1122
Background Gating of single-photon emission computed tomography (SPECT) has significantly improved the reliability and diagnostic accuracy
of myocardial perfusion imaging. The functional parameters derived from this technique, mainly left ventricular volumes and
ejection fraction, have been demonstrated to be accurate and reproducible. They are able to increase the detection of severe
and extensive coronary artery disease and show a significant incremental prognostic power over perfusion abnormalities. Therefore,
the importance given to gated SPECT functional data has progressively grown.
Discussion This circumstance has further expanded the indications for myocardial perfusion imaging and strengthened its position among
the different imaging modalities. Moreover, several studies show that the evaluation of ventricular function may have a leading
part in justifying the execution of perfusion scintigraphy in various clinical conditions.
Aim Aim of this review is to describe this evolution of gated SPECT functional assessment from a supporting rank with respect
to perfusion, to a main actor position in the field of cardiac imaging. 相似文献
9.
Technetium-99m methoxyisobutylisonitrile single-photon emission tomography in hepatocellular carcinoma 总被引:2,自引:0,他引:2
Fukushima Kazuhito Kono Michio Ishii Kazunari Sakai Eiro Hirota Shozo Yuri Hidehisa 《European journal of nuclear medicine and molecular imaging》1997,24(11):1426-1428
Nine lesions in eight patients with hepatocellular carcinoma (HCC) were studied using single-photon emission tomography (SPET)
and technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) to evaluate the pattern of uptake of 99mTc-MIBI in the lesions and the relation between the uptake pattern and the histopathology of HCC. All the lesions were diagnosed
as HCC by percutaneous needle biopsy. Four of the nine lesions showed positive uptake of 99mTc-MIBI, while the other five showed negative uptake. All of the lesions which showed positive uptake were of the compact
type. Of the five lesions that showed negative uptake, four were of the trabecular type while one was of the compact type.
These results suggest that the patterns of 99mTc-MIBI accumulation in HCC are divided into positive and negative types and that these uptake patterns are associated with
the tissue structure of HCC.
Received 10 August and in revised form 15 August 1997 相似文献
10.
Young Hoon Ryu Jong Doo Lee Pyeong Ho Yoon Dong Ik Kim Ho Bun Lee Yee Jin Shin 《European journal of nuclear medicine and molecular imaging》1999,26(3):253-259
The neuro-anatomical substrate of autism has been the subject of detailed investigation. Because previous studies have not
demonstrated consistent and specific neuro-imaging findings in autism and most such studies have been performed in adults
and school-aged children, we performed a retrospective review in young children in search of common functional and anatomical
abnormalities with brain single-photon emission tomography (SPET) using technetium-99m ethyl cysteinate dimer (ECD) and correlative
magnetic resonance imaging (MRI). The patient population was composed of 23 children aged 28–92 months (mean: 54 months) who
met the diagnostic criteria of autism as defined in the DSM-IV and CARS. Brain SPET was performed after intravenous injection
of 185–370 MBq of 99mTc-ECD using a brain-dedicated annular crystal gamma camera. MRI was performed in all patients, including T1, T2 axial and
T1 sagittal sequences. SPET data were assessed visually. Twenty patients had abnormal SPET scans revealing focal areas of
decreased perfusion. Decreased perfusion of the cerebellar hemisphere (20/23), thalami (19/23), basal ganglia (5/23) and posterior
parietal (10/23) and temporal (7/23) areas were noted on brain SPET. By contrast all patients had normal MRI findings without
evidence of abnormalities of the cerebellar vermis, cerebellar hemisphere, thalami, basal ganglia or parietotemporal cortex.
In conclusion, extensive perfusion impairments involving the cerebellum, thalami and parietal cortex were found in this study.
SPET may be more sensitive in reflecting the pathophysiology of autism than MRI. However, further studies are necessary to
determine the significance of thalamic and parietal perfusion impairment in autism.
Received 1 July and in revised form 17 October 1998 相似文献
11.
Hendrik Everaert Christian Vanhove Philippe R. Franken 《European journal of nuclear medicine and molecular imaging》1999,26(10):1298-1303
Electrocardiography gated single-photon emission tomography (gated SPET) allows the assessment of regional perfusion and
function simultaneously and in full spatial congruency. In this study changes in global and regional left ventricular function
in response to dobutamine infusion were assessed in ten healthy volunteers using sequential gated SPET myocardial perfusion
acquisitions. Four consecutive gated SPET images were recorded 60 min after injection of 925 MBq technetium-99m tetrofosmin
on a three-head camera equipped with focussing collimators. Two acquisitions were made at rest (baseline 1 and 2), and the
third and fourth acquisitions were started 5 min after the beginning of the infusion of 5 and 10 μg kg–1 min–1 dobutamine, respectively. Systolic wall thickening (WT) was quantified using a method based on circumferential profile analysis.
Left ventricular ejection fraction (LVEF) and volumes were calculated automatically using the Cedars-Sinai program. Nine of
the ten subjects presented a definite increase in WT during dobutamine infusion. WT increased on average from 46%±14% at baseline
to 71%±23% (range: 37%–106%; P<0.05) during 5 μg kg–1 min–1 dobutamine infusion and to 85%±25% (range: 62%–123%; P<0.05 with respect to WT at 5 μg kg–1 min–1) during 10 μg kg–1 min–1 dobutamine infusion. Apical segments showed the largest WT at baseline. The average WT response to dobutamine was similar
for all parts of the myocardium. It is concluded that changes in WT induced by infusion of low-dose dobutamine can be assessed
by sequential gated SPET myocardial perfusion studies. The ”stress gated SPET” protocol proposed in this study might be helpful
to distinguish viable from scar tissue in patients with coronary artery disease, by demonstrating a preserved inotropic response
in hypoperfused myocardium.
Received 6 March and in revised form 6 May 1999 相似文献
12.
Motoo Oshima Masato Ishihara Hiroaki Sano Shigeki Ohsugi Miyoshi Ohno Shuhei Hayase Mitsuhiro Yokota Hiroshi Akanabe Kengo Ito Sadayuki Sakuma 《European journal of nuclear medicine and molecular imaging》1992,19(7):522-526
Myocardial single photon emission tomography (SPET) using technetium-99m teboroxime (teboroxime) was studied and the results compared with those of thallium-201(thallium) SPET and coronary arteriography in 19 patients. Resting teboroxime SPET was performed initially. Two hours later, exercise teboroxime SPET was performed. Exercise ergometer tests for both teboroxime and thallium were carried out in a supine position. The levels of exercise achieved for both tests were similar. Agreement for the identification of myocardial segments between thallium SPET and teboroxime SPET was 147/171(86%) (NS). When a significant stenosis was defined as 75% or 50%, agreement between two radiopharmaceuticals for the detection of diseased vessels was 89% (NS, = 0.601) or 88% (NS, = 0.713), respectively. In only 2/19 cases were inferior and posterior segments (3/171) difficult to interpret in teboroxime SPET due to hepatic activity. Thus, teboroxime SPET with a short data acquisition time resulted in a rapid completion for each study and had a good correlation with thallium SPET.
Offprint requests to: M. Oshima, M.D., Ph.D. Department of Radiology Nagoya First Red Cross Hospital 相似文献
13.
Ching-yee Oliver Wong Gary E. Meyerrose Samuel Sostre 《European journal of nuclear medicine and molecular imaging》1994,21(5):445-448
Cerebral atrophy often coexists with other brain disorders and by itself may alter the pattern of cerebral perfusion. If unrecognized, it may confound diagnoses based on brain single-photon emission tomography (SPET). In this retrospective study, we describe and evaluate criteria for the diagnosis of cerebral atrophy on technetium-99m hexamethylpropylene amine oxime brain SPET studies. The SPET scans of 11 patients with cerebral atrophy and ten controls were evaluated for the presence of a prominent interhemispheric fissure, presence of prominent cerebral sulci, separation of thalamic nuclei, and pronounced separation of caudate nuclei. The SPET studies were interpreted by two independent observers blind to the findings of magnetic resonance imaging, which provided the final diagnosis of cerebral atrophy. The combination of the four scintigraphic signs was accurate in the diagnosis of cerebral atrophy in 95% of the cases and had a sensitivity of 91% and a specificity of 100%.
Correspondence to: S. Sostre 相似文献
14.
Piotr Lipiec Maria Krzemińska-Pakuła Michał Plewka Jacek Kuśmierek Anna Płachcińska Remigiusz Szumiński Tadeusz Robak Anna Korycka Jarosław D. Kasprzak 《European journal of nuclear medicine and molecular imaging》2009,36(4):587-593
Purpose We investigated the impact of intracoronary injection of autologous mononuclear bone marrow cells (BMC) in patients with acute
ST elevation myocardial infarction (STEMI) on left ventricular volumes, global and regional systolic function and myocardial
perfusion.
Methods The study included 39 patients with first anterior STEMI treated successfully with primary percutaneous coronary intervention.
They were randomly assigned to the treatment group or the control group in a 2:1 ratio. The patients underwent baseline gated
single-photon emission computed tomography (G-SPECT) 3–10 days after STEMI with quantitative and qualitative analysis of left
ventricular perfusion and systolic function. On the following day, patients from the BMC treatment group were subjected to
bone marrow aspiration, mononuclear BMC isolation and intracoronary injection. No placebo procedure was performed in the control
group. G-SPECT was repeated 6 months after STEMI.
Results Baseline and follow-up G-SPECT studies were available for 36 patients. At 6 months in the BMC group we observed a significantly
enhanced improvement in the mean extent of the perfusion defect, the left ventricular perfusion score index, the infarct area
perfusion score and the infarct area wall motion score index compared to the control group (p = 0.01–0.04). However, the changes in left ventricular volume, ejection fraction and the left ventricular wall motion score
index as well as the relative changes in the infarct area wall motion score index did not differ significantly between the
groups.
Conclusion Intracoronary injection of autologous mononuclear BMC in patients with STEMI improves myocardial perfusion at 6 months. The
benefit in infarct area systolic function is less pronounced and there is no apparent improvement of global left ventricular
systolic function. 相似文献
15.
Peter Bartram Jens Toft Birgitte Hanel Samir Ali Finn Gustafsson Jann Mortensen Birger Hesse 《European journal of nuclear medicine and molecular imaging》1998,25(9):1308-1312
Exercise ECG and myocardial single-photon emission tomography (SPET) are fundamental in the non-invasive evaluation of patients
suspected of having coronary artery disease (CAD). The purpose of the present study was to investigate the influence of physiological
left ventricular hypertrophy (LVH) on myocardial sestamibi SPET in healthy young and old athletes. Eighteen young male elite
athletes (ten rowers, five power/weight lifters and three triathletes) and 14 well-trained elderly rowers were studied. All
underwent a bicycle test as part of a 2-day sestamibi SPET protocol. Attenuation correction was not performed. The studies
were evaluated visually and quantitatively analysed by the CEqual program with its reference files and with a file from a
local non-athletic age-matched population. Echocardiographic LVH was an inclusion criterion in the young athletes. Exercise
ECG was normal in all subjects. In at least three of the young athletes a reversible defect was observed by visual analysis.
On quantitative analysis one-third of the young athletes had ”significant” (>10 pixels) defects compared with both the local
reference base and the CEqual reference population. Nearly all defects were found in the anterior or inferior wall. The remaining
subjects, including all old rowers, had normal SPET findings. Anterior and inferior wall defects are so common in healthy
athletes with physiological LVH that the specificity of myocardial SPET, in contrast to exercise ECG, seems to be too low
for evaluation of chest pain in this group. The mechanism of anterior and inferior defects may be related to hot spots (papillary
muscles?) in the lateral wall. The specificity of SPET is maintained in athletes without LVH.
Received 9 March and in revised form 30 May 1998 相似文献
16.
Masatoshi Ishibashi Hidemi Nishida Yuji Hiromatsu Kazuyuki Kojima Masafumi Uchida Naofumi Hayabuchi 《European journal of nuclear medicine and molecular imaging》1997,24(2):197-201
The aim of the study was to compare the accuracy of technetium-99m sestamibi imaging for localization of ectopic parathyroid
glands in patients with hyperparathyroidism with that of magnetic resonance (MR) and computed tomographic (CT) imaging. Eleven
patients with primary (n=3) or secondary (n=8) hyperparathyroidism were studied with99mTc sestamibi parathyroid imaging CT and MR imaging. Images of the neck were acquired at 10 min and 2–3 after tracer injection.
The three patients with primary hyperparathyroidism and five patients with secondary hyperparathyroidism underwent parathyroidectomy.
The ectopic glands were confirmed by histopathological examination of the resected specimens. In respect of 20 parathyroid
glands in the eight patients explored surgically, the sensitivity and specificity of sestamibi imaging were 70% (14/20) and
88%, respectively, those of CT, 40% (8/20) and 88%, and those of MR imaging, 60% (12/20) and 88%. Of these patients, three
had parathyroid adenomas while five had hyperplasia (17 glands). Sestamibi imaging localized eight ectopic parathyroid glands,
which were surgically confirmed (six were located in the thymus and two in the mediastinum). In one patient explored surgically,
the ectopic gland was located outside the field of the MR coil. Although the remaining three cases of secondary hyperparathyroidism
were not confirmed surgically, these patients demonstrated sestamibi uptake in five parathyroid glands, including three ectopic
glands. MR images demonstrated abnormal parathyroid glands in the same regions as sestamibi imaging. Our data indicate that99mTc-sestamibi imaging should be used initially to localize the ectopic parathyroid glands in patients with hyperparathyroidism
for anatomical guidance prior to MR or CT imaging. 相似文献
17.
Akira Yamamoto Naoto Takahashi Masahiro Ishikawa Kazuya Abe Yuko Kobayashi Jin Tamai Kazuo Munakata 《Annals of nuclear medicine》2008,22(9):751-759
Objective To confirm the relationship between left ventricular (LV) function and wall motion synchrony, and to identify the difference
of synchrony between an ischemic heart disease (IHD) patient group and other heart disease (OHD) patient group among classified
groups in heart failure, systolic, and diastolic parameters were compared using electrocardiograph-gated single-photon emission
computed tomography.
Methods and results Twenty IHD and 30 OHD patient groups, comprised New York Heart Association functional class I–III (IHD1-3 and OHD1-3), and
15 controls were examined. The LV functions (ejection fraction, EF; peak-filling rate, PFR) and synchrony, which was estimated
from the time lag between the earliest and latest regional systolic or diastolic temporal parameters (maximum difference of
regional time to end-systole, MD-TES, or maximum difference of regional time to peak filling, MD-TPF), were compared. The
LV function correlated with its synchrony in IHD and OHD (EF vs. MD-TES: r = −0.86, P = 1.3 × 10−6 in IHD and r = −0.69, P = 2.8 × 10−5 in OHD. PFR versus MD-TPF: r = −0.67, P < 0.002 in IHD and r = −0.63, P < 0.0002 in OHD). Dyssynchronous normal EF was observed in three IHD (15%) and six OHD (20%). Dyssynchronous normal PFR was
observed in six IHD (30%) and six OHD (20%). MD-TES was significantly smaller in control group (CG) than in IHD3 and OHD3
(P < 0.005), and in IHD1 than in IHD3 and OHD3 (P < 0.05). MD-TPF was significantly smaller in CG than in IHD2, IHD3, and OHD3 (P < 0.05). However, there was no significant difference between LV synchrony in IHD and OHD, or among LV synchrony of the same
functional classes between these two groups.
Conclusions This study confirms that LV function is correlated with wall motion synchrony. No statistically significant difference was
confirmed in wall motion synchrony between IHD and OHD. However, dyssynchrony appears in the patients without apparent global
LV dysfunction. This feature may facilitate identification of synchronous disorder in HF patients with preserved global LV
function. It is expected that detection of such a disorder may lead to the initiation of appropriate treatments for early
stage HF and prevent its progression. 相似文献
18.
Lipiec P Wejner-Mik P Krzemińska-Pakuła M Kuśmierek J Płachcińska A Szumiński R Kapusta A Kasprzak JD 《Annals of nuclear medicine》2008,22(8):723-726
Objective Parameters of left ventricular systolic function directly influence the management of patients with suspected coronary artery
disease (CAD). Quantitative gated single-photon emission computed tomography (QGS; Cedars-Sinai Medical Center, Los Angeles,
CA, USA) allows the computation of left ventricular ejection fraction (LVEF) from myocardial perfusion imaging studies which
are frequently performed on patients with suspected CAD. Three-dimensional (3D) echocardiography is considered to be the echocardiographic
“gold standard” for the quantification of LVEF. We sought to compare QGS with 3D echocardiography in the evaluation of EF
in patients with suspected CAD.
Methods Ninety-one consecutive patients with suspected CAD, scheduled for coronary angiography, underwent rest electrocardiographic-gated
technetium-99m methoxyisobutylisonitrile SPECT (G-SPECT) with measurement of LVEF by QGS and transthoracic 3D echocardiography
with off-line measurement of LVEF (Tomtec 4D LV Analysis 1.1). The diagnosis of CAD was based on coronary angiography, performed
on every patient.
Results Nine patients were excluded from the analysis owing to unsuitability for 3D echocardiography (8 patients) or G-SPECT (1 patient).
In the remaining group of 82 patients, 71 (87%) had significant CAD, 34 (42%) had a history of myocardial infarction, and
50 (61%) had perfusion defects at rest G-SPECT images. The mean LVEF measured by QGS and 3D echocardiography was 53 ± 13%
and 53 ± 10%, respectively. The mean difference in LVEF between 3D echocardiography and QGS was 0.1 ± 6.0% (P = 0.87), and the correlation between the values obtained by both methods was high (r = 0.88, P < 0.001). The largest discrepancies were observed in patients with small ventricular volumes.
Conclusions In patients undergoing diagnostic work-up for CAD, the measurement of LVEF by QGS algorithm provides high correlation and
satisfactory agreement with the results of reference ultrasound method-3D echocardiography. 相似文献
19.
Gianmauro Sacchetti Eugenio Inglese Angelo S Bongo Franco Aina Marco Brambilla Alberto Baroli Carmelo Cernigliaro Pierfranco Dellavesa Edgardo Pittaluga Marco Rudoni 《European journal of nuclear medicine and molecular imaging》1997,24(10):1230-1236
The aim of this study was to determine the diagnostic accuracy of technetium-99m tetrofosmin myocardial imaging for the localization
of coronary artery stenoses of different degrees of severity. Stress-rest single-photon emission tomography (SPET) was performed
on separate days in 80 patients (64 males, 16 females; mean age 61 years; 43 patients with previous myocardial infarction;
18 patients with pharmacological stress), within 6 months of coronary angiography. Scintigraphic images were blindly and independently
evaluated by three observers. Coronary stenosis was defined as a >50% narrowing in luminal diameter; severe stenosis was defined
as a proximal stenosis of >75% or a peripheral stenosis of >90%. Coronary angiography revealed normal coronary arteries or
insignificant coronary stenosis in 13 patients and significant coronary stenoses in 67 patients. The sensitivity and specificity
of 99mTc-tetrofosmin SPET in respect of severely stenosed vessels were, respectively, 80% and 65% for the left anterior descending
artery (LAD), 100% and 46% for the right coronary artery (RCA) and 58 and 78% for the left circumflex artery (LCx) territories.
Considering all the significantly stenosed vessels, a significant decrease in sensitivity was observed for LAD territories
(to 59%, P=0.05), and a nonsignificant decrease for RCA (88%) and LCx (47%) territories while specificity values remained essentially
unchanged. No significant changes in sensitivity or specificity were observed when regions with previous myocardial infarction
were excluded. In conclusion, the sensitivity of 99mTc-tetrofosmin SPET for the localization of individual stenosed vessels is only moderate when all significant stenoses are
considered, but the ability of this technique to predict the location of severe coronary artery stenoses seems satisfactory,
with the exception of the low specificity in respect of RCA territories.
Received 26 April and in revised form 7 June 1997 相似文献
20.
Eldad Rechavia Alfredo R. Galassi Luis I. Araujo Peter Halson Adriaan A. Lammertsma Terry Jones John P. Lavender Attilio Maseri 《European journal of nuclear medicine and molecular imaging》1992,19(12):1044-1049
To relate technetium-99m 2-methoxy-isobutylisonitrile (99mTc-MIBI) uptake to regional myocardial blood flow (rMBF), 99mTc-MIBI single photon emission tomography (SPET) and H2
15O positron emission tomography (PET) scans were obtained at rest and after dipyridamole infusion in six patients with single vessel coronary artery disease. 99mTc-MIBI and H2
15O data sets were created for each segment perfused by the stenotic vessel and for a normal reference area, assigning regions on the SPET tomograms to comparable regions on the PET by similar transaxial image reconstructions. All patients demonstrated post-dipyridamole 99mTc-MIBI perfusion defects in the territories supplied by the stenotic arteries. Resting rMBF in these regions was slightly lower than that in the normal areas (0.82±0.05 vs 0.90±0.09 ml/g/min, P=NS). A 43%±14% reduction in 99mTc-MIBI activity in the area at risk was coupled with on average a 60%±9% reduction in post-dipyridamole rMBF compared with control regions (0.98±0.08 vs 2.52±0.51 ml/g/min, P<0.001). Thus, SPET assessment of 99mTc-MIBI uptake tends to underestimate the perfusion contrast between areas with normal and areas with low coronary vasodilatory reserve when compared to PET. However, these findings may still not affect the clinical usefulness of 99mTc-MIBI and more extensive studies are required to confirm these results in the clinical environment. 相似文献