血管回声跟踪技术对冠心病患者动脉弹性与血管内皮舒张功能关系的研究

目的 探讨冠心病患者动脉弹性与血管内皮舒张功能的关系.方法 应用E-Tracking技术测量30例冠心病患者与34例正常对照组颈动脉硬化参数,包括压力应变弹性系数(Ep)、硬化度(β)和顺应性(AC),同时采用高分辨率血管超声法检测受试者肱动脉血流介导的内皮依赖性血管舒张功能(FMD),并进行相关分析.结果 冠心病组血流介导的肱动脉舒张反应明显低于对照组[(10.10±3.98)%与(16.32±2.42)%,P＜0.05];冠心病组Ep、β与正常对照组相比明显增高[(135.27±21.10)%与(111.67±29.53)%,P＜0.01]、[(10.18±1.26)%与(9.07±1.95)%,P＜0.01];但冠心病组的AC明显低于正常对照组[(0.56士0.14)%与(0.73士0.18)%,P＜0.05];内皮依赖性血管扩张(EDD%)与Ep、β负相关(r＝-0.634,P＜0.01;r＝-0.505,P＜0.01),与AC呈正相关(r＝0.668,P＜0.01).结论 冠心病患者肱动脉内皮依赖性血管舒张功能受损和动脉弹性降低,且两者之间有相关性,提示 E-Tracking 技术和FMD一样能够判断动脉功能异常,具有简便、快速、无创性、测量结果精确的优点.     

颈、股动脉内-中膜厚度及血管内皮舒张功能与冠心病的相关性

目的:探讨颈动脉、股动脉内-中膜厚度(IMT)及肱动脉流量介导的舒张功能(FMD)与冠心病的相关性.方法:经冠状动脉造影正常者29例(正常组),冠状动脉有病变者76例(冠心病组),利用高频超声检测颈动脉、股动脉IMT及肱动脉FMD.结果:单支病变组、多支病变组颈动脉、股动脉IMT明显高于正常组,肱动脉FMD则明显低于正常组(均P<0.01),单支病变组与多支病变组之间差异亦有统计学意义(P<0.01);冠状动脉病变积分(修正Gensini积分)与颈动脉、股动脉IMT呈明显正相关,与肱动脉FMD呈明显负相关(均P<0.000 1).结论:颈动脉、股动脉IMT及肱动脉FMD与冠心痛存在相关性,超声检测颈动脉、股动脉IMT及肱动脉FMD可为早期发现、治疗和预防冠心病提供依据.     

高分辨率超声技术对冠心病血管内皮功能的评价

目的采用高分辨率超声技术评估冠心病患者肱动脉内皮功能受损情况.方法通过选择性冠状动脉造影确定冠心病组患者28例,非冠心病组26例,在冠状动脉造影前后24h内进行肱动脉超声检查,比较反应性充血和含服硝酸甘油后肱动脉内径和血流变化,并对冠心病易患因素做比较.结果冠心病组较非冠心病组肱动脉血流介导的血管扩张反应(FMD)显著减低(4.17%±2.98%)vs(10.26%±8.41%),P=0.03,但两组含服硝酸甘油后血管内径无明显差异.两组的冠心病易患因子数(P=0.01)和吸烟(P=0.004)有显著性差异.结论应用高分辨率超声技术可非侵入性评价周围血管内皮功能,冠心病患者通常存在肱动脉FMD受损.此技术可作为一种无创性冠状动脉内皮功能检测方法.     

超声对2型糖尿病上下肢动脉内皮功能损伤的对比研究

目的 应用高频超声分别检测并比较2型糖尿病(2DM)患者肱动脉和腘动脉血流介导的内皮舒张功能(Flow-mediated vasodilation,FMD),为临床提供其内皮功能障碍的可靠依据.方法 对50例2DM患者和65例正常人,应用高频超声分别检测肱动脉和腘动脉基础内径、基础状态峰值流速、反应性充血后最大血管内径、峰值流速,分别计算FMD并进行比较.结果 (1)2DM组肱动脉及腘动脉FMD均明显小于正常对照组[(肱动脉:(4.03±1.12)% vs (8.90±2.02)%,P<0.01];腘动脉:[(3.64±1.30)% vs (5.91±1.05)%,P<0.01)];(2)2DM患者腘动脉FMD明显小于肱动脉FMD[(3.64±1.30)% vs (4.03±1.12)%,P<0.01)].结论 2DM时内皮依赖性血管舒张功能明显受损,尤以下肢FMD受损更明显.     

老年冠心病患者血管内皮功能、颈动脉内中膜厚度、冠状动脉钙化积分变化的研究

目的探讨老年冠心病患者的血管内皮功能、颈动脉内中膜厚度及斑块、冠状动脉钙化积分的变化及相互关系.方法对30例老年冠心病组,24例无冠心病老年对照组采用高分辨超声检测肱动脉基础动脉内径(D0)、内皮依赖性血流介导的舒张功能(FMD)、非内皮依赖性硝酸甘油介导的舒张功能(NID),颈动脉超声检测颈动脉内中膜厚度(IMTc)及斑块,螺旋CT检测各冠状动脉钙化积分(CS)及冠脉总钙化积分(TCS).结果冠心病组的FMD、NID低于对照组(P<0.001), D0两组差别无统计学意义(P>0.05);IMTc、CS及TCS明显高于对照组(P<0.01),颈动脉多发性硬斑发生率高于对照组(P<0.01).IMTc与CS、TCS呈正相关(P<0.01),IMTc、CS、TCS与FMD、NID呈负相关(P<0.01).结论老年冠心病患者存在较严重的血管内皮功能失调、颈动脉粥样硬化及冠状动脉钙化.肱动脉舒张功能、颈动脉内中膜厚度及斑块、冠状动脉钙化积分的测定对冠心病的预测和防治具有重要意义.     

超声评价孤立性心房颤动患者血管内皮功能

目的 探讨超声评价孤立性心房颤动(AF)患者血管内皮依赖性舒张功能的临床应用价值. 方法 应用超声多普勒技术测量32例孤立性AF患者(孤立性AF组)及25名健康志愿者(正常对照组)反应性充血及含服硝酸甘油后的肱动脉内径变化,计算百分变化率,并测量左心房容积.结果 孤立性AF组充血试验诱发的肱动脉内径百分变化率(FMD)与正常对照组相比明显减小[(6.14±2.03)% vs (16.50±5.00)%,P<0.01],两组受试者含服硝酸甘油后肱动脉内径百分变化率(NTG-MD)差异无统计学意义(P>0.05).孤立性AF组与正常对照组相比左心房容积明显增大[(45.85±13.72)ml vs (27.33±6.51)ml,P<0.01].孤立性AF患者FMD与左心房容积呈负相关(r=-0.62,P<0.01).结论 AF对血管内皮依赖性舒张功能有损伤作用,孤立性AF患者FMD与左心房构型有关.     

颈动脉内膜-中层厚度及血管内皮功能与2型糖尿病患者大血管病变相关性的研究

目的探讨颈动脉内膜-中层厚度(IMT)与肱动脉内皮依赖性舒张功能(EDD)在糖尿病大血管病变中的测定价值,颈动脉IMT与血流介导的肱动脉内径扩张值(FMD)的相关性及其与2型糖尿病大血管病变危险因素的关联.方法采用彩色多普勒超声检测63例2型糖尿病患者及32例健康人颈动脉IMT、肱动脉内皮依赖性舒张功能.采集心血管病变危险因素.结果糖尿病合并高血压病组颈动脉IMT值(0.98±0.09)、冠心病组颈动脉IMT值(1.12±0.13)高于新诊断糖尿病无并发症组(0.72±0.10,P<0.05);新诊断糖尿病无并发症组颈动脉IMT值又高于对照组,但差异无统计学意义;糖尿病组与正常对照组的肱动脉内径基础值间差异无统计学意义(P>0.05);反应性充血后肱动脉内径变化的百分率,糖尿病组明显低于正常对照组(F＝8.56,P<0.01).糖尿病组颈动脉IMT与反应性充血后肱动脉内径变化的百分率呈显著负相关(r=-0.358,P<0.01).结论 FDM值的降低发生于IMT增高前,新诊断糖尿病患者内皮依赖性舒张功能已下降,糖尿病患者易并发周围大血管粥样硬化性病变.     

高分辨超声技术评价冠心病患者血管内皮功能的临床研究

目的探讨冠心病患者血管内皮依赖性及非内皮依赖性舒张功能的变化。方法对30名冠心病患者和20名正常人采用高分辨超声技术测量反应性充血和含服硝酸甘油后肱动脉的内径变化,评价血流介导的肱动脉舒张功能和硝酸甘油介导的肱动脉舒张功能。结果冠心病患者组的血流介导的肱动脉舒张反应比(3.68±1.91%)和硝酸甘油介导的肱动脉舒张反应比(16.33±3.33%)与对照组比较(分别为6.37±3.59%和23.31±6.63%)显著低于对照组(P<0.01)。另外,线性回归分析结果显示:冠心病患者组的血流介导的肱动脉舒张功能与低密度脂蛋白、肱动脉基础直径呈负相关(r=-0.377,P<0.05;r=-0.422,P<0.05),硝酸甘油介导的肱动脉舒张反应与肱动脉基础直径呈负相关(r=-0.386,P<0.05)。结论冠心病患者血管内皮依赖性及非内皮依赖性舒张功能均受损,肱动脉超声法检测血管舒张功能可用于对冠心病患者内皮功能的评价。     

冠心病患者血管内皮功能与冠状动脉病变严重程度的关系

目的 探讨冠心病患者的血管内皮功能改变及其与冠状动脉病变严重程度的关系.方法 73例拟行冠状动脉造影术的患者,根据冠状动脉造影结果将其分为冠心病组39例和非冠心病组34例.13例健康、无冠心病危险因素者作为对照组.运用高频线阵超声测定肱动脉流量介导的血管扩张作用指标流量介导血管扩张比(FMD)及硝酸酯介导的血管扩张作用指标硝酸酯介导血管扩张比(NTG-MD),评估患者的血管内皮功能状况,以探讨血管内皮功能与冠状动脉狭窄间的关系.结果 冠心病组、非冠心病组和对照组的FMD分别为(4.81±2.33)%、(9.29±3.88)%和(13.58±1.80)%,3组间两两比较差异均有统计学意义(F值为48.012,P＜0.01);NTG-MD分别为(13.72±3.27)%、(15.64±2.65)%、(16.54±2.98)%,3组问差异有统计学意义(F值为6.015,P＜0.01),冠心病组与其余2组相比差异均有统计学意义(P均＜0.05).FMD与管径基础值、冠状动脉受累支数及冠状动脉最大狭窄程度呈负相关(r分别为-0.224、-0.316、-0.721,P分别为0.038、0.003和＜0.001).NTG-MD与管径基础值、冠状动脉受累支数及冠状动脉最大狭窄程度亦呈负相关(r分别为-0.483、-0.258、-0.372,P分别为＜0.001、0.027、0.001).多项逐步回归分析显示FMD与冠状动脉最大狭窄程度、管径基础值呈线性关系(r分别为-0.012、-0.022,P均＜0.001).NTG-MD与管径基础值及冠状动脉最大狭窄程度呈线性关系(r分别为-0.032、-0.0073.P均＜0.001).结论 冠心病患者内皮损害程度与冠状动脉狭窄严重程度之间呈线性相关.     

冠心病患者冠状动脉病变严重程度与内皮祖细胞及血管内皮功能的相关性分析

目的探讨冠心病患者循环血内皮祖细胞(EPCs)数量、血流介导的内皮依赖性血管舒张功能(FMD)的变化及其与冠状动脉病变严重程度的相关性。方法对159例患者根据冠状动脉造影结果,分为冠心病组(101例)及对照组(58例),采用流式细胞术检测所有入选者EPCs水平,并采用高分辨率血管超声法检测其肱动脉FMD。冠心病组依据SYNTAX积分进一步分为低危、中危和高危3个亚组,比较高危、中危、低危三组之间EPCs数量及FMD的差异及与冠状动脉病变程度的相关性。结果与对照组比较,冠心病组患者EPCs数量显著减少,肱动脉FMD亦明显减低(P<0.05),循环血EPCs数量与肱动脉FMD呈显著正相关趋势(r=0.41,P<0.01)。各亚组之间,低危组与高危组比较,EPCs数量水平及FMD有统计学差异(P<0.05),中危组与低危组、中危组与高危组之间比较,EPCs数量水平及FMD均无显著性差异(P>0.05)。EPCs数量及FMD均与冠状动脉造影SYNTAX评分呈负相关(r=-0.381,P<0.01;r=-0.317,P<0.01)。结论冠心病患者循环血EPCs数量较健康人群显著减少,血管内皮功能显著低下,且与冠状动脉病变严重程度呈负相关。     

Temporal heterogeneity of endothelium-dependent and -independent dilatation of brachial artery in patients with coronary artery disease

Background: Endothelial function is routinely assessed with high frequency ultrasound of the brachial artery. Fixed time points (1 post-occlusion and 3 post-nitrate) are commonly used to assess dynamic changes in brachial artery diameter. The underlying assumption is the lack of variability in temporal response to both endothelium-dependent and -independent stimuli. Objective: To evaluate the temporal course of endothelium-dependent (flow-mediated) and endothelium-independent (nitrate-induced) vasodilation of the brachial artery in patients with coronary artery disease (CAD) using high resolution (10 MHz) ultrasound. Methods: Thirty-seven patients with angiographically assessed CAD were prospectively enrolled in the study. End-diastolic, two-dimensional, long axis ultrasonographic images of the brachial artery were digitally stored on-line every 10 s, from baseline up to 4 during flow-mediated and up to 7 during 300 g sublingual nitrate-induced vasodilation of the brachial artery. Results: The mean percent endothelium-dependent flow-mediated maximal dilation (FMD) measured at 60 s was lower than the mean peak FMD (4.8 ± 4.1 vs. 6.6 ± 5.2%; p < 0.01). By 60 s only eight patients (35%) reached their maximum FMD response. The mean time to reach peak FMD was 87 ± 33 s. The mean time for the peak nitrate dilation was 291 ± 73 s. The peak nitrate-induced percent dilation was higher than that measured at 3 min (12.2 ± 6.7 vs. 5.4 ± 4.5%; p < 0.001). By 190 s, only four patients (11%) reached their maximum nitrate response. Conclusion: The routinely used measurement time points for evaluation of FMD and endothelium-independent vasodilation may not be adequate to detect the peak responses of individual patients with CAD.     

流量介导的肱动脉扩张和颈动脉内中膜厚度对冠心病患者发生心血管事件的预测作用

目的探讨流量介导的肱动脉扩张（FMD）和颈动脉内中膜厚度（IMT）能否预测冠心病患者心血管事件的发生。方法150例经冠状动脉造影明确患有冠心病的患者作为观察对象,分别测量每位患者的肱动脉FMD和颈动脉IMT,随访24个月,观察150例患者心血管事件的发生率,并比较心血管事件发生者与未发生者肱动脉FMD和颈动脉IMT的差别。结果150例患者中有21例在24个月的随访时间内发生心血管事件,未发生心血管事件者的肱动脉FMD较发生心血管事件者低,颈动脉IMT在未发生心血管事件者和发生心血管事件者中相差不显著（P〉0．05）。结论肱动脉FMD可以帮助预测冠心病患者心血管事件的发生。     

Reliability of ultrasonography in detecting flow mediated dilation

The reproducibility, interobserver and intraobserver variability of brachial artery flow-mediated dilation (FMD) has previously been reported. However, no study has compared the brachial artery FMD, detected by ultrasonography, simultaneously with reference imaging technique. The aim of this study was to assess the precision and accuracy of ultrasonography in detecting FMD compared to angiography. The study population consisted of 40 patients (13 females, mean age 56 ± 8 years) who underwent elective diagnostic coronary angiography. The ultrasonographic FMD (USFMD) measurements have been performed according to established standards with the subjects laying on the angiography table. Selective left brachial angiography was performed while ultrasonographic measurements of the brachial artery were obtained at baseline and during reactive hyperemia. To assess precision, USFMD was compared with angiographic FMD (AGFMD) by linear regression. The accuracy of the ultrasonographic measurement in comparison to the angiographic measurement was assessed by the Bland and Altman analysis. The mean ± SD of the testing USFMD and AGFMD measurements were 14.1 ± 7.3 and 14.7 ± 7.8%, respectively. Linear regression indicated a high correlation (r = 0.93, P < 0.0001) between ultrasonographic and angiographic measures, with a standard error of estimate of 2.7%. Agreement between measurements was reasonable (95% of limits of agreement, −5.481 to 4,674%). Ultrasonography seems to be reliable technique in detecting FMD.     

Impairment of flow mediated vasodilatation of brachial artery in patients with primary hyperparathyroidism

Background Hyperparathyroid condition might influence endothelial cells. The aim of this study was to assess flow mediated dilatation (FMD) in patients with primary hyperparathyroidism (PHPT). Methods We prospectively evaluated 21 patients with PHPT (9 women, 12 men; aged 50 ± 11 years, serum calcium 11.6 ± 0.7 mg/dl, intact parathyroid hormone (iPTH) 489 ± 495 pg/ml) and 27 healthy control subjects (13 women, 14 men; aged 49 ± 10 years, serum calcium 9.4 ± 0.5 mg/dl, iPTH 28 ± 8.5 pg/ml). Endothelial function, measured as FMD of the brachial artery using ultrasound, was calculated in two groups. To avoid confounding factors, conditions known to affect endothelial function like diabetes mellitus, hypertension, dyslipidemia, smoking, coronary and peripheral artery disease were excluded from both groups. Results FMD was lower in patients with PHPT than that in those without (10.2 ± 5.8 vs. 19.8 ± 5.8, P = 0.0001). FMD negatively correlated with serum calcium (r = −0.55, P = 0.002). Conclusion Endothelium-dependent FMD may impair in patients with PHPT compared to controls. Endothelial dysfunction can contribute to the deleterious cardiovascular effects of PTH excess. Therapy to reduce or retard endothelial dysfunction in patients with PHPT may lead to decreased cardiovascular morbidity and mortality.     

血管回声跟踪技术评价冠心病患者颈动脉弹性与肱动脉内皮功能的相关性

目的探讨颈动脉弹性参数与肱动脉内皮功能的相关性。方法冠心病组、冠状动脉粥样硬化组、健康对照组各30例,回声跟踪技术检测颈动脉弹性参数：压力应变弹性系数（Ep）、硬化参数（β）、顺应性（AC）、脉搏波传导速度（PWVβ）和增大指数（AI）;肱动脉袖带加压检测血流介导的内皮依赖性血管舒张功能（FMD）。结果冠心病、冠状动脉粥样硬化患者Ep、β、PWVβ均较对照组增高,AC、FMD减低（P〈0．01）;所有受试者、冠心病组、冠状动脉粥样硬化组、对照组的FMD分别与Ep、β、PWVβ呈负相关,与AC呈正相关,与AI无相关性。结论颈动脉弹性各参数与肱动脉内皮功能呈高度相关,提示回声跟踪技术能早期、定量反映冠心病患者血管的改变,是评价血管内皮功能简便实用的方法。     

20-MHz Ultrasound for Measurements of Flow-Mediated Dilation and Shear Rate in the Radial Artery

A high-frequency scanning system consisting of a 20-MHz linear array transducer combined with a 20-MHz pulsed Doppler probe was introduced to evaluate the degree of radial artery flow-mediated dilation (FMD [%]) in two groups of patients after 5?min of controlled forearm ischemia followed by reactive hyperemia. In group I, comprising 27 healthy volunteers, FMD (mean?±?standard deviation) was 15.26?±?4.90% (95% confidence interval [CI]: 13.32%–17.20%); in group II, comprising 17 patients with chronic coronary artery disease, FMD was significantly less at 4.53?±?4.11% (95% CI: 2.42%–6.64%). Specifically, the ratio FMD/SR (mean?±?standard deviation), was equal to 5.36?×?10^?4?±?4.64?×?10^?4 (95% CI: 3.54?×?10^?4 to 7.18?×?10^?4) in group I and 1.38?×?10^?4?±?0.89?×?10^?4 (95% CI: 0.70?×?10^?4 to 2.06?×?10^?4) in group II. Statistically significant differences between the two groups were confirmed by a Wilcoxon–Mann–Whitney test for both FMD and FMD/SR (p?<0.01). Areas under receiver operating characteristic curves for FMD and FMD/SR were greater than 0.9. The results confirm the usefulness of the proposed measurements of radial artery FMD and SR in differentiation of normal patients from those with chronic coronary artery disease.     

冠心病患者颈动脉粥样硬化和肱动脉舒张功能的超声检测

目的探讨冠心病患者颈动脉粥样硬化情况和肱动脉内皮依赖性舒张功能的变化以及外周血管超声预测冠心病的临床价值。方法采用高分辨率超声测定132例受试者颈动脉内中膜厚度和斑块积分及肱动脉内皮依赖性舒张功能。结果冠心病组颈动脉内中膜厚度明显大于对照组[(0.87±0.16)mmvs(0.72±0.13)mm,P<0.01]。冠心病组斑块发生率明显高于对照组。冠心病多支病变组mIMTc较单支病变组明显增厚[(0.99±0.17)mmvs(0.85±0.15)mm,P<0.01],其斑块积分也较单支病变组高。在93例接受冠脉造影检查的患者中,有47例阳性的冠心病患者以mIMTc≥0.85mm预测冠心病的有无,其敏感性为72.3%,特异性为76.1%,总符合率74.2%(69/93)。冠心病患者肱动脉内皮依赖性舒张功能明显低于对照组[(6.21±1.92)%vs(9.04±3.03)%,P<0.01],132例受试者颈动脉内中膜厚度与肱动脉内皮依赖性舒张功能呈负相关,而在冠心病患者中两者无相关性。结论颈动脉粥样硬化程度可间接反映冠状动脉病变的程度。冠心病患者存在肱动脉内皮依赖性舒张功能的受损和颈动脉內中膜厚度的增厚。     

彩色多普勒超声评价肱动脉直径和血流介导的扩张反应与冠心病的关系

目的 采用彩色多普勒超声评价肱动脉直径和血流介导的扩张反应(FMD)与冠心病的关系。方法 随机入选因胸痛住院并行冠状动脉造影检查的患者45例，在冠状动脉造影前进行肱动脉超声检查，分别测量肱动脉直径和加压充血后肱动脉直径的变化，通过冠状动脉造影确定冠心病组患者22例，非冠心病组患者23例，分别比较结果。结果 冠心病组较非冠心病组休息时肱动脉直径差异有统计学意义，而FMD则差异无统计学意义。结论 利用超声测量肱动脉直径可以作为一种无创性诊断冠心病的方法。     

Endothelial function and hemodynamics in systemic sclerosis

Introduction: Systemic sclerosis (SSc) is characterized by the development of fibrosis of skin and internal organs that is associated with vascular damage. However, its related parameters have not been fully explored. The aim of this study was to investigate endothelial function in SSc and its relationship with systolic pulmonary artery pressure and systemic arterial compliance (SAC). Methods: We studied 14 SSc females (4 with diffuse and 10 with limited cutaneous form of the disease) and 14 healthy controls matched for age and for cardiovascular risk factors. Endothelium‐dependent dilation (i.e. flow‐mediated) and endothelium‐independent (i.e. nitroglycerin‐induced) dilation of the brachial artery were measured as the percentage of change from baseline (FMD and NMD, respectively). In patients with SSc, SAC, cardiac output (CO), systemic arterial resistance and pulmonary artery pressure were estimated using echocardiography Doppler. Results: Heart rate, brachial artery pressure and body mass index did not differ between patients with SSc and controls. Flow‐mediated vasodilation (FMD) and NMD were significantly decreased in patients with SSc (10·3 ± 8·6 versus 26·6 ± 7·4%, P<0·001; 24·2 ± 8·4 versus 33·3 ± 10·1%, P<0·001, respectively). Postischaemia reactive hyperaemia was lower in patients with SSc (275 ± 185 versus 618 ± 366%, P<0·001). FMD and nitrate‐mediated dilation (NMD) were associated with CO, but not with SAC; moreover, FMD correlated with pulmonary artery pressure and peripheral arterial resistance conversely to NMD. Conclusions: Endothelium function in SSc is impaired independently to SAC. Furthermore, the severity of both small artery and pulmonary artery involvement may impact on endothelium‐dependant function.     

应用彩色多普勒超声评价肱动脉血管内皮功能的研究

目的　探讨彩色多普勒超声(CDFI)评价肱动脉血管内皮功能的临床应用及其意义。方法　对30例原发性高胆固醇血症(PHC)患者给予辛伐他汀(SVT)治疗8周,用CDFI测定治疗前后反应性充血时和含服硝酸甘油后肱动脉内径的变化。结果　PHC患者SVT治疗前反应性充血时肱动脉内径的扩张程度为338%±548%,与正常对照组(1758%±64%)相比在统计学上有显著性差异(P<0001)。SVT治疗8周后反应性充血时肱动脉内径的扩张程度为1468%±505%,与治疗前相比明显改善(P<0001)。结论　应用CDFI可以准确、简便、有效地评价肱动脉血管内皮功能,对早期发现及评估动脉粥样硬化的发生等具有一定的临床价值。