Primary Pericardial Mesothelioma: A Population-Based Propensity Score-Matched Analysis

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Pericardial Mesothelioma Presented as Constrictive Pericardial Disease

The aim of this report is to present a case of malignant mesothelioma of the pericardium and to illustrate points in diagnosis and treatment of this extremely rare disease. On admission to hospital there were signs of cardiac tamponade, which responded to peri-cardial drainage. The patient subsequently deteriorated and signs of constrictive pericarditis were demonstrated by right heart catheterization and angiography. Surgery was undertaken, but the patient died three hours after pericardectomy due to cardiac failure and multiple thromboembolism.

Pericardial mesotheliomas are rare, as are all primary tumours of the heart. The disease is seldom diagnosed antemortem. The aim of this report is to present one further case and discuss points in diagnosis and treatment.     

Primary Malignant Mesothelioma of the Greater Omentum: Report of a Case

We report a rare case of primary malignant mesothelioma of the greater omentum. To our knowledge, only one other such case has been described in the English literature. The patient was a 61-year-old Taiwanese woman without any history of exposure to asbestos, who presented with lower back pain. Abdominal sonography and computed tomography showed a 12 × 9 × 9-cm³ mass occupying the lower abdomen. Laparotomy revealed a tumor in the greater omentum, invading the posterior wall of the uterus, without diffuse mesenteric thickening or multiple small nodules in the peritoneum. We performed en bloc resection of the mass, which involved omentectomy, hysterectomy, and bilateral salpingo-oophorectomy. Microscopically, the tumor cells were arranged in a tubulopapillary pattern lined by a single layer of uniform, cuboidal cells. A pattern of sclerotic stroma with irregular glandular elements was also recognized. Immunohistochemically, the tumor cells showed strong positivity for calretinin. The final pathologic diagnosis was malignant mesothelioma. The patient did not receive chemotherapy or radiotherapy, and has remained in good health without any evidence of recurrence for almost 3 years since her operation.     

原发性心脏心包肿瘤及瘤样病变的外科治疗

为探讨原发性心脏心包肿瘤的发病率及其特征，并评估其治疗方法。病例均经胸部Ｘ线、超声心动图、ＣＴ、ＭＲＩ和心导管检查，并经病理学检查证实诊断。２４例行手术治疗病人中，良性肿瘤２０例术后存活至今，其中１５例术后随访５～１５年无复发；４例恶性肿瘤中３例行部分切除，１例仅做病理学检查，均于术后４个月内复发或转移死亡。作者认为，原发性心脏心包良性肿瘤采用手术治疗常可获得良好结果，恶性肿瘤早期手术结合放疗可延长病人生命。     

Laparoscopy and Primary Diffuse Malignant Peritoneal Mesothelioma: a Diagnostic Challenge

Primary diffuse malignant peritoneal mesothelioma is a rare malignancy with an estimated incidence of 200 to 400 new cases annually in the USA. We describe a case of diffuse malignant peritoneal mesothelioma arising in a 65-year old man who presented ascites of unknown origin. The importance of laparoscopy with subsequent histology of biopsy specimens in the diagnosis of this disease is emphasized. Because of his poor general condition, the patient had no further treatment. Update of treatment is briefly described with particular attention to multimodality approach.     

Editorial Commentary: Simulation-Based Training in Orthopaedic Surgery: Current Evidence and Limitations

Simulation-based training has been widely adopted by surgical educators and is now an essential component of the modern resident’s skills acquisition pathway and career progression. The challenges faced by residents because of lack of exposure as a result of working-time directives—and now the COVID-19 (coronavirus disease 2019) pandemic limiting nonurgent and elective operating—reinforce the need for evidence-based simulation training. Although a wide range of training platforms have been developed, very few have shown transfer of skills. Simulation is thought to enhance the initial phase of the procedural learning curve; however, this hypothesis is yet to be tested in a high-quality study. Nevertheless, in light of the current evidence, simulation-based procedural curricula should be developed using the strengths of multiple different training platforms while incorporating the essential concept of nontechnical skills.     

Pericardial Window for Malignant Pericardial Effusion

Seventeen patients with malignant pericardial effusion were treated by the creation of a pericardial window. This was done through a subxiphoid approach in 13 patients and through limited anterior thoracotomy or sternotomy incisions in 4.There were no deaths and no major complications attributable to the operation. In all patients, relief of the cardiac compression caused by the effusion was immediate and complete. No patient showed a clinically significant recurrence of the effusion, although 1 patient who had received irradiation required pericardiectomy for constriction 5 months later.Survival was determined principally by the extent of the primary malignancy. Six patients died of the primary tumors within 30 days, but 6 survived 3 to 12 months and 2 are alive at 8 and 21 months.It is concluded that creation of a pericardial window, preferably by the subxiphoid approach, is the treatment of choice for malignant pericardial effusion. The procedure provides an accurate diagnosis, carries virtually no mortality or morbidity, and affords immediate and long-lasting relief of cardiac compression.     

Primary Malignant Peritoneal Mesothelioma in an Incarcerated Groin Hernia: Report of a Case

Malignant peritoneal mesothelioma arising from the inguinal hernia sac is rare. We report the case of a 71-year-old man examined in our emergency department for a bilateral inguinoscrotal hernia, which was recurrent in the right groin, and primary and incarcerated in the left groin. An emergency exploratory operation revealed a firm mass, 10cm in diameter, in the left inguinal hernia sac. The remaining peritoneal surface appeared macroscopically normal. Therefore, we resected the mass and performed a Rutkow hernioplasty. The patient was discharged after a short, uneventful recovery, and was referred to the oncology department for adjuvant therapy. He is now well and asymptomatic with no evidence of ascites, 26 months after his operation. A mesothelioma of the hernial sac peritoneum was the final histological diagnosis.     

Editorial Commentary: Indications for Lateral Extra-Articular Tenodesis in Primary Anterior Cruciate Ligament Reconstruction

Lateral extra-articular tenodesis and other anterolateral procedures improve patient outcomes when combined with anterior cruciate ligament reconstruction. Failure rates are >50% lower in young patients at high risk of reinjury. We defined patients at high risk as those aged 14 to 25 years with 2 or more factors of the following criteria: 1) returning to contact pivoting sport, 2) high-grade anterolateral rotatory laxity, as measured by pivot shift test (grade 2 or higher), and 3) generalized ligamentous laxity (Beighton score greater than 4) or knee hyperextension recurvatum of greater than 10°. Other indications may include Segond fracture, chronic anterior cruciate ligament lesion, radiographic lateral femoral notch sign, and lateral coronal plane laxity. A clearer understanding of indications determined by a comprehensive clinical assessment and risk stratification is needed. As indications continue to be “stretched,” we need to better understand the role of lateral extra-articular tenodesis and when to employ it in our practice.     

Editorial Commentary: Proper Indications for Primary Labral Resection and Reconstruction Versus Primary Labral Repair Remain Vague and Undefined

Primary labral reconstruction for complex hip pathologies has shown outcomes and complication rates similar to those of labral repair. As surgeons become more proficient and versatile in their hip arthroscopy techniques, we are seeing increasing feedback supporting reconstructions in the primary setting. Patients with severe pincer impingement, hypotrophic labrums, labral ossification, or irreparable degenerative tearing demonstrate notable improvement and satisfaction after primary labral reconstruction. However, there still is benefit to retaining native labral tissue when feasible. Biomechanical studies show loss of suction seal and increased contact pressures with labral reconstructions versus repairs. Although primary labral reconstruction is a necessary skill and treatment option particularly for the complex hip, the pendulum may be starting to swing too far away from repairs or augmentations. Proper indications for primary labral reconstruction continue to evolve and are not yet black and white in the literature. Regardless, surgeons may rest assured that patients are demonstrating appropriate improvement and safety with either preferred surgical option.     

Editorial Commentary: Big Data and Machine Learning in Medicine

Recent research using machine learning and data mining to determine predictors of prolonged opioid use after arthroscopic surgery showed that Artificial Neural Networks showed superior discrimination and calibration. Other machine learning algorithms, such as Naïve Bayes, XG Boost, Gradient Boosting Model, Random Forest, and Elastic Net, were also reliable despite slightly lower Brier scores and mean areas under the curve. Machine learning and data mining have limitations, however, and outputs are reliant on large sample sizes and the accuracy of big data. Poor-quality data and the lack of confounding variables are further limitations. There is no doubt that predictive modeling, artificial intelligence, machine learning, and data mining will become a major component of the physician’s practice, and doctors of medicine and related researchers should become familiar with these techniques. Physicians require an understanding of data science for the following reasons: monitoring of large databases could allow early diagnosis of pathologic conditions in individual patients; multiparameter data can be used to assist in the development of care pathways; data visualization could help with interpretation of medical images; understanding artificial intelligence workflow and machine learning will help us with understanding early warning signs of disease; and data science will facilitate personalized medicine with which clinicians can predict treatment outcomes.     

Treatment of Primary Peritoneal Mesothelioma by Continuous Hyperthermic Peritoneal Perfusion (CHPP)

Background: Primary peritoneal mesothelioma is a locally aggressive disease that is difficult to treat or even palliate. Continuous hyperthermic peritoneal perfusion (CHPP) with cisplatin (CDDP) allows uniform, high regional delivery of chemotherapeutics and hyperthermia to the peritoneal surface for the treatment of peritoneal tumors. This article summarizes the results of 18 patients with peritoneal mesothelioma treated with CHPP.Methods: From June 1993 through April 1998, 18 patients with primary peritoneal mesothelioma (13 male, 5 female; median age, 51 years) underwent surgical exploration and tumor debulking followed by a 90-minute CHPP with CDDP and hyperthermia as part of three consecutive phase I trials conducted at the National Cancer Institute. Seventeen of 18 patients had malignant peritoneal mesothelioma, 13 with associated ascites. One patient had a symptomatic, multiply recurrent, benign, cystic peritoneal mesothelioma. Three patients who had a recurrence after a prolonged progression-free interval (>6 months) after CHPP underwent re-treatment. CHPP parameters included median cisplatin dose of 530 mg (range, 187–816), perfusate volume 6.0 liter (range, 4–9), flow 1.5 liter/min (range, 1–2), intraperitoneal temperature 41°C (range, 38.7–43.2), and central temperature 38.6°C (range, 36.8–39.7).Results: Median follow-up after CHPP is 19 months (range, 2–56) with no operative or treatment-related mortality. Overall operative morbidity was 24% and included two patients with superficial wound infection and one patient each with atrial fibrillation, pancreatitis, fascial dehiscence, ileus, line sepsis, and clostridium difficile colitis. The major treatment-related toxicity was systemic renal toxicity at doses above what was defined as the maximum tolerated dose of cisplatin. Nine of 10 patients had resolution of their ascites postoperatively. Three patients who developed recurrent ascites (27, 22, and 10 months after initial treatment) were re-treated and had resolution of their ascites with ongoing responses at 24, 6, and 4 months after the second perfusion. The median progression-free survival was 26 months, and the overall 2-year survival was 80%. The median overall survival has not been reached.Conclusions: CHPP with cisplatin can be performed safely with no mortality and minimal morbidity. In selected patients, successful palliation in the abdomen and long-term survival, compared with historical controls, can be achieved with aggressive surgical debulking and CHPP. Re-treatment after initial response can result in a second long-term response.     

Pericardial flap aortopexy for tracheomalacia

Tracheomalacia is frequently associated with esophageal atresia and vascular compression of the thoracic viscera. Suture aortopexy, as first described by Gross, has become the most commonly used surgical procedure for alleviating the symptoms of tracheomalacia. External stenting, implantation of cartilage graft, and tracheal resection have been tried in severe cases not amenable to aortopexy. A standard aortopexy was attempted in an infant who had undergone division of the posterior portion of a double aortic arch. Because of very tight posterior attachments of the mediastinal structures, the aortic arch could not be brought up to the sternum without undue tension. A 3 x 2 cm flap of pericardium was formed, based at the aortic root. The free end was then sutured to the undersurface of the sternum, thereby pulling the aorta toward the sternum under gentle, controlled tension. The patient was easily extubated and has remained symptom free. Pericardial flap aortopexy is a relatively simple procedure with minimal risk to the aorta or trachea. It may be the preferred initial procedure in the surgical management of tracheomalacia.     

Pericardial substitutes: a survey

Many thoracic surgeons have used pericardial substitutes to reduce the risk of reoperation, but there have been few reports of these procedures. Therefore, we used a questionnaire to gather information on experience with use of pericardial substitutes and to document the findings at reoperation. A six-question survey was sent to 2,344 members of The Society of Thoracic Surgeons, requesting surgeons to list their experience with pericardial substitutes and at reoperation in patients with these substitutes in place. Of the 634 surgeons who responded to the survey, 120 reported the insertion of 3,828 pericardial substitutes. Two hundred thirty-six reoperations were reported by 89 surgeons. None of the pericardial substitutes was reported to be completely successful in facilitating reoperation. The experience with polytetrafluoroethylene (PTFE) pericardial substitutes was reported to be significantly more satisfactory than that with all other substitutes (p = 0.0004 by chi-square analysis), but 14% of surgeons who used PTFE said they were dissatisfied at reoperation. Based on the results of this survey, we suggest caution, careful documentation, and long-term follow-up studies before widespread use of pericardial substitutes can be recommended.