The pre-existing T cell landscape determines the response to bispecific T cell engagers in multiple myeloma patients

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Taxanes trigger cancer cell killing in vivo by inducing non-canonical T cell cytotoxicity

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Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell,macrophage, and B cell function

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Systematic elucidation and pharmacological targeting of tumor-infiltrating regulatory T cell master regulators

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Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity

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Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation

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Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer

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Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses

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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

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A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity

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Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

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The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth

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Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

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Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells

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Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

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GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity

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CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

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Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy

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Phenotypic plasticity and reduced tissue retention of exhausted tumor-infiltrating T cells following neoadjuvant immunotherapy in head and neck cancer

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Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer

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